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| 1 | Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade显示文摘The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progressIn this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrenee and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis. | Jiaxing Cui Hongfei Cui Mingran Yang Shiyu Du Junfeng Li Yingxue Li Liyang Liu Xuegong Zhang Shao Li | 2019 | Protein & Cell2019，10，7： | 21 |
| 2 | Anaerobic benzene biodegradation by a pure bacterial culture of Bacillus cereus under nitrate reducing conditions显示文摘A pure culture using benzene as sole carbon and energy sources was isolated by screening procedure from gasoline contaminated soil.The analysis of the 16S rDNA gene sequence,morphological and physiological characteristics showed that the isolated strain was a member of genus Bacillus cereus.The biodegradation performance of benzene by B.cereus was evaluated,and the results showed that benzene could be efficiently biodegraded when the initial benzene concentration was below 150 mg/L.The metabolites of anaerobic nitrate-dependent benzene oxidation by strain B.cereus were identified as phenol and benzoate.The results of substrate interaction between binary combinations for benzene,phenol and benzoate showed that the simultaneous presence of benzene stimulated the degradation of benzoate,whereas the addition of benzene inhibited the degradation of phenol.Benzene degradation by B.cereus was enhanced by the addition of phenol and benzoate,the enhanced effects were more pronounced at higher concentration.To our knowledge,this is the first report that the isolated bacterial culture of B.cereus can efficiently degraded benzene under nitrate reducing conditions. | Junfeng Dou Aizhong Ding Xiang Liu Yongchao Du Dong Deng Jinsheng Wang | 2010 | Journal of Environmental Sciences2010，22，5： | 6 |
| 3 | Geochemistry of Pyrite from the Gangcha Gold Deposit, West Qinling Orogen, China: Implications for Ore Genesis显示文摘The Gangcha gold deposit was discovered in 2011 in the Xiahe-Hezuo region, West Qinling Orogen, China. Five types of pyrite have been identified in the ore according to the detailed mineral paragenetic studies. Geochemical data are presented for type I pyrite(py1) rim-core zonation and for the different types of pyrite based on in-situ laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and electron probe microanalysis(EPMA). The results show that pyrites are characterized with heterogeneous Au concentrations, which indicate that Au occurs mainly as micro-or nano-particle native inclusions. Time-resolved depth profiles demonstrate that As, Co and Ni occur as solid solutions in pyrite, whereas Cu, Pb, Zn and Ag occur mainly as inclusions. Trace element concentrations differ between rims and cores in py1, and the differences also exist within different pyrite types. These differences indicate complex chemical evolution of the ore-forming fluids, and the overall geology, geochronology, and stable isotope and pyrite data suggest that the ore-forming fluids were closely linked to magmatic activity during the Triassic Period in West Qinling orogenic belt. | NIE Xiao SHEN Junfeng LIU Haiming DU Baisong WANG Shuhao LI Jie XU Liwei WANG Ran | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 5 |
| 4 | Hierarchical porous cellulose/lanthanide hybrid materials as luminescent sensor显示文摘Photoluminescent hybrid materials containing carboxymethyl cellulose and lanthanide ions(Eu3+, Tb3+)were prepared by a facile method under ambient conditions. Lanthanide ions were covalently grafted to the cellulose framework through coordination with the carboxylic groups of the cellulose. Hybrid materials were fabricated as hydrogel and aerogel. As shown by SEM and pore parameters, aerogel materials which were obtained by supercritical CO_2 drying show hierarchical porous structure. The photoluminescence spectrum of the hybrid materials shows the characteristic red emission of Eu3+ ion and green emission of Tb^(3+). Further luminescent investigations reveal that these hybrid materials can detect Fe^(3+) with relative selectivity and high sensitivity, which suggests that the hybrid materials could be a promising luminescent probe for selectively sensing Fe^(3+) ion. | Wentao Fan Jiaojiao Du Junfeng Kou Zeyu Zhang Fengyi Liu | 2018 | Journal of Rare Earths2018，36，10： | 5 |
| 5 | Granulocyte colony-stimulating factor ameliorates coronary artery elastin breakdown in a mouse model of Kawasaki disease显示文摘 | Liu Junfeng Chen Zhi Du Zhongdong Lu Dunxiang | 2014 | Chinese Medical Journal2014，，21： | 5 |
| 6 | An Investigation on Low Frequency Fatigue Damage of Mooring Lines Applied in a Semi-Submersible Platform显示文摘Assessing the fatigue life of mooring systems is important for deep water structures. In this paper, a comprehensive fatigue analysis is conducted on the mooring lines applied in a semi-submersible platform with special focus on the low frequency(LF) fatigue damage. Several influential factors, including water depth, wave spectral parameters, and riser system, are considered. Numerical simulation of a semi-submersible platform with the mooring/riser system is executed under different conditions, and the fatigue damage of mooring lines is assessed by using the time domain analysis method as a benchmark. The effects of these factors on the mooring line tension and the fatigue damage are investigated and discussed in detail. Research results indicate that the LF fatigue damage only accounts for a very small portion of the total damage, although the LF components dominate the global motion response and the mooring line tension of the semi-submersible platform. However, it is demonstrated that the LF fatigue damage is clearly affected by the influential factors. The increase in water depth and spectral peak periods, and the existence of risers can weaken the contribution of the LF components to the mooring line fatigue damage, while the fatigue damage due to the LF components increases with the increase of significant wave height. | DU Junfeng WANG Shuqing CHANG Anteng LI Huajun | 2016 | Journal of Ocean University of China2016，15，3： | 4 |
| 7 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 8 | Pressureless crystallization of glass toward scintillating composite with high crystallinity for radiation detection显示文摘The construction of scintillating ceramics is of great technological importance for various fundamental applications, including medical diagnostic, security inspection, resource exploration and particle physics. The chief challenge is the facile and scalable synthesis of scintillating ceramics with the desirable combination of pore-free, reliable mechanical properties and excellent scintillating performance. Here we present a pressureless glass crystallization strategy for the construction of scintillating composite with high crystallinity. The fabricated scintillating composites are featured by small optical turbidity, excellent mechanical properties, and efficient scintillating luminescence with the scintillating light yield of 15,000 pH/MeV and about 2.46 times higher than that of the commercial BGO single crystal. Moreover, the scintillating composite derived radiation detector device is successfully elaborated. The practical application for monitoring gamma ray is demonstrated and the precision of the device is less than that of the tolerable deviation of 30%. Our results suggest an innovative approach for expanding the category of scintillating material candidates, pointing to practical application in the field of radiation detection. | Junzhou Tang Shichao Lv Ziyu Lin Guanxin Du Manyun Tang Xu Feng Junpeng Guo Xiang Li Junfeng Chen Lei Wei Jianrong Qiu Shifeng Zhou | 2022 | Journal of Materials Science & Technology2022，，34： | 2 |
| 9 | Dynamic Integrity Measurement Model Based on vTPM显示文摘With the development of cloud computing, virtualization technology has been widely used in our life. Meanwhile, it became one of the key targets for some attackers. The integrity measurement in virtual machine has become an urgent problem. Some of the existing virtualization platform integrity measurement mechanism introduces the trusted computing technology, according to a trusted chain that the Trusted Platform Module(TPM) established for trusted root to measure the integrity of process in static. But this single chain static measurement cannot ensure the dynamic credible in platform running. To solve the problem that the virtual trusted platform can not guarantee the dynamic credibility, this paper put forward Dynamic Integrity Measurement Model(DIMM) based on virtual Trusted Platform Module(v TPM) which had been implemented with typical virtual machine monitor Xen as an example. DIMM combined with virtual machine introspection and event capture technology to ensure the security of the entire user domain. Based on the framework, this paper put forward Self-modify dynamic measurement strategy which can effectively reduce the measurement frequency and improve the measurement performance. Finally, it is proved that the validity and feasibility of the proposed model with comparison experiments. | Ruizhong Du Wangyang Pan Junfeng Tian | 2018 | China Communications2018，15，2： | 2 |
| 10 | Enhanced tribological properties of aligned graphene-epoxy composites显示文摘The random distribution of graphene in epoxy matrix hinders the further applications of grapheneepoxy composites in the field of tribology.Hence,in order to fully utilize the anisotropic properties of graphene,highly aligned graphene-epoxy composites(AGEC)with horizontally oriented structure have been fabricated via an improved vacuum filtration freeze-drying method.The frictional tests results indicated that the wear rate of AGEC slowly increased from 5.19x10^(-6)mm^(3)/(N-m)to 2.87x10^(-5)mm^(3)/(N-m)with the increasing of the normal load from 2 to 10 N,whereas the friction coefficient(COF)remained a constant of 0.109.Compared to the neat epoxy and random graphene-epoxy composites(RGEC),the COF of AGEC was reduced by 87.5%and 71.2%,and the reduction of wear rate was 86.6%and 85.4%at most,respectively.Scanning electron microscope(SEM)observations illustrated that a compact graphene self-lubricant film was formed on the worn surface of AGEC,which enables AGEC to possess excellent tribological performance.Finally,in light of the excellent tribological properties of AGEC,this study highlights a pathway to expand the tribological applications of graphene-epoxy composites. | Yuefeng DU Zhenyu ZHANG Dong WANG Lezhen ZHANG Junfeng CUI Yapeng CHEN Mingliang WU Ruiyang KANG Yunxiang LU Jinhong YU Nan JIANG | 2022 | Friction2022，10，6： | 2 |
| 11 | Simultaneous quantification of 18 bioactive constituents in Ziziphus jujuba fruits by HPLC coupled with a chemometric method显示文摘The fruit of Ziziphus jujuba Mill., known as Hongzao(or Hong-Zao) in Chinese and cultivated in China for more than 4 000 years, has shown to have hepatoprotective property. In previous study, we have isolated and identified 27 known compounds from Z. jujuba fruits, which demonstrated anti-tumor activity. In this study, a high-performance liquid chromatography-diode-array detection-mass spectrometry(HPLC-DAD-MS) method was successfully applied to the simultaneous characterization and quantitation of 18 constituents in 28 Z. jujuba samples, comprised of 12 cultivars from different regions in China, by comparing their HPLC retention times, MS spectra, UV spectra, and NMR data with those of reference compounds. The quantitative method was validated with excellent linearity(R^(2 )> 0.999 1), preferable intra-and inter-day precisions(RSD < 2.78%), and good recoveries(94.96%–102.65%). The content variation of 18 compounds was analyzed by a chemometric method(hierarchical cluster analysis). In addition, these constituents showed protection against carbon tetrachloride(CCl_(4)) intoxicated Hep G2 cell lines by decreasing lactic dehydrogenase(LDH) levels. Results in this study illustrated that the content of all 18 compounds examined has significant difference and variation among cultivars and extracts. The proposed method can serve as a prerequisite for quality control of bioactive compounds in Z. jujuba products. | Tianyi Wang Sen Guo Xiameng Ren Junfeng Du Lu Bai Xueqin Cui Chi-Tang Ho Naisheng Bai | 2022 | Food Science and Human Wellness2022，11，4： | 2 |
| 12 | Phenomenological analysis of B→PP decays with QCD Factorization显示文摘 | Du Dongsheng Gong Haijun Sun Junfeng | 2002 | Phys Rev2002，65，07： | 1 |
| 13 | Novel alternative therapy for spinal tuberculosis during surgery: reconstructing with anti-tuberculosis bioactivity implants显示文摘 | JunFeng Dong ShengMin Zhang HaoMing Liu XinZhi Li YongHui Liu YingYing Du | 2014 | Expert Opinion on Drug Delivery2014，，3： | 1 |
| 14 | Phenomenologieal analysis of eharmless decays B1→PP, PV with QCD faetorization显示文摘 | Sun Junfeng Zhu Guaihuai Du Dongsheng | 2003 | Phys Rev2003，68，05： | 1 |
| 15 | Genetic variation in IL28B is associated with the development of hepatitis B-related hepatocellular carcinoma显示文摘 | Shan Ren Junfeng Lu Xiaofei Du Yanxiang Huang Lina Ma Honglei Huo Xinyue Chen Lai Wei | 2012 | Cancer Immunology Immunotherapy2012，，9： | 1 |
| 16 | An Extension of the Win Theorem: Counting the Number of Maximum Independent Sets显示文摘Win proved a well-known result that the graph G of connectivity κ(G) withα(G) ≤κ(G) + k-1(k ≥ 2) has a spanning k-ended tree, i.e., a spanning tree with at most k leaves. In this paper, the authors extended the Win theorem in case when κ(G) = 1 to the following: Let G be a simple connected graph of order large enough such that α(G) ≤ k + 1(k ≥ 3) and such that the number of maximum independent sets of cardinality k + 1 is at most n-2k-2. Then G has a spanning k-ended tree. | Wanpeng LEI Liming XIONG Junfeng DU Jun YIN | 2019 | Chinese Annals of Mathematics,Series B2019，40，3： | 1 |
| 17 | Study of Bc→B(*)P, BV decays with QCD factorization显示文摘 | Sun Junfeng Yang Yueling Du Wenjie | 2008 | Phys Rev2008，77，11： | 1 |
| 18 | A spectroscopic and molecular modeling study of sinomenine hydrochloride binding to transferring 显示文摘 | DU Hong XIANG Junfeng ZHANG Yazhou | 2007 | Bioorg Med Chem Lett2007，17，6： | 1 |
| 19 | Probability Distribution of the Hull Motion and Mooring Line Tension of Two Floating Systems显示文摘The statistical and distribution characteristics of the responses of a floater and its mooring lines are essential in designing floating/mooring systems.In general,the dynamic responses of offshore structures obey a Gaussian distribution,assuming that the structural system,and sea loads are linear or weakly nonlinear.However,mooring systems and wave loads are considerably nonlinear,and the dynamic responses of hull/mooring systems are non-Gaussian.In this study,the dynamic responses of two types of floaters,semi-submersible and spar platforms,and their mooring lines are computed using coupled dynamic analysis in the time domain.Herein,the statistical characteristics and distributions of the hull motion and mooring line tension are discussed and compared.The statistical distributions of the dynamic responses have strong non-Gaussianity and are unreasonably fitted by a Gaussian distribution for the two floating and mooring systems.Then,the effects of water depth,wave parameters,and low-frequency and wave-frequency components on the non-Gaussianity of the hull motion,and mooring line tension are investigated and discussed.A comparison of the statistical distributions of the responses with various probability density functions,including the Gamma,Gaussian,General Extreme Value,Weibull,and Gaussian Mixture Model(GMM)distributions,shows that the GMM distribution is better than the others for characterizing the statistical distributions of the hull motion,and mooring line tension responses.Furthermore,the GMM distribution has the best accuracy of response prediction. | ZHANG Deqing DU Junfeng WANG Junrong CHANG Anteng | 2020 | Journal of Ocean University of China2020，19，2： | 1 |
| 20 | 洛铂和奥沙利铂对结直肠癌细胞系生物学行为影响的实验研究(英文)显示文摘Objective: The aim of the study was to observe the effects of lobaplatin and oxaliplatin on biological behavior of colorectal carcinoma cell line. Methods: The human colorectal carcinoma cell line LoVo and HR-8348 were used in the present study, and different concentrations of lobaplatin and oxaliplatin served as inhibitors. The invasion and metastasis potential were evaluated with Transwell chamber, and cell inhibition ratio was measured with MTT assay. Results: Lobaplatin and oxaliplatin could significantly decrease the abilities of invasion and metastasis of LoVo and HR-8348 as compared with the control group (P < 0.01), but no difference between lobaplatin and oxaliplatin groups was observed (P > 0.05). No difference was found in the cell inhibition ratio between the lobaplatin and oxaliplatin groups (P > 0.05). Lobaplatin could inhibit colorectal carcinoma cells that oxaliplatin couldn’t do. Conclusion: Lobaplatin is a new antitumor platinum drug and can inhibit colorectal carcinoma cells. Moreover, lobaplatin could also inhibit colorectal carcinoma cells which are resistant to oxaliplatin. | Xue Bai Bo Yu Junfeng Du Shujun Yuan Fuyi Zuo Liang Sun | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 1 |
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