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| 1 | Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases显示文摘AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact test.RESULTS There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways. | Morten L Halling Jens Kjeldsen Torben Knudsen Jan Nielsen Lars Koch Hansen | 2017 | World Journal of Gastroenterology2017，23，33： | 9 |
| 2 | Auxin Binding Protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Pengfei Leng Qing Ji Torben Asp Ursula K. Frei Christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark Jones Priyanka Gajjar Sisi Liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt | 2017 | Molecular Plant2017，10，10： | 2 |
| 3 | 查看详情显示文摘 | Torben S Thomas M Kjartan F Sφren L F Christian P | | 0，，： | 1 |
| 4 | First flush effects in an urban catchment area in Aalobrg 显示文摘 | Torben L Kirsten B Margit R A | 1998 | Water Sci Technol1998，37，1： | 1 |
| 5 | The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers显示文摘 | Michal Cohen‐Eliav Regina Golan‐Gerstl Zahava Siegfried Claus L Andersen Kasper Thorsen Torben F ?rntoft David Mu Rotem Karni | 2013 | J Pathol2013，，4： | 1 |
| 6 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets显示文摘 | Claus L A Jens L J Torben F | 2004 | Cancer Research2004，64，15： | 1 |
| 7 | Flux Distributions in Anaerobic, Glucose-limited Continuous Cultures of Saccharomyces cerevisiae 显示文摘 | Torben L Nissen Ulrik Schulze Jens Nielsen | 1997 | Microbiology1997，143，： | 1 |
| 8 | Daratumumab, a CD38 monoclonal antibody in patients with multiple mye- loma - data from a doseesealation phase study 显示文摘 | Torben P Henk L Peter G | 2014 | Blood ( ASH annual meeting Abstracts )2014，124，21： | 1 |
| 9 | Antifertility vaccines 显示文摘 | Peter JD Torben L Ivan MR | 2002 | Trends in Immunol2002，23，4： | 1 |
| 10 | Analyzing rating transitions and rating drift with continuous observations 显示文摘 | David L Torben M S | 2002 | Journal of Banking & Finance2002，26，2： | 1 |
| 11 | Characterization and three-dimensional structures of two dis?tinct bacterial xyloglucanases from families GH5 and GH12显示文摘 | TRACEY M G FARID M I KATHERINE M JENS M E SHIRLEY R JOHAN P T MADS E B PER L J STEFFEN D KATJA S J TORBEN V B KEITH S W HARRY B GIDEON J D | 2007 | Journal of Biological Chemistry2007，282，19： | 1 |
| 12 | Antifertility vaccines显示文摘 | Peter JD Torben L Ivan MR | 2002 | Trends in Immunol2002，23，4： | 1 |
| 13 | Normalization of re-al-time quantitative reverse transcription-PCR data:Amodel-based variance estimation approach to identifygenes suited for normalization,applied to bladder andcolon data sets显示文摘 | Claus L A Jens L J Torben F O | 2004 | Cancer Res2004，64，： | 1 |
| 14 | Brain tumor imaging using small-angle x-ray scattering tomography显示文摘 | Torben H Jensen Martin Bech Oliver Bunk Maria Thomsen Andreas Menzel Audrey Bouchet Géraldine Le Duc Robert Feidenhans’l Franz Pfeiffer | 2011 | Physics in Medicine and Biology2011，，： | 1 |
| 15 | Normalization of real-time quantitative reverse transcription PCR data: A model-based vari ance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets 显示文摘 | Claus L A Jens L J Torben F Q | 2004 | Cancer Research2004，64，8： | 1 |
| 16 | Does high nitrogen loading prevent clear-water conditions in shallow lakes at moderately high phosphorus concentrations? 显示文摘 | MARI? A A GONZA? L S ERIK J JOAN G MARTIN S JENS PEDER J TORBEN L FRANK L | 2004 | Freshwater Biology2004，，10： | 1 |
| 17 | Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies显示文摘 | Katja Kannisto Vetvik Tonje Sonerud Mona Lindeberg Torben Lüders Ragnhild H. St?rkson Kristin Jonsdottir Eirik Frengen Kirsi H. Pietil?inen Ida Bukholm | 2014 | Metabolism2014，，： | 1 |
| 18 | Verification of the effectiveness of TMDs using wind tunnel section model tests显示文摘 | Flora L Torben S | 1996 | Journal of Wind Engineering and Industrial Aerodynamics1996，64，2： | 1 |
| 19 | Com- mon genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: Re- sults from the odense androgen study显示文摘 | ELKE P WENDY B TORBEN L N | 2010 | Calcif Tis- sue Int2010，86，： | 1 |
| 20 | Diversity of aerobic methanotrophic bacteria in a permafrostActive layer soil of the lena delta,siberia显示文摘 | Susanne L Katja R Torben S | 2009 | Microb Ecol2009，57，6： | 1 |
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