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| 1 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 3 | Gastroenterostoma after Billroth antrectomy as a premalignant condition显示文摘Gastric stump carcinoma(GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1 and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be ofspecial interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency. | Robert Sitarz Ryszard Maciejewski Wojciech P Polkowski G Johan A Offerhaus | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 4 | Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis显示文摘One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation(FMT) in active collagenous colitis(CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC. | Sezin Günaltay Lech Rademacher Elisabeth Hultgren Hornquist Johan Bohr | 2017 | World Journal of Gastroenterology2017，23，7： | 4 |
| 5 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 6 | Early-onset gastric cancer:Learning lessons from the young显示文摘There is by no means a clear-cut pattern of mutations contributing to gastric cancers,and gastric cancer research can be hampered by the diversity of factors that can induce gastric cancer,such as Helicobacter pylori infection,diet,ageing and other environmental factors.Tumours are unquestionably riddled with genetic changes yet we are faced with an unsolvable puzzle with respect to a temporal relationship.It is postulated that inherited genetic factors may be more important in early-onset gastric cancer (EOGC) than in gastric cancers found in older patients as they have less exposure to environmental carcinogens.EOGC,therefore,could provide a key to unravelling the genetic changes in gastric carcinogenesis.Gastric cancers occurring in young patients provide an ideal background on which to try and uncover the initiating stages of gastric carcinogenesis.This review summarizes the literature regarding EOGC and also presents evidence that these cancers have a unique molecular-genetic phenotype,distinct from conventional gastric cancer. | Anya N Milne G Johan A Offerhaus | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 7 | Pulsed light for food decontamination: a review显示文摘 | Vicente M. Gómez-López Peter Ragaert Johan Debevere Frank Devlieghere | 2007 | Trends in Food Science & Technology2007，，9： | 2 |
| 8 | Stent Thrombosis in New-Generation Drug-Eluting Stents in Patients With STEMI Undergoing Primary PCI显示文摘 | Giovanna Sarno Bo Lagerqvist Johan Nilsson Ole Frobert Kristina Hambraeus Christoph Varenhorst Ulf J. Jensen Tim T?dt Matthias G?tberg Stefan K. James | 2014 | Journal of the American College of Cardiology2014，，1： | 2 |
| 9 | Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘 | Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers | 2006 | IEEE Selected Topics in Quantum Electronics2006，12，05： | 1 |
| 10 | Distant effect s of India Eurasia convergence and Mesozoic intracontinental deformation in Central Asia:Constraints from apatite fission-track thermo- chronology显示文摘 | Johan D G Michael M B Peter V H | 2006 | Journal of Asian Earth Sciences2006，，3： | 1 |
| 11 | Early‐onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age显示文摘 | RalphCarvalho Anya NAMilne Bastiaan Pvan Rees EricCaspers LuísCirnes CéuFigueiredo G Johan AOfferhaus Marian AJWeterman | 2004 | J Pathol2004，，1： | 1 |
| 12 | Mineral absorption and excretion as affected by microbial phytase,and their effect on energy metabolism in young piglets 显示文摘 | Arie K K Walter J J G Johan W S | 2005 | J Nutr2005，135，： | 1 |
| 13 | 257 ankle arthroplasties performed in Norway between 1994 and 2005显示文摘 | Bj?rg-Tilde S Fevang Stein A Lie Leif I Havelin Johan G Brun Arne Skredderstuen Ove Furnes | 2007 | Acta Orthopaedica2007，，5： | 1 |
| 14 | Effects of immunosup- pression by cyclosporine A on allogenic uterine transplant in the rat显示文摘 | Klaus G Shamima NA Johan M | 2012 | Eur J Obstet Gynecol Reprod Bio12012，163，1： | 1 |
| 15 | Quality of life and metabolic status in mildly depressed women with type 2 diabetes treated with paroxetine:A single-blind randomized placebo controlled trial 显示文摘 | Maria PH Kristian W Johan G | 2003 | BMC family practice2003，14，： | 1 |
| 16 | Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27 显示文摘 | JOHANE G HERMAN L JACQUES H | 1997 | J Cell Sci- ence1997，110，3： | 1 |
| 17 | Comparative proteomics ofindustrial lager yeast reveals differential expression of Thecerevisiae and non-cerevisiae parts of their genomes显示文摘 | Robert C Johan P John S G | 2007 | Proteomics2007，7，22： | 1 |
| 18 | Palatal ulceration as the first sign of pul- monary tuberculosis: A case report显示文摘 | Mogammad Thabit Peck Lawrence X G Stephen Johan Marnewick | 2012 | Tropical Doctor2012，42，1： | 1 |
| 19 | A quantification of short-term macroaggregate dynamics: influences of wheat residue input and texture显示文摘 | STEVEN D G JOHAN S CYNTHIA B | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 20 | Fatigue life improvement of AISI304L cruciform welded joints by cryogenic treatment显示文摘 | Johan Singh P Guha B Achar D R G | 2003 | Engineering Failure Analysis2003，10，1： | 1 |
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