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| 1 | 云南宣威晚二叠世末生物灭绝期C1煤的地球化学特征显示文摘云南宣威雁塘煤矿晚二叠世末期C1煤层蕴含了二叠纪—三叠纪界线事件演化以及宣威肺癌高发原因方面的重要信息。本文对该矿C1煤层(包括三个分层——B1、B2和B3)进行了刻槽分层采样,采用X射线荧光光谱和电感耦合等离子体质谱测试了24个样品中常量和微量元素。利用偏光显微镜和带能谱的扫描电镜(SEMEDX)对煤中的显微组分及矿物组成进行微区分析,利用X射线衍射对低温灰化后的煤样作了矿物的半定量分析。结果表明,雁塘矿C1煤中常量元素Ca、Mn、Si含量明显高于中国煤均值;与华南二叠纪煤平均值、中国煤平均值、世界煤平均值以及地壳元素丰度相比较,雁塘矿C1煤中的W、Co、Mo、Cd、Pb、Be、Sb、Cu、Ni、Zn、Zr和V等12种微量元素相对比较富集。结合相关分析和SEM-EDX微区分析方法,对C1煤中微量元素的赋存状态进行分析发现Cs、Ga、Nb、Ba、Rb、Th、Tl、U与灰分显著正相关,表明这些元素主要以无机矿物态赋存,其它元素赋存状态复杂。结合C1煤中12种富集元素在垂向上的含量分布特征,推断Co、Cu、V、Zn应主要来源于峨眉山玄武岩风化产物;Be和Zr主要受同沉积火山灰影响;Ni则可能受峨眉山玄武岩风化及同沉积火山灰的共同影响;同沉积火山灰是C1煤中W来源之一;Sb可能受中低温热液的影响。C1煤中Zr与我国南方其他地区P/T界线粘土岩中Zr的富集规律一致。C1煤中富集的微量元素与宣威肺癌高发区可吸入颗粒物中的高含量元素一致,推断C1煤的燃烧可能与宣威肺癌高发有关。C1煤中富集的有毒有害微量元素可能与二叠纪—三叠纪之交生物大灭绝期的独特环境有密切关系。 | 邵龙义 王娟 侯海海 张名泉 汪浩 SPIRO Baruch LARGE David 周义平 | 2015 | 地质学报2015，89，1： | 17 |
| 2 | Arsenic speciation in fish from Greek coastal areas显示文摘Arsenic speciation analysis was conducted on fish samples(sardine and anchovy) collected from six areas along the Greek coastline, i.e. Artemisium Straits, Thermaikos Gulf, Amvrakikos Gulf,Strymonian Gulf, Thracian Sea, and Elefsina Gulf. Total arsenic levels ranging from 11.8 to62.6 mg As/kg dry weight were determined. Arsenobetaine, a non-toxic form of arsenic, was found to be the main arsenic species, present at 8.6 to 58.8 mg As/kg dry weight, accounting for67–95% of the total arsenic. Also detected in all fish samples was dimethylarsinic acid, although at considerably lower concentrations, ranging from 0.072–0.956 mg As/kg dry weight.Monomethylarsonic acid was detected at low levels in all anchovy samples, and only in sardines from one area. Finally, inorganic arsenic in the form of arsenate was detected only in fish at one area, indicating the possible effect of an environmental parameter on its presence at detectable amounts. Statistical analysis revealed the environmental variables, such as salinity,total organic carbon and nitrogen, ammonium, phosphate, total phosphorus, dissolved oxygen and pressure index, are potentially correlated to As species concentrations. Furthermore, based on factor analysis, the biological parameters, such as fish weight, lipids, protein and ash content,that are correlated to As species concentrations of fish were also identified. The interrelationship of arsenobetaine and dimethylarsinic acid concentrations within each fish species was evaluated. | Ioanna Kalantzi Kyriaki Mylona Katerina Sofoulaki Manolis Tsapakis Spiros A.Pergantis | 2017 | Journal of Environmental Sciences2017，29，6： | 11 |
| 3 | Mirizzi syndrome type Ⅴa:A rare coexistence of double cholecysto-biliary and cholecysto-enteric fistulae显示文摘Mirizzi syndrome is a rare cause of intermittent obstructive jaundice,where an impacted stone in the cystic duct or Hartmann's pouch mechanically obstructs the common bile duct(CBD) .We report a rare case of double cholecysto-biliary and cholecysto-enteric fistulae,in a 75-year-old female patient,presenting with a right upper quadrant abdominal pain and intermittent obstructive jaundice.Endoscopic retrograde cholangiopancreatography suggested Mirizzi syndrome.Operative findings included erosions of the lateral wall of the CBD and the second portion of the duodenum due to impacted gallstones.The defects were reconstructed primarily and a Kehr tube was inserted.The patient had an uneventful postoperative course and was discharged on the 14th postoperative day. | Pavlos Lampropoulos Nikolaos Paschalidis Athanasios Marinis Spiros Rizos | 2010 | World Journal of Radiology2010，2，10： | 10 |
| 4 | 三裂叶野葛毛状根的诱导及其固体培养和液体培养显示文摘发根农杆菌 (Agrobacteriumrhizogenes)ATCC15 834感染三裂叶野葛 (Puerariaphaseoloides)叶片外植体 2 0d后产生毛状根 ,毛状根可直接从叶片外植体叶脉处或从叶脉处产生的愈伤组织上产生。感染 35d后 ,约 85 %的叶片外植体产生毛状根。毛状根能在无外源生长调节剂的MS固体和液体培养基上自主生长。PCR扩增结果表明 ,发根农杆菌Ri质粒的rolB和rolC基因已在三裂叶野葛毛状根基因组中整合并得到表达。与固体培养的毛状根相比 ,在液体培养基中培养的毛状根不仅生长迅速 ,也不会形成愈伤组织。在无外源生长调节剂的液体MS培养基中培养 15d的三裂叶野葛毛状根的鲜重、干重、可溶性总糖含量及细胞内活性氧 (ROS)含量分别为固体培养毛状根的1.5 9倍、1.18倍、5 .2 5倍和 1.16倍。 | 施和平 权宏 Spiros Kintzios | 2003 | 生物工程学报2003，19，3： | 10 |
| 5 | 三裂叶野葛毛状根的培养及其葛根素的产生显示文摘发根农杆菌ATCC15834感染三裂叶野葛叶片外植体20天后,从其切口叶脉处产生的愈伤组织上产生毛状根。感染35天后约85%的叶片外植体产生毛状根。毛状根能在无外源生长调节剂的MS固体和液体培养基上自主生长,但在液体培养基中培养的毛状根生长更迅速,也不会形成愈伤组织。毛状根线粒体膜电势的荧光染色结果表明,液体培养的毛状根细胞线粒体的膜电势比固体培养的毛状根高11.8倍。PCR结果证实,发根农杆菌Ri质粒的rolB和rolC基因已在三裂叶野葛毛状根基因组中整合并得到表达。HPLC测定结果表明,三裂叶野葛毛状根中的葛根素含量约为对照根(种子萌发产生的幼苗根)的2.5倍,达1.190 mg/g.dry.wt;并比多年生葛根生药片的葛根素含量高6.7%。 | 施和平 梁朋 Spiros Kintzios | 2003 | 实验生物学报2003，36，6： | 9 |
| 6 | 最小二乘谱及其在超导重力观测数据分析中的应用显示文摘运用投影理论和基于向量空间中最小二乘平差原理,介绍了最小二乘谱分析方法,给出了最小二乘谱的计算公式。利用加拿大超导重力观测数据实例,讨论了最小二乘谱分析的策略和步骤。 | 尹晖 Spiros D.Pagiatakis | 2005 | 武汉大学学报(信息科学版)2005，30，7： | 7 |
| 7 | Selection criteria for liver resection in patients with hepatocellular carcinoma and chronic liver disease显示文摘Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual occurrence of one million new cases. An etiologic association between HBV infection and the development of HCC has been established with a relative risk 200-fold greater than in non-infected individuals. Hepatitis C virus is also proving an important predisposing factor for this malignancy with an incidence rate of 7% at 5 years and 14% at 10 years. The prognosis depends on tumor stage and degree of liver function, which affect the tolerance to invasive treatments. Although surgical resection is generally accepted as the treatment of choice for HCC, new treatment strategies, such as local ablative therapies, transarterial embolization and liver transplantation, have been developed nowadays. With increasing detection of small HCCs from screening programs for cirrhotic patients, it is foreseen that locoregional therapy will play an important role in the near future. | Spiros G Delis Christos Dervenis | 2008 | World Journal of Gastroenterology2008，14，22： | 7 |
| 8 | Current role of bloodless liver resection显示文摘Liver resections are demanding operations which can have life threatening complications although they are performed by experienced liver surgeons. Recently new technologies are applied in the field of liver surgery, having one goal: safer and easier liver operations. The aim of this article is to address the issue of bloodless liver resection using radiofrequency energy. Radionics, Cool-tipTM System and Tissue Link are some of the devices which are using radiofrequency energy. All information included in this article, refers to these devices in which we have personal experience in our unit of liver surgery. These devices take advantage of its unique combination of radiofrequency current and internal electrode cooling to perform sealing of the small vessels and biliary radicals. Dissection is also feasible with the cool-tip probe. For the purposes of this study patient sex, age, type of disease and type of surgical procedure in association with the duration of parenchymal transection, blood loss, length of hospital stay, morbidity and mortality were analyzed. Cool-tip RF device may provide a unique, simple and rather safe method of bloodless liver resections if used properly. It is indicated mostly in cirrhotic patients with challenging hepatectomies (segment Ⅷ, central resections). The total operative time is eliminated and the average blood loss is significantly decreased. It is important to note that this technique should not be applied near the hilum or the vena cava to avoid damage of these structures. | Spiros G Delis Juan Madariaga A Bakoyiannis Ch Dervenis | 2007 | World Journal of Gastroenterology2007，13，6： | 7 |
| 9 | Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity,to curtail dependence on host tissue:molecular mode显示文摘The role of the transcription factor NF-κB in shaping the cancer microenvironment is becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF-κB function, and causes extensive changes in genomic chromatin that ultimately drastically alter cell-specific gene expression. NF-κB regulates the expression of cytokines and adhesion factors that control interactions among adjacent cells. As such, NF-κB fine tunes tissue cellular composition, as well as tissues' interactions with the immune system. Therefore, NF-κB changes the cell response to hormones and to contact with neighboring cells. Activating NF-κB confers transcriptional and phenotypic plasticity to a cell and thereby enables profound local changes in tissue function and composition. Research suggests that the regulation of NF-κB target genes is specifically altered in cancer. Such alterations occur not only due to mutations of NF-κB regulatory proteins, but also because of changes in the activity of specific proteostatic modules and metabolic pathways. This article describes the molecular mode of NF-κB regulation with a few characteristic examples of target genes. | Spiros A.Vlahopoulos | 2017 | Cancer Biology & Medicine2017，14，3： | 6 |
| 10 | Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer显示文摘瞄准:与周期性的溃疡为十二指肠溃疡在外科以后流血在病人评估 omeprazole 维护治疗。方法:我们与周期性的溃疡为十二指肠溃疡在外科以后流血学习了 15 个连续病人。维护治疗在溃疡愈合以后被给的 Omeprazole (20 mg/d ) 。除了临床的后续,回廊 24-h 胃的 pH 试金与以前的十二指肠溃疡外科而是没有溃疡复发在那些病人和控制被执行在前并且在 omeprazole 治疗期间。结果:所有 15 溃疡在为 2 瞬间与 omeprazole (40 mg/d ) 被对待以后被愈合。有二的十一个病人(1-9 ) 周期性的溃疡流血的事件完成了后续(43, 12-72 瞬间) 。任何一个都没他们有一个流血事件当时在 omeprazole 上。一个病人中止了治疗并且有周期性的流血。在病人的胃的 pH<4 的中部的 24-h 部分时间是 80, 46-95% ,并且被归结为 32,由 omeprazole (P=0.002 ) 的 13-70% 。结论:有 omeprazole (20 mg/day ) 的长期的维护治疗在阻止周期性的溃疡流血是有效的。 | Konstantinos Demertzis Dimitrios Polymeros Theodoros Emmanuel Konstantinos Triantafyllou Pericles Tassios Spiros D Ladas | 2006 | World Journal of Gastroenterology2006，12，5： | 5 |
| 11 | 考试测评与语言能力标准对接中的若干问题显示文摘在教育改革背景下,对考试测评与语言能力标准的对接需求显著增加,这不仅体现在对学生语言能力进步的监测上,也体现在标准化考试的使用过程中。将考试的内容和分数与语言能力标准中的不同等级进行对接,可以增强考试分数在不同教育背景下的可解释性。通过对语言测评与CEFR对接研究的分析,讨论考试测评与语言能力框架对接中的一些重要问题,并对《中国英语能力等级量表》与考试的对接提出建议。 | Spiros Papageorgiou 刘洋(译) | 2019 | 中国考试2019，0，8： | 5 |
| 12 | Colonic gas explosion during therapeutic colonoscopy with electrocautery显示文摘有电镀物品烙术的治疗学的结肠镜检查广泛地在全世界被使用。足够的结肠的清洁为这个过程的安全被认为一个关键因素。结肠的煤气的爆炸稀罕,在有电镀物品的结肠镜检查期间是最令人恐惧的因医生之治疗而引的复杂并发症之一烙术。这复杂并发症是到爆炸集中的结肠的气体的累积的结果,但是可以被过细的肠准备阻止。这评论的目的是为治疗学的结肠镜检查讨论指示和肠准备的类型,并且与电镀物品烙术为结肠镜检查为足够的肠准备贡献建议。 | Spiros D Ladas George Karamanolis Emmanuel Ben-Soussan | 2007 | World Journal of Gastroenterology2007，13，40： | 5 |
| 13 | Two cameras detect more lesions in the small-bowel than one显示文摘AIM:To explore the feasibility of dual camera capsule (DCC)small-bowel(SB)imaging and to examine if two cameras complement each other to detect more SB lesions.METHODS:Forty-one eligible,consecutive patients underwent DCC SB imaging.Two experienced investigators examined the videos and compared the total number of detected lesions to the number of lesions detected by each camera separately.Examination tolerability was assessed using a questionnaire.RESULTS:One patient was excluded.DCC cameras detected 68 positive findings(POS)in 20(50%)cases.Fifty of them were detected by the'yellow'camera,48 by the'green'and 28 by both cameras;44%(n=22)of the'yellow'camera’s POS were not detected by the'green'camera and 42%(n=20)of the'green' camera’s POS were not detected by the'yellow'camera.In two cases,only one camera detected significant findings.All participants had 216 findings of unknown significance(FUS).The'yellow','green'and both cameras detected 171,161,and 116 FUS,respectively;32%(n=55)of the'yellow'camera’s FUS were not detected by the'green'camera and 28%(n=45)of the'green'camera’s FUS were not detected by the 'yellow'camera.There were no complications related to the examination,and 97.6%of the patients would repeat the examination,if necessary.CONCLUSION:DCC SB examination is feasible and well tolerated.The two cameras complement each other to detect more SB lesions. | Konstantinos Triantafyllou Ioannis S Papanikolaou Kostis Papaxoinis Spiros D Ladas | 2011 | World Journal of Gastroenterology2011，17，11： | 5 |
| 14 | Long‐term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis显示文摘 | Jiannis Vlachogiannakos Nikos Viazis Panagiota Vasianopoulou Irene Vafiadis Dimitrios G Karamanolis Spiros D Ladas | 2013 | J Gastroenterol Hepatol2013，，3： | 4 |
| 15 | Surgical resection of a solitary liver metastasis from nasopharyngeal carcinoma: a case report显示文摘BACKGROUND: Nasopharyngeal carcinoma (NPC) has a propensity to develop distant metastases at a high rate and with poor prognosis. Metastatic sites are usually multifocal and involve bones, lungs, liver and distant lymph nodes. Management of metastatic disease is essentially palliative and is based on chemotherapy. METHODS: A 50-year-old man with a solitary liver metastasis from a newly diagnosed NPC was treated by segmentectomy. Prior to surgery, neoadjuvant chemo therapy followed by concurrent chemoradiotherapy was administered. RESULTS: Complete remission of the primary disease was achieved, although the size of the hepatic lesion was increased. After resection of the liver metastasis, no signs of local or distant recurrence was noted during the 6-month follow up. CONCLUSION: Although surgical treatment has a limited role in metastatic NPC, there are rare cases of localized disease with a reasonable outcome after resection. | Spiros Delis Ioannis Biliatis Antonia Bourli Nikolaos Kapranos Christos Dervenis | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 4 |
| 16 | Rare cystic liver lesions: A diagnostic and managing challenge显示文摘Cystic formations within the liver are a frequent finding among populations.Besides the common cystic lesions,like simple liver cysts,rare cystic liver lesions like cystadenocarcinoma should also be considered in the differential diagnosis.Thorough knowledge of each entity’s nature and course are key elements to successful treatment.Detailed search in PubMed,Cochrane Database,and international published literature regarding rare cystic liver lesions was carried out.In our research are included not only primary rare lesions like cystadenoma,hydatid cyst,and polycystic liver disease,but also secondary ones like metastasis from gastrointestinal stromal tumors lesions.Up-to date knowledge regarding diagnosis and management of rare cystic liver lesions is provided.A diagnostic and therapeutic algorithm is also proposed.The need for a multidisciplinary approach by a team including radiologists and surgeons familiar with liver cystic entities,diagnostic tools,and treatment modalities is stressed.Patients with cystic liver lesions must be carefully evaluated by a multidisciplinary team,in order to receive the most appropriate treatment,since many cystic liver lesions have a malignant potential and evolution. | Andreas Bakoyiannis Spiros Delis Charina Triantopoulou Christos Dervenis | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 17 | SHRIMP zircon U-Pb ages from coal beds across the Permian-Triassic boundary, eastern Yunnan, southwestern China显示文摘The first SHRIMP zircon U e Pb ages from coal beds close to the end-Permian mass extinction are reported from the C_1 coal seam in the Yantang Mine in Laibin Town, Xuanwei County, eastern Yunnan Province.Zircons were extracted from kaolinite claystone layers, defined as tonsteins(volcanic ash deposits), in the subseam B_1 and B_3 of the coal seam C_1.The U-Pb ages are 252.0 ± 2.3 Ma and 250.3 ± 2.1 Ma for the sub-seam B_1 and B_3, respectively. Within analytical uncertainties, these U-Pb ages include the time period of the onset of the mass extinction at 251.941 ± 0.037 Ma, which was obtained from the marine Meishan section in Zhejiang Province, ~1600 km away from the Yantang Mine. These new ages represent not only the first and closest ages to the PTB mass extinction in terrestrial coal beds, but also ages from the nearest site to the Emeishan volcanoes investigated so far. Therefore these new data provide the most accurate stratigraphic horizon of terrestrial facies of the end-Permian extinction in South China. The Emeishan volcanoes were likely the source of volcanic ash in the coal seams at the Xuanwei County and broader areas in South China. Furthermore, the minerals and geochemistry characteristics of the C_1 coal seam also implied the influences of contemporaneous volcanic activities. | Juan Wang Long-Yi Shao Hao Wang Baruch Spiro David Large | 2018 | Journal of Palaeogeography2018，7，2： | 4 |
| 18 | A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulation显示文摘AIM: During endoscopic retrograde cholangiopancreatography (ERCP), selective cannulation of the common bile duct (CBD) is required in most of the cases.METHODS: From June 2001 till December 2002, all patients referred to our unit for ERCP were considered for entry into the study. Selective CBD cannulation was first attempted with a standard catheter with or without the use of a guidewire. In cases, where CBD cannulation was considered unsuccessful, patients were crossed over to a double-lumen sphincterotome and a guidewire. All patients were hospitalized for 24 h after the procedure in order to assess the incidence of post-ERCP complications.RESULTS: The study sample consisted of 158 patients.Selective CBD cannulation using a standard ERCP catheter with or without the assistance of a guidewire, was accomplished in 129 patients (success rate: 81.65%).From the 29 patients who were crossed over to a sphincterotome and a guidewire, selective CBD cannulation was achieved in 24; the overall success rate rising to 96.8%. Meanwhile, the use of this technique did not increase the incidence of post-ERCP complications.CONCLUSION: The use of a sphincterotome and a guidewire increases the success rate of selective bile duct cannulation in cases that this has not been accomplished with a standard catheter. | Georgios Karamanolis Aikaterini Katsikani Nikos Viazis Gerasimos Stefanidis Spilios Manolakopoulos Spiros Sgouros Efthimia Papadopoulou Apostolos Mantides | 2005 | World Journal of Gastroenterology2005，11，11： | 3 |
| 19 | Liver transplantation for severe hepatic trauma:Experience from a single center显示文摘Liver transplantation has been reported in the literature as an extreme intervention in cases of severe and complicated hepatic trauma.The main indications for liver transplant in such cases were uncontrollable bleeding and postoperative hepatic insufficiency.We here describe four cases of orthotopic liver transplantation after penetrating or blunt liver trauma.The indications were liver failure,extended liver necrosis,liver gangrene and multiple episodes of gastrointestinal bleeding related to portal hypertension,respectively.One patient died due to postoperative cerebral edema.The other three patients recovered well and remain on immunosuppression.Liver transplantation should be considered as a saving procedure in severe hepatic trauma,when all other treatment modalities fail. | Spiros G Delis Andreas Bakoyiannis Gennaro Selvaggi Debbie Weppler David Levi Andreas G Tzakis | 2009 | World Journal of Gastroenterology2009，15，13： | 3 |
| 20 | Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice显示文摘 | Konstantinos Triantafyllou Nikos Viazis Panagiotis Tsibouris Georgios Zacharakis Chryssostomos Kalantzis Demetrios G. Karamanolis Spiros D. Ladas | 2014 | Gastrointestinal Endoscopy2014，，2： | 3 |
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