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| 1 | Colorectal cancer of the young displays distinct features of aggressive tumor biology:A single-center cohort study显示文摘BACKGROUND In recent years,a decrease in incidence and mortality of colorectal cancer(CRC)has been observed in developed nations,presumably through public disease awareness and increased screening efforts.However,a rising incidence of CRC in young patients below the age of 50 years has been reported in several studies.AIM To study tumor biology in CRC patients below 50 years of age.METHODS All patients with CRC were prospectively enrolled in our single-center oncologic database from January 2013 to December 2018 and were grouped and analyzed according to age(≥50 and<50 years).Clinical as well as histopathological features were analyzed and compared.The study was approved by the local Ethics Committee.Fisher’s exact test or t-test was used to test for differences between the groups,as appropriate.All statistical analysis was performed with IBM SPSS software Version 25(SPSS Inc,Armonk,NY,United States)and with RStudio using R Version 3.4.1(RStudio,Boston,MA,United States).RESULTS Seventeen percent of the 411 patients were younger than 50 years.Young patients were more often diagnosed with locally advanced T4-tumors and lymph node metastases(36.6%and 62%vs 17.7%and 42%;P<0.01).In addition,a higher frequency of poorly differentiated(G3)tumors(40%vs 22.4%P<0.05)was observed.More than every second patient below 40 years of age(51.8%)had distant metastases at diagnosis with a significant higher rate ring of signet cell differentiation compared to patients≥50 years(14.8%,P<0.05).Mutational status(KRAS,NRAS,BRAF,MSI)as well as selected behavioral risk factors showed no significant differences.CONCLUSION Distinct histopathologic features of increased biologic aggressiveness are found in patients with CRC of young-onset.Those patients present more frequently with more advanced tumor stages compared to older patients.Features of aggressive tumor biology underscore the need for earlier uptake of routine screening measures. | Matteo Mueller Marcel Andre Schneider Barla Deplazes Daniela Cabalzar-Wondberg Andreas Rickenbacher Matthias Turina | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 2 | Early Serum Procalcitonin, Interleukin-6, and 24-Hour Lactate Clearance: Useful Indicators of Septic Infections in Severely Traumatized Patients显示文摘 | Adrian Billeter Matthias Turina Burkhardt Seifert Ladislav Mica Reto Stocker Marius Keel | 2009 | World Journal of Surgery2009，，3： | 2 |
| 3 | Left Ventricular Myocardial Structure in Aortic Valve Disease Before, Intermediate, and Late After Aortic Valve Replacement显示文摘 | Hans P. Krayenbuehl Otto M. Hess E. Scott Monrad Jakob Schneider Gerhard Mall Marko Turina | 1989 | Circulation1989，，： | 1 |
| 4 | The clinical significance of an elevated postoperative glucose value in nondiabetic patients after colorectal surgery : evidence for the need for tight glucose con- trol? 显示文摘 | Kiran RP Turina M Hammel J | 2013 | Ann Surg2013，258，4： | 1 |
| 5 | Cardiovascular disease in pregnancy 显示文摘 | Oechslin E Turina J Lauper U | 1999 | Ther Umsch1999，56，10： | 1 |
| 6 | Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects显示文摘 | Turina M Fry DE Polk HC | 2005 | Crit Care Med2005，33，7： | 1 |
| 7 | Guidelines for reporting mortality and morbidity after cardiac valve interventions显示文摘 | Akins CW Miller DC Turina MI | 2008 | J Thorac Cardiovasc Surg2008，135，： | 1 |
| 8 | Intestinal per- foration following blunt abdominal trauma in patients with pre-existing inguinal hernia 显示文摘 | Neuhaus V Turina M Colombo G | 2009 | Chirurg2009，80，3： | 1 |
| 9 | Alveolar interleukin-10 regulates neutrophil apoptosis in severely traumatized patients显示文摘 | Turina M Hoth JJ Turpen RM | 2007 | J Trauma2007，63，4： | 1 |
| 10 | Performance charac teristics of hemofilters with heparin surface coating: An experimental study 显示文摘 | Ludwig LK Turina M | 1992 | J Extra Corpor Technol1992，，3： | 1 |
| 11 | useful indicators of septic infections in severely traumatized patients,and 24-hour lactate clearance,in- terleukin-6,Early serum procalcitonin,World J Surg显示文摘 | Billeter A Turina M Seifert B et al 33 (3) | | 0，，： | 1 |
| 12 | Early serum procalcitonin, in ter- leukin-6, an d 24-hour lactate clearance : useful indicators of septic in- fections in severely traumatized patients 显示文摘 | Illeter A Turina M Se ifert B | | World J Surg0，33，3： | 1 |
| 13 | Viralinfectionsin meloncropsofcenralnorthem Italy 显示文摘 | RUBIES AUTONELL C BALLANTE M TURINA M | 1999 | InformatoreFitopatologieo1999，46，： | 1 |
| 14 | Spontaneous course of aortic valve disease显示文摘 | Turina J Hess O Sepulcri F | 1987 | Eur Heart J1987，8，5： | 1 |
| 15 | Apoptosis and necrosis:a review for surgeons显示文摘 | McHugh P Turina M | 2006 | Surg Infect(Larchmt)2006，7，1： | 1 |
| 16 | Perfusion without systemic heparinization for rewarming in accidental hypothermia显示文摘 | Garcia E Turina M | 1991 | Ann Thorac Surg1991，52，： | 1 |
| 17 | The clinical anatomy of the sinus node artery显示文摘 | Berdajs D Patonay L Turina MI | 2003 | Ann Thorac Surg2003，76，3： | 1 |
| 18 | Alveolar interleukin-10 regulates neutrophil apoptosis in severely traumatized patients显示文摘 | Turina M Hoth JJ Turpen RM | 2007 | J Trauma2007，63，4： | 1 |
| 19 | Early serum procalcitonin,interleukin-6,and 24-hour lactate clearance:useful indicators of septic infections in severely traumatized patients显示文摘 | Billeter A Turina M Seifert B | 2009 | World J Surg2009，33，3： | 1 |
| 20 | Acute hyperglycemia and the innate immune system:clinical,cellular,and molecular aspects显示文摘 | Turina M Fry DE Polk HC Jr | 2005 | Crit Care Med2005，33，7： | 1 |
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