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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Effects of Core-shell Latex Morphology on Film Forming Behavior显示文摘 | Michael J Devon John L Gardon Glen Roberts | 1990 | Journal of Applied Polymer Science1990，39，10： | 1 |
| 3 | Association of FABP5 Expression With Poor Survival in Triple-Negative Breast Cancer显示文摘 | Rong-Zong Liu Kathryn Graham Darryl D. Glubrecht Devon R. Germain John R. Mackey Roseline Godbout | 2011 | The American Journal of Pathology2011，，3： | 1 |
| 4 | Characteristics of a chamber used for electrooptical device performance measurements in the presence of fog 显示文摘 | Cohen D K John H H Devon G C | 1982 | Optical Society of America1982，21，13： | 1 |
| 5 | Twenty-five-year results after charnley total hip arthroplasty in patients less than fifty years old显示文摘 | Jay D John J Devon D | 2003 | J Bone and Joint Surg(Am)2003，85，： | 1 |
| 6 | Characteristics of a chamber used for electrooptical device performance measurements in the presence of fog显示文摘 | COHEN D K JOHN H H DEVON G C | 1982 | Optlcal Society of America1982，21，13： | 1 |
| 7 | Effects of core-shell latex morphology on film forming behavior显示文摘 | Michael J Devon John L | 1990 | Journal of Applied Polymer Science1990，39，： | 1 |
| 8 | 一种测定棉纤维成熟度的绝对基准方法显示文摘前言关于评价棉纤维样品品质最值得注意的问题之一,是如何精确量度样品中纤维的成熟度分布。这种方法最好应是直接、快速的, | DEVON P.THIBODEAUX JOHN B.PRICE 宋琦 宋钧才 | 1991 | 纤维标准与检验1991，，2： | 0 |
| 9 | Inter-and intra-rater reliability of diffusion tensor imaging parameters in the normal pediatric spinal cord显示文摘AIM: To assess inter- and intra-rater reliability(agreement) between two region of interest(ROI) methods in pediatric spinal cord diffusion tensor imaging(DTI). METHODS: Inner-Field-of-View DTI data previously acquired from ten pediatric healthy subjects(mean age = 12.10 years) was used to assess for reliability. ROIs were drawn by two neuroradiologists on each subject data twice within a 3-mo interval. ROIs were placed on axial B0 maps along the cervical spine using free-hand and fixed-size ROIs. Agreement analyses for fractional anisotropy(FA), axial diffusivity, radial diffusivity and mean diffusivity were performed using intra-class-correlation(ICC) and Cronbach's alpha statistical methods.RESULTS: Inter- and intra-rater agreement between the two ROI methods showed moderate(ICC = 0.5) to strong(ICC = 0.84). There were significant differences between raters in the number of pixels selected using free-hand ROIs(P < 0.05). However, no significant differences were observed in DTI parameter values. FA showed highest variability in ICC values(0.10-0.87). Cronbach's alpha showed moderate-high values for raters and ROI methods. CONCLUSION: The study showed that high reproducibility in spinal cord DTI can be achieved, and demonstrated the importance of setting detailed methodology for post-processing DTI data, specifically the placement of ROIs. | Nadia Barakat Pallav Shah Scott H Faro John P Gaughan Devon Middleton MJ Mulcahey Feroze B Mohamed | 2015 | World Journal of Radiology2015，7，9： | 0 |
| 10 | Trends and outcomes of liver transplantation among older recipients in the United States显示文摘BACKGROUND The average age of recipients and donors of liver transplantation(LT)is increasing.Although there has been a change in the indications for LT over the years,data regarding the trends and outcomes of LT in the older population is limited.AIM To assess the clinical characteristics,age-related trends,and outcomes of LT among the older population in the United States.METHODS We analyzed data from the United Network for Organ Sharing database between 1987-2019.The sample was split into younger group(18-64 years old)and older group(≥65 years old).RESULTS Between 1987-2019,155758 LT were performed in the United States.During this period there was a rise in median age of the recipients and percentage of LT recipients who were older than 65 years increased(P<0.05)with the highest incidence of LT among older population seen in 2019(1920,23%).Common primary etiologies of liver disease leading to LT in older patients when compared to the younger group,were non-alcoholic steatohepatitis(16.4%vs 5.9%),hepatocellular carcinoma(14.9%vs 6.9%),acute liver failure(2.5%vs 5.2%),hepatitis C cirrhosis(HCV)(19.2%vs 25.6%)and acute alcoholic hepatitis(0.13%vs 0.35%).In older recipient group female sex and Asian race were higher,while model for end-stage liver disease(MELD)score and rates of preoperative mechanical ventilation were lower(P<0.01).Median age of donor,female sex,body mass index(BMI),donor HCV positive status,and donor risk index(DRI)were significantly higher in older group(P<0.01).In univariable analysis,there was no difference in post-transplant length of hospitalization,one-year,three-year and five-year graft survivals between the two groups.In multivariable Cox-Hazard regression analysis,older group had an increased risk of graft failure during the five-year post-transplant period(hazard ratio:1.27,P<0.001).Other risk factors for graft failure among recipients were male sex,African American race,re-transplantation,presence of diabetes,mechanical ventilation at the time of LT,higher MELD score,presence of portal vein thrombosis,HCV positive status,and higher DRI.CONCLUSION While there is a higher risk of graft failure in older recipient population,age alone should not be a contraindication for LT.Careful selection of donors and recipients along with optimal management of risk factors during the postoperative period are necessary to maximize the transplant outcomes in this population. | Kenji Okumura Joon Sub Lee Abhay Dhand Hiroshi Sogawa Gregory Veillette Devon John Ryosuke Misawa Roxana Bodin David C Wolf Thomas Diflo Seigo Nishida | 2022 | World Journal of Transplantation2022，12，8： | 0 |
| 11 | 一次住院期间间隔四至七天先后行双侧全膝关节置换显示文摘背景:本文的研究目的是通过比较一次住院间隔4~7天分阶段(以下简称分段)进行双侧全膝关节置换和同一麻醉下依次进行双侧全膝关节置换或分别住院分期进行单侧全膝关节置换的情况,评价三组中伴发并发症的类型和发生率。方法:我们调用电啮数据库巾的资料和医疗记录,回顾性分析了两位医生所做的332例双膝关节置换的患者,其中241例患者是在住院时,间隔4~7天分段进行了双侧全膝关节置换,26例患者是一次手术依次进行了双侧全膝关节置换,65例患者分二次住院、分期进行了双侧全膝炎节置换。根据病例资料,对主要并发症(包括死亡、冉次手术、心肌梗死和肺栓塞)和次要并发症(包括心房纤维性颤动、深静脉血栓和尿道感染)进行评价。结果:接受双侧全膝荚节置换者,依次组和分期组比分段组的总并发症发生率高2.5倍。所有组的主要并发症的发生都较为罕见.但以分期组的发生率较高。总并发症发生率在分段组(13%)比在依次组(35%)或在分期组(31%)明显要低(p=0.0009)。分段组患者的住院时间比依次组的患者多4天(p=0.0001)。结论:一次住院间隔4~7天分段进行双侧全膝关节置换是一种安全实用的双侧全膝关节置换方法。 | CHRISTOPHER D. SLIVA JOHN J. CALLAGHAN DEVON D. GOETZ STEPHEN G.TAYLOP 李玉军(译) | 2005 | 骨科动态2005，1，3： | 0 |
| 12 | Inferior outcomes of liver transplantation for hepatocellular carcinoma during early-COVID-19 pandemic in the United States显示文摘BACKGROUND Early in the coronavirus disease 2019(COVID-19)pandemic,there was a significant impact on routine medical care in the United States,including in fields of transplantation and oncology.AIM To analyze the impact and outcomes of early COVID-19 pandemic on liver transplantation(LT)for hepatocellular carcinoma(HCC)in the United States.METHODS WHO declared COVID-19 as a pandemic on March 11,2020.We retrospectively analyzed data from the United Network for Organ Sharing(UNOS)database regarding adult LT with confirmed HCC on explant in 2019 and 2020.We defined pre-COVID period from March 11 to September 11,2019,and early-COVID period as from March 11 to September 11,2020.RESULTS Overall,23.5%fewer LT for HCC were performed during the COVID period(518 vs 675,P<0.05).This decrease was most pronounced in the months of March-April 2020 with a rebound in numbers seen from May-July 2020.Among LT recipients for HCC,concurrent diagnosis of non-alcoholic steatohepatitis significantly increased(23 vs 16%)and alcoholic liver disease(ALD)significantly decreased(18 vs 22%)during the COVID period.Recipient age,gender,BMI,and MELD score were statistically similar between two groups,while waiting list time decreased during the COVID period(279 days vs 300 days,P=0.041).Among pathological characteristics of HCC,vascular invasion was more prominent during COVID period(P<0.01),while other features were the same.While the donor age and other characteristics remained same,the distance between donor and recipient hospitals was significantly increased(P<0.01)and donor risk index was significantly higher(1.68 vs 1.59,P<0.01)during COVID period.Among outcomes,90-day overall and graft survival were the same,but 180-day overall and graft were significantly inferior during COVID period(94.7 vs 97.0%,P=0.048).On multivariable Coxhazard regression analysis,COVID period emerged as a significant risk factor of post-transplant mortality(Hazard ratio 1.85;95%CI:1.28-2.68,P=0.001).CONCLUSION During COVID period,there was a significant decrease in LTs performed for HCC.While early postoperative outcomes of LT for HCC were same,the overall and graft survival of LTs for HCC after 180 days were significantly inferior. | Inkyu S Lee Kenji Okumura Ryosuke Misawa Hiroshi Sogawa Gregory Veillette Devon John Thomas Diflo Seigo Nishida Abhay Dhand | 2023 | World Journal of Hepatology2023，15，4： | 0 |
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