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| 1 | On the Eve of Upgrading Antidepressants:(R)-Ketamine and Its Metabolites显示文摘Ketamine is a noncompetitive N-methyl-D-aspartate receptor(NMDAR)antagonist th has attracted widespread attention for its rapid-onset antidepressant effects,especially in individuals with treatment-resistant depression and suicidal ideation[1-3].Compared with the traditional antidepressants that take weeks,if not months,to benefit patients and are associated with a high rate of relapse,ketamine exerts its antidepressant effects | Kai Yuan Ying Han Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 2 | STAT3 associates with vacuolar H^+-ATPase and regulates cytosolic and lysosomal pH显示文摘 | Bin Liu Johan Palmfeldt Lin Lin Alexandria Colaco Knut K. B, Clemmensen Jinrong Huang Fengping Xu Xin Liu Kenji Maeda Yonglun Luo Marja Jaattela | 2018 | Cell Research2018，28，10： | 5 |
| 3 | Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant显示文摘Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide.Conventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hindered their ability to attain beneficial effects in depressed individuals at high risk of suicide.The non-competitive Nmethyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans.The emergence of ketamine as a fastacting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression.However,its safety and toxicity remain a concern.In this review,we focus on the limitations of ketamine,including neurotoxicity,cognitive dysfunction,adverse events associated with mental status,psychotomimetic effects,cardiovascular events,and uropathic effects.Studies have shown that its safety and tolerability profiles are generally good at low doses and with short-term treatment in depressed patients.The adverse events associated with ketamine usually occur with very high doses that are administered for prolonged periods of time and can be relieved by cessation.The antidepressant actions of its two enantiomers,S-ketamine(esketamine) and R-ketamine,are also discussed.R-ketamine has greater antidepressant actions than S-ketamine,without ketamine-related sideeffects.Future treatment strategies should consider using Rketamine for the treatment of depressed patients to decrease the risk of adverse events associated with long-term ketamine use. | Weili Zhu Zengbo Ding Yinan Zhang Jie Shi Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 4 | Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways显示文摘 | Tatsuya Yamasoba Frank R. Lin Shinichi Someya Akinori Kashio Takashi Sakamoto Kenji Kondo | 2013 | Hearing Research2013，，： | 2 |
| 5 | Nationwide epidemiological survey of chronic pancreatitis in Japan显示文摘 | Yingsong Lin Akiko Tamakoshi Seiki Matsuno Kazunori Takeda Tetsuo Hayakawa Motoji Kitagawa Satoru Naruse Takashi Kawamura Kenji Wakai Rie Aoki Masayo Kojima Yoshiyuki Ohno | 2000 | Journal of Gastroenterology2000，，2： | 2 |
| 6 | Mesomorphic behavior of new benzothiazole liquid crystals having Schiff base linker and terminal methyl group显示文摘heterocycles 的一个相应系列, 6-methyl-2-(4-alkoxybenzylidenamino ) benzothiazoles,被综合并且描绘了使用英尺红外, 1H 和 13C NMR 和集体度谱的分析。二形互变的 nematic 阶段为更矮的成员被观察。近晶的 A 阶段仅仅向前从 octyloxy 衍生物出现了。在 benzothiazole 碎片和 Schiff 基础连接的终端甲基组影响了现在的系列的具有由中胚叶发达的行为。 | Sie Tiong Ha Kok Leei Foo Hong Cheu Lin Masato M.Ito Kazuma Abe Kenji Kunbo S.Sreehari Sastry | 2012 | Chinese Chemical Letters2012，23，7： | 2 |
| 7 | Preparation and adsorption Properties of Poly (N - vinylformamideJacryloni- trile) Chelating Fiber for Heavy Metal Ions 显示文摘 | Hal Lin Mutsumi Kimura Kenji Hanabusa | 2002 | Journal of Applied Polymer Science2002，85，： | 1 |
| 8 | Purification and Characterization of Caprine Ghrelin and Its Effect on Growth Hormone Release显示文摘 | Takanori Ida Mikiya Miyazato Xing-Zi Lin Hiroyuki Kaiya Takahiro Sato Keiko Nakahara Noboru Murakami Kenji Kangawa Masayasu Kojima | 2010 | Journal of Molecular Neuroscience2010，，1： | 1 |
| 9 | Psychological attitudes and risk of breast cancer in Japan: a prospective study显示文摘 | Kenji Wakai Masayo Kojima Kazuko Nishio Sadao Suzuki Yoshimitsu Niwa Yingsong Lin Takaaki Kondo Hiroshi Yatsuya Koji Tamakoshi Akio Yamamoto Shinkan Tokudome Hideaki Toyoshima Akiko Tamakoshi | 2007 | Cancer Causes & Control2007，，3： | 1 |
| 10 | MPA第十届手机摄影大赛“剪影”组获奖作品显示文摘 | Liz Anderson John Nieto Piotr Benklewski Halu C Wai Ying Kwok Jason Greene Robin Robertis Petyr Campos Gordana Cavkoska Scott Fitzgerald Aqua Lin Luigi Di Gioia Mohmmad Mohsenifar Luis Rodriguez Mai McCann Roy Pan Anna Witkowska Kenji Lin Anders Andersson Samantha Degrassi Heather McAlister Mona Jumaan Jian Cui Vivian Jim Cara Gallardo Weil Dan Liu Benny Lau | 2022 | 数码摄影2022，，2： | 0 |
| 11 | 塑料晶体的庞压卡效应显示文摘制冷对现代社会至关重要,世界上25%到30%的电力用于制冷。例如,食品储存和空调的使用等都需要耗费大量的电力。目前的制冷技术主要还是以传统蒸汽压缩循环为主,但由于具有加剧全球变暖的潜力危险,人们一直尝试找到更好的替代方案。在这背景下,基于固态相变热效应的制冷技术作为一种很有前途的替代技术,在近几十年来一直是研究者们关注的重点。但是,由于其等温爛变化小,所需驱动动能大以及材料性能有限等种种劣势均限制了其应用推广。 | Bing Li Yukinobu Kawakita Seiko Ohira-Kawamura Takeshi Sugahara Hui Wang Jingfan Wang Yanna Chen Saori I.Kawaguchi Shogo Kawaguchi Koji Ohara Kuo Li Dehong Yu Richard Mole Takanori Hattori Tatsuya Kikuchi Shin-ichiro Yano Zhao Zhang Zhe Zhang Weijun Ren Shangchao Lin Osami Sakata Kenji Nakajima Zhidong Zhang 李巧红 | 2019 | 家电科技2019，0，3： | 0 |
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