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| 1 | Diagnostic and prognostic value of circulating micro RNAs in heart failure with preserved and reduced ejection fraction显示文摘micro RNAs(mi RNAs) are powerful regulators of posttranscriptional gene expression and play an important role in pathophysiological processes. Circulating mi RNAs can be quantified in body liquids and are promising biomarkers in numerous diseases. In cardiovascular disease mi RNAs have been proven to be reliable diagnostic biomarkers for different disease entities. In cardiac fibrosis(CF) and heart failure(HF) dysregulated circulating mi RNAs have been identified,indicating their promising applicability as diagnostic biomarkers. Some mi RNAs were successfully tested in risk stratification of HF implementing their potential use as prognostic biomarkers. In this respect mi RNAs might soon be implemented in diagnostic clinical routine. In the young field of mi RNA based research advances have been made in identifying mi RNAs as potential targets for the treatment of experimental CF and HF. Promising study results suggest their potential future application as therapeutic agents in treatment of cardiovascular disease. This article summarizes the current state of the various aspects of mi RNA research in the field of CF and HF with reduced ejection fraction as well as preserved ejection fraction. The review provides an overview of the application of circulating mi RNAs as biomarkers in CF and HF and current approaches to therapeutically utilize mi RNAs in this field of cardiovascular disease. | Christian Schulte Dirk Westermann Stefan Blankenberg Tanja Zeller | 2015 | World Journal of Cardiology2015，7，12： | 11 |
| 2 | Age Structure and Growth of Degraded Populus euphratica Floodplain Forests in North-west China and Perspectives for Their Recovery显示文摘The Populus euphratica floodplain forests along the lower reaches of the Tarim River in continental-arid Xinjiang (north-west China) have been declining in recent decades as a result of dam constructions and the withdrawal of water from the river. Since 2000,controlled flooding has been carried out to counteract this process of degradation. However,the consequences of a changing water regime for the floodplain ecosystem are not yet sufficiently investigated. In 2004 we sampled a total of 150 P. euphratica trees along two transects at the middle and lower reaches of the Tarim River to compare the age structure and growth of these two tree populations. The anthropogenic drawdown of the groundwater table had no effect on the average growth of the trees at the lower reaches. However,tree growth abruptly increased after controlled flooding,thus showing distinct signs of recovery. | Janneke Westermann Stefan Zerbe Dieter Eckstein | 2008 | Journal of Integrative Plant Biology2008，50，5： | 9 |
| 3 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 4 | System security of hybrid AC-HVDC-systems challenges and new approaches for combined security assessment,preventive optimization and curative actions显示文摘The intense application of Voltage Source Converter based HVDC interconnections and grids will result in a hybrid AC-HVDC-system. The operation of such a system becomes complex regarding system security and system operation. This paper describes major challenges and proposes potential solutions, including a combined security assessment, preventive optimization and curative actions. A coordination of both systems enables an efficient application of existing transport capacity. | Florian Sass Tom Sennewald Franz Linke Dirk Westermann | 2018 | Global Energy Interconnection2018，1，5： | 7 |
| 5 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 6 | 血中的淋巴细胞亚群是淋巴系统的诊断指标吗?显示文摘淋巴细胞通过血液不断出入淋巴和非淋巴器官。因此,一般来说血中淋巴细胞亚群的测定可以反映淋巴系统的情况。近年来,通过对不同疾病患者血中一套淋巴细胞亚群参数的测定,发现很多疾病会引起参数的变化。但除疾病外,许多因素(包括紧张、吸烟、服药、运动及衰老等)也能影响血中的淋巴细胞,不同因素引起的变化很容易掩盖有诊断价值的改变,如:T 淋巴细胞的数量随取样时间不同所产生的波动可达100%。因此要得到可重复的结果是很困难的,这也清楚地指明取样的高度标准化、染色及评价技术的必要性。但是,问题在于外周血淋巴细胞是否能完全反映整个淋巴系统的内部状况(见表)。 | Westermann J 富欣 | 1991 | 国外医学(免疫学分册)1991，14，6： | 5 |
| 7 | Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: “Why did recent clinical trials fail?”显示文摘Heart failure(HF) is the leading cause of hospitalization among older adults and the prevalence is growing with the aging populations in the Western countries. Epidemiologic reports suggest that approximately 50% of patients who have signs or symptoms of HF have preserved left ventricular ejection fraction. This HF type predominantly affects women and the elderly with other co-morbidities, such as diabetes, hypertension, and overt volume status. Most of the current treatment strategies are based on morbidity benefits such as quality of life and reduction of clinical HF symptoms. Treatment of patients with HF with preserved ejection fraction displayed disappointing results from several large randomized controlled trials. The heterogeneity of HF with preserved ejection fraction, understood as complex syndrome, seems to be one of the primary reasons. Here, we present an overview of the current management strategies with available evidence and new therapeutic approach from drugs currently in clinical trials, which target diastolic dysfunction, chronotropic incompetence, and risk factor management. We provide an outline and interpretation of recent clinical trials that failed to improve outcome and survival in patients with HF with preserved ejection fraction. | Peter Moritz Becher Nina Fluschnik Stefan Blankenberg Dirk Westermann | 2015 | World Journal of Cardiology2015，7，9： | 3 |
| 8 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 9 | Recuperation of severe tumoral calcinosis in a dialysis patient: A case report显示文摘BACKGROUND One of the common late sequela in patients with end-stage renal disease(ESRD)is the calcium phosphate disorder leading to chronic hypercalcemia and hyperphosphatemia causing the precipitation of calcium salt in soft tissues.Tumoral calcinosis is an extremely rare clinical manifestation of cyst-like soft tissue deposits in different periarticular regions in patients with ESRD and is characterized by extensive calcium salt containing space-consuming painful lesions.The treatment of ESRD patients with tumoral calcinosis manifestation involves an increase in or switching of renal replacement therapy regimes and the adjustment of oral medication with the goal of improved hypercalcemia and hyperphosphatemia.CASE SUMMARY We describe a 40-year-old woman with ESRD secondary to IgA-nephritis and severe bilateral manifestation of tumoral calcinosis associated with hypercalcemia,hyperphosphatemia and tertiary hyperparathyroidism.The patient was on continuous ambulatory peritoneal dialysis and treatment with vitamin D analogues.After switching her to a daily hemodialysis schedule and adjusting the medical treatment,the patient experienced a significant dissolution of her soft tissue calcifications within a couple of weeks.Complete remission was achieved 11 mo after the initial diagnosis.CONCLUSION Reduced patient compliance and subsequent insufficiency of dialysis regime quality contribute to the aggravation of calcium phosphate disorder in a patient with ESRD leading to the manifestation of tumoral calcinosis.However,the improvement of the treatment strategy and reinforcement of patient compliance enabled complete remission of this rare disease entity. | Lukas Westermann Lisa K Isbell Marie K Breitenfeldt Frederic Arnold Elvira Rothele Johanna Schneider Eugen Widmeier | 2019 | World Journal of Clinical Cases2019，7，23： | 2 |
| 10 | A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer显示文摘 | Grosen EA Katschinski DM | 2001 | Eur J Cancer2001，37，9： | 1 |
| 11 | Role of left ventricular stiffness in heart failure with normal ejection fraction 显示文摘 | Westermann D Kasner M Steendijk P | 2008 | Circulation2008，117，16： | 1 |
| 12 | Acute pancreatitis in rat: effect of sodium taurocholate, CCK- 8, and Sec on pancreatic micoacirculation 显示文摘 | Plusczyk T Westermann S Rathgeb D | 1997 | Am J Physiol1997，272，： | 1 |
| 13 | Delayed presentation of an enterocutaneous fistula after tension-free vaginal tape sling 显示文摘 | Westermann L B Brown A Long J B | 2011 | Female Pelvic Mcd Reconstr Surg2011，17，5： | 1 |
| 14 | GPU-friendly high-quality terrain rendering显示文摘 | Schneider J Westermann R | 2006 | Journal of WSCG2006，14，13： | 1 |
| 15 | Dynamics of N20 pro- duction from activated sludge显示文摘 | Gejlsbjerg B Frette L Westermann P | 1998 | Water Research1998，32，7： | 1 |
| 16 | Long-term survival data of triple modality treatment of stage IIB-III- IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia-an update显示文摘 | Westermann A Mella O Van Der Zee J | 2012 | Int J Hyper- thermia2012，28，6： | 1 |
| 17 | Linear Algebra Operators for GPU Implementation of Numerical Algorithms显示文摘 | Kruger J Westermann R | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 18 | GPU-friendly High- qualily Terrain Rendering显示文摘 | Schneider J Westermann R | 2006 | Journal of WSCG2006，14，1： | 1 |
| 19 | A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer 显示文摘 | Westermann AM Grosen EA Katschinski DM | 2001 | Eur Cancer2001，37，9： | 1 |
| 20 | The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements显示文摘 | TSCHOPE C KASNER M WESTERMANN D | 2005 | Eur Heart J2005，26，： | 1 |
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