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| 1 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 2 | Pretreatment methods to improve sludge anaerobic degradability: A review显示文摘 | H. Carrère C. Dumas A. Battimelli D.J. Batstone J.P. Delgenès J.P. Steyer I. Ferrer | 2010 | Journal of Hazardous Materials2010，，1： | 5 |
| 3 | 水通道蛋白对人体皮肤重要性的研究显示文摘目的探讨水通道蛋白(AQPs)在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30~40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21~60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中,AQP3从基底层到粒层均有表达,但在角质层下方开始消失,AQP3和Claudin-1的表达与一种透明质酸盐受体CD44的表达呈负相关。对20~80岁之间的健康女性皮肤间接免疫荧光研究也发现,在衰老和长期慢性光暴露时皮肤AQP3表达会明显减少。结论人类皮肤供水系统缺陷可能与年龄有关,水通道蛋白在维持皮肤正常生理功能等方面具有重要意义。 | Frédéric Bonté Emmanuelle Noblesse Miléne Juan Jean Marc Verbawatz Marc Dumas | 2009 | 中华皮肤科杂志2009，42，5： | 4 |
| 4 | Recurrent intracerebral hemorrhage显示文摘 | J.-P. Neau P. Ingrand C. Couderq M.-P. Rosier M. Bailbe P. Dumas P. Vandermarcq R. Gil | 1997 | Neurology1997，，1： | 3 |
| 5 | Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder显示文摘 | Alicia Flausse Christel Henrionnet Manuel Dossot Dominique Dumas Sébastien Hupont Astrid Pinzano Didier Mainard Laurent Galois Jacques Magdalou Evelyne Lopez Pierre Gillet Marthe Rousseau | 2013 | J. Biomed. Mater. Res2013，，11： | 2 |
| 6 | Stoichiometric des, monocristaux de metaniobate de, lithium显示文摘 | LERNER P LEGRAS C DUMAS J P | 1968 | J Cryst Growth1968，34，： | 2 |
| 7 | The evolution of pulmonary cryptococcosis Clinical implication from a study of 41 patients with and without compromising host factors显示文摘 | Kerkering TM Duma RJ Shadomy S | 1981 | Ann Inter Med1981，94，： | 1 |
| 8 | Bmp4 is required for the generation of primordial germ cells in the mouse embryo 显示文摘 | Lawson K A Duma N R Roelen B A | 1999 | Genetics Development1999，13，： | 1 |
| 9 | Relationship between myocardial injury and soluble P-selectin in non-ST elevation acute coronary syndromes显示文摘 | Yazici M Demircan S Duma K | 2005 | Circ J2005，69，5： | 1 |
| 10 | Advances in Germanium Ddtector Teehnology显示文摘 | Sangsingkeow Pat Berry KevinD Dumas Edward J | 2003 | Nu- clear Instruments and Methods in Physics Research SectionA: Accelerators Spectrometers Detectors and Associated Equipment2003，505，122： | 1 |
| 11 | Purification and characterization of acetohydroxy acid reductoisomerase from spinach chloroplasts 显示文摘 | Dumas R Joyard J Douce R | 1989 | Biochemical Journal1989，262，： | 1 |
| 12 | Stimulation of Fibroblasts glycosaminoglycan synthesis by Eriobotrya japonica extact显示文摘 | Bonte Frederic Dumas Marc Petit Veronique | 2001 | Revista Boliviana de Quimica2001，18，1： | 1 |
| 13 | Microelectrode guided posteroventral medial radiofrequency pallidotomy for Parkinson's disease显示文摘 | KOPYOV O JACQUES D DUMA C | 1997 | J Neurosurg1997，87，： | 1 |
| 14 | First evidence of a calcium transient in flowering plants at fertilization显示文摘 | Digonnet Aldon Leduc Dumas Rougier | 1997 | Development1997，124，： | 1 |
| 15 | Left ventricular diverticulum in two adult patients 显示文摘 | Yazici M Demircan S Duma K | 2005 | Int Heart J2005，46，1： | 1 |
| 16 | Maternal infection rates afret cesareAn delivery by Pfannenstiel or Joel-Cohen incision: amuiticenter surveillance study显示文摘 | Dumas AM Girard R Ayzac L | 2009 | Eur J Obstet Gynecol Reprod Biol2009，147，2： | 1 |
| 17 | Ascaleable synthesis of BAY 43-9006 : a potent Raf ki-nase inhibitor for the treatment of cancer 显示文摘 | BANKSTON D DUMAS J NATERO R | 2002 | OrgProc Res Dev2002，6，6： | 1 |
| 18 | A polyamidoamine dendrimer as a selective colorimetric and ratiometric fluorescent sensor for Li ^+ cations in alkali media 显示文摘 | Grabchev I Dumas S Chovelon J M | 2009 | Dyes Pigm2009，82，： | 1 |
| 19 | Prop- ranolol for severe hemangiomas of infancy 显示文摘 | L6aut6-Labrbze C Dumas dela Roque ED Hubiche T | 2008 | N Engl J Med2008，358，24： | 1 |
| 20 | Propranolol for severe hemangiomas of infancy显示文摘 | Lé auté-Labrè ze C Dumas de la Roque E Hubiche T | 2008 | N Engl J Med2008，358，24： | 1 |
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