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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Enhanced cellular accumulation of a P-glycoprotein substrate,rhodamine-123,by caco-2 cells using low molecular weight methoxypolyethylene glycol-block-polycaprolactone diblock copolymers显示文摘 | Jason Z John J Mandeep B | 2002 | Euro J Phar and Biopharmaceutics2002，54，3： | 1 |
| 3 | Electrospun polyacrylonitrile nanofibers containing a high concentration of wel -aligned multiwal carbon nanotubes显示文摘 | Haoqing H Ge Jason J Jun Z | | 0，，05： | 1 |
| 4 | Increased BCAR1 predicts poor outcomes of non-small cell lung cancer in multiple-center pa tients显示文摘 | Deng B Sun Z Jason W | 2013 | Ann Surg Oncol2013，203，： | 1 |
| 5 | 显示文摘 | Li J Zhang Z Jason R | 2002 | Clin Chem2002，48，： | 1 |
| 6 | Three- dimensional optical metamaterial with a negative refractive index显示文摘 | JASON V ZHANG Shuang THOMAS Z | 2008 | Nature2008，455，7211： | 1 |
| 7 | Urbanization and Energy in China: Issues and Implications 显示文摘 | David F G Jason Z Y | 2004 | Urbanization and Social Welfare in China2004，，： | 1 |
| 8 | A pyramid approach to motion tracking显示文摘 | Z Z Jason Q M Jonathan | 2001 | Real-Time Imaging2001，7，3： | 1 |
| 9 | HIV-1 v-inducedapoptosis is cell cycle dependent and requires Bax but not ant显示文摘 | JOSHUA L A JASON L ERIK S Z | 2006 | J Pathog2006，2，12： | 1 |
| 10 | C5a R Expression in a Novel GFP Reporter Gene Knockin Mouse:Implications for the Mechanism of Action of C5a R Signaling in T Cell Immunity显示文摘 | Jason D Lin Z Takashi M | 2012 | J Immunol2012，188，20： | 1 |
| 11 | Devel- opment and application of a muhimodal contrast ggent for SPECT/CT hybrid imaging 显示文摘 | Jason M C Lawrence W D Zhen W Z etal | 2011 | Bioconjug Chem2011，22，： | 1 |
| 12 | Electrospun polyacrylonitrile nanofibers containing a high concentration of well-aligned multiwall carbon Nanotubes 显示文摘 | Hou H Q Jason J Ge Zeng J Li Q Reneker D H Greiner A Cheng S Z D | 2005 | Chem Mater2005，17，： | 1 |
| 13 | Six degree- of- freedom active vibration control using the Stewart platforms显示文摘 | Geng Z Jason Haynes Leonard S | 1994 | IEEE Transactions on Control Systems Technology1994，2，1： | 1 |
| 14 | HIV-1 v-induced apoptosis is cell cycle dependent and requires bax but not ant显示文摘 | Joshua L A Jason L Erik S Z | 2006 | J Pathog2006，2，12： | 1 |
| 15 | Mutations in the Gene Encoding IFT Dynein Complex Component WDR34 Cause Jeune Asphyxiating Thoracic Dystrophy显示文摘 | Miriam Schmidts Julia Vodopiutz Sonia Christou-Savina Claudio R. Cortés Aideen M. McInerney-Leo Richard D. Emes Heleen H. Arts Beyhan Tüysüz Jason D’Silva Paul J. Leo Tom C. Giles Machteld M. Oud Jessica A. Harris Marije Koopmans Mhairi Marshall Nursel El | 2013 | The American Journal of Human Genetics2013，，5： | 1 |
| 16 | Dynamic traffic grooming in optical burst-switched networks 显示文摘 | FARID F QIONG Z JASON J | 2005 | Journal of Lightwave Technology2005，23，10： | 1 |
| 17 | Six Degree-of-Freedom Active Vibration Control Using the Stewart Platforms显示文摘 | Z Jason Geng Leonard S Haynes | 1994 | IEEE Transactions on Control systems Technology March1994，2，1： | 1 |
| 18 | Estrogen receptor p2negatively regulates the transactivation of estrogen receptor ain human breast cancer cells显示文摘 | Chunyan Z Jason M Michel T | 2007 | Cancer Res2007，67，8： | 1 |
| 19 | STATl-dependent and STATl-independent gene expression in murine immune cells following stimulation with interfer on-alpha显示文摘 | Gregory B L Michael D R | 2007 | Cancer Immunol Immunother2007，56，： | 1 |
| 20 | A phosphotidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans显示文摘 | Jason Z Morris Heidi A Tissenbaum Garry Ruvkun | 1996 | Nature1996，382，： | 1 |
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