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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Cultured keratinocyte grafting on various biologic matrices显示文摘1IntroductionCulturedkeratinocytesasrelativelydiferenti-atiedsheetgraftshaveimprovedthecareforburnsandotherwounds.Forthelastd... | Stark GB△ Horch RE Voigt M Kopp J Saied S Jiao XY | 1998 | 第二军医大学学报1998，19，S1： | 3 |
| 4 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 5 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 6 | Mushy/semi-solid metal forming technology-present and future显示文摘 | Kiuchi M Kopp R | 2002 | Annals of the CIRP2002，51，2： | 1 |
| 7 | Changes during isolation and culture of tobacco mesophyll protopiasts显示文摘 | Gigot C Kopp M Schmitt C | 1975 | Protoplasma1975，84，： | 1 |
| 8 | Evidence-based medicine in the therapy of the acute respiratory distress syndrome 显示文摘 | Kopp R Kuhlen R Max M | 2002 | Intens Care Med2002，28，3： | 1 |
| 9 | Microbial influence on tolerance and opportunities for intervention with prebiotics/ probiotics and bacterial lysates显示文摘 | Pfefferle PI Prescott SL Kopp M | 2013 | J Allergy Clin Immunol2013，131，6： | 1 |
| 10 | Magic traits in speciation:‘magic' but not rare显示文摘 | Servedio MR Van Doom GS Kopp M Frame AM Nosil P | | 0，，： | 1 |
| 11 | Indicators of psycholo$ical distress among fe- male physicians in Hungary 显示文摘 | Gyrffy Z Kopp M | 2013 | Orv HefiI2013，154，25： | 1 |
| 12 | Advances in NDI elastomer chemistry显示文摘 | Prolingheuer E C Barnes J M Kopp R | 1992 | J Elastomers Plast1992，24，3： | 1 |
| 13 | NF- kappa B and Rel proteins: evolutionarily conserved mediators of immune responses显示文摘 | Ghosh S May M J Kopp EB | 1998 | Annu Rev Immunol1998，16，1： | 1 |
| 14 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 15 | Renal bone inorphogenetic proteins-7 protects against diabetic nephropathy 显示文摘 | Wang S de Caestecker M Kopp J | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 16 | Cathodoluminescent microstratigraphy in gangue dolomite,the Mascot-Jefferson City Districe 显示文摘 | Ebers M L Kopp O C | 1979 | Tennessee Econ Geol1979，74，4： | 1 |
| 17 | Analysis of a magnetoelastic sensor magnetics 显示文摘 | COPELAND R L KOPP M O' HANDLEY R C | 1994 | IEEIE Transactions1994，30，5： | 1 |
| 18 | Effects of a microbial phytase on the utilization of the phosphorus by op in a diet based on soyabean meal 显示文摘 | Schafer A Koppe W M Mper-Burgdoec K H | 1995 | Water Science and Technology1995，31，： | 1 |
| 19 | Effects of a microbial phytase on the utilization of native phosphorus by carp in a diet based on soybean meal显示文摘 | Schfer A Koppe W M Meyer-Burgdorff K H et a/ | 1995 | Water Science and Technology1995，31，10： | 1 |
| 20 | Adipocyte chemerin release is induced by insulin without being translated to higher levels in vivo显示文摘 | Bauer S Bala M Kopp A | 2012 | Eur J Clin Invest2012，42，11： | 1 |
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