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| 1 | Clinical approaches to non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH),leading to fibrosis and potentially cirrhosis,and it is one of the most common causes of liver disease worldwide.NAFLD is associated with other medical conditions such as metabolic syndrome,obesity,cardiovascular disease and diabetes.NASH can only be diagnosed through liver biopsy,but noninvasive techniques have been developed to identify patients who are most likely to have NASH or fibrosis,reducing the need for liver biopsy and risk to patients.Disease progression varies between individuals and is linked to a number of risk factors.Mechanisms involved in the pathogenesis are associated with diet and lifestyle,influx of free fatty acids to the liver from adipose tissue due to insulin resistance,hepatic oxidative stress,cytokines production,reduced very low-density lipoprotein secretion and intestinal microbiome.Weight loss through improved diet and increased physical activity has been the cornerstone therapy of NAFLD.Recent therapies such as pioglitazone and vitamin E have been shown to be beneficial.Omega 3 polyunsaturated fatty acids and statins may offer additional benefits.Bariatric surgery should be considered in morbidly obese patients.More research is needed to assess the impact of these treatments on a long-term basis.The objective of this article is to briefly review the diagnosis,management and treatment of this disease in order to aid clinicians in managing these patients. | Katherine JP Schwenger Johane P Allard | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 3 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 4 | Gastroenterostoma after Billroth antrectomy as a premalignant condition显示文摘Gastric stump carcinoma(GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1 and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be ofspecial interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency. | Robert Sitarz Ryszard Maciejewski Wojciech P Polkowski G Johan A Offerhaus | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 5 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 6 | Analysis of orthopedic surgical procedures in children with cerebral palsy显示文摘BACKGROUND Orthopedic surgery in children with cerebral palsy(CP)aims to improve function and prevent deformities.Each child’s condition in CP is unique and many covariables influence surgical decision-making including a patient's age and their functional level.Little is known about the frequency of different types of orthopedic surgery in children with CP who have varied functional levels,particularly in countries from Latin America.AIM To assess the type of orthopedic surgical procedures in relation to age and gross motor function in children with CP.METHODS This retrospective study included all children with CP(n=245)treated with elective orthopedic surgery at a Uruguayan university hospital between October 2010 and May 2016 identified from a surgical database.Eighteen children(7%)were lost to follow-up due to missing medical charts.Demographics,gross motor function classification(GMFCS),and orthopedic surgeries were obtained from the medical records of 227 children.Chi-squared tests and analysis of variance were used to assess the frequency of surgery,accounting for GMFCS levels.Mean age for soft tissue vs bone surgery was compared with the independent samples t-test.RESULTS A total of 711 surgical procedures were performed between 1998 and 2016.On average,children had 3.1 surgical procedures and the mean age at first surgery was 8.0 years.There were no significant differences in age at first surgery among GMFCS levels(P=0.47).The most common procedures were lower leg soft tissue surgery(n=189,27%),hip tenotomy(n=135,19%),and hamstring tenotomy(n=104,14%).For children with GMFCS level Ⅰ,the mean number of surgeries per child[1.8(range 1-9)]differed significantly at P<0.05 in children with GMFCS levels Ⅱ[3.2(1-12)],Ⅲ[3.2(1-8)],Ⅳ[3.3(1-13)],and Ⅴ[3.6(1-11)].Within Ⅱ,Ⅲ,Ⅳ,and Ⅴ,there was no significant difference in mean number of surgeries per child when comparing across the groups.The proportion of soft tissue surgery vs bone surgery was higher in GMFCS levels Ⅰ-Ⅲ(80%-85%)compared to levels IV(68%)and V(55%)(P<0.05).CONCLUSION The frequency of surgical procedures per child did not increase with higher GMFCS level after level Ⅰ.However,the proportion of bone surgery was higher in GMFCS levels Ⅳ-Ⅴ compared to Ⅰ-Ⅲ. | Ignacio Rehbein Viviana Teske Ignacio Pagano Alejandro Cúneo María Elena Pérez Johan von Heideken | 2020 | World Journal of Orthopedics2020，11，4： | 2 |
| 7 | Preparation and characterization of hydrocortisone particles Using a supercriti cai fluids extraction process 显示文摘 | Sitaram P Velaga Raonf Ghaderi Johan Carlfors | 2002 | Int J Pharm2002，231，2： | 1 |
| 8 | Esomeprazole for Prevention and Resolution of Upper Gastrointestinal Symptoms in Patients Treated With Low-dose Acetylsalicylic Acid for Cardiovascular Protection: The OBERON Trial显示文摘 | James M. Scheiman Johan Herlitz Sander J. Veldhuyzen van Zanten Angel Lanas Stefan Agewall Emma C. Nauclér Lars-Erik Svedberg Péter Nagy | 2013 | Journal of Cardiovascular Pharmacology2013，，： | 1 |
| 9 | Wireless Ad hoc networking:the art of networking without a network显示文摘 | Frod Ighm Johan Sson P | 2000 | Ericsson Review2000，，4： | 1 |
| 10 | Comparative proteomics ofindustrial lager yeast reveals differential expression of Thecerevisiae and non-cerevisiae parts of their genomes显示文摘 | Robert C Johan P John S G | 2007 | Proteomics2007，7，22： | 1 |
| 11 | Experimental investigation of the Tra-nsformation and Release to Gas Phase of Potas- sium and Chlorine during Straw Pyrolysis 显示文摘 | P A Jensen F J Frandsen K D Johan - senetal | 2000 | Energy & Fuels2000，14，6： | 1 |
| 12 | The effects of ester chain length and temperature on the catalytic chain transfer polymerization of methacrylates显示文摘 | Johan P A Heuts Darren J Forster Thomas P Davis | 1999 | Macromolecules1999，32，： | 1 |
| 13 | Fatigue life improvement of AISI304L cruciform welded joints by cryogenic treatment显示文摘 | Johan Singh P Guha B Achar D R G | 2003 | Engineering Failure Analysis2003，10，1： | 1 |
| 14 | Influence of culture pH on survival of Lactobacillus reuteri subjected to freeze-drying显示文摘 | Johan P Hahn-H?gerdal B | 2000 | International Journal of Food Microbiology2000，55，： | 1 |
| 15 | Catalytic chain transfer and its derived macromonomers显示文摘 | Johan P A Heuts Niels M B Smeets | 2011 | Polym Chem2011，，2： | 1 |
| 16 | Pichia anomala as a biocontrol agent of Penicillium roqueforti in high moisture wheat,rye,barley,and oats stored under airtight conditions显示文摘 | Stina P Johan S | | 0，，05： | 1 |
| 17 | Crystallization mechanism of zeolite beta from(TEA)2O,Na2O and K2O containing aluminosilicate gels显示文摘 | JOAQUIN P P JOHAN A M PETER A J | 1987 | Appl Catal1987，13，1： | 1 |
| 18 | Midterm angiographic outcome of single - vessel intracoronary stent placement in diabetic versus nondiabetic patients: A matched comparative study显示文摘 | Lau K W Ding Z P Johan A | 1998 | Am Heart J1998，136，1： | 1 |
| 19 | Partial discharges at DC voltage: their mechanism, detection and analysis显示文摘 | Morshuis P H F Johan J S | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，2： | 1 |
| 20 | Influence of ligand structure on the stability and oxidation of copper nanoparticles显示文摘 | Kanninen P Johans C Merta J | 2008 | J Colloid Interface Sci2008，318，1： | 1 |
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