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| 1 | Immunological mechanisms and therapeutic targets of fatty liver diseases显示文摘Alcoholic liver disease(ALD)and nonalcoholic fatty liver disease(NAFLD)are the two major types of chronic liver disease worldwide.Inflammatory processes play key roles in the pathogeneses of fatty liver diseases,and continuous inflammation promotes the progression of alcoholic steatohepatitis(ASH)and nonalcoholic steatohepatitis(NASH).Although both ALD and NAFLD are closely related to inflammation,their respective developmental mechanisms differ to some extent.Here,we review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation associated with fatty liver diseases and the differences in the progression of ASH and NASH.Multiple cell types in the liver,including macrophages,neutrophils,other immune cell types and hepatocytes,are involved in fatty liver disease inflammation.In addition,microRNAs(miRNAs),extracellular vesicles(EVs),and complement also contribute to the inflammatory process,as does intertissue crosstalk between the liver and the intestine,adipose tissue,and the nervous system.We point out that inflammation also plays important roles in promoting liver repair and controlling bacterial infections.Understanding the complex regulatory process of disrupted homeostasis during the development of fatty liver diseases may lead to the development of improved targeted therapeutic intervention strategies. | Hua Wang Wajahat Mehal Laura E.Nagy Yaron Rotman | 2021 | Cellular & Molecular Immunology2021，18，1： | 10 |
| 2 | A Dialogue between the Sirene Pathway in Synergids and the Fertilization Independent Seed Pathway in the Central Cell Controls Male Gamete Release during Double Fertilization in Arabidopsis显示文摘 | Nicolas Rotman Mathieu Gourgues Anne-Elisabeth Guitton Jean-Emmanuel Faure Frederic Berger | 2008 | Molecular Plant2008，1，4： | 5 |
| 3 | 化放疗——癌症治疗的一个新起点显示文摘放疗同时连续输注化疗已使许多恶性肿瘤患者提高了缓解率和生存率.该法治疗晚期直肠、食管及膀胱癌疗效可观,治疗头颈部恶性肿瘤可使照射剂量减少15%~30%,在治疗妇科肿瘤、软组织肉瘤及肝转移癌中也显示出一定的优势.目前,与该治疗方法相关的化疗药物的选择、化放疗的有效结合及最佳放疗剂量和分割仍有待解决. | Rotman MZ 李建彬 满运艳 | 1993 | 国外医学(肿瘤学分册)1993，20，2： | 3 |
| 4 | Emerging trends in hepatocellular carcinoma incidence and mortality显示文摘 | Basile Njei Yaron Rotman Ivo Ditah Joseph K. Lim | 2015 | Hepatology2015，，1： | 3 |
| 5 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 6 | Genetic similarity of Candida albicans strains from vaginitis patients and their partners显示文摘 | Schmld J Rotman M Reed B | 1993 | J Clin Microbiol1993，31，1： | 1 |
| 7 | A phase Ⅲ randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic fea- tures: follow-up of a gynecologic oncology group study 显示文摘 | Rotman M Sedlis A Piedmonte M R | 2006 | lnt J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 8 | Recursive partitioning analysis(RPA) of prognostic factors in three Radiation Therapy Oncology Group(RTOG) brain metastases trials显示文摘 | GASPAR L SCOTT C ROTMAN M | 1997 | Int J Radiat Oncol Biol Phys1997，37，4： | 1 |
| 9 | Submaximal exercise testing显示文摘 | Sheffield L T Rotman D Reeves J J | | J S C Med Ass0，，： | 1 |
| 10 | Medial pancreatectomy for tumors of the neck of the pancreas显示文摘 | Rotman N Sastre B Fagniez PL | 1993 | Surgery1993，113，5： | 1 |
| 11 | Low weight predicts neutropenia and peginterferon alfa-2a dose reductions during treatment for chronic hepatitis C显示文摘 | Rotman Y Katz L Cohen M | | 0，，05： | 1 |
| 12 | A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features follow - up of a gynecologic oncology group study 显示文摘 | Rotman M Sedlis A Piedmonte MR | 2006 | lnt J Radiation Oncology Biol Phys2006，65，1： | 1 |
| 13 | Potential impact of global climate change on malaria risk显示文摘 | Martens WJ Niessen LW Rotmans J | 1995 | Environ Health Perspect1995，103，5： | 1 |
| 14 | The morcellator Knife: a new laparoscopie instrument for supraeervical hysterectomy and morcellation显示文摘 | Hasson HM Rotman C Rana N | 2000 | Obstet C ynecol2000，96，4： | 1 |
| 15 | A Phase Ⅲ randomized trial of postoperative pelvic irradiation in stage ⅠB cervical carcinoma with poor prognostic features:follow-up of a gynecological oncology group study显示文摘 | Rotman MZ Sedlis A Piedmonte MR | 2006 | Int J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 16 | Potential impact of global climate change on malaria risk 显示文摘 | Martens WJ Niessen LW Rotmans J | 1995 | Environ Health Per- spect1995，103，： | 1 |
| 17 | Recognition of Schistosoma mansoni cathepsins B and by human lgG1 and lgG4 antibodies显示文摘 | Grogan J Rotmans P Ghoneim H | 1997 | Parasite Immunol1997，19，5： | 1 |
| 18 | Molecular properties of calcium channels in skeletal muscle and neurons显示文摘 | Catterall WA de Jongh K Rotman E | 1993 | Ann N Y Acad Sci1993，681，： | 1 |
| 19 | A randomized tri- al of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix af- ter radical hysterectomy and pelvic lymphadenectomy:A Gynecologic Oncology Group Study 显示文摘 | Sedlis A Bundy BN Rotman MZ | 1999 | Gynecol Oncol1999，73，2： | 1 |
| 20 | In vivo cell seeding with anti-CD34 antibodies successfully accelerates endothelialization but stimulates intimal hyper- plasia in porcine arteriovenous expanded polytetrafluoroeth- ylene grafts 显示文摘 | ROTMANS Jl HEYLIGERS JM VERHAGEN HJ | 2005 | Circulation2005，112，1： | 1 |
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