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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Drug induced acute pancreatitis: Does it exist?显示文摘As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When confronted with a patient with acute pancreatitis and no clear etiology defined as an absence alcoholism, gallstones(ultrasound and/or MRI), a normal triglyceride level, and absence of tumor, it often appears reasonable to consider a drug as the cause of acute pancreatitis. Over 100 drugs have been implicated by case reports as causing acute pancreatitis. While some of these case reports are well written, many case reports represent poorly written experiences of the clinician simply implicating a drug without a careful evaluation. Over-reliance on case reports while ignoring randomized clinical trials and large pharmacoepidemiologic surveys has led to confusion about drug induced acute pancreatitis. This review will explain that drug induced acute pancreatitis does occur, but it is rare, and over diagnosis leads to misconceptions about the disease resulting in inappropriate patient care, increased litigation and a failure to address the true entity: idiopathic acute pancreatitis. | Scott Tenner | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 3 | Drug-Induced Acute Pancreatitis: An Evidence-Based Review显示文摘 | Nison Badalov Robin Baradarian Kadirawel Iswara Jianjun Li William Steinberg Scott Tenner | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 4 | Laboratory Diagnostic Tests in Acute Pancreatitis显示文摘 | Joseph Smotkin Scott Tenner | 2002 | Journal of Clinical Gastroenterology2002，，4： | 1 |
| 5 | Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis显示文摘 | Scott Tenner Carlos Fernandez-del Castillo Andrew Warshaw William Steinberg John Hermon-Taylor Jorge E. Valenzuela Mohammed Hariri Michael Hughes Peter A. Banks | 1997 | International Journal of Pancreatology1997，，2： | 1 |
| 6 | Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis显示文摘 | Scott Tenner Carlos Fernandez-del Castillo Andrew Warshaw William Steinberg John Hermon-Taylor Jorge E. Valenzuela Mohammed Hariri Michael Hughes Peter A. Banks | 1997 | International Journal of Pancreatology1997，，2： | 1 |
| 7 | Acute pancreatitis: Nonsurgical management显示文摘 | Scott Tenner Peter A. Banks | 1997 | World Journal of Surgery1997，，2： | 1 |
| 8 | Acute Pancreatitis显示文摘 | William Steinberg Scott Tenner | 1994 | N Engl J Med1994，330，： | 1 |
| 9 | Drug-Induced Acute Pancreatitis: An Evidence-Based Review显示文摘 | Nison Badalov Robin Baradarian Kadirawel Iswara Jianjun Li William Steinberg Scott Tenner | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 1 |
| 10 | Acute pancreatitis: Nonsurgical management显示文摘 | Scott Tenner Peter A. Banks | 1997 | World Journal of Surgery1997，，2： | 1 |
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