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| 1 | Cholecystokinin hyperresponsiveness in functional dyspepsia显示文摘机能性消化不良(FD ) 是还不明确的病原学的普通混乱。消化不良的症状通常是联系的饭并且建议一个协会到胃肠(官方补给) 感觉运动的机能障碍。缩胆囊素(CCK ) 是在胃肠的功能起一个重要规章的作用的确定的大脑勇气肽。它禁止胃的活动性并且经由辣椒辣素倒空敏感迷走神经小径。倒空上的效果经由它近似的胃和幽门上的行动。CCK 也涉及食物摄取的规定。导致饱足经由迷走神经 afferents 响应饭和幕在内脏被释放。而且, CCK 也被显示了涉及恐慌的混乱,焦虑和疼痛的致病。另外的 neurotransmitters 象血清素那样并且也不肾上腺素可以在官方补给的活动的协作与 CCK 被含有。另外, CCK 的静脉内的管理被观察了在 FD 复制症状,这效果能被颠茄碱和 loxiglumide 两个都堵住(CCK -- 一个对手) 。对 CCK 的改变的回答可能为通常观察的胃的感觉运动的机能障碍负责,是可能的,它然后可以与消化不良的症状的开始被联系。 | ASB Chua PWN Keeling | 2006 | World Journal of Gastroenterology2006，12，17： | 27 |
| 2 | 地电化学法在南澳大利亚寻找隐伏金矿的研究显示文摘地电化学法是一种借外加电场作用,将呈活动态的金属离子迁移到特制接收装置,收集并分析接收器上的电解物,可发现与矿有关的金属离子异常,从而达到找矿和评价目的的一种找矿方法。利用地电化学法在澳大利亚干燥近沙漠化钙质层覆盖区的Challenger金矿和Kalkaroo铜金矿进行可行性试验结果显示:在上述已知矿体的剖面上均测出了清晰的地电化学异常,而同时开展的土壤地球化学测量无异常显示。表明利用地电化学法在南澳大利亚干燥近沙漠化覆盖区寻找隐伏金属矿床是有效的。在此基础上,利用该方法在Challenger金矿区外围及深部进行了找矿预测,发现了3个有利的成矿靶区,并经工程验证发现1个金矿体,获得了相应的金储量,取得了良好的社会经济效益。 | 文美兰 罗先熔 熊健 曾南石 侯宝宏 John Keeling | 2010 | 地质与勘探2010，46，1： | 23 |
| 3 | Role of cholecystokinin and central serotonergic receptors in functional dyspepsia显示文摘机能性消化不良的症状被上面的腹的不快或疼痛描绘,早饱足,饭后的充分,膨胀,恶心并且呕吐。它非常是长期的混乱,与症状 3 瞬间每器质性病的年,和没有证据。不正常的活动性,改变的内脏的感觉,和精神分析聚会因素都作为主要 pathophysiological 机制被识别了。这些 pathophysiological 机制交往生产观察症状,这被相信。消化不良基于主导的症状被分成了三亚群。象 Dysmotility 一样消化不良描述其综合征通常与一个胃的感觉运动的机能障碍有关的病人的亚群。大脑勇气肽缩胆囊素(CCK ) 和血清素(5-HT ) 分享某些生理的效果。被显示了胃的倒空减少并且影响饱足。而且, CCK 导致了取决于的厌食可能经由中央小径行动的 serotonergic 功能。我们相信和一只亢奋的应答的海角工作到 CCK 或他们的相互作用的中央 serotonergic 受体的畸形可能为在机能性消化不良(FD ) 的症状的开始负责。 | Andrew Seng Boon Chua PWN Keeling TG Dinan | 2006 | World Journal of Gastroenterology2006，12，9： | 16 |
| 4 | Central serotonergic and noradrenergic receptors in functional dyspepsia显示文摘机能性消化不良是上面的腹的不快或疼痛,早饱足,马达畸形,当器质性病不在时的腹的膨胀和恶心描述的综合征。中枢神经系统在进行并且处理内脏的信号起一个重要作用。在大脑处理疼痛,感觉和感情方面的回答的改变可以是在机能性消化不良的致病的关键因素。中央 serotonergic 和也不肾上腺素能的受体系统涉及处理马达,感觉并且胃肠道的分泌活动。内脏的超敏性当前在机能性消化不良被认为是为马达改变和腹的疼痛负责的机制。一些研究建议在中央 serotonergic 和可以部分解释一些机能性消化不良的症状的也不肾上腺素能的系统有改变。在自主神经系统的改变可以在在内脏的敏感的马达畸形和这些病人的增加被含有。去甲肾上腺素是在交感神经系统的主要 neurotransmitter,再,在这个系统工作的改变可以在运动机能导致变化。机能性消化不良在病人和社会上引起可观的负担。机能性消化不良的病理生理学充分没被理解,但是在由 serotonergic 和也不肾上腺素能的系统的中央处理的改变可以为症状的至少一些提供貌似合理的解释并且为未来提供可能的治疗目标。 | S O'Mahony TG Dinan PW Keeling ASB Chua | 2006 | World Journal of Gastroenterology2006，12，17： | 13 |
| 5 | Multifractal modelling and spectrum analysis: Methods and applications to gamma ray spectrometer data from southwestern Nova Scotia, Canada显示文摘Multifractal spectrum, autocorrelation/semivariogram and power spectrum are three dif- ferent functions characterizing a field or measure from different aspects. These functions are interre- lated in such that the autocorrelation/semivariogram and power spectrum are related to the low order statistical moments (0 to 2 nd) which may determine the local multifractality (τ ″(1)) of a multifractal measure. A better understanding of the interrelationships among these three functions is important because, on one hand, the multifractal modelling characterizes a multifractal measure in a more de- tailed manner since it involves moments of all orders. On the other hand, the commonly used semivariogram and power spectrum functions can be used as alternatives to study the dominant mul- tifractal properties around the mean measure. Moreover, semivariogram and power-spectrum func- tions provide spatial and spectral information, which is highly valued in geological applications. A new fractal relation found between area and power-spectrum will be useful for investigation of new meth- ods of spatial-spectral analysis for pattern recognition, anomaly separation, classification, etc. These results have been demonstrated with the case study of modelling gamma ray spectrometer data from the mineral district, southwestern Nova Scotia, Canada. The results have shown that the values of uranium (U), thorium (Th) and potassium (K) may possess monofractal properties whereas the ratios of these values show high multifractality. The values of the ratios U/K and U/Th show relatively large variances and may provide more information for distinguishing the distinct phases of the granites, country rocks as well as possible gold mineralization-associated regional hydrothermal alteration zones. In addition, the power spectra for U, Th, K, U/Th and U/K consistently show two distinct power-law relationships for two ranges of wave number 12≤ω ≤160 km and 0≤ω ≤12 km. These properties might provide useful thresholds for separating the power-spectrum values into two types of patterns to reflect different influences of possible geological processes such as hydrothermal altera- tion in the study area. | CHENG Qiuming1,2 1. State Key Lab of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China 2. Department of Earth and Space Science and Engineering, Department of Geography, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada | 2006 | Science China Earth Sciences2006，49，3： | 8 |
| 6 | CHIM-geoelectrochemical method in search of concealed mineralisation in China and Australia显示文摘A version of the geoelectrochemical prospecting technique developed in China was demonstrated in China and Australia to test its suitability under both Chinese and Australian conditions.This paper briefly describes the mechanism and effectiveness of the technique applied to search of concealed mineralisation through regolith cover,based on both experimental and field tests.This paer deals with three main aspects of the method: a) how metallic ions are released from orebodies by electrochemical dissolution;b)how these ions migrate to the collector and are deposited as elements by electrochemical extraction in the presence of an electric field; and c) the effectiveness of the method illustrated by some case studies. | LUO Xianrong HOU Baohong WEN Meilanna ZENG Nanshi John Keeling Roger Fidler Adrian Fabris | 2008 | Chinese Journal Of Geochemistry2008，27，2： | 8 |
| 7 | 当代护理人员的困境及其解脱显示文摘为研究解决护理人员的心身耗竭综合征问题,作者在结合过去类似经验及同有关护理人员广泛交换意见的基础上,参考各类文献资料制定了“心身耗竭综合征及其背景和克制的策略”的课程。本文对其详细内容进行了论述。 | Keel P 康汉珍 | 1992 | 国外医学(护理学分册)1992，11，5： | 7 |
| 8 | 简阳、眉山农村健康保险医疗服务利用及费用分析显示文摘本文旨在分析和研究第一批试点村保险实施后的医疗服务利用,医疗费用的影响因素及变化趋势,为健康保险试点的进一步实施和管理提供依据。一、资料来源 (一) | 何廷尉 普翔凌 Emmett Keele | 1987 | 中国农村卫生事业管理1987，，10： | 7 |
| 9 | The complexities underlying age-related macular degeneration: could amyloid beta play an important role?显示文摘Age-related macular degeneration(AMD) causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as well as non-genetic/environmental risks are recognized, its complex aetiology makes it difficult to identify susceptibility, or indeed what type of AMD develops or how quickly it progresses in different individuals. Here we summarize the literature describing how the Alzheimer's-linked amyloid beta(Aβ) group of misfolding proteins accumulate in the retina. The discovery of this key driver of Alzheimer's disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of AMD. We argue that Aβ fundamentally differs from other substances which accumulate in the ageing retina, and discuss our latest findings from a mouse model in which physiological amounts of Aβ were subretinally-injected to recapitulate salient features of early AMD within a short period. Our discoveries as well as those of others suggest the pattern of Aβ accumulation and pathology in donor aged/AMD tissues are closely reproduced in mice, including late-stage AMD phenotypes, which makes them highly attractive to study dynamic aspects of Aβ-mediated retinopathy. Furthermore, we discuss our findings revealing how Aβ behaves at single-cell resolution, and consider the long-term implications for neuroretinal function. We propose Aβ as a key element in switching to a diseased retinal phenotype, which is now being used as a biomarker for latestage AMD. | Savannah A. Lynn Eloise Keeling Rosie Munday Gagandeep Gabha Helen Griffiths Andrew J.Lotery J.Arjuna Ratnayaka | 2017 | Neural Regeneration Research2017，12，4： | 6 |
| 10 | 肝素诱发的血小板减少治疗指南显示文摘推荐总结
所有患者使用任何一种肝素时,用药开始都要计数血小板。
在100天之内曾接受肝素治疗的患者,需要计数血小板用药前及用药24小时后血小板数目。
所有使用普通肝素的患者,在用药的4~14天之间需要隔日计数血小板。 | Keeling D Davidson S Watson H 曹丽娟(编译) 王兆钺(审校) | 2006 | 国际输血及血液学杂志2006，29，6： | 5 |
| 11 | 口服华法令应用指南(对2005年第三版的修订)显示文摘英国血液学标准委员会(The British Committee for Standards in Haematology,BCSH)于1998年发表了第三版口服抗凝药物用药指南。当2005年6月修订时,委员们认为第三版的绝大多数推荐仍然是实用的,无需发行第四版。然而委员们也注意到一些关于抗凝的新资料。像原来版本中口服抗凝药物这一术语在此次修订中指的是口服维生素K拮抗剂(vitamin K Antagonists,VKA),如华法令。新的非维生素K拮抗剂正处于临床试验中,还没有被批准使用。当这些药物能用于临床时,将出版针对这些药物应用指南。此指南的对象是与治疗抗凝患者有关的卫生保健人员。 | Baglin TP Keeling DM Watson HG 苏燕华(编译) 王兆钺(审校) | 2006 | 国际输血及血液学杂志2006，29，6： | 4 |
| 12 | Older people and their social spaces: A study of well-being and attachment to place in Aotearoa New Zealand显示文摘 | Janine L. Wiles Ruth E.S. Allen Anthea J. Palmer Karen J. Hayman Sally Keeling Ngaire Kerse | 2008 | Social Science & Medicine2008，，4： | 3 |
| 13 | 不育男性与正常供体内及两者间精液参数的变异显示文摘Objective: To determine within-and between-subject variation of semen parameters in infertile and normal men. Design: Retrospective analysis of 74 infertile men and 65 normal men producing five or more ejaculates each. Setting: Clinical andrology laboratory. Subject(s): Men presenting to an infertility clinic for semen analysis and normal men providing donor semen for cryopreservation. Intervention(s): None. Main Outcome Measure(s): Within-subject coefficients of variation (CVw) and between-subject coefficients of variation (CVb), calculated for sperm count, motility, and velocity, semen volume, and motility and velocity after cryopreservation. Result(s): The number of ejaculates ranged 5-20 in patients (479 total) and 5-136 in donors (2,043 total). Sperm counts, motility, and velocity were statistically greater in donors, whereas semen volume was significantly greater in patients. The CVw in patients and donors was greatest in sperm counts (54.2%and 45.8%, respectively)-and lowest in velocity (20.1%and 19.9%, respectively). The CVb in patients and donors was markedly higher than CVw for all parameters in both patients and donors. The CVw was lower, and the CVb was higher, in donors compared with patients. The CVw was not affected by age of the individual or abstinence period. Cryopreservation resulted in a marked increase in variability. Intraclass correlations indicated that a minimum of three semen samples were required to achieve reliability. Conclusion(s): These data indicate large within-and between-subject variation in sperm parameters, especially sperm count, in both patients and healthy donors, and further substantiate the need for measurement of multiple ejaculates before characterizing a man as normal or infertile. | Keel B.A. 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，4： | 3 |
| 14 | Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?显示文摘 | Timothy G. Dinan Eamonn M.M. Quigley Salah M.M. Ahmed Paul Scully Sinead O’Brien Liam O’Mahony Siobhan O’Mahony Fergus Shanahan P.W. Napoleon Keeling | 2006 | Gastroenterology2006，，2： | 3 |
| 15 | Modified High-order Upwind Method for Convection Diffusion Equation显示文摘Abstract In this paper, we study the high-order upwind finite difference method for steady convection-diffusionproblems. Based on the conservative convection-diffusion equation, a high-order upwind finite difference schemeon nonuniform rectangular partition for convection-diffusion equation is proposed. The proposed scheme is inconversation form, satisfies maximum value principle and has second-order error estimates in discrete H^1 norm.To illustrate our conclusion, several numerical examples are given. | Wei-dong ZHAO, Dong LIANGSchool of Mathematics and System Sciences, Shandong University, Jinan 250100, ChinaDepartment of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada | 2002 | Acta Mathematicae Applicatae Sinica2002，18，1： | 2 |
| 16 | 有症状门诊病人深静脉血栓形成的诊断,临床评价和D-二聚体分析可能减少对影像学诊断的需要显示文摘深静脉血栓形成(DVT)的年发病率为48~182/10万,一般估计为1/1000.DVT病死率为1%~5%,发病率和病死率与年龄密切相关.慢性疼痛、肿胀、偶尔腿部皮肤溃疡等血栓后综合征见于1/3发生过DVT的患者.血栓后综合征可出现较早,也可迟至10年才出现,总的发病率为2年23%,5年28%.患者如使用弹力加压袜至少2年以上,腿部病变的发生率可减半.对DVT及其后果警惕性的提高使得要做检查的患者数量增加,其中许多人属于低风险性,反映在检查报告中DVT阳性诊断率下降. | Keeling DM Mackie IJ Moody A Watson HG 吴淑燕 王兆钺 | 2004 | 国外医学(输血及血液学分册)2004，27，5： | 2 |
| 17 | Ionic conductivity anomaly in soil cover——Exploration of blind mineralization beneath regolith cover显示文摘This paper briefly describes the formation of ionic conductivity anomalies in soil cover, and the characteristics of ionic composition that forms conductivity anomalies, based on the theory of geoelectrochemical halo. Based on some practical results of soluble ions in soil cover and soil conductivity derived from a number of mining areas of both China and overseas, here we present the correlation of a conductivity anomaly with the ionic composition and establish a model for the formation of conductivity anomalies in soil cover. The results indicate that the formation of a conductivity anomaly is not a simple transformation of a secondary geochemical anomaly. A conductivity anomaly is formed as the result of electrochemical and chemical processes, by transformation of orebody into various ionic haloes through four physicochemical processes: 1) dissolution of the orebody, 2) migration of dissolved matter, 3) conversion of matter near the surface, and 4) the formation of ionic conductivity anomalies. The conductivity anomaly, as a physical parameter, essentially represents the integration of various geochemical compositions and is controlled by a set of particular ionic groups. | KEELING John L. | 2010 | Science China Earth Sciences2010，53，5： | 2 |
| 18 | Early Serum Procalcitonin, Interleukin-6, and 24-Hour Lactate Clearance: Useful Indicators of Septic Infections in Severely Traumatized Patients显示文摘 | Adrian Billeter Matthias Turina Burkhardt Seifert Ladislav Mica Reto Stocker Marius Keel | 2009 | World Journal of Surgery2009，，3： | 2 |
| 19 | Getting into action-The UK adventure tourism market 显示文摘 | Keeling A | | English Tourism Council0，，： | 1 |
| 20 | Endotoxin tolerance after severe injury and its regulatory mechanisms显示文摘 | Keel M Schregenberger N Steckholzer U | 1996 | J Trauma1996，41，3： | 1 |
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