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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | Possible involvement of Von Willebrand factorin pancreatic graft thrombosis after kidney-pancreas transoplantation:a retrospectivestudy显示文摘 | Kessler L Wiesel ML Boudjema K | 1998 | Clin Transplant1998，12，1： | 1 |
| 4 | The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，9： | 1 |
| 5 | The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions 显示文摘 | KESSLER L G BARNHART H X BUCKLER A J | 2014 | Stat Methods Med Res2014，24，1： | 1 |
| 6 | 显示文摘 | Kessler L Wiesel ML Attali P | 1998 | Diabetes Metab1998，24，4： | 1 |
| 7 | Lifetime cooecurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the national comorbidity survey 显示文摘 | Kessler R C Crum R M Warner L A | 1997 | Archives of General Psychiatry1997，54，： | 1 |
| 8 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 9 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Passive ventricular remodeling in cardiac disease: focus on heterogeneity显示文摘 | KESSLER E L BOULAKSIL M VAN RIJEN H V | 2014 | Front Physiol2014，5，5： | 1 |
| 11 | Possible involvement of von willebrand factor in pancreatic graft thrombosis after kidney - pancreas transplantation: a retrospective study显示文摘 | Kessler L Wiesel ML Boudjema K | 1998 | Clin Transplant1998，12，1： | 1 |
| 12 | Suitability of MDCK ceils grown in a serum-free medium for influenza virus production 显示文摘 | KESSLER N THOMAS-ROCHE G GERENTES L | 1999 | Dev Biol Stand1999，98，： | 1 |
| 13 | The prevalence and effects of a- dult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers 显示文摘 | Kessler RC Adler L Ames M | 2005 | J Occup Environ Med2005，47，6： | 1 |
| 14 | Von Willebrand factor in diabetic angiopathy显示文摘 | Kessler L Wiesel ML Attali P | 1998 | Diabetes Metab1998，24，4： | 1 |
| 15 | Expression of ACC oxidase genes differs among sex genotypes and sex phases in cucumber显示文摘 | Kahana A Silbemtein L Kessler N | 1999 | Plant Molecular Biol1999，41，4： | 1 |
| 16 | The natural history of calf vein thrombosis : lysis of thrombi and develop- ment of reflux 显示文摘 | Masuda E M Kessler D M Kistner R L | 1998 | J Vase Surg1998，28，1： | 1 |
| 17 | Fracture mechanisms of the Strombus gigas conch shell : implica-tions for the design of brittle laminates 显示文摘 | KUHN- SPEARING L T KESSLER H CHATEAU E | 1996 | Journal of MaterialsScience1996，31，24： | 1 |
| 18 | Species Richness-Productivity Relationships of Tropical Terrestrial Ferns at Regional and Local Scales显示文摘 | KESSLER M SALAZAR L HOMEIER J | 2014 | Journal of Ecology2014，102，6： | 1 |
| 19 | The Di- mensionality of Counterproductivity: Are All Counterproductive Behaviors Created Equal 显示文摘 | Spector P E Fox S Penney L M Bruursema K Goh A Kessler S | 2006 | Journal of Vocational Behavior2006，，03： | 1 |
| 20 | The prevalence and correlates of adult ADHD in the United States: results from the National Co- morbidity Survey Replication 显示文摘 | Kessler RC Adler L Barkley R | 2006 | Am J Psychiatry2006，163，4： | 1 |
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