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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study显示文摘 | WEN Ying JIANG Li XU Yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI Yu- hang WU Da-wei WANG Yu-shan SUN Ren-hua HU Zhen-jie CAO Xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA Xiao-chun YU Xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin | 2013 | Chinese Medical Journal2013，，23： | 40 |
| 3 | Global warming weakening the inherent stability of glaciers and permafrost显示文摘The Cryosphere has been undergoing a worldwide retreat, as seen in the decrease in the areal extent and volume of glaciers and in the areal extent of permafrost. This paper presents a systematic examination of the inherent stability changes of glaciers and permafrost caused by warming. Various study results suggest that over the past 30 years, the internal temperature of glaciers and permafrost exhibits an overall accelerating warming trend. The warming rate peaked in the mid-2000s and slowed slightly for several years afterward. In recent years, however, the warming rate has seemed to pick up again. The warming of glaciers and permafrost has exerted great impact on their stability, displayed as intensified melting,increased glacier surging, enlargement of supraglacial lakes, and increased permafrost degradation.Even without a future temperature increase, some glaciers will continue to shrink, and the number of surging glaciers will increase. The transition from low-temperature to high-temperature permafrost is a noticeable warning sign of a comprehensive degradation of permafrost. These results indicate that‘‘warming' glaciers and permafrost will exert significant impacts on the hydrology, ecology, and stability of engineering in cold regions. | Yongjian Ding Shiqiang Zhang Lin Zhao Zhongqin Li Shichang Kang | 2019 | Science Bulletin2019，64，4： | 37 |
| 4 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 5 | Role of PERK/eIF2α/CHOP Endoplasmic Reticulum Stress Pathway in Oxidized Low-density Lipoprotein Mediated Induction of Endothelial Apoptosis显示文摘Objective PERK/eI F2α/CHOP is a major signaling pathway mediating endoplasmic reticulum(ER) stress related with atherosclerosis.Oxidized LDL(ox-LDL) also induces endothelial apoptosis and plays a vital role in the initiation and progression of atherosclerosis.The present study was conducted to explore the regulatory effect of ox-LDL on PERK/e IF2α/CHOP signaling pathway in vascular endothelial cells.Methods The effects of ox-LDL on PERK and p-e IF2α protein expression of primary human umbilical vein endothelial cells(HUVECs) were investigated by Western blot analysis.PERK gene silencing and selective eI F2α phosphatase inhibitor,salubrinal were used to inhibit the process of ox-LDL induced endothelial cell apoptosis,caspase-3 activity,and CHOP mR NA level.Results Ox-LDL treatment significantly increased the expression of PERK,PERK-mediated inactivation of e IF2α phosphorylation,and the expression of CHOP,as well as the caspase-3 activity and apoptosis.The effects of ox-LDL were markedly decreased by knocking down PERK with stable transduction of lentiviral sh RNA or by selective eI F2α phosphatase inhibitor,salubrinal.Conclusion This study provides the first evidence that ox-LDL induces apoptosis in vascular endothelial cells mediated largely via the PERK/eI F2α/CHOP ER-stress pathway.It adds new insights into the molecular mechanisms underlying the pathogenesis and progression of atherosclerosis. | TAO Yong Kang YU Pu Lin BAI Yong Ping YAN Sheng Tao ZHAO Shui Ping ZHANG Guo Qiang | 2016 | Biomedical and Environmental Sciences2016，29，12： | 21 |
| 6 | Combined monitoring of evoked potentials during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms显示文摘在外科期间监视的背景 Neurophysiologic 是阻止永久神经病学的损害源于外科的操作。改进 intraoperative neuromonitoring 的精确性和敏感, transcranial 监视电的刺激马达联合唤起了潜力( TES-MEPs ), somatosensory 唤起了潜力( SSEP )和 brainstem 听觉的唤起的潜力( BAEP )为邻近与 SSEP 联合 TES-MEPs 监视的 brainstem 和 intracranial aneurysms.Methods 的损害在 microsurgery 被尝试象 intracranial 一样与邻近 brainstem 的损害在 68 个连续病人被尝试一在他们之中, 31 个病人(31 个手术, 28 个以后的头部的窝肿瘤, 3 个以后的发行量动脉瘤) 也受到 BAEP 监视。监视结果和临床的结果的关联是 68 个病人的唤起的潜力(EP ) 监视联合在 64 被做的学习 prospectively.Results (94.1%) 。监视的 MEP 为 4 个病人(5.9%) 是不可能的。没有复杂并发症在在所有病人监视联合期间被观察。(66.2%) 在 45, 68 个病人,, EP 是稳定的,并且他们是神经病学地未经触动的。马达机能障碍被 MEP 在 4 在 8 个病人,在 5 的 SSEP ,和 BAEP 检测, respectively.Conclusions A 结束关系在手术后的马达功能之间存在, TES-MEPs monitoring.TES-MEPs 的结果在检测马达机能障碍,而是联合 EP 比 SSEP 和 BAEP 优异用作一只保险箱,为马达神经系统的功能监视的 intraoperative 的有效、侵略的方法。为邻近 brainstem 和 intracranial 动脉瘤的损害在 microsurgery 期间联合 EP 监视可以检测潜在地危险的演习并且改进随后的过程的安全。 | KANG De-zhi WU Zan-yi LAN Qing YU Liang-hong LIN Zhang-ya WANG Chen-yang LIN Yuan-xiang | 2007 | Chinese Medical Journal2007，，18： | 20 |
| 7 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 8 | Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China,2017显示文摘Background:After the scale-up of antiretroviral therapy(ART)for HIV infected people,increasing numbers of patients have pretreatment drug resistance(PDR).In this study,the prevalence of PDR was evaluated in adults initiating antiretroviral therapy in China.Methods:Blood samples were obtained from 1943 patients who initiated antiretroviral therapy(ART)in 2017 from 13 provinces or cities in China.Pol sequences were used to analyze drug resistance and construct transmission networks.Logistic regression model was used to estimate the potential factors associated with PDR.Results:In total,1711 eligible patients(76.0%male;87.8%aged≥25 years)were included,of which 117(6.8%)had PDR.The highest rates of PDR were 12.2%in Liangshan Prefecture of Sichuan and 9.3 and 8.9%in Dehong and Lincang Prefecture of Yunnan.A multivariate logistic regression analysis revealed that PDR was significantly higher among intravenous drug users(adjusted Odds Ratio(aOR)=2.64,95%CI:1.57–4.44)and individuals from Liangshan,Dehong,and Lincang(aOR=2.04,95%CI:1.26–3.30).In total,754 sequences were used to generate 164 transmission networks.Five transmission networks had two or three sequences containing the same mutations,two networks contained subjects from Liangshan,and one network contained subjects from Dehong.Conclusions:Overall,the PDR prevalence was moderate,with a particularly high prevalence in areas with severe HIV epidemics.These results indicate the importance of continuous PDR monitoring in patients initiating antiretroviral therapy. | Rui-Hua Kang Shu-Jia Liang Yan-Ling Ma Shu Liang Lin Xiao Xin-Hui Zhang Hong-Yan Lu Xiao-Qin Xu Shui-Bin Luo Xiao-Guang Sun Lin Chen Jian-Mei He Guo-Hui Wu Ling-Jie Liao Hui Xing Yi-Ming Shao Yu-Hua Ruan | 2020 | Infectious Diseases of Poverty2020，9，3： | 17 |
| 9 | Is frailty associated with short-term outcomes for elderly patients with acute coronary syndrome?显示文摘BackgroundFrailty 由于老化并且逐渐地是在心血管的药的一个新预示的因素老病人的复杂自然。有希望地分析在哪个脆弱与 .MethodsPatients 变老的急性冠的症候群(交流) 为老病人预言短期的结果的方式有用、有意义 ≥65 年,与从心病学的交流的诊断,部门和医学部门被包括从单个中心。包括医学症候群的临床的数据用全面医学评价被收集。脆弱根据临床的脆弱规模被定义,风险上的合作病态的影响被冠的动脉疾病(CAD ) 确定 —特定的索引。病人们被跟随在上面由临床的访问或电话,咨询和中部的后续时间是 120 天。后面起来项目包括了所有原因死亡, unscheduled 回来访问,在里面医院和周期性的主要不利心血管的事件。Multivariable 回归幸存分析用考克斯 regression.ResultsOf 被执行 352 个病人,(43.18%) 152 根据学习仪器被认为脆弱(5 − 7 在规模上) ,并且(26.42%) 93 中等或严重地被考虑脆弱(6 − 7 在规模上) 。包括不能自制,秋天历史,视觉缺陷,听觉缺陷,便秘,长期的疼痛,睡觉混乱,牙齿的问题,焦虑或消沉的医学症候群,和谵妄比在非脆弱的病人更经常在脆弱的病人( P = 0.000 , 0.031 , 0.009 , 0.014 , 0.000 , 0.003 , 0.022 , 0.000 , 0.074 ,和 0.432 ,分别地)。为性别调整了,年龄,冠的动脉疾病的严厉(离开了主要冠的动脉损害) 并且由考克斯幸存分析的合作病态(CAD 特定的索引) ,脆弱被发现到强烈并且独立地为主要合成结果与风险被联系:所有原因死亡[危险比率(HR )= 5.393;95% CI:1.477 − 19.692, P = 0.011 ] 并且 unscheduled 回来访问(HR = 2.832;95% CI:1.140 − 7.037, P = 0.025 ).ConclusionsComprehensive 医学评价和临床的脆弱的规模在有交流的老病人的评估是有用的。脆弱强烈并且独立地与交流为老病人与短期的结果被联系。 | Lin KANG Shu-Yang ZHANG Wen-Ling ZHU Hai-Yu PANG Li ZHANG Ming-Lei ZHU Xiao-Hong LIU Yong-Tai LIU | 2015 | Journal of Geriatric Cardiology2015，12，6： | 16 |
| 10 | Susceptibility-weighted Imaging in Thrombolytic Therapy of Acute Ischemic Stroke显示文摘 | Lin Li Ming-Su Liu Guang-Qin Li Yang Zheng Tong-Li Guo Xin Kang Mao-Ting Yuan | 2017 | Chinese Medical Journal2017，，20： | 15 |
| 11 | Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome显示文摘 | HE Quan-ying FENG Jing ZHANG Xilong LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun WANG Bei LIN Qi-chang ZHANG Jin-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2012 | Chinese Medical Journal2012，，10： | 15 |
| 12 | The Arabidopsis bZIP1 Transcription Factor Is Involved in Sugar Signaling, Protein Networking, and DNA Binding显示文摘糖发信号是种使用集成各种各样的内部、外部的暗示完成滋养的动态平衡的机制,调停发展节目,和清晰压力回答。许多 bZIP 抄写因素被知道涉及营养素或应力发信号。Arabidopsis S1 组 bZIP 基因, AtbZIP1,在介绍学习的以前的基因表情作为糖敏感的基因被识别(植物房间。16, 21282150 ) 。在这份报告,我们证明 AtbZIP1 的表示被糖以一个快、敏感、可逆的方法镇压。AtbZIP1 的糖压抑被表明部件的保存的糖影响, hexokinase。除是调整糖的基因以外, AtbZIP1 能调停糖发信号并且影响基因表示,植物生长,和开发。当碳营养素是有限的时, AtbZIP1 原因的功能的获得或损失处于早幼苗建立的率变化。phenotypic 分析的结果显示 AtbZIP1 充当早幼苗生长的一个否定管理者。用在 microarray 分析的 gain-of-function 和 loss-of-function 植物,通常认为的调整 AtbZIP1 的基因的二个集合被识别了。在他们之中,糖应答的基因是高度过去代表的,含有在调停糖的基因表示的 AtbZIP1 的一个角色。用酵母二混血儿(Y-2-H ) 屏蔽,双分子的荧光互补(BiFC ) 分析,我们能概括广泛的 C/S1 AtbZIP 蛋白质交往在生活房间的网络。最后,我们证明 AtbZIP1 能在 vitro 绑基于 ACGT 的主题并且有约束力的特征看起来被在 AtbZIP1 和 C 组 AtbZIPs 之间的 heterodimerization 影响,包括 AtbZIP10 和 AtbZIP63。 | Shin Gene Kang John Price Pei-Chi Lin Jong Chan Hong Jyan-Chyun Jang | 2010 | Molecular Plant2010，3，2： | 13 |
| 13 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 14 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 15 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 16 | Reverse reconciliation for continuous variable quantum key distribution显示文摘An efficient and practical post-processing technique based on reverse reconciliation for continuous variable quantum key distribution is proposed and simulated with low-density parity check (LDPC) codes. MultiLevel Coding/ MultiStage Decoding, which fully utilizes optimization technique such as vector quantization and iterative decoding and the optimal channel coding most close to the Shannon limit, was used to realize efficient reverse reconciliation algorithm. Simulation results showed that the proposed method can improve the secure key distribution rate to 2.2 kb/s and the coding efficiency to 0.89 over 20 km in single-mode optical fiber. Moreover, there still is room for much improvement. | LU ZhiXin 1,2 , YU Li 1,2 , LI Kang 1,2 , LIU BingCan 1,2,3 , LIN JianGui 1,2 , JIAO RongZhen 1,2 & YANG BoJun 1,21 School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China 2 Key Laboratory of Information Photonics and Optical Communication, Ministry of Education, Beijing University of Posts and Telecommunications, Beijing 100876, China 3 Department of Fundamental Courses, Academy of Armored Force Engineering, Beijing 100072, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 12 |
| 17 | A novel synthesis strategy to improve cycle stability of LiNio.8Mno.1Co0.1O2 at high cut-off voltages through core-shell structuring显示文摘Nickel-rich cathode materials have attracted considerable interest because of their high specific capacities,voltage ranges,and low cost.However,serious capacity attenuation and poor rate performance limit their application.This study proposes a novel strategy to improve the cycle stability of the nickel-rich LiNi0.sCo0.1Mn0.1O2(NCM811)layer material by designing core-shell LiNio.sCoo.1 Mno.102(CS-NCM811).CS-NCM811 is designed by the characteristic reaction between dimethylglyoxime(C4H8N2O2)and nickel ion to form Ni(C4H7N2O2)2-The CS-NCM811 is characterized with high nickel content in its core and high manganese content on its surface,leading to a high capacity and excellent cycle stability.The capacity retention of CS-NCM811 was 72.8%,much higher than that of NCM811(47.1%)after 500 cycles at a rate of 5 C.Not only is this method a no vel strategy to desig n high capacity cathode materials but also provides some new in sights into the cycle stability of nickel-rich layered cathode materials. | Kang Wu Qi Li Rongbin Dang Xin Deng Minmin Chen Yu Lin Lee Xiaoling Xiao Zhongbo Hu | 2019 | Nano Research2019，12，10： | 12 |
| 18 | New strategy for designing orangish-redemitting phosphor via oxygen-vacancyinduced electronic localization显示文摘Phosphor-converted white-light-emitting diodes(pc-WLED)have been extensively employed as solid-state lighting sources,which have a very important role in people’s daily lives.However,due to the scarcity of the red component,it is difficult to realize warm white light efficiently.Hence,red-emitting phosphors are urgently required for improving the illumination quality.In this work,we develop a novel orangish-red La_(4)GeO_(8):Bi^(3+) phosphor,the emission peak of which is located at 600 nm under near-ultraviolet(n-UV)light excitation.The full width at half maximum(fwhm)is 103 nm,the internal quantum efficiency(IQE)exceeds 88%,and the external quantum efficiency(EQE)is 69%.According to Rietveld refinement analysis and density functional theory(DFT)calculations,Bi^(3+) ions randomly occupy all La sites in orthorhombic La_(4)GeO_(8).Importantly,the oxygen-vacancy-induced electronic localization around the Bi3+ions is the main reason for the highly efficient orangish-red luminescence.These results provide a new perspective and insight from the local electron structure for designing inorganic phosphor materials that realize the unique luminescence performance of Bi^(3+) ions. | Yi Wei Gongcheng Xing Kang Liu Guogang Li Peipei Dang Sisi Liang Min Liu Ziyong Cheng Dayong Jin Jun Lin | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 19 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 20 | Quasi-solid-state nanocrystalline TiO2 solar cells using gel network polymer electrolytes based on polysiloxanes显示文摘A quasi-solid-state dye-sensitized nanocrystal-line porous TiO2 film solar cell was fabricated using a novel gel network polymer electrolyte based on polysiloxanes with both polyethylene oxide internal plasticized side chains and quaternary ammonium groups. The cell exhibited better photoelectrical conversion performance under 60 mW/cm2 irradiation. The short photocurrent (Isc) of 5.0 mA/cm2 and open voltage (Voc) of 0.68 V were achieved, and the energy conversion efficiency (h ) and fill factor (ff) were 3.4% and 0.60, respectively. | LI Weiying, KANG Junjie, LI Xueping, FANG Shibi, LIN Yuan, WANG Guiqiang & XIAO Xurui Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China | 2003 | Chinese Science Bulletin2003，48，7： | 11 |
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