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| 1 | DISTRIBUTION AND CHARACTERIZATION OF POLYCYCLIC AROMATIC HYDROCARBON COMPOUNDS IN AIRBORNE PARTICULATES OF EAST ASIA显示文摘A review is presented on the distribution and characterization of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, including nitro-PAHs and hydro-PAHs, on atmospheric particulates of East Asia. Generally, PAH compounds with two or three aromatic rings are released mainly into the gas phase, while those containing three or more aromatic rings are associated with particulate matter (PM) emission. Particle-associated PAHs are primarily adsorbed on fine particles, and little associated with coarse particles. Investigation into the concentration level of PAHs in different areas can serve not only to reflect the pollutant status and sources but also to lead to the formulation of control strategies. The results of the present study show that China has more severe PAH pollution than such East Asian countries as Ja-pan and Korea. | Yan Liu Libin Liu Jin-Ming Lin Ning Tang Kazuichi Hayakawa | 2006 | China Particuology2006，4，6： | 14 |
| 2 | Comparison of machine learning methods for ground settlement prediction with different tunneling datasets显示文摘This study integrates different machine learning(ML) methods and 5-fold cross-validation(CV) method to estimate the ground maximal surface settlement(MSS) induced by tunneling.We further investigate the applicability of artificial intelligent(AI) based prediction through a comparative study of two tunnelling datasets with different sizes and features.Four different ML approaches,including support vector machine(SVM),random forest(RF),back-propagation neural network(BPNN),and deep neural network(DNN),are utilized.Two techniques,i.e.particle swarm optimization(PSO) and grid search(GS)methods,are adopted for hyperparameter optimization.To assess the reliability and efficiency of the predictions,three performance evaluation indicators,including the mean absolute error(MAE),root mean square error(RMSE),and Pearson correlation coefficient(R),are calculated.Our results indicate that proposed models can accurately and efficiently predict the settlement,while the RF model outperforms the other three methods on both datasets.The difference in model performance on two datasets(Datasets A and B) reveals the importance of data quality and quantity.Sensitivity analysis indicates that Dataset A is more significantly affected by geological conditions,while geometric characteristics play a more dominant role on Dataset B. | Libin Tang SeonHong Na | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 4 |
| 3 | Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs显示文摘Blastocyst complementation by pluripotent stem cell(PSC)injection is believed to be the most promising method to generate xenogeneic organs.However,ethical issues prevent the study of human chimeras in the late embryonic stage of development.Primate embryonic stem cells(ESCs),which have similar pluripotency to human ESCs,are a good model for studying interspecies chimerism and organ generation.However,whether primate ESCs can be used in xenogenous grafts remains unclear.In this study,we evaluated the chimeric ability of cynomolgus monkey(Macaca fascicularis)ESCs(cmESCs)in pigs,which are excellent hosts because of their many similarities to humans.We report an optimized culture medium that enhanced the anti-apoptotic ability of cmESCs and improved the development of chimeric embryos,in which domesticated cmESCs(D-ESCs)injected into pig blastocysts differentiated into cells of all three germ layers.In addition,we obtained two neonatal interspecies chimeras,in which we observed tissue-specific D-ESC differentiation.Taken together,the results demonstrate the capability of D-ESCs to integrate and differentiate into functional cells in a porcine model,with a chimeric ratio of 0.001-0.0001 in different neonate tissues.We believe this work will facilitate future developments in xenogeneic organogenesis,bringing us one step closer to producing tissue-specific functional cells and organs in a large animal model through interspecies blastocyst complementation. | Rui Fu Dawei Yu Jilong Ren Chongyang Li Jing Wang Guihai Feng Xuepeng Wang Haifeng Wan Tianda Li Libin Wang Ying Zhang Tang Hai Wei Li Qi Zhou | 2020 | Protein & Cell2020，11，2： | 4 |
| 4 | Scanning for signatures of geographically restricted selection based on population genomics analysis显示文摘Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection. | DENG LiBin TANG XiaoLi KANG Jian WANG QingYun ZENG ChangQing | 2007 | Chinese Science Bulletin2007，52，19： | 3 |
| 5 | MXene-GaN van der Waals metal-semiconductor junctions for high performance multiple quantum well photodetectors显示文摘A MXene-GaN-MXene based multiple quantum well photodetector was prepared on patterned sapphire substrate by facile drop casting.The use of MXene electrodes improves the responsivity and reduces dark current,compared with traditional Metal-Semiconductor-Metal(MSM)photodetectors using Cr/Au electrodes.Dark current of the device using MXene-GaN van der Waals junctions is reduced by three orders of magnitude and its noise spectral intensity shows distinct improvement compared with the traditional Cr/Au–GaN–Cr/Au MSM photodetector.The improved device performance is attributed to low-defect MXene-GaN van der Waals interfaces.Thanks to the high quality MXene-GaN interfaces,it is possible to verify that the patterned substrate can locally improve both light extraction and photocurrent collection.The measured responsivity and specific detectivity reach as high as 64.6 A/W and 1.93×1012 Jones,respectively,making it a potential candidate for underwater optical detection and communication.The simple fabrication of MXene-GaN-MXene photodetectors spearheaded the way to high performance photodetection by combining the advantages of emerging 2D MXene materials with the conventional III-V materials. | Lingzhi Luo Yixuan Huang Keming Cheng Abdullah Alhassan Mahdi Alqahtani Libin Tang Zhiming Wang Jiang Wu | 2021 | Light(Science & Applications)2021，10，10： | 1 |
| 6 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 7 | Solution-processed,flexible and broadband photodetector based on CsPbBr_(3)/PbSe quantum dot heterostructures显示文摘Due to their promising applications in foldable displays,optical communication equipment and environmental monitoring systems,flexible and broadband optoelectronic devices have gained extensive attention in recent years.Here,a flexible and broadband photodetector based on CsPbBr_(3)/PbSe quantum dot(QD) heterostructures is firstly presented.The integrated QD heterostructures possess consecutive detection range from ultraviolet(UV) to long-wave length infrared(LW-IR) regions with efficient light absorption and chemical stability,in comparison with the pristine PbSe QDs.Systematic material characterizations reveal the improved exciton dissociation,carrier transport and carrier lifetime of the QD heterostructures.Flexible photodetector Ag/CsPbBr_(3)/PbSe/Ag demonstrate a high responsivity of 7.17 A/W with a specific detectivity of 8.97 × 10^(12) Jones under 25 μW/cm^(2) 365 nm illumination at 5 V.Furthermore,it could maintain 91.2 %(or 94.9 %) of its initial performance even after bending for thousands of times(or exposing in ambient air for 4 weeks).More importantly,its re s ponse time is shortened more than three orders of magnitude as that of pristine PbSe QDs-based photodetectors.Therefore,it provides a feasible and promising method for the next-generation high-performance broadband photodetectors via constructing heterostructures of various QDs. | Jinming Hu Shengyi Yang Zhenheng Zhang Hailong Li Chandrasekar Perumal Veeramalai Muhammad Sulaman Muhammad Imran Saleem Yi Tang Yurong Jiang Libin Tang Bingsuo Zou | 2021 | Journal of Materials Science & Technology2021，，9： | 1 |
| 8 | Probabilistic stability analysis of Bazimen landslide with monitored rainfall data and water level fluctuations in Three Gorges Reservoir, China显示文摘Landslide is a common geological hazard in reservoir areas and may cause great damage to local residents’life and property.It is widely accepted that rainfall and periodic variation of water level are the two main factors triggering reservoir landslides.In this study,the Bazimen landslide located in the Three Gorges Reservoir(TGR)was back-analyzed as a case study.Based on the statistical features of the last 3-year monitored data and field instrumentations,the landslide susceptibility in an annual cycle and four representative periods was investigated via the deterministic and probabilistic analysis,respectively.The results indicate that the fluctuation of the reservoir water level plays a pivotal role in inducing slope failures,for the minimum stability coefficient occurs at the rapid decline period of water level.The probabilistic analysis results reveal that the initial sliding surface is the most important area influencing the occurrence of landslide,compared with other parts in the landslide.The seepage calculations from probabilistic analysis imply that rainfall is a relatively inferior factor affecting slope stability.This study aims to provide preliminary guidance on risk management and early warning in the TGR area. | Wengang ZHANG Libin TANG Hongrui LI Lin WANG Longfei CHENG Tingqiang ZHOU Xiang CHEN | 2020 | Frontiers of Structural and Civil Engineering2020，14，5： | 1 |
| 9 | Degradation of methyl orange through synergistic effect of zirconia nanotubes and ultrasonic wave显示文摘 | Jianling Zhao Xixin Wang Libin Zhang Xiaorui Hou Ying Li Chengchun Tang | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 10 | Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity显示文摘 | Guoyue Yuan Libin Zhou Jinfeng Tang Ying Yang Weiqiong Gu Fengying Li Jie Hong Yanyun Gu Xiaoying Li Guang Ning Mingdao Chen | 2005 | Diabetes Research and Clinical Practice2005，，3： | 1 |
| 11 | CsPbI nanorods as the interfacial layer for high-performance,all-solution-processed self-powered photodetectors显示文摘Heterojunction is regarded as a crucial step toward realizing high-performance devices,particularly,forming gradient energy band between heterojunctions benefits self-powered photodetectors.Therefore,in this paper,the synthesis of CsPbI3 nanorods(NRs)and its application as the interfacial layer in high-performance,all-solution-processed self-powered photodetectors are presented.For the bilayer photodetector ITO/ZnO(100 nm)/PbS-TBAI(150 nm)/Au,a responsivity of 3.6 A/W with a specific detectivity of 9.8×10^(12)Jones was obtained under 0.1 mW/cm^(2)white light illumination at zero bias(i.e.in self-powered mode).Meanwhile,the photocurrent was enhanced to an On/Off current ratio of 105 at zero bias with an open circuit voltage of 0.53 V for trilayer photodetector ITO/ZnO(100 nm)/PbSTBAI(150 nm)/CsPbI3(250 nm)/Au,in which the CsPbI3 NRs layer works as the interfacial layer.As a result,a specific detectivity of 4.5×10^(13)Jones with a responsivity of 11.12 A/W was obtained under0.1 mW/cm^(2) white light illumination,as well as the rising/decaying time of 0.57 s/0.41 s with excellent stability and reproducibility upto four weeks in air.The enhanced-performance is ascribed to the mismatch bandgap between PbS-TBAI/CsPbI_(3)interface,which can suppress the carrier recombination and provide efficient transport passages for charge carriers.Thus,it provides a feasible and efficient method for high-performance photodetectors. | Muhammad Imran Saleem Shangyi Yang Attia Batool Muhammad Sulaman Chandrasekar Perumal Veeramalai Yurong Jiang Yi Tang Yanyan Cui Libin Tang Bingsuo Zou | 2021 | Journal of Materials Science & Technology2021，，16： | 1 |
| 12 | In- fluence of halide ions on inhibitive performance of cetyl trimethyl ammonium bromide in various concen- trations of phosphoric acid for cold rolled steel 显示文摘 | Xueming Li Libin Tang Hongcheng Liu | 2008 | corrosion science2008，62，15： | 1 |
| 13 | Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy显示文摘Population genomic approaches, which take advantages of high-throughput genotyping, are powerful yet costly methods to scan for selective sweeps. DNA-pooling strategies have been widely used for association studies because it is a cost-effective alternative to large-scale individual genotyping. Here, we performed an SNP-MaP (single nucleotide polymorphism microarrays and pooling) analysis using samples from Eurasia to evaluate the efficiency of pooling strategy in genome-wide scans for selection. By conducting simulations of allelotype data, we first demonstrated that the boxplot with average heterozygosity (HET) is a promising method to detect strong selective sweeps with a moderate level of pooling error. Based on this, we used a sliding window analysis of HET to detect the large contiguous regions (LCRs) putatively under selective sweeps from Eurasia datasets. This survey identified 63 LCRs in a European population. These signals were further supported by the integrated haplotype score (iHS) test using HapMap II data. We also confirmed the European-specific signatures of positive selection from several previously identified genes (KEL, TRPV5, TRPV6, EPHB6). In summary, our results not only revealed the high credibility of SNP-MaP strategy in scanning for selective sweeps, but also provided an insight into the population differentiation. | Libin Deng Xiaoli Tang Wei Chen Jiari Lin Zhiqing Lai Zuoqi Liu Dake Zhang | 2010 | Genomics, Proteomics & Bioinformatics2010，8，4： | 0 |
| 14 | Gene2DGE: A Perl Package for Gene Model Renewal with Digital Gene Expression Data显示文摘For transcriptome analysis, it is critical to precisely define all the transcripts across the whole genome. More and more digital gene expression (DGE) scannings have indicated the presence of huge amount of novel transcripts in addition to the known gene models. However, almost all these studies still depend crucially on existing annotation. Here, we present Gene2DGE, a Perl software package for gene model renewal with DGE data. We applied Gene2DGE to the mouse blastomere transcriptome, and defined 98,532 read-enriched regions (RERs) by read clustering supported by more than four reads for each base pair. Taking advantage of this ab initio method, we refined 2,104 exonic regions (4% of a total of 48,501 annotated transcribed regions) with remarkable extension into un-annotated regions (>50 bp). For 5% of uniquely mapped reads falling within intron regions, we identified 13,291 additional possible exons. As a result, we renewed 4,788 gene models, which account for 39% of a total of 12,277 transcribed genes. Furthermore, we identified 12,613 intergenic RERs, suggesting the possible presence of novel genes outside the existing gene models. In this study, therefore, we have developed a suitable tool for re-newal of known gene models by ab initio prediction in transcriptome dissection. The Gene2DGE package is freely available at http://gffzz7910605137224006h6nnowouncuvn60pp.ffgz.tsg.suse.edu.cn/. | Xiaoli Tang Libin Deng Dake Zhang Jiari Lin Yi Wei Qinqin Zhou Xiang Li Guilin Li Shangdong Liang | 2012 | Genomics, Proteomics & Bioinformatics2012，10，1： | 0 |
| 15 | Genetic Flux Between H1 and H2 Haplotypes of the 17q21.31 Inversion in European Population显示文摘The chromosome 17q21.31 inversion is a 900-kb common structural polymorphism found primarily in European population.Although the genetic flux within inversion region was assumed to be considerable suppressed, it is still unclear about the details of genetic exchange between the H1(non-inverted sequence)and H2(inverted sequence) haplotypes of this inversion.Here we describe a refined map of genetic exchanges between pairs of gene arrangements within the 17q21.31 region.Using HapMap phase II data of 1,546 single nucleotide polymorphisms, we successfully deduced 96 H1 and 24 H2 haplotypes in European samples by neighbor-joining tree reconstruction. Furthermore, we identified 15 and 26 candidate tracts with reciprocal and non-reciprocal genetic exchanges, respectively.In all 15 regions harboring reciprocal exchange, haplotypes reconstructed by clone sequencing did not support these exchange events, suggesting that such signals of exchange between two sister chromosomes in certain heterozygous individual were caused by phasing error regions.On the other hand, the finished clone sequencing across 4 of 26 tracts with non-reciprocal genetic flux confirmed that this kind of genetic exchange was caused by gene conversion.In summary, as crossover between pairs of gene arrangements had been considerably suppressed, gene conversion might be the most important mechanism for genetic exchange at 17q21.31. | Libin Deng Xiaoli Tang Xiangwen Hao Wei Chen Jiari Lin Yangyu Yu Dake Zhang Changqing Zeng | 2011 | Genomics, Proteomics & Bioinformatics2011，9，3： | 0 |
| 16 | Consensus on diagnostic criteria for Yin deficiency syndrome in hypertension:a modified Delphi study显示文摘OBJECTIVE:To reach consensus on the diagnostic criteria for Yin deficiency syndrome in hypertension(YDSH)patients by a modified Delphi method.METHODS:Our study was consistent with T/CACM 1032-2017.The methodology of RAND/UCLA appropriateness was used to develop consensus guidance statements.A nationwide panel of experienced clinical experts from 19 provinces was constructed.These experts were all prominent in Traditional Chinese Medicine(TCM)of cardiovascular diseases.This consensus process consisted of two rounds of questionnaires and a final round of consultation to analyze the weight score of each item.Moreover,the data extraction process is carried out independently by third-party researchers(LIANG Junya,SUN Yang,and DU Xiaona).When there is disagreement in all three rounds,the expert panel group(odd number)are invited to vote,and the one with more votes wins.In the questionnaires,participants were asked to rate the appropriateness of each syndrome item using a nine-point Likert scale.The consensus was defined as a panel median rating 1-3 or 7-9 without disagreement.And then the diagnostic criteria of YDSH were formed according to the weight score in the final round.RESULTS:Twenty-eight experts(84.8%)participated in the first round,and thirty-one(93.9%)finished the second round.After two rounds,the consensus of YDSH was reached on 11 items(25.6%),including symptoms,signs,and pulse condition.Twenty-one experts(63.6%)completed the final round in which they used a grading system for each item.Red tongue with scanty fur had the highest weighting(22.8%),followed by heat in the palms and soles(20.1%).CONCLUSIONS:The consensus-based diagnostic criteria for YDSH,formed by a modified Delphi method,can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our YDSH criteria. | HE Yun HE Jing XU Xiangru LI Haixiao SHI Rongwei LIANG Junya ZHOU Ying ZHU Yao CHEN Xiaohu TANG Shuhua XIAO Min ZHAN Libin PEI Yinghao JIANG Weimin | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 17 | A Photodetector based on ZnO Nanorods显示文摘In this work,a photodetector based on ZnO nanorods array was vertically grown on the nanoZnO film.ZnO nanorods playing two roles in the photodetector,as the materials of absorbing UV light and carrier transport path.We used the solgel method to prepare the ZnO seed solution and annealed to get nano-ZnO film.Then,ZnO nanorods array were fabricated by | Wentao Cheng Libin Tang Jinzhong Xiang Rongbin Ji | 2016 | 功能材料信息2016，13，2： | 0 |
| 18 | Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human autosomes显示文摘Transmission distortion(TD) is a significant departure from Mendelian predictions of genes or chromosomes to offspring.While many biological processes have been implicated,there is still much to be understood about TD in humans.Here we present our findings from a genome-wide scan for evidence of TD using haplotype data of 60 trio families from the International HapMap Project.Fisher's exact test was applied to assess the extent of TD in 629,958 SNPs across the autosomes.Based on the empirical distribution of PFisher and further permutation tests,we identified 1,205 outlier loci and 224 candidate genes with TD.Using the PANTHER gene ontology database,we found 19 categories of biological processes with an enrichment of candidate genes.In particular,the 'protein phosphorylation' category contained the largest number of candidates in both HapMap samples.Further analysis uncovered an intriguing non-synonymous change in PPP1R12B,a gene related to protein phosphorylation,which appears to influence the allele transmission from male parents in the YRI(Yoruba from Ibadan,Nigeria) population.Our findings also indicate an ethnicity-related property of TD signatures in HapMap samples and provide new clues for our understanding of TD in humans. | Libin Deng Dake Zhang Elliott Richards Xiaoli Tang Jin Fang Fei Long Yan Wang | 2009 | Journal of Genetics and Genomics2009，36，12： | 0 |
| 19 | Mediator complex components are frequent targets for genetic alterations in various types of human cancer显示文摘The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ(RNAPⅡ)in all eukaryotes(Allen and Taatjes,2015).This complex,which consists of at least 30 polypeptides,can be divided into four structurally distinct sub-modules including the head,middle,tail,and cyclin-dependent kinase 8(CDK8) | Libin Deng Cheng Zhang Duling Miao Xiaoli Tang Shiwen Luo Hong-Bo Xin Huidong Shi | 2017 | Journal of Genetics and Genomics2017，44，12： | 0 |
| 20 | OsLTP47 may function in a lipid transfer relay essential for pollen wall development in rice显示文摘In plants,lipid transfer proteins(LTPs)transport pollen wall constituents from the tapetum to the exine,a process essential for pollen wall development.However,the functional cooperation of different LTPs in pollen wall development is not well understood.In this study,we have identified and characterized a grassspecific LTP gene,Os LTP47,an important regulator of pollen wall formation in rice(Oryza sativa).Os LTP47 encodes a membrane-localized LTP and in vitro lipid-binding assays confirms that Os LTP47 has lipidbinding activity.Dysfunction of Os LTP47 causes disordered lipid metabolism and defective pollen walls,leading to male sterility.Yeast two-hybrid and pull-down assays reveal that Os LTP47 physically interacts with another LTP,Os C6.These findings suggest that the plasma membrane-localized Os LTP47 may function as a mediator in a lipid transfer relay through association with cytosolic and/or locular Os C6 for pollen wall development and that various LTPs may function in a coordinated manner to transport lipid molecules during pollen wall development. | Libin Chen Chonghui Ji Degui Zhou Xin Gou Jianian Tang Yongjie Jiang Jingluan Han Yao-Guang Liu Letian Chen Yongyao Xie | 2022 | Journal of Genetics and Genomics2022，49，5： | 0 |
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