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| 1 | Reduced dose of Bacillus Calmette-Guérin versus full dose of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer after transurethral resection bladder tumor: a meta-analysis of randomized controlled trials显示文摘 | Qin Xin Wu Keming Xie Libo Zhao Sixiu Lu Yiping | 2014 | Chinese Medical Journal2014，，22： | 4 |
| 2 | Spatial heterogeneity of urban soils:the case of the Beijing metropolitan region,China显示文摘Introduction:Urban soils are large pools of carbon,nitrogen,and other elements,supporting plant growth,sustaining biogeochemical cycles,and serving as the foundation for maintaining ecosystem function and services of urban green spaces(UGS).Quantifying urban soil properties is essential for assessing urban ecosystem services and detecting pollution.Characterizing spatial heterogeneity of urban soil properties,which may change with land use or urbanization,is crucial for understanding urban ecosystem functions.Methods:We collected 466 soil composite samples across the Beijing metropolitan region and then analyzed the heterogeneity of soil properties in UGS of Beijing metropolitan region by ANOVA along the urbanization gradient spanning different land uses.Results:Our results show that soil properties vary considerably among land-use types and along the urban-rural gradient.Soil moisture content,soil organic carbon(SOC),available phosphorus,available potassium,total nitrogen(TN),the ratio of SOC:TN(C/N),Pb,and Cu increased notably from suburbs to the urban core,while soil pH,bulk density,TN,Cr,Ni,and Mn were not significantly different across urbanization levels.Most soil properties,except soil TN,Cu,Cr,Ni,exhibited significant differences between different land uses.The highest levels of soil nutrients and heavy metals were found in roadsides and residential areas among all the land uses.Conclusions:The spatial heterogeneity of urban soils in the Beijing metropolitan region is mainly attributable to the different land uses.Soil nutrient content has increased in UGS due to fertilization and pollution.Contamination of urban soils by heavy metals is due largely to traffic emissions and pollution by industrial and household wastes.Although human activities tend to augment urban soil nutrient pools to maximize certain ecosystem services,they may inadvertently compromise these and other services by increasing pollution.Knowledge of urban soil spatial heterogeneity in UGS is indispensable for improving urban ecosystem management. | Qizheng Mao Ganlin Huang Alexander Buyantuev Jianguo Wu Shanghua Luo Keming Ma | 2014 | Ecological Processes2014，3，1： | 2 |
| 3 | Prevenlence of infection among former commercial plasma donors in rural eastern China显示文摘 | Wu Zunyou Rou Keming Detels Roger | 2001 | Health Plocy and Planning2001，16，1： | 1 |
| 4 | Thermogravimetry-mass spectrometry on the pyrolysis process of Lyocell fibers with and without catalyst显示文摘 | Wu Qilin Pan Ning Deng Keming | 2008 | Carbohydrate Polymers2008，72，： | 1 |
| 5 | MXene-GaN van der Waals metal-semiconductor junctions for high performance multiple quantum well photodetectors显示文摘A MXene-GaN-MXene based multiple quantum well photodetector was prepared on patterned sapphire substrate by facile drop casting.The use of MXene electrodes improves the responsivity and reduces dark current,compared with traditional Metal-Semiconductor-Metal(MSM)photodetectors using Cr/Au electrodes.Dark current of the device using MXene-GaN van der Waals junctions is reduced by three orders of magnitude and its noise spectral intensity shows distinct improvement compared with the traditional Cr/Au–GaN–Cr/Au MSM photodetector.The improved device performance is attributed to low-defect MXene-GaN van der Waals interfaces.Thanks to the high quality MXene-GaN interfaces,it is possible to verify that the patterned substrate can locally improve both light extraction and photocurrent collection.The measured responsivity and specific detectivity reach as high as 64.6 A/W and 1.93×1012 Jones,respectively,making it a potential candidate for underwater optical detection and communication.The simple fabrication of MXene-GaN-MXene photodetectors spearheaded the way to high performance photodetection by combining the advantages of emerging 2D MXene materials with the conventional III-V materials. | Lingzhi Luo Yixuan Huang Keming Cheng Abdullah Alhassan Mahdi Alqahtani Libin Tang Zhiming Wang Jiang Wu | 2021 | Light(Science & Applications)2021，10，10： | 1 |
| 6 | SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus显示文摘 | Huihui Sun Yuehua Zhang Jianmin Liang Xiaoyan Liu Xiuwei Ma Husheng Wu Keming Xu Jiong Qin Yu Qi Xiru Wu | 2008 | Journal of Human Genetics2008，，8： | 1 |
| 7 | Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure显示文摘 | Yu Fu Zhengang Zhao Yeke Wu Keming Wu Xiaouan Xu Yue Liu Chongyi Tong | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
| 8 | A novel and efficient source-path discovery and maintenance method for application layer multicast显示文摘 | Jianqun Cui Naixue Xiong Jong Hyuk Park Keming Jia Libing Wu | 2012 | Computers and Electrical Engineering2012，，： | 1 |
| 9 | The HIV/AIDS epidemic in China:history,current strategies and future challenges显示文摘 | WU Zunyou ROU Keming CUI Haixia | 2004 | AIDS Edu Prey2004，16，3： | 1 |
| 10 | Preparation and Properties of Polyacrylamide/Sodium Alginate Hydrogel and the Effect of Fe^(3+)Adsorption on Its Mechanical Performance显示文摘The preparation and application of functional hydrogels based on natural polysaccharides have always been a hot research topic.In this study,using acrylamide(AM)monomer,N,N'-methylene bisacrylamide(MBA)as crosslinking agent,potassium persulfate(K2S2O8)as initiator,in the presence of natural polysaccharide sodium alginate(SA),the PAM/SA hydrogel was prepared by free radical polymerization.Fourier transform infrared spectroscopy(FT-IR),swelling performance tests,scanning electron microscope(SEM),thermogravimetric analysis(TGA),UV-visible spectrophotometer,mechanical property measurements were carried out to analyze the composition,morphology,and performance of the hydrogels.The swelling behavior,dye adsorption performance,and the mechanical properties of PAM/SA hydrogels before and after Fe^(3+)adsorption were studied.The experimental results showed that the introduction of SA with 4.7%,7.8%,and 10.3%effectively improved the mechanical and dye adsorption properties of PAM composite hydrogels.The adsorption capacity of PAM/4.7%SA and PAM/10.3%SA hydrogels at equilibrium can reach 40.01 and 44.02 mg/g for methylene blue,which is higher than the value 13.58 mg/g of pure PAM hydrogel.The compressive strength of pure PAM hydrogel is 0.124 MPa.When the SA content is 4.7%,7.8%,and 10.3%,the compressive strength of the PAM/SA hydrogel was corresponding to 0.130 MPa,0.134 MPa,and 0.152 MPa,respectively.Fe^(3+)was introduced into the PAM/SA hydrogels,and PAM/SA/Fe^(3+)double-network hydrogels with excellent mechanical properties could be prepared by adjusting the SA content(4.7%,7.8%,and 10.3%),soaking time(1 h,2 h,3 h,4 h,5 h,6 h),and Fe^(3+)concentration(4.76%,7.41%,9.09%,and 13.04%).Under the same Fe^(3+)concentration of 9.09%and adsorption time of 4 h,the compressive strengths of the PAM/4.7%SA,PAM/7.8%SA,and PAM/10.3%SA hydrogels could reach 0.354 MPa,0.767 MPa,and 0.778 MPa,respectively. | Zheng Cao Yang Zhang Keming Luo Yinqiu Wu Hongxin Gao Junfeng Cheng Chunlin Liu Guoliang Tao Qingbao Guan Lei Zhang | 2021 | Journal of Renewable Materials2021，9，8： | 1 |
| 11 | Important clinical features of atypical antipsychotics in acute bipolar depression that inform routine clinical care: a review of pivotal studies with number needed to treat显示文摘English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, 'bipolar depression/bipolar disorder', 'placebo',and 'trial'.The parameters of response(≥50%improvement on MADRS,Montgomery-Asberg Depression Rating Scale total score),remission(either ≤12 or 8 on MADRS total score at endpoint),discontinuation due to adverse events(DAEs),somnolence,≥7%weight gain,overall extrapyramidal side-effects(EPSs),and akathisia,were extracted from originally published primary outcome papers.The number needed to treat to benefit(NNT) for response and remission or harm(NNH) for DAEs or other side effects relative to placebo were estimated and presented with the estimate and 95%confidence interval.Olanzapine monotherapy,olanzapine-fluoxetine combination(OFC),quetiapine-IR monotherapy,quetiapine-XR monotherapy,lurasidone monotherapy,and lurasidone adjunctive therapy were superior to placebo with NNTs for responses of 11-12,4,7-8,4,4-5,and 7,and NNTs for remission of 11-12,4,5-11,7,6-7,and 6,respectively.There was no significant difference between OFC and lamotrigine,and between aripiprazole or ziprasidone and placebo in response and remission.Olanzapine monotherapy,quetiapine-IR,quetiapine-XR,aripiprazole,and ziprasidone 120-160 mg/day had significantly increased risk for DAEs with NNHs of 24,8-14,9,12,and 10,respectively.For somnolence,quetiapine-XR had the smallest NNH of 4.For ≥7%weight gain,olanzapine monotherapy and OFC had the smallest NNHs with both of 5.For akathisia,aripiprazole had the smallest NNH of 5.These findings suggest that among the FDA-approved agents including OFC,quetiapine-IR and-XR,lurasidone monotherapy and adjunctive therapy to a mood stabilizer,the differences in the NNTs for response and remission are small,but the differences in NNHs for DAEs and common side-effects are large.Therefore,the selection of an FDA-approved atypical antipsychotic for bipolar depression should be based upon safety and tolerability. | Keming Gao Chengmei Yuan Renrong Wu Jun Chen Zuowei Wang Yiru Fang Joseph R.Calabrese | 2015 | Neuroscience Bulletin2015，31，5： | 1 |
| 12 | Production and in vitro antioxidant activity of exopolysaccharide by a mutant, Cordyceps militaris SU5-08显示文摘 | Rongshan Lin Honghong Liu Suqian Wu Lifei Pang Mengshi Jia Keming Fan Shouhua Jia Le Jia | 2012 | International Journal of Biological Macromolecules (-)2012，，1： | 1 |
| 13 | Woody plant cell walls:Fundamentals and utilization显示文摘Cell walls in plants,particularly forest trees,are the major carbon sink of the terrestrial ecosystem.Chemical and biosynthetic features of plant cell walls were revealed early on,focusing mostly on herbaceous model species.Recent developments in genomics,transcriptomics,epigenomics,transgenesis,and associated analytical techniques are enabling novel insights into formation of woody cell walls.Here,we review multilevel regulation of cell wall biosynthesis in forest tree species.We highlight current approaches to engineering cell walls as potential feedstock for materials and energy and survey reported field tests of such engineered transgenic trees.We outline opportunities and challenges in future research to better understand cell type biogenesis for more efficient wood cell wall modification and utilization for biomaterials or for enhanced carbon capture and storage. | Wei Li Ying-Chung Jimmy Lin Ying-Lan Chen Chenguang Zhou Shuang Li Nette De Ridder Dyoni M.Oliveira Lanjun Zhange Baocai Zhang Jack P.Wang Changzheng Xu Xiaokang Fu Keming Luo Ai-Min Wu Taku Demura Meng-Zhu Lu Yihua Zhou Laigeng Li Toshiaki Umezawa Wout Boerjan Vincent L.Chiang | 2024 | Molecular Plant2024，17，1： | 0 |
| 14 | The internal efficiency in higher education:An analysis based on economies of scope显示文摘已有的关于中国高校效率的文献多集中于研究高校的规模(规模经济),更深层次的关于高校内部运行效率尤其是内部产出组合效率(范围经济)的研究寥寥无几。中国高校的教学和科研资源是否互补、本科生教育和研究生培养资源是否共享等重大问题缺少理论探讨和经验研究。在高等教育资源稀缺的现实背景下,研究高校范围经济对于实现中国高等教育内涵式发展意义重大。使用多产出成本函数,并利用教育部直属高校数据对中国高校的本科生教育、研究生培养和科研活动之间的资源互补状况进行的研究发现:中国高校提供这些产出时未充分共享资源,其中研究生的培养较为孤立,范围不经济程度较高;在考虑中国高校的教学和科研质量后,高校产出间的资源不共享程度更为加大。反思范围不经济的原因,主要在于中国高校的设备、师资、图书的条块分割和内部管理体制的交叉重叠,同时,现行的研究生培养方式导致了研究生培养的相对割裂。因此,有关部门在制定高等教育管理政策时应充分考虑到高校内部资源的共享和互补,还应重视学校的类型和办学地点对高校内部资源配置的影响。 | CHENG Gang WU Keming | 2008 | Frontiers of Education in China2008，3，1： | 0 |
| 15 | Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins显示文摘Background:Existing treatments for cholangiocarcinoma have poor efficacy.However,chimeric antigen receptor-T(CAR-T)cells are emerging as a potential therapeutic strategy.Solid tumors possess multiple adverse factors in an immunosuppressive microenvironment that impair CAR-T cell infiltration and function.This study aimed to improve the function of CAR-T cells through knock down immune checkpoints and immunosuppressive molecular receptors.Methods:We evaluated the expression of epidermal growth factor receptor(EGFR)and B7 homolog 3 protein(B7H3)antigens in cholangiocarcinoma tissues using immunohistochemistry and screened specific immune checkpoints in the cholangiocarcinoma microenvironment via flow cytometry.Subsequently,we engineered CAR-T cells targeting EGFR and B7H3 antigens.We simultaneously knocked down immune checkpoints and immunosuppressive molecular receptors in CAR-T cells by constructing two clusters of small hairpin RNAs and evaluated the engineered CAR-T cells for antitumor activity both in vitro,using tumor cell lines and cholangiocarcinoma organoid models,and in vivo,using humanized mouse models.Results:We observed high expression of EGFR and B7H3 antigens in cholangiocarcinoma tissues.EGFR-CAR-T and B7H3-CAR-T cells demonstrated specific anti-tumor activity.We found an abundance of programmed cell death protein 1(PD-1),T cell immunoglobulin and mucin domain-containing protein 3(Tim-3),and T cell immunoglobulin and ITIM domain(Tigit)on infiltrated CD8^(+)T cells in the cholangiocarcinoma microenvironment.We then decreased the expression of these 3 proteins on the surface of CAR-T cells,named PTG-scFV-CAR-T cells.Furthermore,we knocked-down the expression of transforming growth factor beta receptor(TGFβR),interleukin-10 receptor(IL-10R),and interleukin-6 receptor(IL-6R)of PTG-scFV-CAR-T cells.Those cells,named PTG-T16R-scFVCAR-T cells,potently killed tumor cells in vitro and promoted apoptosis of tumor cells in a cholangiocarcinoma organoidmodel.Finally,the PTG-T16R-scFv-CART cells showed greater inhibitory effect on tumor growth in vivo,and were superior in prolonging the survival of mice.Conclusions:Our results revealed that PTG-T16R-scFV-CAR-T cells with knockdown of sextuplet inhibitory molecules exhibited strong immunity against cholangiocarcinoma and long-term efficacy both in vitro and in vivo.This strategy provides an effective and personalized immune cell therapy against cholangiocarcinoma. | Yidan Qiao Jie Chen Xuemei Wang Shumei Yan Jizhou Tan Baijin Xia Yongjian Chen Keming Lin Fan Zou Bingfeng Liu Xin He Yiwen Zhang Xu Zhang Hui Zhang Xiangyuan Wu Lijuan Lu | 2023 | Cancer Communications2023，43，7： | 0 |
| 16 | Dynamics of Exciton Transport in Two-Dimensional Materials显示文摘In recent years,two-dimensional(2D)materials have attracted extensive interests due to the large exciton binding energy different from bulk materials.Many peculiar properties have been discovered that have farreaching perspectives in the next generation of optoelectronic devices.In this review,we introduce the forms of exciton existence in 2D materials and several promising 2D materials with good applications at first.Then,we summarize relevant contemporary tools for probing exciton dynamics and methods of regulating 2D exciton transport,for instance,electrical regulation,stress/surface wave regulation and moirépotential regulation,etc.Finally,we conclude the general development of regulation in 2D materials and propose several possible opportunities of application prospect. | Xia Yuexing Zhang Shuai Wu Keming Gong Yiyang Yue Shuai Liu Xinfeng | 2023 | 中国激光2023，50，1： | 0 |
| 17 | Advances in Synthesis and Application of Nanometer Drug Carriers显示文摘The main reason for the formation of nano-biotechnology is due to the penetration of nanotechnology in the biological fi eld, nanotechnology research center is the study of nano-drug carrier. Nano-drug system targeted drug delivery to achieve drug release, increase the insoluble drugs and peptide drug bio-effi ciency, reduce the toxicity and application of drugs and other aspects of the development of good prospects, and thus become one of the key research in recent years’ fi eld. Synthesis and application of nanometer drug carriers this review is presented in recent years and its application to provide a comprehensive basis for the treatment process. Describes the nature and preparation of nano-drug carrier methods, in recent years, people have been widely concerned by scholars. Compared with the nano-drug delivery, the general pharmaceutical cannot have to extend the role of drugs, strong effi cacy, and the advantages of small drug response. Nano-materials, the specific surface area, surface activity, high catalytic efficiency, surface active center, adsorption capacity and other characteristics, which has many excellent features and new features. | Jianping Wu Keming Wang Yuquan Peng | 2018 | Characterization and Application of Nanomaterials2018，1，1： | 0 |
| 18 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 19 | Human-robot interface based on sEMG envelope signal for the collaborative wearable robot显示文摘Surface electromyography(sEMG)control interface is a common method for human-centered robotics.Researchers have frequently improved the recognition accuracy of sEMG through multichannel or high-precision signal acquisition devices.However,this increases the cost and complexity of the control system.Therefore,this study developed a control interface based on the sEMG enveloped signal for a collaborative wearable robot to improve the accuracy of sEMG recognition based on the time-domain(TD)features.Specifically,an acquisition device is developed to obtain the sEMG envelope signal,and 11 types of TD features are extracted from the sEMG envelope signal acquired from the upper limb.Furthermore,a dimension reduction method based on the correlation coefficient is proposed,transforming the 11-dimensional feature into a five-dimensional envelope feature set without decreasing the accuracy.Moreover,a recognition algorithm based on a neural network has also been proposed for gesture classification.Finally,the recognition accuracy of the proposed method,principal component analysis(PCA)feature set,and Hudgins TD feature set is compared,with their accuracy at 84.39%,72.44%,and 70.89%,respectively.Therefore,the results indicate that the envelope feature set performs better than the common gesture recognition method based on signal channel sEMG envelope signal. | Ziyu Liao Bai Chen Dongming Bai Jiajun Xu Qian Zheng Keming Liu Hongtao Wu | 2023 | Biomimetic Intelligence & Robotics2023，3，1： | 0 |
| 20 | Strong in-plane optical anisotropy in 2D van der Waals antiferromagnet VOCl显示文摘Two-dimensional(2D)van der Waals(vdW)magnetic materials with strong in-plane anisotropy can make possible novel applications such as optospintronics and strain sensors.In this work,the strong in-plane optical anisotropy in 2D vdW antiferromagnet VOCl has been systematically investigated.The optical brightness and absorption coefficient exhibit evident periodic variation with the change of incident polarization,unveiling the strong in-plane anisotropic optical absorption.The Raman intensity in this material shows obvious dependence on the polarization angle of incident laser,demonstrating that the phonon properties possess strong in-plane anisotropy.Besides,we have also realized in-situ visualization of in-plane optical reflection anisotropy in this material.Moreover,the strong second harmonic generation(SHG)signal can only be detected when the incident polarization is along specific in-plane crystal orientations,illustrating the presence of strong in-plane nonlinear optical anisotropy.These findings will benefit the applications of VOCl in the field of polarization-dependent electronics and spintronics. | Tianle Zhang Jiantao Du Wenjun Wang Keming Wu Shuai Yue Xinfeng Liu Wanfu Shen Chunguang Hu Minghui Wu Zhe Qu Shengxue Yang Chengbao Jiang | 2023 | Nano Research2023，16，5： | 0 |
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