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| 1 | The Sandfish's Skin:Morphology,Chemistry and Reconstruction显示文摘The sandfish is a lizard having the remarkable ability to move in desert sand in a swimming-like fashion. The most out-standing adaptations to this mode of life are the low friction behaviour and the extensive abrasion resistance of the sandfish skin against sand, outperforming even steel. We investigated the topography, the composition and the mechanical properties of sandfish scales. These consist of glycosylated keratins with high amount of sulphur but no hard inorganic material, such as silicates or lime. Remarkably, atomic force microscopy shows an almost complete absence of attractive forces between the scale surface and a silicon tip, suggesting that this is responsible for the unusual tribological properties. The unusual glycosylation of the keratins was found to be absolutely necessary for the described phenomenon. The scales were dissolved and reconstituted on a polymer surface resulting in properties similar to the original scale. Thus, we provide a pathway towards exploitation of the reconstituted scale material for future engineering applications. | Werner Baumgartner Friederike Saxe Agnes Weth David Hajas Darwin Sigumonrong Jens Emmerlich Martin Singheiser Wolfgang Bhme Jochen M. Schneider | 2007 | Journal of Bionic Engineering2007，4，1： | 10 |
| 2 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 3 | Pancreatic Cancer Surgery in the New Millennium: Better Prediction of Outcome显示文摘 | Werner Hartwig Thilo Hackert Ulf Hinz Alexander Gluth Frank Bergmann Oliver Strobel Markus W. Büchler Jens Werner | 2011 | Annals of Surgery2011，，2： | 5 |
| 4 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 5 | Small (Sendai Negative) Branch-Duct IPMNs: Not Harmless显示文摘 | Stefan Fritz Miriam Klauss Frank Bergmann Thilo Hackert Werner Hartwig Oliver Strobel Bogata D. Bundy Markus W. Büchler Jens Werner | 2012 | Annals of Surgery2012，，2： | 3 |
| 6 | MicroRNA in rectal cancer显示文摘In rectal cancer,one of the most common cancers worldwide,the proper staging of the disease determines the subsequent therapy.For those with locally advancedrectal cancer,a neoadjuvant chemoradiotherapy(CRT) is recommended before any surgery.However,response to CRT ranges from complete response(responders) to complete resistance(non-responders).To date we are not able to separate in advance the first group from the second,due to the absence of a valid biomarker.Therefore all patients receive the same therapy regardless of whether they reap benefits.On the other hand almost all patients receive a surgical resection after the CRT,although a watch-and-wait procedure or an endoscopic resection might be sufficient for those who responded well to the CRT.Being highly conserved regulators of gene expression,micro RNAs(mi RNAs) seem to be promising candidates for biomarkers.Many studies have been analyzing the mi RNAs expressed in rectal cancer tissue to determine a specific mi RNA profile for the ailment.Unfortunately,there is only a small overlap of identified mi RNAs between different studies,posing the question as to whether different methods or differences in tissue storage may contribute to that fact or if the results simply are not reproducible,due to unknown factors with undetected influences on mi RNA expression.Other studies sought to find mi RNAs which correlate to clinical parameters(tumor grade,nodal stage,metastasis,survival) and therapy response.Although several mi RNAs seem to have an impact on the response to CRT or might predict nodal stage,there is still only little overlap between different studies.We here aimed to summarize the current literature on rectal cancer and mi RNA expression with respect to the different relevant clinical parameters. | azadeh azizian jens gruber b michael ghadimi jochen gaedcke | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 7 | Management of infection in acute pancreatitis显示文摘 | Werner Hartwig Jens Werner Waldemar Uhl Markus W. Büchler | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，4： | 3 |
| 8 | Anaplastic pancreatic cancer: Presentation, surgical management, and outcome显示文摘 | Oliver Strobel Werner Hartwig Frank Bergmann Ulf Hinz Thilo Hackert Lars Grenacher Lutz Schneider Stefan Fritz Matthias M. Gaida Markus W. Büchler Jens Werner | 2011 | Surgery2011，，2： | 2 |
| 9 | Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon显示文摘 | Stefan Fritz Thilo Hackert Werner Hartwig Florian Rossmanith Oliver Strobel Lutz Schneider Katja Will-Schweiger Mechthild Kommerell Markus W. Büchler Jens Werner | 2010 | The American Journal of Surgery2010，，1： | 2 |
| 10 | Cachexia but not obesity worsens the postoperative outcome after pancreatoduodenectomy in pancreatic cancer显示文摘 | Thomas Pausch Werner Hartwig Ulf Hinz Thomas Swolana Bogota D. Bundy Thilo Hackert Lars Grenacher Markus W. Büchler Jens Werner | 2012 | Surgery2012，，3： | 2 |
| 11 | Preconditioning with ischemia:a delay of lethal cell injury in myocardium显示文摘 | MURRY C E JENNINGS R B REIMER K A | 1986 | Circulation1986，74，： | 1 |
| 12 | Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium显示文摘 | Murry C E Jennings R B Reimer K A | 1986 | Circulation1986，74，5： | 1 |
| 13 | The dynamic selection of coordination mechanisms显示文摘 | Excelente-Toledo C B Jennings N R | 2004 | Journal of Autonomous Agents and Multi-Agent Systems2004，9，12： | 1 |
| 14 | Heritability of venous function in humans显示文摘 | Jens J Marina B Jens T | 2004 | Arts Throm Vasc Biol2004，24，5： | 1 |
| 15 | Perineal one- stage pull- through for Hirschsprung's disease 显示文摘 | Albanese CT Jennings RW Smith B | 1999 | J Pediatr Surg1999，34，3： | 1 |
| 16 | Developing reliable, repeatable, and accessible methods to provide high-resolution estimates of fish- ing-effort distributions from vessel monitoring system (VMS) data 显示文摘 | Lee J South A B Jennings S | 2010 | Ices Journal of Marine Science Journal Du Conseil2010，67，6： | 1 |
| 17 | Prevention of angiotensin II-induced aortic aneurysm and associated path-ogenesis by inhibiting CYPIB1 or its gene disruption (ApoE-/-/Cyplbl-/-mice) 显示文摘 | Thirunavukkarasu S N Khan N Jennings B | 2015 | The FASEB Journal2015，29，1： | 1 |
| 18 | Time-dependent attenuator for dynamic range reduction of lidar signals显示文摘 | STEFAN L VOLKER W JENS B | 1997 | Appl Opt1997，36，15： | 1 |
| 19 | A novel route for the preparation of dimeric tetraorganodistannoxanes 显示文摘 | JENS B DAINIS D VONG S K | 2002 | J Organomet Chem2002，659，： | 1 |
| 20 | Myocardialnecrosis induced by temporary occlusion of coronary atery in the dog 显示文摘 | Jennings R B Sommers H M Smyth G A | 1960 | Arch Pathol1960，70，1： | 1 |
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