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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | 儿童NTRK重排间叶源性肿瘤临床病理学观察显示文摘目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision法检测免疫组织化学表型,荧光原位杂交(FISH)检测相关基因并对NTRK基因重排进行克隆性分析。结果:该组5例患儿,3例男性,2例女性。年龄从3个月到13岁,部位包括软组织(膝、胸腔、腹壁)和肾,肿瘤大小为4.5~12.5 cm。组织学检查主要呈梭形细胞肿瘤,浸润性生长,可伴有炎性细胞。免疫表型上,肿瘤细胞阳性表达Pan-TRK,分子检测均存在NTRK基因重排,包括DCTN1-NTRK1的发现。除2例目前接受靶向药物治疗,其余均为无疾病进展病例,随访时间9~29个月。结论:NTRK重排间叶源性肿瘤,其肿瘤发生部位广泛,组织学图像多变。免疫组织化学Pan-TRK可以帮助诊断,NTRK基因检测确认其存在重排是诊断的金标准,对不能完整切除或有复发、转移病例建议靶向药物治疗。 | 殷敏智 马靖 何巧 沈萍 陈洁枫 金晓婷 张忠德 Chik Hong Kuick Chen Huiyi Eileen Hui Qi Ng Sze Jet Aw Kenneth Tou En Chang | 2020 | 中华病理学杂志2020，49，7： | 6 |
| 3 | 具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌临床病理学观察显示文摘目的:探讨具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌(ESC RCC)临床病理特征、免疫组织化学及分子遗传学特征和预后。方法:收集2017年至2018年2例ESC RCC临床资料,HE和免疫组织化学染色(EnVision)法进行形态学观察;荧光原位杂交检测TFE3、TFEB断裂重排基因;分子基因检测,PCR扩增,二代测序。结果:2例ESC RCC为男性,年龄分别9岁8个月和13岁,均发生在右肾。肿瘤大小5~7 cm,切面囊实性,灰红、灰白鱼肉样。显微镜下肿瘤具有纤维性包膜,肿瘤细胞突破胞膜。肿瘤细胞弥漫分布,圆形、多边性,胞质丰富,嗜伊红,可见大小不一的空泡,呈透明细胞样;部分区域类似乳头样结构,可见纤维轴心。细胞核圆形、泡状核,易见多核及巨核细胞,核分裂象未见;少量大小不一的囊样结构,囊壁可见单层瘤细胞被覆呈钉突样。间质见厚壁血管,灶状淋巴细胞浸润;较多嗜伊红坏死,可见钙化和胆固醇结晶。免疫组织化学阳性表达:PAX8(弥漫)、细胞角蛋白(CK)20、广谱细胞角蛋白(CKpan,局灶)、CD10(1例局灶/1例弥漫)、INI1、波形蛋白、CD68阳性,Ki-67阳性指数5%~10%。HMB45、S-100蛋白、Melan A、p53、结蛋白、TFE3、CK7、CK19、上皮细胞膜抗原(EMA)、CD56、嗜铬粒素A(CgA)、突触素、CD30、CD117、WT1、平滑肌肌动蛋白(SMA)阴性。分子遗传学检测:TFE3、TFEB断裂重排阴性。二代测序:例1,TSC2 p.Lys574Ter(0.198);例2,TSC2 p.Arg406Ter(0.355)。结论:ESC RCC儿童发病比较罕见,容易误诊,其具有独特的病理形态学特征、免疫表型和分子遗传学改变,预后较好。 | 杨文萍 Kenneth Tou En Chang 徐红艳 Chik Hong Kuick Eileen Hui Qi Ng 黄慧 熊枫 吴艳 曾松涛 樊金星 Xinyi Loh | 2020 | 中华病理学杂志2020，49，7： | 3 |
| 4 | Risk Factors and Prognostic Factors of Local Recurrence after Radiofrequency Ablation of Hepatocellular Carcinoma显示文摘 | Vincent Wai-To Lam Kelvin Kwok-Chai Ng Kenneth Siu-Ho Chok Tan-To Cheung Jimmy Yuen Helen Tung Wai-Kuen Tso Sheung-Tat Fan Ronnie T.P. Poon | 2008 | Journal of the American College of Surgeons2008，，1： | 2 |
| 5 | Plasma MMP-2, MMP-9 and N-BNP in Long-Term Survivors Following Complicated Myocardial Infarction: Relation to Cardiac Magnetic Resonance Imaging Measures of Left Ventricular Structure and Function显示文摘 | Stein Orn Cord Manhenke Iain B. Squire Leong Ng Inder Anand Kenneth Dickstein | 2007 | Journal of Cardiac Failure2007，，10： | 2 |
| 6 | Tradeoffs Among Free-Flow Speed, Capacity, Cost, and Environmental Footprint in Highway Design显示文摘 | Chen Feng Ng Kenneth A Small | 2012 | Transportation2012，39，6： | 1 |
| 7 | Usefulness of Atrioventricular Delay Optimization Using Doppler Assessment of Mitral Inflow in Patients Undergoing Cardiac Resynchronization Therapy显示文摘 | Navin Kedia Kenneth Ng Carolyn Apperson-Hansen Chaohui Wang Patrick Tchou Bruce L. Wilkoff Richard A. Grimm | 2006 | The American Journal of Cardiology2006，，6： | 1 |
| 8 | A Correlative Analysis of Actin Filament Assembly, Structure, and Dynamics显示文摘 | MICHEL OS KENNETH NG UELI A | 1997 | The Journal of Cell Biology1997，138，： | 1 |
| 9 | 在数据安全性和真实性方面符合21 CFR Part 11的要求显示文摘 | Kenneth Ng | 2007 | 毒理学杂志2007，21，4： | 1 |
| 10 | Usefulness of the microSeq 500 16S ribosomal DNA-based bacterial identification system for identification of clinically significant bacterial isolates with ambiguous biochemical profiles 显示文摘 | Woo Patrick C Y Ng Kenneth H L Lau Ausanna K P | 2003 | Journal of Clinical Microbiology2003，41，： | 1 |
| 11 | Plasma MMP-2, MMP-9 and N-BNP in Long-Term Survivors Following Complicated Myocardial Infarction: Relation to Cardiac Magnetic Resonance Imaging Measures of Left Ventricular Structure and Function显示文摘 | Stein Orn Cord Manhenke Iain B. Squire Leong Ng Inder Anand Kenneth Dickstein | 2007 | Journal of Cardiac Failure2007，，10： | 1 |
| 12 | Liver transplantation for hepatocellular carcinoma: the Hong Kong experience显示文摘 | Kelvin K. Ng Chung Mau Lo See Ching Chan Kenneth S. Chok Tan-To Cheung Sheung Tat Fan | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 13 | Impact of diabetes mellitus on survival in South East Asian patients with congestive heart failure due to left ventricular systolic dysfunction显示文摘 | Raymond Lee Siew-Pang Chan Jennifer Wong Diana Lau Kheng-Thye Ho Kenneth Ng | 2008 | International Journal of Cardiology2008，，1： | 1 |
| 14 | Continuing Professional Development for Middle Leaders in Primary Schools in Hong Kong显示文摘 | Ng S Kenneth Chan T | 2014 | Journal of Educational Administration2014，52，6： | 1 |
| 15 | Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide显示文摘 | Priscilla T.Y. Leung Yu Wang Sarah S.T. Mak W.C. Ng Kenneth M.Y. Leung | 2011 | Aquatic Toxicology2011，，1： | 1 |
| 16 | Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells显示文摘(CR2/CD21 ) 补充受体 2 主要在它形成部分地,工作调制 B 房间受体信号力量的 coreceptor 建筑群的部分的成熟 B 房间的表面上被表示。CR2/CD21 表示紧在整个 B 房间开发被调整以便 CR2/CD21 不能在 pre-B 上被检测或严重地区分了血浆房间。CR2/CD21 表示是在 B 房间成熟的 upregulated 并且能被表明小径的 IL-4 和 CD40 导致。我们以前在近似倡导者和涉及调整基础、织物特定的表示的 CR2/CD21 的第一 intron 描绘了元素。我们现在把这些分析递 CR2/CD21 核心倡导者。我们证明在成熟 B 房间, CR2/CD21 抄写从一个非一致 TATA 盒子,一个开始者元素和一个下游的倡导者元素调整的集中的 TSS 继续。而且,在 pre-B 对成熟 B 房间的一般 transcriptional 机械的占有排队与 CR2/CD21 表示水平相关并且显示可接近性必须切换从的那个倡导者对不活跃在过渡 B 房间窗户期间活跃。 | Rhonda L Taylor Mark N Cruickshank Mahdad Karimi Han Leng Ng Elizabeth Quail Kenneth M Kaufman John B Harley Lawrence J Abraham Betty P Tsao Susan A Boackle Daniela Ulgiati | 2016 | Cellular & Molecular Immunology2016，13，1： | 1 |
| 17 | N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment显示文摘 | Boon-Seng Soh Kristina Buac Huansheng Xu Edward Li Shi-Yan Ng Hao Wu Jolanta Chmielowiec Xin Jiang Lei Bu Ronald A Li Chad Cowan Kenneth R Chien | 2014 | Cell Research2014，24，12： | 0 |
| 18 | Hemorrhagic pancreatitis from fenofibrate and metformin toxicity:a case report显示文摘Fibrates have been used for over forty-odd years to manage dyslipidemia and are generally considered safe and well-tolerated.^([1])However,little is known about the toxicity offibrates in overdose,[2]and most of the knowledge about fibrate toxicity comes from extrapolated observations of adverse effects encountered at therapeutic doses instead. | Marcus Aik Beng Lee Mingwei Ng Paul Yugendra Yiju Yao R Ponampalam Boon Kiat Kenneth Tan | 2023 | World Journal of Emergency Medicine2023，14，6： | 0 |
| 19 | 慢即是快——紧凑道路设计思路显示文摘按照联邦州际高速公路系统设定的标准修建、扩容快速路耗资巨大,且对环境产生不利影响。然而由于交通拥堵,仅有少数出行者才能体验到快速驾驶的优势。探讨了道路设计的另一种思路——设计更紧凑的道路,或者说车道数更多但车道宽度更窄的道路。对比常规设计和紧凑设计两种思路下快速路车速、通行能力、行程时间指标,结果显示在高峰时段车辆排队严重时,紧凑设计具有较明显的优势。由于紧凑设计对道路安全性的影响尚未定论,建议设置更低的限速并采取措施禁止超速行为。最后指出,紧凑设计可增加道路通行能力以缓解交通拥堵,因此其适用范围得到扩展。 | Kenneth A.Small Chen Feng Ng 姜洋 解建华 Kenneth A. Small Chen Feng Ng 姜洋(译) 解建华(译) | 2013 | 城市交通2013，11，2： | 0 |
| 20 | A case of persistent refractory hypoglycemia from polysubstance recreational drug use显示文摘Dear editor,Studies have revealed a significant prevalence of mixed substance abuse,[1-3]and a focused approach towards polysubstance use has been emphasized.[4]Among recreational drugs,cases of hypoglycemia from ecstasy,[5]amphetamine,[6]eutylone,[7]and cannabinoid[8]use have been reported,but none of these cases have had persistent refractory hypoglycemia. | Jie Er Janice Soo Mingwei Ng Terence Kee Liem Chong Boon Kiat Kenneth Tan R Ponampalam | 2023 | World Journal of Emergency Medicine2023，14，1： | 0 |
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