|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 2 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 3 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 4 | Medical student depression and its correlates across three international medical schools显示文摘BACKGROUND Medical students have high rates of depression, anxiety, and burnout that have been found to affect their empathy, professional behaviors, and performance as a physician. While studies have examined predictors for burnout and depression in the United States (US), no study, to our knowledge, has compared depression in medical students cross-culturally, or has attempted to examine the effect of factors influencing rates including burnout, exercise, stress, unmet mental health needs, and region. AIM To examine rates of depression in three international cohorts of medical students, and determine variables that may explain these differences. METHODS Convenience samples of medical students from three countries (US, China, and a Middle Eastern country whose name remains anonymous per request from the school) were surveyed in this observational study. Using the Patient Health Questionnaire-2 (PHQ-2) and a modified Maslach Burnout Inventory, depression and burnout were examined among medical students from the three cohorts (n = 473). Chi-square test and analysis of variance were used to examine differences in demographics, behavioral, and psychological variables across these three schools to identify potentially confounding descriptive characteristics. Analysis of covariance compared depression and the emotional exhaustion component of burnout identified through Principal Component Analysis across countries. Multiple linear regression was used to analyze the impact of demographic, behavioral, and psychological variables on screening positive for depression. RESULTS Medical students from the Middle Eastern country had the highest rates of positive depression screens (41.1%), defined as a PHQ-2 score of ≥ 3, followed by China (14.1 %), and then the US (3.8%). More students in the Middle Eastern school had unmet mental health needs (50.8%) than at the medical school in China (34.8%) or the school in the US (32.8%)(Pearson chi-square significance < 0.05). Thus, PHQ-2 scores were adjusted for unmet mental health needs;however, the Middle Eastern country continued to have the highest depression. Adjusting for PHQ-2 score, medical students from the US scored the highest on emotional exhaustion (a measure of burnout). Demographic variables did not significantly predict medical student depression;however, lack of exercise, unmet mental health needs, stress, and emotional exhaustion predicted nearly half of depression in these cohorts. In comparison to the US, coming from the Middle Eastern country and China predicted higher levels of depression. CONCLUSION Depression rates differ in three international cohorts of medical students. Measured factors contributed to some observed differences. Identifying sitespecific prevention and intervention strategies in medical student mental health is warranted. | Jessica A Gold Xinran Hu Gan Huang Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Mickey Trockel Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Robert M Rohrbaugh Kirsten M Wilkins | 2019 | World Journal of Psychiatry2019，9，4： | 2 |
| 5 | Gut/brain axis and the microbiota显示文摘 | Mayer Emeran A Tillisch Kirsten Gupta Arpana | 2015 | Journal of Clinical Investigation2015，，3： | 2 |
| 6 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 7 | The metabolic syndrome in patients with chronic bronchitis and COPD frequency and associated Consequences for systemic inflammation and physical inactivity显示文摘 | Watz H Waschki B Kirsten A | 2009 | Chest2009，136，4： | 1 |
| 8 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 9 | Identification of chlorogenic acid as a resistance factor for thrips in chrysanthemum 显示文摘 | KIRSTEN A L FEDERICA M YOUNG H C et a l | 2009 | Plant Physiology2009，150，3： | 1 |
| 10 | B- Type natriuretic peptide and ischemia in patients with stable coronary disease-data from the heart and soul study 显示文摘 | Kirsten BD Maria A Nelson BS | 2003 | Circulation2003，108，24： | 1 |
| 11 | First flush effects in an urban catchment area in Aalobrg 显示文摘 | Torben L Kirsten B Margit R A | 1998 | Water Sci Technol1998，37，1： | 1 |
| 12 | Content of heterocyclic amines and polycyclic aromatic hydrocarbons in pork, beef and chicken barbecued at home by Danish consumers显示文摘 | MARGIT D A LENE D O KIRSTEN K | 2013 | Meat Science2013，93，1： | 1 |
| 13 | Paleofluids and recent fluids in the upper continental crust: Results from the German Continental Deep Drilling Program ( KTB ) 显示文摘 | Moller P Weise S M Ahhaus E Bach W Behr H J Borchardt R Brauer K Drescher J Erzinger J Faber E Hansen B T Horn E E Huenges E Kampf H Kessels W Kirsten T Landwehr D Lodemann M Machon L Pekdeger A Pielow H U Reutel C Simon K Walther J Weinlich F H Zimmer M | 1997 | Journal of Geophysical Research1997，102，18： | 1 |
| 14 | A random- ised, placebo- and active-controlled dose-finding study of aclidin- ium bromide administered twice a day in COPD patients 显示文摘 | SINGH D MAGNUSSEN H KIRSTEN A | 2012 | Pulm Pharmacol Ther2012，25，3： | 1 |
| 15 | Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme显示文摘 | KRUG N HOHLFELD J M KIRSTEN A M | 2015 | N Engl J Med2015，372，： | 1 |
| 16 | Bioactive compounds in foods:Their role in the prevention of cardiovascular disease and cancer显示文摘 | Kris-Etherton P Hecker K Bonanome A Coval S Binkoski A Kirsten H Griel A Etherton T | | 0，，： | 1 |
| 17 | The metabolic syndrome in patients with chronic bronchitis and COPD:Frequency and associated consequences for systemic inflammation and physical inactivity显示文摘 | Watz H Waschki B Kirsten A | 2009 | Chest2009，136，4： | 1 |
| 18 | The adapter protein apop totic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis显示文摘 | Kirsten L Helga A E Stephan F S | 2001 | J Biol Chem2001，276，29： | 1 |
| 19 | Selective enclathration of picolines显示文摘 | Susan A Bourne Kirsten C Corin Luigi R Nassimbeni | 2005 | Crystal Growth & Design2005，5，1： | 1 |
| 20 | Many ribosomal protein genes are cancer genes in Zebrafish显示文摘 | ADAM A KIRSTEN C S KEVIN L | 2004 | PLoS Biology2004，2，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员