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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Self-healing structural composite materials显示文摘 | Kessler M R Sottos N R White S R | 2003 | Composites Part A2003，34，： | 1 |
| 3 | Self-healing structural com- posite materials显示文摘 | Kessler M R Sottos N R White S R | 2003 | Composites Part A: applied science and manu- facturing2003，34，8： | 1 |
| 4 | Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma显示文摘 | Breslau N Kessler RC Chilcoat HD | 1998 | Arch Gen Psychiatry1998，55，7： | 1 |
| 5 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 6 | In situ poly- (urea- formaldehyde) microencapsulation of dicyclopentadiene 显示文摘 | Brown E N Kesslers M R Sottost N T | 2003 | Journal of Microencapsulation2003，20，6： | 1 |
| 7 | Suitability of MDCK ceils grown in a serum-free medium for influenza virus production 显示文摘 | KESSLER N THOMAS-ROCHE G GERENTES L | 1999 | Dev Biol Stand1999，98，： | 1 |
| 8 | Nerve-Sparing Radical Cystectomy and Orthotopic Bladder Replacement in Female Patients显示文摘 | Bhatta Dhar N Kessler TM Mills RD | 2007 | Eur Urol2007，52，4： | 1 |
| 9 | In situ poly (urea-formaldehyde) microencapsulation of dicyclopentadiene显示文摘 | Brown E N Kessler M R Sottos N R | 2003 | Journal of Microencapsulation2003，20，6： | 1 |
| 10 | Expression of ACC oxidase genes differs among sex genotypes and sex phases in cucumber显示文摘 | Kahana A Silbemtein L Kessler N | 1999 | Plant Molecular Biol1999，41，4： | 1 |
| 11 | Appendicitis:evaluation of sensitivity,specificity,and predictive values of US,Doppler US,and laboratory findings显示文摘 | Kessler N Cyteval C Gallix B | 2004 | Radiology2004，230，2： | 1 |
| 12 | Identification of environmental chemicals that induce yolk malabsorption in zebrafish using automated image segmentation 显示文摘 | KALASEKAR S M ZACHARIA E KESSLER N | 2015 | Reproductive Toxicology2015，55，： | 1 |
| 13 | Tonsillectomy versus partial tonsillectomy for OSAS in children, 10 years post-surgery follow-up 显示文摘 | Eviatar E Kessler A Shlamkovitch N | 2009 | Int J Pediatr Otorhinolaryngol2009，73，5： | 1 |
| 14 | The strror criterion in DSW-Ⅳposttraumatic stress disorder:an empirical investigation显示文摘 | Breslau N Kessler R C | 2001 | Biol Psychiatry2001，50，9： | 1 |
| 15 | Neuropilin-1 and neuropi- lin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor显示文摘 | Shraga-Heled N Kessler O Prahst C | 2007 | FASEB J2007，21，3： | 1 |
| 16 | A comparison of alpha and beta diversity patterns of ferns, bryophytes and macrolichens in tropical montane forests of southern Ecua- dor 显示文摘 | Mandl N Lehnert M Kessler M | 2010 | Biodiversity and Conservation2010，19，8： | 1 |
| 17 | Evaluation of the cyber glove as a whole-hand input device 显示文摘 | KESSLER D G HODGES L F WALKER N | 1995 | ACM Transactions on Computer-Human Interaction1995，2，4： | 1 |
| 18 | Helical CT of Large Bowel Obstruction显示文摘 | Taourel P Kessler N Lesnik A | 2003 | Abdom Imaging2003，28，2： | 1 |
| 19 | Dependence of ZnO : AI properties on the substrate to target position in RF sputtering显示文摘 | Couzinie-Devy F Barreau N Kessler J | 2008 | Thin Solid Films2008，516，20： | 1 |
| 20 | Guilt, an- ger, and pride about in-group environmental behav- iour: Different emotions predict distinct intentions 显示文摘 | HARTH N S LEACH C W KESSLER T | 2013 | Journal of Environmental Psychology2013，34，： | 1 |
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