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| 1 | Colorectal cancer screening:20 years of development and recent progress显示文摘Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily increasing.This trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality rates.Each year,approximately 8000 people are diagnosed with CRC and some 4000 die from this malignancy.Twenty years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in 2000.Originally,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT positivity.The program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of gynecologists.Since the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening program.The overall program expanded to cover 25.0%of the target population by 2011.However,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared. | Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav Dusek | 2014 | World Journal of Gastroenterology2014，20，14： | 16 |
| 2 | How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?显示文摘The incidence and prevalence of metabolic syndrome(MS) and colorectal cancer(CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions(adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same- obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian(Asia-Pacific Colorectal Screening Score; APCS) and Polish populations. | Stepan Suchanek Tomas Grega Ondrej Ngo Gabriela Vojtechova Ondrej Majek Petra Minarikova Nagyija Brogyuk Bohus Bunganic Bohumil Seifert Ladislav Dusek Miroslav Zavoral | 2016 | World Journal of Gastroenterology2016，22，36： | 10 |
| 3 | 股骨干骨折——扩髓和不扩髓髓内钉比较显示文摘治疗股骨干骨折,采用不扩髓髓内钉比扩髓髓内钉手术时间明显缩短,而且失血也少。但是,扩髓钉的骨愈合更快,延迟愈合更少。两者都没有显著增加包括肺损害等其它并发症的风险。功能结果不能确定。 | James F.Kellam Ladislav Nagy Rodrigo F.Pesantez 陈国奋 顾立强 | 2004 | 中华创伤骨科杂志2004，6，9： | 8 |
| 4 | Colorectal cancer screening in Europe显示文摘Colorectal cancer(CRC)is the second most frequent malignant disease in Europe.Every year,412 000people are diagnosed with this condition,and 207 000patients die of it.In 2003,recommendations forscreening programs were issued by the Council of the European Union(EU),and these currently serve as thebasis for the preparation of European guidelines forCRC screening.The manner in which CRC screening iscarried out varies significantly from country to countrywithin the EU,both in terms of organization and thescreening test chosen.A screening program of onesort or another has been implemented in 19 of 27 EUcountries.The most frequently applied method is testing stool for occult bleeding(fecal occult blood test,FOBT).In recent years,a screening colonoscopy hasbeen introduced,either as the only method(Poland)orthe method of choice(Germany,Czech Republic). | Miroslav Zavoral Stepan Suchanek Filip Zavada Ladislav Dusek Jan Muzik Bohumil Seifert Premysl Fric | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 5 | Cardiac rehabilitation and its essential role in the secondary prevention of cardiovascular diseases显示文摘Cardiovascular diseases are the most common causes of mortality worldwide.They are frequently the reasons for patient hospitalization,their incapability for work,and disability.These diseases represent a significant socio-economic burden affecting the medical system as well as patients and their families.It has been demonstrated that the etiopathogenesis of cardiovascular diseases is significantly affected by lifestyle,and so modification of the latter is an essential component of both primary and secondary prevention.Cardiac rehabilitation(CR)represents an efficient secondary prevention model that is especially based on the positive effect of regular physical activity.This review presents an overview of basic information on CR with a focus on current trends,such as the issue of the various training modalities,utilization,and barriers to it or the use of telemedicine technologies.Appropriate attention should be devoted to these domains,as CR continues evolving as an effective and readily available intervention in the future. | Petr Winnige Robert Vysoky Filip Dosbaba Ladislav Batalik | 2021 | World Journal of Clinical Cases2021，9，8： | 8 |
| 6 | 天然色素染料敏化太阳能电池的制备显示文摘通过萃取西藏林芝核桃果皮、江孜沙棘果实以及拉萨紫草根部的天然色素,分析研究了西藏天然色素光吸收性能;利用以上3种天然色素以及它们的混合色素,研制了染料敏化太阳能电池。结果表明,核桃与紫草的混合色素(TiO2薄膜多层)DSSC电池效率最高,达到8.2%。 | 诺桑 措加旺姆 次仁 罗布 卓嘎 次仁央金 Ladislav Kocbach Jakob Stamnes | 2013 | 材料导报(纳米与新材料专辑)2013，27，2： | 6 |
| 7 | 美国晚期老年痴呆症患者放弃维持生命治疗病例分析显示文摘目的分析美国老年痴呆症患者放弃维持生命治疗的决策。方法对美国某老年痴呆症专科护理中心(BDSC)的10个病例作纵向性研究,分析北美文化及医疗照护文化对放弃维持生命治疗决策的影响。结果BDSC有2个放弃维持生命治疗决策的模式(1)尊重患者意愿,预立遗嘱放弃维持生命治疗;(2)考虑患者的生存质量,预立遗嘱放弃维持生命治疗。放弃管饲及放弃抗生素治疗的考虑不同,前者基于共识的信念,后者是对生存质量的考虑。结论BDSC所倡议的照护模式得以实践,显示对传统医护价值有三方面的转变。一是当老年痴呆症到了晚期,接受患者已步入死亡的事实;二是将传统医护焦点从拯救生命转变至重视生存质量;三是专注临终关怀,并竭尽所能,让患者在生命最后的一段日子得到最好的照顾。 | 彭美慈 Ladislav Volicer 梁颖琴 | 2005 | 中华老年医学杂志2005，24，4： | 5 |
| 8 | Petrogenesis and Tectonic Implications of Peralkaline A-Type Granites and Syenites from the Suizhou-Zaoyang Region,Central China显示文摘In this study, we present systematic petrological, geochemical, LA-ICP-MS zircon U-Pb ages and Nd isotopic data for the A-type granites and syenites from Suizhou-Zaoyang region. The results show that the peralkaline A-type granites and syenites were episodically emplaced in Suizhou-Zaoyang region between 450±3 and 441±7 Ma which corresponds to Late Ordovician and Early Silurian periods, respectively. Petrologically, the syenite-peralkaline granite association comprises of nepheline normative-syenite and alkaline granite in Guanzishan and quartz normative syenite and alkaline granite in Huangyangshan. The syenite-granite associations are ferroan to alkali in composition. They depict characteristics of typical OIB(oceanic island basalts) derived A-type granites in multi-elements primitive normalized diagram and Yb/Ta vs. Y/Nb as well as Ce/Nb vs. Y/Nb binary plots. Significant depletion in Ba, Sr, P, Ti and Eu indicates fractionation of feldspars, biotite, amphiboles and Ti-rich augite. The values of ?Nd(t) in Guanzishan nepheline syenite and alkaline granite are +1.81 and +2.26, respectively and the calculated two-stage model age for these rocks are 1 040 and 1 003 Ma, respectively. On the other hand, the Huangyangshan alkaline granite has ?Nd(t) values ranging from +2.61 to +3.46 and a relatively younger two-stage Nd model age values ranging from 906 to 975 Ma, respectively. Based on these data, we inferred that the Guanzishan nepheline syenites and granites were formed from fractional crystallization of OIB-like basic magmas derived from upwelling of metasomatized lithospheric mantle. The Huangyangshan quartz syenite and granite on the other hand, were formed from similar magmas through fractional crystallization with low input from the ancient crustal rocks. Typically, the rocks exhibit A1-type granite affinity and classified as within plate granites associated with the Ordovician crustal extension and the Silurian rifting. | Hafizullah Abba Ahmed Changqian Ma Lianxun Wang Ladislav A.Palinkas Musa Bala Girei Yuxiang Zhu Mukhtar Habib | 2018 | Journal of Earth Science2018，29，5： | 5 |
| 9 | 桡骨远端骨折——手术与非手术治疗比较显示文摘有一些证据表明外科治疗,包括开放复位内固定(ORIF)或经皮穿针固定(不包括Kapandji穿针),其功能结果优于保守治疗。不过,仍需要大规模的研究和更长的随访来证实这些结论。 | James F.Kellam Branco Kopjar Ladislav Nagy Rodrigo F.Pesantez 陈国奋 顾立强 | 2004 | 中华创伤骨科杂志2004，6，10： | 5 |
| 10 | Clinical outcomes of radiofrequency catheter ablation of atrial fibrillation in octogenarians lO-year experience of a one high-volume center显示文摘Background Prevalence of atrial fibrillation (AF) increases with age. Radiofrequency catheter ablation (RFCA) is an establishedtreatment option superior to antiarrhythmics (AAs). In this study, we investigated safety and efficacy of RFCA of AF in octogenarians.Methods From our database, we extracted procedural and follow-up data for patients 〉 80 years with symptomatic AF undergoing RFCAand compared this population to RFCA patients 〈 50 years. All patients underwent pulmonary vein isolation (PVI) supplemented by linearlesions in PVI-nonresponders. Arrhythmia-free survival was assessed using seven day Holter every three months post procedure. All patientscompleted their 12 months follow-up. Results Fifty patients aged ≥80 years (80.5 ± 1.6 years) were compared to 259 patients aged 〈 50years (43.5±5.5 years). The RFCA complication rate did not vary between groups. No differences in procedural characteristics were seenafter being analyzed by type of AF. Among patients with paroxysmal AF, 71.4% octogenarian vs. 84.7% young patients was free of anyarrhythmia, without AAs, after single procedure. For non-paroxysmal AF, arrhythmia-free survival without AAs, was considerably lower(58.6% octogenarians vs. 81.2% younger patients, P = 0.023). If AAs were used, arrhythmia-free survival for paroxysmal AF increased to90.5% and 92.1% in octogenarians and younger patients, respectively; and in non-paroxysmal AF it increased to 79.3% vs. 88.4%. ConclusionsRFCA is a safe and effective strategy to achieve normal sinus rhythm in a highly selected group of octogenarians. Paroxysmal AF ablation inoctogenarians has similar clinical effectiveness as that seen in much younger patients. Non-paroxysmal AF ablation has lower, but still rea-sonable clinical effectiveness. | Alan Bulava Jiri Hanis Ladislav Dusek | 2017 | Journal of Geriatric Cardiology2017，14，9： | 5 |
| 11 | Remotely monitored telerehabilitation for cardiac patients: A review of the current situation显示文摘Cardiac rehabilitation through center-based programs is an effective multicomponent intervention for the secondary prevention of cardiovascular diseases.Despite the benefits it brings,patients’participation in rehabilitation programs remains low.In this work,the latest relevant literature regarding remotely monitored cardiac telerehabilitation(TR)was reviewed considering its efficiency and utilization.The main objective was to assess whether TR has the potential to be an appropriate alternative form of rehabilitation.A total of 105 publications on this topic were screened out of 747 full-text articles that were read and evaluated,of which 12 were considered suitable for inclusion in the final review.Feasibility,efficiency,and safety were assessed for each TR intervention.The results of our evaluation indicate that TR seems to be a usable,effective,and safe alternative rehabilitation for patients with heart disease.Most of the currently published articles have studied remotely monitored TR intervention offering a comprehensive approach,which indicates the significant development and steps forward in this field of study.Our research evidence supports the implementation of TR,which could positively influence barriers in participating in cardiac rehabilitation programs. | Ladislav Batalik Katerina Filakova Katerina Batalikova Filip Dosbaba | 2020 | World Journal of Clinical Cases2020，8，10： | 4 |
| 12 | Gustilo ⅢB 和ⅢC 高能量胫骨骨折——截肢与保肢的比较显示文摘截肢和保肢患者长期的功能和心理结果相似。如果早期不截肢而采取保肢,就必须考虑到:二期截肢的风险(5%~14%)、潜在的并发症(保肢术通常更高)以及住院时间延长。由于胫骨骨折严重程度不同采取的治疗可能不同(G ustiloⅢC型比ⅢB型更可能截肢),这使得对比很困难,而且相关的队列研究文献很少。 | Ladislav Nagy Branko Kopjar Norbert P.Südkamp 陈国奋 顾立强 | 2005 | 中华创伤骨科杂志2005，7，5： | 4 |
| 13 | A new analytical model for thermal stresses in multi-phase materials and lifetime prediction methods显示文摘基于稳固的连续统的力学的基本方程,纸在周期性地分布式的球形的粒子在一个无限的矩阵与不同分布代表的各向同性的连续统为有弹性的热压力的决心雇用一个分析模特儿, imaginarily 与等于内部粒子的距离的尺寸划分了成相同房间,在粒子表面上包含一个中央球形的粒子与或没有一个球形的信封。因而,作为关于分析建模的一个模型系统, multi-particle-( 信封) 矩阵系统对多相的材料的四种类型适用。作为粒子体积部分 v ,沿着三互相垂直的轴的内部粒子的距离 d 1, d 2, d 3,和粒子和信封半径的功能, R 1和 R 2,分别地,在房间以内的热压力,在矩阵,信封和粒子代表的阶段的热扩大系数作为差别的后果在一个冷却过程期间被发源。分析 --( 试验性) 为多相的材料的计算一生预言方法被建议,它能与真实多相的材料的参数的适当的值在工程被使用。 | Ladislav Ceniga | 2008 | Acta Mechanica Sinica2008，24，2： | 3 |
| 14 | New findings in the genetics of schizophrenia显示文摘New findings in schizophrenia genetics are based on genome-wide association studies(GWAS), research into DNA copy number variations(CNVs), and endophenotypes. More than 70 genes have recently been suspected to be involved in the genetic background of schizophrenia based on the GWAS′s results. They are typically related to neurodevelopment/neuroplasticity, immunology and neuroendocrinology. Nevertheless, for many detected genes their possible relationship to schizophrenia etiopathogenesis is still unknown. The CNVs at genome loci 1q21.1(candidate gene e.g., PRKAB2), 2p16.3(candidate gene e.g., NRXN1), 3q29(candidate genes e.g., BDH1, DLG1, PAK2 or TFRC), 15q11.2(candidate gene e.g., CYFIP1), 15q13.3(candidate gene e.g., CHRNA7), 16p13.1(candidate genes e.g.,NTAN1 or NDE1) and 22q11.2(candidate genes e.g., COMT, GSTT2 or PRODH) were associated with schizophrenia most frequently. Genetic research of schizophrenia endophenotypes, usually neurophysiological, neuromotoric, neurocognitive, neuroanatomical, neurological orpersonality-related, will help us to discover the role of relevant genes in the pathogenesis of schizophrenia. It is also necessary to integrate knowledge from other research platforms in schizophrenia, like epigenetics, studies of gene-environment interactions, transcriptomics, proteomics, metabolomics, neuroimaging and psychopathology. A better knowledge of the genetic background of schizophrenia can lead to changes in the treatment, prevention and genetic counselling. It may also reduce stigma in this severe mental disorder. | Ladislav Hosak | 2013 | World Journal of Psychiatry2013，3，3： | 2 |
| 15 | Effect of gap size and forest type on mineral nitrogen forms under different soil properties显示文摘Gaps play a key role in forest ecosystem development and result from either natural processes or targeted forest management activities.The aim of this study was to investigate the interrelationships of soil properties in each of three forest types and two treatments,and to identify factors that influence levels of soil mineral nitrogen forms.The relation between mineral nitrogen and factors of soil parameters and stand type(European beech,Norway spruce,mixed stand)categories were investigated.The spruce forest type stored significant nitrogen in both mineral forms of nitrogen.Moreover,there was a significant linear dependence between N-NO3^-(nitrate anion)concentrations and cation exchange capacity(CEC)parameters such as base cation contents(S-CEC)and potential ureolytic activities(UreasePot),as well as between N-NH4^+(ammonium cation)concentrations and both hydrolytic acidities(Ha-CEC)and ureolytic activities.The dependence of N-NO3^-concentrations on S-CEC contents and UreasePot was negative,especially in adjacent stand.The dependence of N-NH4^+concentrations on Ha-CEC and UreasePot was week in the beech and mixed forest types while it was significantly positive in the spruce forest type. | Ales Kucera Ladislav Holik Elena Munoz Cerro Jan Petricek | 2020 | Journal of Forestry Research2020，31，2： | 2 |
| 16 | Impact of the COVID‑19 outbreak on the US equity sectors:Evidence from quantile return spillovers显示文摘The aim of this study is to examine the extreme return spillovers among the US stock market sectors in the light of the COVID-19 outbreak.To this end,we extend the now-traditional Diebold-Yilmaz spillover index to the quantiles domain by building networks of generalized forecast error variance decomposition of a quantile vector autoregressive model specifically for extreme returns.Notably,we control for common movements by using the overall stock market index as a common factor for all sectors and uncover the effect of the COVID-19 outbreak on the dynamics of the network.The results show that the network structure and spillovers differ considerably with respect to the market state.During stable times,the network shows a nice sectoral clustering structure which,however,changes dramatically for both adverse and beneficial market conditions constituting a highly connected network structure.The pandemic period itself shows an interesting restructuring of the network as the dominant clusters become more tightly connected while the rest of the network remains well separated.The sectoral topology thus has not collapsed into a unified market during the pandemic. | Syed Jawad Hussain Shahzad Elie Bouri Ladislav Kristoufek Tareq Saeed | 2021 | Financial Innovation2021，7，1： | 2 |
| 17 | Secukinumab provided significant and sustained improvement in the signs and symptoms of ankylosing spondylitis:results from the 52-week,PhaseⅢChina-centric study,MEASURE 5显示文摘Background:Secukinumab demonstrated sustained efficacy in patients with ankylosing spondylitis(AS)through 5 years in pivotal Phase III studies.Here,we present efficacy and safety results(52-week)of secukinumab in patients with AS from the MEASURE 5 study.Methods:MEASURE 5 was a 52-week,Phase III,China-centric study.Eligible patients were randomly assigned(2:1)to receive subcutaneous secukinumab 150 mg or placebo weekly for the first five doses and then once every 4 weeks(q4w).All placebo patients switched to secukinumab 150 mg q4w starting at Week 16.Primary endpoint was Assessments of SpondyloArthritis international Society(ASAS)20 at Week 16.Randomization was stratified by region(China vs.non-China).Results:Of 458 patients(secukinumab 150 mg,N=305;placebo,N=153)randomized,327(71.4%)were from China and 131(28.6%)were not from China.Of these,97.7%and 97.4%patients completed Week 16 and 91.1%and 95.3%(placebo-secukinumab)patients completed Week 52 of treatment.The primary endpoint was met;secukinumab significantly improved ASAS20 response at Week 16 vs.placebo(58.4%vs.36.6%;P<0.0001);corresponding rate in the Chinese population was 56.0%vs.38.5%(P<0.01).All secondary efficacy endpoints significantly improved with secukinumab 150 mg in the overall population at Week 16;responses were maintained with a trend toward increased efficacy from Week 16 to 52.No new or unexpected safety signals were reported up to Week 52.Conclusions:Secukinumab 150 mg demonstrated rapid and significant improvement in signs and symptoms of AS.Secukinumab was well tolerated and the safety profile was consistent with previous reports.Efficacy and safety results were comparable between the overall and Chinese populations. | Feng Huang Fei Sun Wei-Guo Wan Li-Jun Wu Ling-Li Dong Xiao Zhang Tae-Hwan Kim Raj Sengupta Ladislav Senolt Yi Wang Hao-Min Qiu Brian Porter Sibylle Haemmerle | 2020 | Chinese Medical Journal2020，，21： | 2 |
| 18 | Early Serum Procalcitonin, Interleukin-6, and 24-Hour Lactate Clearance: Useful Indicators of Septic Infections in Severely Traumatized Patients显示文摘 | Adrian Billeter Matthias Turina Burkhardt Seifert Ladislav Mica Reto Stocker Marius Keel | 2009 | World Journal of Surgery2009，，3： | 2 |
| 19 | Zn_(x)Cd_(1-x)S量子点组成与其光催化活性的关系显示文摘Aqueous colloidal dispersions containing Znx Cd1‐x S quantum dots (QDs) of different x compositions were prepared by precipitating zinc and cadmium acetates with sodium sulphide,in the presence of a cetyltrimethylammonium bromide stabilizer.Ultraviolet‐visible absorption spectroscopy was used to determine the transition energies of the QDs,which in turn were used to calculate their sizes,which depended on their composition.The QD size decreased with increasing Zn content.The photocatalytic activity of the Znx Cd1‐x S QDs was studied by the decomposition of methylene blue under ultraviolet irradiation,at a maximum intensity at 365 nm (3.4 e V).Three different photo‐catalytic activity regions were observed,which depended on the Zn content.The quantum levels of the QDs could be excited by incident irradiation,and influenced the resulting photocatalytic activity.Maximum photocatalytic activity was achieved at x = 0.6,where the QD transition energy was equal to the irradiation photon energy.The photocatalytic efficiency of the QDs depended on their surface area and arrangement of quantum levels,because of the quantum size effect. | Alice Hospodková Ladislav Svoboda Petr Praus | 2015 | 催化学报2015，36，3： | 2 |
| 20 | Myelodysplastic and myeloproliferative type of chronic myelomonocytic leukemia — distinct subgroups or two stages of the same disease?显示文摘 | Jaroslava Voglová Ladislav Chrobák Radana Neuwirtová Vera Malasková Libor Straka | 2001 | Leukemia Research2001，，6： | 2 |
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