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| 1 | Hydroxycut hepatotoxicity:A case series and review of liver toxicity from herbal weight loss supplements显示文摘Dietary supplements represent an increasingly common source of drug-induced liver injury. Hydroxycut is a popular weight loss supplement which has previously been linked to hepatotoxicity, although the individual chemical components underlying liver injury remain poorly understood. We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and summarize the existing literature on commonly used weight loss supplements, and their individual components which have demon-strated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted. | Lily Dara Jennifer Hewett Joseph Kartaik Lim | 2008 | World Journal of Gastroenterology2008，14，45： | 10 |
| 2 | Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in the United States and represents an increasingly important etiology of hepatocellular carcinoma(HCC) with annual cumulative incidence rates ranging from 2% to 12% in cohorts of NAFLD cirrhosis. While the risk of progression of NAFLD to HCC remains higher among patients with fibrosis or cirrhosis, an increasing amount of literature describes NAFLD-HCC as a disease that can occur in the absence of cirrhosis. Efforts to characterize the pathogenesis of NAFLD-HCC have suggested mechanisms that strongly associate with states of hyperinsulinemia and chronic inflammation, cellular mechanisms including adaptive immune responses and hepatic progenitor cell populations, and genetic polymorphisms including mutations of PNPLA3. Current literature describes NAFLD-HCC mostly as a disease of late presentation with lower rates of receipt of curative therapy and worse prognosis. However, a growing body of evidence has reported comparable and potentially more favorable disease-free and overall survival rates among patients with NAFLD-HCC after receipt of curative treatment. This review summarizes current evidence of epidemiology, pathophysiology, disease presentation, demand and receipt of curative therapy, post-treatment outcomes, and overall survival of NAFLD-associated HCC. | Carrie R Wong Mindie H Nguyen Joseph K Lim | 2016 | World Journal of Gastroenterology2016，22，37： | 5 |
| 3 | Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice显示文摘Cre/lox P technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in2-month-old mice, Dmp1-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction. In the bone marrow, Cre activity is evident in certain stromal cells adjacent to the blood vessels, but not in adipocytes. Outside the skeleton, Dmp1-Cre marks not only the skeletal muscle fibers, certain cells in the cerebellum and the hindbrain but also gastric and intestinal mesenchymal cells that express Pdgfra. Confirming the utility of Dmp1-Cre in the gastrointestinal mesenchyme, deletion of Bmpr1 a with Dmp1-Cre causes numerous large polyps along the gastrointestinal tract, consistent with prior work involving inhibition of BMP signaling.Thus, caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types. | Joohyun Lim Joseph Burclaff Guangxu He Jason C Mills Fanxin Long | 2017 | Bone Research2017，5，1： | 4 |
| 4 | American Gastroenterological Association Institute Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation During Immunosuppressive Drug Therapy显示文摘 | K. Rajender Reddy Kimberly L. Beavers Sarah P. Hammond Joseph K. Lim Yngve T. Falck-Ytter | 2015 | Gastroenterology2015，，1： | 3 |
| 5 | Laparoscopic resection of gastrointestinal stromal tumors:Does laparoscopic surgery provide an adequate oncologic resection?显示文摘Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI tract.Surgical resection remains the mainstay of non-metastatic disease.However,the ability to provide an adequate oncologic resection using laparoscopic surgery is still an area of debate.This is a thorough review of the current literature,looking particularly at the use of laparoscopic surgery for larger GISTs and the long-term oncologic outcomes compared to the results of open surgery.Laparoscopic resections provide an adequate oncologic result for GISTs of all sizes,including those greater than 5 cm in size. | Joseph J Kim James Y Lim Scott Q Nguyen | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 6 | Emerging trends in hepatocellular carcinoma incidence and mortality显示文摘 | Basile Njei Yaron Rotman Ivo Ditah Joseph K. Lim | 2015 | Hepatology2015，，1： | 3 |
| 7 | A stochastic model for risk management in global supply chain networks显示文摘 | Mark Goh Joseph Y.S. Lim Fanwen Meng | 2006 | European Journal of Operational Research2006，，1： | 2 |
| 8 | The relationship of in vivo 31 P MR spectroscopy to histology in chronic hepatitis C显示文摘 | Adrian K.P. Lim Nayna Patel Gavin Hamilton Joseph V. Hajnal Robert D. Goldin Simon D. Taylor-Robinson | 2003 | Hepatology2003，，4： | 2 |
| 9 | Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience显示文摘 | Jason N. Rogart Dhanpat Jain Uzma D. Siddiqui Tal Oren Joseph Lim Priya Jamidar Harry Aslanian | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 10 | Heart Rate Variability Analysis Using Correlation Dimension and Detrended Fluctuation Analysis 显示文摘 | ACHARYA R U LIM C M JOSEPH P | 2002 | ITBM-RBM2002，23，6： | 1 |
| 11 | Heart rate variability: a review显示文摘 | U. Rajendra Acharya K. Paul Joseph N. Kannathal Choo Min Lim Jasjit S. Suri | 2006 | Medical & Biological Engineering & Computing2006，，12： | 1 |
| 12 | Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure显示文摘 | Elahi MM Lim MY Joseph RN | 2004 | Eur J Cardiothorac Surg2004，26，5： | 1 |
| 13 | Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure显示文摘 | Elahi MM Lim MY Joseph RN | 2004 | Eur J Cardiothorac Surg2004，26，： | 1 |
| 14 | Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure显示文摘 | Maqsood M. Elahi Ming Yann Lim Robin N. Joseph Ramana Rao V. Dhannapuneni Tomasz J. Spyt | 2004 | European Journal of Cardio-Thoracic Surgery2004，，5： | 1 |
| 15 | M1477: A Prospective, Multicenter, Randomized, Double Blinded Controlled Study to Determine Whether a Single Dose of Intraduodenal Indomethacin Can Decrease the Incidence and Severity of Post-ERCP Pancreatitis显示文摘 | Farshad Elmi Federico Rossi Joseph K. Lim Harry R. Aslanian Uzma D. Siddiqui Fred S. Gorelick Hillary Drumm Priya A. Jamidar | 2010 | Gastrointestinal Endoscopy2010，，5： | 1 |
| 16 | Investigation prior to thyroglossal duct cyst excision 显示文摘 | Joseph J Lim K Ramsden J | 2012 | Ann R Coll Surg Engl2012，94，3： | 1 |
| 17 | Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure显示文摘 | Elahi MM Lim MY Joseph RN | 2004 | Eur J Cardiothorac Surg2004，26，5： | 1 |
| 18 | Giant single coronary system with coronary cameral fistula diagnosed on MSCT显示文摘 | Kean H. Soon Joseph Selvanayagam Kevin W. Bell Sie H. Tang Jeremy Pereira William Chan Yean L. Lim | 2005 | International Journal of Cardiology2005，，2： | 1 |
| 19 | Cervical dysplasia: Assessing methylation status (Methylight) of CCNA1, DAPK1, HS3ST2, PAX1 and TFPI2 to improve diagnostic accuracy显示文摘 | Elaine H. Lim Shi Len Ng Jia Liang Li Alexander R. Chang Joseph Ng A. Ilancheran Jeffrey Low Swee Chong Quek Eng Hseon Tay | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 20 | Orbital Inflammatory Disease显示文摘 | Joseph R. Lutt Lyndell L. Lim Pramit M. Phal James T. Rosenbaum | 2008 | Seminars in Arthritis and Rheumatism2008，，4： | 1 |
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