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| 1 | Anti-apoptotic treatment in mouse models of age-related hearing loss显示文摘Age-related hearing loss(AHL),or presbycusis,is the most common neurodegenerative disorder and top communication deficit of the aged population.Genetic predisposition is one of the major factors in the development of AHL.Generally,AHL is associated with an age-dependent loss of sensory hair cells,spiral ganglion neurons and stria vascularis cells in the inner ear.Although the mechanisms leading to genetic hearing loss are not completely understood,caspase-family proteases function as important signals in the inner ear pathology.It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL.Here,we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment. | Fengchan Han Oumei Wang Quanxiang Cai | 2016 | Journal of Otology2016，11，1： | 4 |
| 2 | Klotho基因敲除小鼠听觉功能分析显示文摘目的探究Klotho基因对小鼠听觉功能的影响。方法 PCR鉴定WT和Klotho-/-CBA小鼠基因型,出生20天后记录个体形态学表型及体重指标,并进行ABR测试听觉功能。结果 klotho基因敲除小鼠基因组可检测到约900bp特征DNA片段,野生型小鼠特征条带为500bp,杂合子小鼠兼有两种特征片段;此外klotho基因敲除小鼠个体瘦小,且出生后25天时已出现ABR反射异常现象,表现为老年性聋。结论 Klotho蛋白与老年性聋存在一种潜在的制约性平衡关系,并在保护听觉功能方面扮演重要角色。 | 李瑶函 李蓓莹 郭小玮 赵青 朱青青 卞国强 袁娜 邱士伟 董艳粉 时晰 乔月华 | 2016 | 世界最新医学信息文摘2016，16，94： | 0 |
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