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| 1 | Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects显示文摘In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitatingthe hepatorenal syndrome.Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation.As a bridge to this treatment,knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs,antibiotics,drugs with specific effects on fibrogenesis and inflammation,and drugs that target specific receptors. | S?ren M?ller Jens H Henriksen Flemming Bendtsen | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 2 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 3 | Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice显示文摘AIM: To optimize the experimental protocols for a simple, sensitive and accurate bleeding assay.METHODS: Bleeding assay was performed in mice by tail tip amputation, immersing the tail in saline at 37 ℃, continuously monitoring bleeding patterns and measuring bleeding volume from changes in the body weight. Sensitivity and extent of variation of bleeding time and bleeding volume were compared in mice treated with the P2 Y receptor inhibitor prasugrel at various doses or in mice deficient of Fc Rγ, a signaling protein of the glycoprotein VI receptor.RESULTS: We described details of the bleeding assay with the aim of standardizing this commonly used assay. The bleeding assay detailed here was simple to operate and permitted continuous monitoring of bleedingpattern and detection of re-bleeding. We also reported a simple and accurate way of quantifying bleeding volume from changes in the body weight, which correlated well with chemical assay of hemoglobin levels(r2 = 0.990, P < 0.0001). We determined by tail bleeding assay the dose-effect relation of the anti-platelet drug prasugrel from 0.015 to 5 mg/kg. Our results showed that the correlation of bleeding time and volume was unsatisfactory and that compared with the bleeding time, bleeding volume was more sensitive in detecting a partial inhibition of platelet's haemostatic activity(P < 0.01). Similarly, in mice with genetic disruption of Fc Rγ as a signaling molecule of P-selectin glycoprotein ligand-1 leading to platelet dysfunction, both increased bleeding volume and repeated bleeding pattern defined the phenotype of the knockout mice better than that of a prolonged bleeding time.CONCLUSION: Determination of bleeding pattern and bleeding volume, in addition to bleeding time, improved the sensitivity and accuracy of this assay, particularly when platelet function is partially inhibited. | Yang Liu Nicole L Jennings Anthony M Dart Xiao-Jun Du | 2012 | World Journal of Experimental Medicine2012，2，2： | 6 |
| 4 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 5 | Oxidation and Thermal Fatigue Behaviors of Two Type Hot Work Steels During Thermal Cycling显示文摘Thermal fatigue test has been carried out on widely used hot work steel 4Cr5MoSiV1and a low alloyed steel 3Cr3MoV in temperature range of 200to 700℃.Tempering resistance,as well as high temperature hardness/strength of steel specimens,works as a dominating material parameter on thermal fatigue resistance.During the heating period,high hardness can depress the inelastic deformation.This deformation is the origination of tensile stress,which acts as the driving force of heat checking during the cooling period.The cyclic strain-oxidation interaction can speed up the damage on surface defects,which plays an obvious role in initiation of thermal cracks.On4Cr5MoSiV1steel specimens,borders between the matrix and inclusions such as titanium compounds,or lager carbides such as primary carbides,are focused by strain and attacked by oxidation,and are main initiating places of cracks.While on 3Cr3MoV steel specimens,larger strain causes plastic deformation concentrating around grain boundaries.Then the following oxidation accelerates this grain boundary damage and creates cracks. | MIN Yong-an Bergstrm Jens WU Xiao-chun XU Luo-ping | 2013 | Journal of Iron and Steel Research(International)2013，20，11： | 5 |
| 6 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 7 | Intelligent agents:theory and practice显示文摘 | Wooldridge M Jennings N R | | 0，，： | 4 |
| 8 | 用传统方法与计算机辅助精液分析软件CRISMAS分析166名丹麦青年男性精液样本的结果比较显示文摘本研究以166名丹麦青年男性精液为样本,通过评估精于浓度和活力来比较传统精液分析与计算机辅助精液分析方法(CASA)(哥本哈根Rigshospitalet图像屋精子运动分析系统,CRISMAS软件4.6版本)。CRISMAS软件测定精子的浓度把精子活力分为三类。传统分析方法将精子活力分为四种状态。为了便于二者的比较,本文将传统的四种状态根据精子速度等级重新分为三个状态:rapidly progressive(A),slowly progressive(B)和non-progressive(C+D)。两种方法所研究的参数之间都有显著差异(P〈0.001)。与传统方法相比,CRISMAS高估了精子浓度以及快速运动精子的比例,因而低估了慢速运动和非运动精子。为分析研究结果是否会随精液分析时间而起伏变动,将精液分析结果按分析同期分为四个层次。结果表明CRISMAS对活力的分析结果比传统分析方法稳定,但两种方法都未表现出任何趋势。显然,无法比较CRISMAS CASA和传统分析方法在精子浓度和精子活力方面的分析结果。在临床上使用该软件时以及用其研究这些精子特性时需要说明这一点。 | Anne Vested Cecilia H Ramlau-Hansen Jens P Bonde Ane M Thulstrup Susanne L Kristensen Gunnar Toft | 2011 | Asian Journal of Andrology2011，13，3： | 3 |
| 9 | Therapeutic Application of Caspase 1/Interleukin-1β-Converting Enzyme Inhibitor Decreases the Death Rate in Severe Acute Experimental Pancreatitis显示文摘 | Adam S. Paszkowski Bettina Rau Jens M. Mayer Peter M?ller Hans G. Beger | 2002 | Annals of Surgery2002，，1： | 2 |
| 10 | Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation显示文摘 | Ashutosh Chaudhry Robert M. Samstein Piper Treuting Yuqiong Liang Marina C. Pils Jan-Michael Heinrich Robert S. Jack F. Thomas Wunderlich Jens C. Brüning Werner Müller Alexander Y. Rudensky | 2011 | Immunity2011，，4： | 2 |
| 11 | A new approach for fuel injection into a solar receiver/ reactor:Numerical and experimental investigation显示文摘An innovative and efficient design of solar receivers/reactors can enhance the production of clean fuels via concentrated solar energy.This study presents a new jet-type burner nozzle for gaseous feedstock injection into a cavity solar receiver inspired from the combustion technology.The nozzle design was adapted from a combustion burner and successfully implemented into a solar receiver and studied the influence of the nozzle design on the fluid mixing and temperature distribution inside the solar receiver using a 7 kW solar simulator and nitrogen as working fluid.Finally,a thorough computational fluid dynamics (CFD) analysis was performed and validated against the experimental results.The CFD results showed a variation of the gas flow pattern and gas mixing after the burner nozzle adaptation,which resulted an intense effect on the heat transfer inside the solar receiver. | M Helal Uddin Nesrin Ozalp Jens Heylen Cedric Ophoff | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 2 |
| 12 | Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial显示文摘 | Dietmar H. Borchert Matthias Federlein Frauke Fritze-Büttner Jens Burghardt Britta Liersch-L?hn Yüksel Atas Verena Müller Oskar Rückbeil Stefan Wagenpfeil Stefan Gr?ber Klaus Gellert | 2014 | Surgical Endoscopy2014，，6： | 2 |
| 13 | 一把椅子抵住这时间的洪流显示文摘关于人与物是如何互相影响的,我想一把汉斯·瓦格纳(HANS J.WEGNER)的椅子便能说明这两者间全部的关系。 | msright PP M?bler Mikkel Adsb?l Jens Mourits S?rensen Erik Brahl Rasmus Koch Studio Katja Kejser Kasper Holst Pedersen | 2015 | 设计2015，28，22： | 2 |
| 14 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 15 | Intelligent agent:theory and practice显示文摘 | Wooldridge M Jennings N R | 1995 | Knowledge Engineering Review1995，10，2： | 1 |
| 16 | Hydration simulation of C3S显示文摘 | JENNINGS H M JOHNSON | 1986 | Am Ceram Soc1986，69，5： | 1 |
| 17 | Developing multiAgent systems: the gaia methodology显示文摘 | F Zambonelli N Jennings M Wooldridge | 2003 | ACM Transactions on Software Engineering and Methodology2003，12，3： | 1 |
| 18 | Induction of defense responses in tobacco by the protein Nepl from Fusarium oxysporum显示文摘 | Jennings J C Apel-Birkhold P C Mock N M | 2001 | Plant Science2001，161，： | 1 |
| 19 | A model for the microstructure of calcium silicate hydrate in cement paste 显示文摘 | JENNINGS H M | 2000 | Cem Coner Res2000，30，1： | 1 |
| 20 | Intelligent Agents:Theory and Practice显示文摘 | M Wooldridge N R Jennings | 1995 | The Knowledge Engineering Review1995，10，2： | 1 |
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