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| 1 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 2 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 3 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 4 | Client-level predictors of treatment engagement,outcome and dropout:moving beyond demographics显示文摘Background Despite the availability of evidence-based treatments for posttraumatic stress disorder(PTSD),significant heterogeneity in the effectiveness of PTSD treatment persists,especially in community settings.Client demographics used to understand this variability in treatment outcome and dropout have yielded mixed results.Despite increasing evidence for the importance of attending to treatment engagement in community settings,few studies have explored client-level predictors.Aim The purpose of this study is to explore client-level predictors of treatment outcome and dropout beyond client demographics,and to identify client-level predictors of treatment engagement in community settings.Method Secondary data analysis was conducted with data collected as part of an implementation-effectiveness hybrid study of cognitive processing therapy(CPT)for PTSD in a diverse community healthcentre.Providers(n=19)treated(n=52)clients as part of their routine clinical care.Non-demographic client-level predictors included barriers to treatment,quality of life,session-level language and employment history assessed at baseline.Treatment engagement included number of weeks in the study,number of sessions with repeated CPT content,number of unique CPT sessions attended,frequency of session attendance and consistency of session attendance.Results Results showed language as a significant predictor of treatment engagement.There were significant differences between Spanish and English-speaking clients,with the former having a tendency to repeat more session content than the latter(β=1.4 sessions,p=0.003),and also less likely to attend treatment frequently(r=0.62,p=0.009)and consistently(r=0.57,p=0.027)if high logistical and financial barriers were endorsed.Irrespective of language,clients who reported high quality of life at baseline were less likely to repeat CPT session content(β=-0.3,p=0.04),and those with increased baseline barriers to treatment had deceleration in PTSD symptom improvement over time(β=-0.62,p<0.05).In terms of treatment engagement moderators impacting treatment outcome,clients who repeated more session content were more likely to complete treatment(0R=1.84,p=0.037).Conclusion Identification of client-level predictors of treatment engagement,outcome and dropout is essential to optimise treatment,particularly in community settings. | Soo-jeong Youn Margaret-Anne Mackintosh Shannon Wiltsey Stirman Kay lie A Patrick Yesenia Aguilar Silvan Anna D Bartuska Derri L Shtasel Luana Marques | 2019 | General Psychiatry2019，32，6： | 2 |
| 5 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 6 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 7 | Physical properties of dewatered wastewater sludge for landfilling 显示文摘 | Koening A Kay J N Wan I M | 1996 | War Sci Tech1996，34，34： | 2 |
| 8 | Brain magnetic resonance imaging with contrast dependent on blc, od oxygenation显示文摘 | Ogawa S Lee T M Kay A R | 1990 | Proceedings of the National Academy of Sciences USA1990，87，98： | 1 |
| 9 | Herpes simplex keratitis 显示文摘 | Kaye S Choudhary A | 2006 | Prog Retin Eye Res2006，25，4： | 1 |
| 10 | The sequence of the rice phytochrome gene显示文摘 | Kay S A Keith B Shinozaki K | | 0，，： | 1 |
| 11 | 查看详情显示文摘 | A M Ruschak M Slassi L E Kay | | 0，，13： | 1 |
| 12 | Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes显示文摘 | van Duin D Kaye K S Neuner E A | 2013 | DiangMicrobiollnfectDis2013，75，2： | 1 |
| 13 | Preparation of TiO2 (anatase) films on electrodes by anodlc oxidative hydrolysis of TiCl3显示文摘 | Kavan L O' Regan B Kay A | 1993 | Electroanal Chem1993，346，： | 1 |
| 14 | Tissue selec tive action of tamoxifen methiodide,raloxifene and tamoxifen on creatine kinas e B activity in vitro and in vivo显示文摘 | Waisman A Kaye AM | 1996 | J Steroid Biochem Mol Biol1996，59，56： | 1 |
| 15 | T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity显示文摘 | VERHOEF A ALEXANDER C KAY AB | 2005 | PLoS Med2005，2，3： | 1 |
| 16 | Conversion of light to electricity by cis-X2 bis (2,2-biphyridyl-4,4-dicarboxylate)rutheninm (Ⅱ) charge-transfer sensitizers (X=CI^-,Br,I^-,CN^-,and SCN) on nanocrystalline TiO2 electrodes 显示文摘 | NAZERUDD1N M K KAY A RADICIO I | 1993 | J Am Ceram Soc1993，115，14： | 1 |
| 17 | Treatment of polymyositis and dermaomyositis显示文摘 | Kaye S A Isenberg D A | 1994 | Br Hos J Med1994，52，9： | 1 |
| 18 | Conversion of light to electricity by cis-X2 Bis (2,2'-bipyidyl-4,4'-dicaboxylate) ruthenium charge-transfer sensitizes (X = Cl-,Bt-,I-,CN-and SCN-) on nanocrystalline TiO2 electrodes显示文摘 | Nazeetuddin M K Kay A Rodicicio I | 1993 | Am Chem Soc1993，115，： | 1 |
| 19 | Column Studies to Investigate the Fate of Veterinary Antibiotics in Clay Soils following Slurry Application to Agricultural Land显示文摘 | KAY P BLACKWELL P A BOXALL A B A | 2005 | Chemosphere2005，60，4： | 1 |
| 20 | Solution of piece-wise-linear ordinary differential equations using waveform relaxation and Laplace transforms 显示文摘 | KAYE R J VINCENTELLI A S | 1983 | IEEE Trans on CAS1983，30，： | 1 |
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