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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 3 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 4 | Case study on the first immigration of fall armyworm,Spodoptera frugiperda invading into China显示文摘The fall armyworm(FAW),Spodoptera frugiperda is one of the most damaging crop pests,and it has become major threat to the food security of many countries.In order to monitor possible invasion of this pest into China,a searchlight trap was established in March 2018 in western Yunnan Province,China,where it has served as the'first station'for many pests that have migrated from Myanmar to China.A number of suspected FAW moths were captured and identified by DNA sequencing.The results showed that the FAW moth was first captured on December 11 and formed its first immigration peak in mid-December 2018.DNA detection revealed that the early invading FAW population was the'corn-strain'.The field survey indicated that the pest mainly colonized corn in Pu’er,Dehong and Baoshan areas.Migration trajectory simulation implied that the moths might have mainly come from the eastern area in the mid-latitude region of Myanmar(20-25°N,94-100°E).This case study confirmed the first immigration of FAW into China,and will be helpful for guiding monitoring and management work to control this pest. | SUN Xiao-xu HU Chao-xing JIA Hui-ru WU Qiu-lin SHEN Xiu-jing ZHAO Sheng-yuan JIANG Yu-ying WU Kong-ming | 2021 | Journal of Integrative Agriculture2021，20，3： | 66 |
| 5 | Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC. | Jiang YF Yang ZH Hu JQ | 2000 | World Journal of Gastroenterology2000，6，1： | 57 |
| 6 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 7 | SHRIMP zircon U-Pb age and Nd isotopic study on the Nyainqêntanglha Group in Tibet显示文摘The Nyainqêntanglha Group is traditionally viewed as the oldest metamorphic basement in the Lhasa block, but its formation age and tectonic setting remain debate. Zircons extracted from the metamorphic sequence of volcanics and intrusions of the Nyainqêntanglha Group, 10 km west of Nam Co in northern Lhasa block, have been investigated by cathodolu- minescence (CL), backscattered (BSE) and dated by ion microprobe (SHRIMP). We conclude that the U-Pb age of 787±9 Ma of zircons from the trondhjemite imposes a constraint on maxi- mum protolith age, and minimum formation age of the Nyainqêntanglha Group is constrained by U-Pb age of 748±8 Ma of zircons from the granite. The formation age of the Nyainqêntanglha Group is consistent with sedimentary age of Greater Himalayan rocks, showing that they devel- oped coevally in an arc-basin tectonic setting of Neoproterozoic active continental margin along the northern margin of the India shield. The inherited zircons from the tholetiite and granite give older 207Pb/206Pb ages from 947 to 1766 Ma. The positive εNd( t ) value indicates that the mafic rocks were derived from the depleted mantle, but contaminated by the older continental crustal material. Integrated Nd model age and U-Pb age data provide excellent evidence for the exis- tence of Mesoproterozoic basement in the Lhasa block during Neoproterozoic time. | HU Daogong1, WU Zhenhan1, JIANG Wan1, SHI Yuruo2, YE Peisheng1 & LIU Qisheng1 1. Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China 2. Institute of Geology, Chinese Academy of Geological Sciences, Beijing SHRIMP Centre, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，9： | 49 |
| 8 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 9 | China cardiovascular diseases report 2015: a summary显示文摘 | Wei-Wei CHEN Run-Lin GAO Li-Sheng LIU Man-Lu ZHU Wen WANG Yong-Jun WANG Zhao-Su WU Hui-Jun LI Dong-Feng GU Yue-Jin YANG Zhe ZHENG Li-Xin JIANG Sheng-Shou HU | 2017 | Journal of Geriatric Cardiology2017，14，1： | 46 |
| 10 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 11 | Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study显示文摘 | WEN Ying JIANG Li XU Yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI Yu- hang WU Da-wei WANG Yu-shan SUN Ren-hua HU Zhen-jie CAO Xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA Xiao-chun YU Xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin | 2013 | Chinese Medical Journal2013，，23： | 40 |
| 12 | One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces显示文摘编辑技术 CRISPR 的指导 RNA 的 DNA 定期聚类 interspaced 短 palindromic repeats/Cas9 被用来介绍双 stranded 闯入染色体并且在细菌指导随后的地点特定的插入 / 删除或基因材料的代替例如 Escherichia coli,链球菌肺病,和乳杆菌 reuteri。在这研究,我们建立了在 Streptomyces 基因操作为使用编辑 plasmid pKCcas9dO 的一个高效率的 CRISPR/Cas9 染色体,它包括目标特定的指南 RNA,优化 codon 的 cas9,和二个指导相同的修理模板。由交付编辑 plasmids 进模型紧张 Streptomyces coelicolor M145 的 pKCcas9dO 系列,通过一步舞 intergeneric 转移,我们完成了与60%100%的高效率在不同层次编辑的染色体,包括单个基因删除,例如 actII-orf4 ,整顿,和 glnR ,并且单个大尺寸的基因簇删除,扮演 21.3 kb , undecylprodigiosin 红 31.6 kb ,和 Ca 2+-dependent 抗菌素例如 actinorhodin 的抗菌素 biosynthetic 簇 82.8 kb 。而且,我们也分别地与 54% 和 45% 的高效率认识到 actII-orf4 和整顿,并且 ACT 和红 biosynthetic 基因簇的同时的删除。最后,我们使用了这个系统介绍核苷酸点变化进 rpsL 基因,它与抵抗授与异种到链球菌。用这个系统,显著地,为一个轮染色体修正要求的时间被三分之一个减少或为常规方法的那些的一个一半。这些结果清楚地显示实质地编辑系统的确定的 CRISPR/Cas9 染色体改进与当前存在的方法相比编辑效率在的染色体 Streptomyces,和它在另外的放线菌种类为申请有诺言到染色体修正。 | He Huang Guosong Zheng Weihong Jiang Haifeng Hu Yinhua Lu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 37 |
| 13 | Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer:the FUTURE trial显示文摘Triple-negative breast cancer(TNBC)is a highly heterogeneous disease,and molecular subtyping may result in improved diagnostic precision and targeted therapies.Our previous study classified TNBCs into four subtypes with putative therapeutic targets.Here,we conducted the FUTURE trial(ClinicalTrials.gov identifer:NCT03805399),a phaseⅠb/Ⅱsubtyping-based and genomic biomarker-guided umbrella trial,to evaluate the efficacy of these targets.Patients with refractory metastatic TNBC were enrolled and stratifed by TNBC subtypes and genomic biomarkers,and assigned to one of these seven arms:(A)pyrotinib with capecitabine,(B)androgen receptor inhibitor with CDK4/6 inhibitor,(C)anti PD-1 with nab-paclitaxel,(D)PARP inhibitor included,(E)and(F)anti-VEGFR included,or(G)mTOR inhibitor with nab paclitaxel.The primary end point was the objective response rate(ORR).We enrolled 69 refractory metastatic TNBC patients with a median of three previous lines of therapy(range,1-8).Objective response was achieved in 20(29.0%,95%confidence interval(CI):18.7%-41.2%)of the 69 intention-to-treat(ITT)patients.Our results showed that immunotherapy(arm C),in particular,achieved the highest ORR(52.6%,95%CI:28.9%-75.6%)in the ITT population.Arm E demonstrated favorable ORR(26.1%,95%C:10.2%-48.4%in the ITT population)but with more high grade(23)adverse events.Somatic mutations of TOP2A and CD8 immunohistochemical score may have the potential to predict immunotherapy response in the immunomodulatory subtype of TNBC.In conclusion,the phaseⅠb/ⅡFUTURE trial suggested a new concept for TNBC treatment,demonstrating the clinical beneft of subtyping-based targeted therapy for refractory metastatic TNBC. | Yi-Zhou Jiang Yin Liu Yi Xiao Xin Hu Lin Jiang Wen-ia Zuo Ding Ma Jiahan Ding Xiaoyu Zhu Jianjun Zou Claire Verschraegen Daniel G.Stover Virginia Kaklamani Zhong-Hua Wang Zhi-Ming Shao | 2021 | Cell Research2021，31，2： | 37 |
| 14 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 15 | Prospective multicenter randomized trial comparing physician versus patient transfer for primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction显示文摘背景:主要经皮的冠的干预(一种总线标准) 与尖锐圣片断举起为病人作为第一种治疗学的选择被识别了心肌的梗塞(STEMI ) 。把病人转移到一个一种总线标准中心的策略最近与尖锐 STEMI 为那些被推荐对一种总线标准不能的医院在场,它包括设备或富有经验的操作员的缺乏。在中国,一些本地医院与一种总线标准设备被装备了,但是他们没有医生们为执行主要一种总线标准限制了的 interventional。这研究被进行估计把医生转移到与尖锐 STEMI 为病人执行主要一种总线标准的一所装备一种总线标准的医院的策略的可行性,安全和功效。方法:有症状演讲 = 的 334 个连续 STEMI 病人到 2007 年 11 月的从 2005 年 11 月的五所本地医院里的 12 个小时被使随机化由任何一个医生转移收到主要一种总线标准(医生转移组, n=165 ) 或耐心的转移(耐心的转移组, n=169 ) 策略。Door-to-balloon 时间,在里面医院和 30 天的主要不利心脏的事件(向,包括的死亡,非致命的重新梗塞,和目标容器 revascularization ) 在二个组之间被比较。结果:在二个组之间的基线特征是可比较的。在心肌的梗塞(TIMI ) 的血栓溶解 3 流动在起始的血管造影术在医生转移组在更多的病人被揭示(17.6% 对 10.1% , P<0.05 ) 。主要一种总线标准的成功率(96.3% 对 95.4% , P>0.05 ) 并且一些医院停留在二个组之间是类似的((15+/-4 ) 天对(14+/-3 ) 天, P>0.05 ) 。在医生转移组, door-to-balloon 时间显著地被弄短((95+/-20 ) 纪录对(147+/-29 ) 纪录, P<0.0001 ) 并且更多的病人与不到 90 纪录的 door-to-balloon 时间收到了主要一种总线标准(21.2% 对 7.7% , P<0.001 ) 。在住院期间,向发生在在医生和耐心的转移的 6.7% 病人和 11.2% 组,分别地(P=0.14 ) 。在 30 天的临床的后续,死亡的出现率,非致命的重新梗塞,和目标容器 revascularization (TVR ) 是 3.6% 对 5.9% , 4.2% 对 8.9% ,和 1.2% 对 2.4% 在医生和病人转移组,分别地(所有 P>0.05 ) 。累积合成向显著地被减少(8.9% 对 17.2% , P=0.03 ) 并且向免费幸存(91.0% 对 82.9% , P<0.05 ) 显著地在 30 天在医生转移组被改进。结论:把医生转移到本地医院与尖锐 STEMI 为病人执行主要一种总线标准的策略在减少 door-to-balloon 时间和 30 天的向率可行、安全、有效。 | ZHANG Qi ZHANG Rui-yan QIU Jian-ping ZHANG Jun-feng WANG Xiao-long JIANG Li LIAO Min-lei ZHANG Jian-sheng HU Jian YANG Zheng-kun SHEN Wei-feng | 2008 | Chinese Medical Journal2008，，6： | 33 |
| 16 | Impact of different clinical pathways on outcomes of patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the RAPID-AMI study显示文摘背景当前的指南作为选择的第一治疗支持主要经皮的冠的干预(主要一种总线标准)( 与 thrombolytic 治疗对比) 为有尖锐圣片断举起的病人心肌的梗塞(STEMI ) 特别当在 12 小时症状发作以内交付了时。我们试图从 2005 年 11 月与 STEMI.Methods 在病人在结果在灌注延期和随后的改进的减小上评估不同临床的小径的影响到 2007 年 11 月,有明确的 STEMI 的 546 个连续病人,在在紧急情况房间的到达之上是 triaged 经历主要一种总线标准,被包括。他们, 271 个病人直接被带到 catheterization 实验室(快速的组) ,并且 275 个病人首先进入冠的照顾单位(CCU ) 或心脏的病房,然后转了到 catheterization 实验室(非快速的组) 。主要端点是 door-to-balloon ( D28 )时间,并且第二等的端点包括了山峰 CK-MB 水平和主要心脏的不利事件(向)的率在住院期间并且在30天的临床的 follow-up.Results 基线临床的特征包括死亡,梗塞,或目标容器 revascularization 估计的梗塞尺寸, angiographic 特征和程序的成功率在二个组之间是可比较的,除了更多的病人以前收到了 glycoprotein b/a 受体禁止者之外一D2B 时间被弄短((108 ? ㈨ ? 洠污 ???? 畯 ? 晡整 ? 桴 ? 灯牥瑡潩 ? 慷 ? 楳湧晩捩湡汴 ? 楨桧牥琠慨 ? 桴瑡漠 ? 桴 ? 湫 ' 覞煬潠 P 潲灵吗?? | ZHANG Qi ZHANG Rui-yan QIU Jian-ping JIN Hui-gen ZHANG Jun-feng WANG Xiao-long JIANG Li LIAO Min-lei HU Jian DING Feng-hua ZHANG Jian-sheng SHEN Wei-feng | 2009 | Chinese Medical Journal2009，，6： | 32 |
| 17 | Rice leaf inclination2, a VIN3-1ike protein, regulates leaf angle through modulating cell division of the collar显示文摘作为一个重要农学的特点,叶子的倾斜为庄稼建筑学和谷物收益是关键的。理解控制米饭叶角度的分子的机制,一米饭叶 inclination2 (lc2,三等位基因) 异种被识别并且机能上地描绘了。比作野类型的植物, lc2 异种在薄板的近轴的外皮由于增加的细胞分割扩大了叶角度关节。LC2 基因通过位置的克隆被孤立,并且编码开花结实促进法感觉迟钝的 3-like 蛋白质。LC2 的互补表示颠倒了 lc2 植物的扩大的叶角度,证实它在控制叶倾斜的角色。LC2 主要在叶开发期间在薄板关节被表示,并且特别地,被植物激素 abscisic 酸, gibberellic 酸,植物生长素,和 brassinosteroids 导致。LC2 在原子核是局部性的, LC2 的缺点导致房间分割和荷尔蒙应答的基因的改变的表示,显示在调整叶倾斜和调停的荷尔蒙效果的 LC2 的一个重要角色。 | Shu-Qing Zhao Jiang Hu Long-Biao Guo Qian Qian Hong-Wei Xue | 2010 | Cell Research2010，20，8： | 34 |
| 18 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 19 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 20 | Laparoscopic vs open left hepatectomy for hepatolithiasis显示文摘AIM: To explore the feasibility and therapeutic effect of total laparoscopic left hepatectomy (LLH) for hepatolithiasis. METHODS: From June 2006 to October 2009, 61 consecutive patients with hepatolithiasis who met the inclusion criteria for LLH were treated in our institute. Of the 61 patients with hepatolithiasis, 28 underwent LLH (LLH group) and 33 underwent open left hepatectomy (OLH group). Clinical data including operation time, intraoperative blood loss, postoperative complication rate, postoperative hospital stay time, stone clearance and recurrence rate were retrospectively analyzed and compared between the two groups. RESULTS: LLH was successfully performed in 28 patients. The operation time of LLH group was longer than that of OLH group (158 ± 43 min vs 132 ± 39 min, P < 0.05) and the hospital stay time of LLH group was shorter than that of OLH group (6.8 ± 2.8 d vs 10.2 ± 3.4 d, P < 0.01). No difference was found in intraoperative blood loss (180 ± 56 mL vs 184 ± 50 mL), postoperative complication rate (14.2% vs 15.2%), and stone residual rate (intermediate rate 17.9% vs 12.1% and final rate 0% vs 0%) between the twogroups. No perioperative death occurred in either group. Fifty-seven patients (93.4%) were followed up for 2-40 mo (mean 17 mo), including 27 in LLH group and 30 in OLH group. Stone recurrence occurred in 1 patient of each group. CONCLUSION: LLH for hepatolithiasis is feasible and safe in selected patients with an equal therapeutic effect to that of traditional open hepatectomy. | Tu, Jin-Fu Jiang, Fei-Zhao Zhu, Heng-Liang Hu, Ru-Ying Zhang, Wei-Jian Zhou, Zhen-Xu | 2010 | World Journal of Gastroenterology2010，16，22： | 30 |
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