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| 1 | N-terminal truncated RHT-1 proteins generated by translational reinitiation cause semi-dwarfing of wheat Green Revolution alleles显示文摘The unprecedented wheat yield increases during the Green Revolution were achieved through the introduc-tion of the Reduced height(Rht)-B1b and Rht-D1b semi-dwarfing alleles.These Rht-1 alleles encode growth-repressing DELLA genes containing a stop codon within their open reading frame that confers gibberellin(GA)-insensitive semi-dwarfism.In this study,we successfully took the hurdle of detecting wild-type RHT-1 proteins in different wheat organs and confirmed their degradation in response to GAs.We further demonstrated that Rht-B1b and Rht-D1b produce N-terminal truncated proteins through trans-lational reinitiation.Expression of these N-terminal truncated proteins in transgenic lines and in Rht-D1c,an allele containing multiple Rht-D1b copies,demonstrated their ability to cause strong dwarfism,resulting from their insensitivity to GA-mediated degradation.N-terminal truncated proteins were detected in spikes and nodes,but not in the aleurone layers.Since Rht-B 1b and Rht-D1b alleles cause dwarfism but have wild-type dormancy,this finding suggests that tissue-specific differences in translational reinitiation may explain why the Rht-1 alleles reduce plant height without affecting dormancy.Taken together,our findings not only reveal the molecular mechanism underlying the Green Revolution but also demonstrate that trans-lational reinitiation in the main open reading frame occurs in plants. | Karel Van De Velde Stephen GThomas Floor Heyse Rim Kaspar Dominique Van Der Straeten Antje Rohde | 2021 | Molecular Plant2021，14，4： | 8 |
| 2 | Soil Parameter Identification for Wheel-terrain Interaction Dynamics and Traversability Prediction显示文摘这篇论文为为穿越未知地面的 wheeled 车辆识别土壤参数论述一种新奇技术。识别土壤参数为预言车辆列车间的挂钩拉和车轮驱动器转矩被要求,它能接着在未知地面上被用于 wheeled 车辆的 traversability 预言,拖拉控制,和表演优化。建议技术基于牛顿 Raphson 方法。一个车轮土壤相互作用模型的一种接近的形式为这个目的基于合成 Simpson 鈥檚 统治被采用。要鉴别的关键土壤参数是内部磨擦角度,砍变丑模量,和 lumped 压力下沉系数。第四个参数,结合,不与车辆列车间的挂钩拉太相关,并且在鉴定进程期间被分配平均的值。识别参数与已知的价值相比,并且出现在同意。鉴定方法相对快、柔韧。识别土壤参数能有效地被用来与好精确性预言列车间的挂钩拉和车轮驱动器转矩。识别土壤参数的使用被介绍为穿越未知地面的 wheeled 车辆设计一个 traversability 标准。关键词土壤参数 - traversability - 牛顿 Raphson - 合成 Simpson 鈥檚 统治 - wheeled 车辆这个工作被 EPSRC 部分地支持(没有。GR/S31402/01 ) 。Suksun Hutangkabodee 在 1976 在泰国出生了。他收到了 B.Eng。在来自 Chulalongkorn 大学的 mechanical engineering,曼谷,在 1999 的泰国。他从国王鈥檚 学院伦敦,在电脑辅助的 mechanical engineering 收到了他的 M.Sc 学位在 2002 的英格兰,并且当前在一样的机构向一个博士正在工作。他的研究兴趣包括车辆地面相互作用动力学和土壤参数鉴定。Yahya Hashem Zweiri 获得了他的 B.Sc。在来自乔丹乔丹的大学的 Mechanical Engineering 的度和他在从国王鈥檚 学院伦敦,的柴油机引擎建模和评价的博士学位英格兰, 2003。他当前是在在国王鈥檚 学院伦敦的 Mechanical Engineering 的部门的一个研究家伙,研究无人的地面车辆的车辆地面相互作用动力学。他也是在 Mechanical Engineering 的部门的一个助教,亩鈥檛a h 大学,乔丹,并且从亩鈥檛a h 当前休假大学。他让超过 16 年在机械系统的建模,评价,和控制研究经验,并且在国际杂志和会议论文录出版了超过 40 篇审阅研究论文。他的研究兴趣包括非线性的建模,评价,和控制。Lakmal Dasarath Seneviratne 从国王鈥檚 学院伦敦在 Mechanical Engineering 获得了他的 B.Sc (Eng ) 和博士度。他当前是在在国王鈥檚 学院伦敦的 Mechatronics 的一个教授。他也是在国王鈥檚 学院伦敦设计的 Mechatronics 和生产系统的中心的主任。他的主要研究兴趣包括机器人学和聪明的自治系统。塞内威拉特内教授是 IEEE 的一个成员。Kaspar Althoefer 从工业大学 Aachen 在电子工程保持一个学位,德国。他在国王鈥檚 学院伦敦(KCL ) 在电、电子的工程的部门执行了他的博士研究,在他在 1997 完成了博士的地方。他现在是在在 KCL 的 Mechanical Engineering 的部门的一个讲师。自从 1992,从事关于 mechatronics 的研究,他在基于机器人的应用的区域有广泛的专家知识,察觉到并且嵌入的智力。阿尔索弗博士是 IEEE 和 IEE 的一个成员。 | Suksun Hutangkabodee Yahya Hashem Zweiri Lakmal Dasarath Seneviratne Kaspar Althoefer | 2006 | International Journal of Automation and computing2006，3，3： | 8 |
| 3 | 眼前节内眼手术应用5%吡咯烷酮碘两种不同用法的前瞻性随机化比较研究显示文摘目的:确定5%吡咯烷酮碘采用两种不同的方法(结膜囊滴两滴和10ml溶液穹窿结膜冲洗)对降低结膜囊菌群的功效。方法:在这项前瞻性对照实验中。将行眼前节手术的200只眼随机分为对照组和研究组。两组病例术前均给予氧氟沙星滴眼液局部点眼和5%吡咯烷酮碘眶周区域皮肤擦洗消毒。术前对照组眼结膜囊内给予2滴5%吡咯烷酮碘溶液,研究组眼用5%吡咯烷酮碘溶液冲洗穹窿结膜。分别于术前和术后4个时间点行结膜细菌培养。结果:研究组78只眼中20只眼(26%)术前结膜细菌培养阳性:对照组94只眼中40只眼(43%)为阳性(P=0.02)。手术结束时。研究组78只眼中14只眼(18%)、对照组94只眼中30只眼(32%)结膜细菌培养阳性(PP=0.05)。结论:手术时应用5%吡咯烷酮碘溶液冲洗穹窿结膜与结膜囊仅点入两滴相比。前者显著降低了结膜细菌培养阳性率。 | Herminia Mino de Kaspar Robert T. Chang Kuldev Singh Peter R. Egbert Mark S. Blumenkranz Christopher N. Ta 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 6 |
| 4 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 5 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 6 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver显示文摘Dear Editor,The sodium taurocholate(TC)co-transporting polypeptide NTCP(SLC10A1)is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma into the cytoplasm of liver cells.NTCP was originally cloned from rat and demonstrated to be localized in the basolateral membrane.1 Its activity is a key component of bile acid homeostasis and enterohepatic circulation of bile salts(Fig.1a),a process that includes at least three additional transporter proteins,namely BSEP,ASBT and OSTα/β.2,3 In addition to its role in mediating bile salt uptake,NTCP also serves as the receptor of the human hepatitis B and D viruses.4 The mechanism by which NTCP recognizes and transports bile salts is not understood,in part because no structural insight into the interaction of NTCP with its substrates is available.While recent studies reported structures of NTCP bound to inhibitory nanobodies5 or Fab fragments,6,7 no substrate-binding pockets were identified. | Hongtao Liu Rossitza N.Irobalieva Rose Bang-Sørensen Kamil Nosol Somnath Mukherjee Parth Agrawal Bruno Stieger Anthony A.Kossiakoff Kaspar P.Locher | 2022 | Cell Research2022，32，8： | 2 |
| 7 | Immunohistochemical Characterization of Pancreatic Tumors Induced by Dimethylbenzanthracene in Rats显示文摘 | Ramon E. Jimenez Kaspar Z’graggen Werner Hartwig Fiona Graeme-Cook Andrew L. Warshaw Carlos Fernandez-del Castillo | 1999 | The American Journal of Pathology1999，，4： | 2 |
| 8 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 9 | The glass model: a strategy for quantifying global environmental security 显示文摘 | Alcamo J Endejan M B Kaspar F | 2001 | Environmental Science & Policy2001，4，1： | 1 |
| 10 | Microstructural aspects and optimization of thin slab direct rolling of steels显示文摘 | KASPAR R | 2003 | Steel Research International2003，74，5： | 1 |
| 11 | On the role of oxygen storage in three-way catalysis显示文摘 | MONTE R D KASPAR J | 2004 | Topics in Catalysis2004，28，14： | 1 |
| 12 | Laboratory Simulation of the Thermomechanical Processing of Steel显示文摘 | Oskar Pawelski Radko Kaspar Dusseldorf | 1988 | Materialpriifung1988，30，： | 1 |
| 13 | Quantitative determination of physical and chemical measurands in honey by near-infrared spectrometry显示文摘 | Kaspar R Werner L Stefan B | 2007 | Europe Food Res earc h Technology2007，225，： | 1 |
| 14 | Blastocyst implantation depends on maternal expression of leukamia inhibitory factor 显示文摘 | Steward CL Kaspar P Brunet LJ | 1992 | Nature1992，359，3： | 1 |
| 15 | Hydrogenation of α, β- unsaturated aldehydes over Pt-Sn/Nylon 显示文摘 | Farnetti E Pesce M Kaspar J | 1986 | J Chem Soc Chem Commun1986，，10： | 1 |
| 16 | Clinical and pathological teatures of pachyonychia congenital显示文摘 | Leachman SA Kaspar RL Fleckman P | 2005 | J Investig Dermatol Symp Proc2005，10，： | 1 |
| 17 | How to do a safe pancreatic anastomosis显示文摘 | Kaspar Z'graggen Waldemar Uhl Helmut Friess Markus W. Büchler | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，6： | 1 |
| 18 | Biosynthesis of granulysin, a novel cytolytic molecule显示文摘 | Kaspar AA Poulain FR | 1999 | Mol Immunol1999，36，7： | 1 |
| 19 | A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo 显示文摘 | Villa A Trachsel E Kaspar M | 2008 | Int J Cancer2008，122，11： | 1 |
| 20 | Easily calculable measure for the complexity of spatio-temporal patterns 显示文摘 | Kaspar K Schuster H G | 1987 | Physical Review A1987，36，2： | 1 |
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