|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | Endoscopic management of Crohn's strictures显示文摘Symptomatic intestinal strictures develop in more than one third of patients with Crohn's disease(CD) within 10 years of disease onset. Strictures can be inflammatory, fibrotic or mixed and result in a significant decline in quality of life, frequently requiring surgery for palliation of symptoms. Patients under the age of 40 with perianal disease are more likely to suffer from disabling ileocolonic disease thus may have a greater risk for fibrostenotic strictures. Treatment options for fibrostenotic strictures are limited to endoscopic and surgical therapy. Endoscopic balloon dilatation(EBD) appears to be a safe, less invasive and effective alternative modality to replace or defer surgery. Serious complications are rare and occur in less than 3% of procedures. For non-complex strictures without adjacent fistulizaation or perforation that are less than 5 cm in length, EBD should be considered as first-line therapy. The aim of this review is to present the current literature on the endoscopic management of small bowel and colonic strictures in CD, which includes balloon dilatation, adjuvant techniques of intralesional injection of steroids and anti-tumor necrosis factor, and metal stent insertion. Short and long-term outcomes, complications and safety of EBD will be discussed. | Talat Bessissow Jason Reinglas Achuthan Aruljothy Peter L Lakatos Gert Van Assche | 2018 | World Journal of Gastroenterology2018，24，17： | 10 |
| 3 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 4 | Five-year mortality and coronary heart disease development after normal coronary angiogram显示文摘 | Jason T McMullan Christopher J Lindsell Andra L Blomkalns | 2011 | World Journal of Emergency Medicine2011，2，1： | 6 |
| 5 | Interaction of obesity and inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) is a chronic inflammatory condition of unknown etiology that is thought to result from a combination of genetic, immunologic and environmental factors. The incidence of IBD has been increasing in recent decades, especially in developing and developed nations, and this is hypothesized to be in part related to the change in dietary and lifestyle factors associated with modernization. The prevalence of obesity has risen in parallel with the rise in IBD, suggesting a possible shared environmental link between these two conditions. Studies have shown that obesity impacts disease development and response to therapy in patients with IBD and other autoimmune conditions. The observation that adipose tissue produces pro-inflammatory adipokines provides a potential mechanism for the observed epidemiologic links between obesity and IBD, and this has developed into an active area of investigative inquiry. Additionally, emerging evidence highlights a role for the intestinal microbiota in the development of both obesity and IBD, representing another potential mechanistic connection between the two conditions. In this review we discuss the epidemiology of obesity and IBD, possible pathophysiologic links, and the clinical impact of obesity on IBD disease course and implications for management. | Jason W Harper Timothy L Zisman | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 6 | Androgen deprivation therapy-associated vasomotor symptoms显示文摘雄激素剥夺治疗(ADT ) 广泛地在局部地先进、变形的前列腺癌症的治疗被用作标准治疗。当有效时, ADT 与多重副作用被联系,包括减少的性欲,可勃起的机能障碍,糖尿病,肌肉音调的损失和改变的身体作文,骨质疏松症,类脂化合物变化,记忆损失, gynecomastia 和热闪光。为热闪光的治疗的文学的宽度在女人比那在男人是小得多的。当热闪光的神经质的治疗被显示了有效时,多重非神经质的药和治疗方法也被开发了。这篇文章在拿 ADT 的病人为热闪光的治疗考察当前的选择。 | Jason M Jones Manish Kohli Charles L Loprinzi | 2012 | Asian Journal of Andrology2012，14，2： | 4 |
| 7 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 8 | Methods for the development and assessment of atrial fibrillation and heart failure dog models显示文摘与动物的发展报导 Medtronic 经验的目的用为 AF 模型,的为 CHF.Methods 的为 AF 和 microemboli 的高率的踱步为 atrial 纤维性颤动( AF )和长期的心失败( CHF )当模特儿一根 atrial 皮带被纳入 Medtronic 协同作用 neurostimulator ,它被规划在开关责任 cycle.Atrial natnuretic 肽( ANP )在 50 Hz 刺激,大脑 natriuretic 肽( BNP )和N终端职业人员大脑 natriuretic 肽( NT-proBNP )皮脂腺囊瘤;在精选时间 points.For CHF 模型,的 assayed 在 62,400 beads/mL 的 90 m 聚苯乙烯 microspheres 的连续注射( Polybead , Polysciences 公司)被执行导致全球局部缺血,有每周监视的任何一个和 embolization 时间表(集团 1 , n = 25 )或与监视的双周刊和 emboliation 时间表(集团 2 , n36 ) .Echocardiograms 每周与 ventriculograms 和磁性的回声成像扫描一起被使用估计心脏的功能和 ANP , BNP 和 NT-proBNP 是为 AF 模型的 monitored.Results ,为 CHF 模型,遇见 CHF 端点的日子在集团 2 .For 在集团 1 和 89 是 116 AF 和 CHF 模型, NT-proBNP 与在为动物的搜索的研究人员为估计基于设备的治疗的安全和功效建模的我们为 AF 和 CHF 狗模型的发展和评价的经验可以帮助的疾病 states.Conclusion 的发展相关很好。 | Jon F Urban Renee L Gerhart Jason R Krzeszak Corey R Leet Linnea R Lentz Carolyn B McClay | 2011 | Journal of Geriatric Cardiology2011，8，3： | 3 |
| 9 | Positioning of old and new biologicals and small molecules in the treatment of inflammatory bowel diseases显示文摘The past decade has brought substantial advances in the management of inflammatory bowel diseases(IBD). The introduction of tumor necrosis factor(TNF) antagonists, evidence for the value of combination therapy, the recog-nition of targeting lymphocyte trafficking and activation as a viable treatment, and the need for early treatment of high-risk patients are all fundamental concepts for current modern IBD treatment algorithms. In this article, authors review the existing data on approved biologicals and small molecules as well as provide insight on the current positioning of approved therapies. Patient stratification for the selection of specific therapies, therapeutic targets and patient monitoring will be discussed as well. The thera-peutic armamentarium for IBD is expanding as novel and more targeted therapies become available. In the absence of comparative trials, positioning these agents is becoming difficult. Emerging concepts for the future will include an emphasis on the development of algorithms which will facilitate a greater understanding of the positioning of novel biological drugs and small molecules in order to best tailor therapy to the patient. In the interim, anti-TNF therapy remains an important component of IBD therapy with the most real-life evidence and should be considered as first-line therapy in patients with complicated Crohn's disease and in acute-severe ulcerative colitis. The safety and efficacy of these ‘older' anti-TNF therapies can be optimized by adhering to therapeutic algorithms which combine clinical and objective markers of disease severityand response to therapy. | Jason Reinglas Lorant Gonczi Zsuzsanna Kurt Talat Bessissow Peter L Lakatos | 2018 | World Journal of Gastroenterology2018，24，32： | 3 |
| 10 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 11 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 12 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 13 | An elastic plastic damage formulation for concrete:application to elementary tests and comparison with an isotropic damage model 显示文摘 | JASON L HUERTA A PIJAUDIER-CABOT G | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，： | 1 |
| 14 | Optimization and implementation of periodic cruise for a hypersonic vehicle 显示文摘 | Chen Robert H Williamson Walton R Speyer Jason L | 2006 | Journal of Guidance Control and Dynamics2006，29，5： | 1 |
| 15 | Some electrical effects of the adsorption of water vapour by anodized aluminum 显示文摘 | JASON A C WOOD J L | 1955 | Proceedings of the Physical Society1955，，68： | 1 |
| 16 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 17 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 18 | Mica: a wireless platform for deeply embedded networks显示文摘 | Hill Jason L Culler David E | 2002 | IEEE Micro2002，22，6： | 1 |
| 19 | Extraction and quan- tification of daidzein and genistein in food 显示文摘 | Jason L Ieslie J C Bluek W I | 1998 | Ana- lytical Biochemistiy1998，264，1： | 1 |
| 20 | Express of a heterolo- gous manganese superoxide dismutase gene in intestinal lactobacilli provides protection against hydrogen peroxide toxicity显示文摘 | JOSE M B JASON M A STEPHEN L L | 2004 | Appl Envi- ron Microbioi2004，70，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员