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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Effect of length on compressive strain softening of concrete显示文摘 | Jansen D C Shah S P | 1997 | Journal of Engineering Mechanics American Society of Civil Engineering1997，123，1： | 2 |
| 5 | Growth Model of Oriented Crystals of Zeolite Si-ZSM-5 显示文摘 | Koegler J H van Bekkum H Jansen J C | 1997 | Zeolites1997，19，： | 2 |
| 6 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 7 | Overgrowth of mesoprous MCM-41 on faujasite显示文摘 | Kloetstra K R Zandbergen H W Jansen J C | 1996 | Microporous mater1996，，6： | 1 |
| 8 | Improvement of Regeneration of Jycopersicon Pennelli Protoplasts by Decreasing Ethylene Production显示文摘 | Jansen C E Snel E A M | 1991 | Plant Cell Report1991，9，： | 1 |
| 9 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 10 | Cognitive functions after surgery and stenting for extracranial stenosis of the carotid artery显示文摘 | Jansen C Ringleb P Bockler D | 2008 | Nervenarzt2008，79，12： | 1 |
| 11 | The influence of temperature and storage time at RT on nucleation of the β' phase in a 6082 Al-Mg-Si alloys显示文摘 | Marioara C D Andersen S J Jansen J | 2003 | Acta Materialia2003，51，： | 1 |
| 12 | Managing traceability information in manufacture显示文摘 | Jansen Vullers M H van Dorp C A Beuens A J M | 2003 | International Journal of Information Management2003，，23： | 1 |
| 13 | Infections associated with medical devices:pathogenesis, management and prophylaxis显示文摘 | Von Eiff C Jansen B Kohnen W | 2005 | Drugs2005，65，2： | 1 |
| 14 | Effect of Additives in the Casting Solution on the Formation of PVDF Membranes 显示文摘 | FONTANANOVA E JANSEN J C CRISTIANO A | 2006 | Desalination2006，192，13： | 1 |
| 15 | Biochemical hallmarks of tyrosine hydroxylase deficiency显示文摘 | Br(a)utigam C Wevers RA Jansen RJ | | 0，，： | 1 |
| 16 | Tachykinins substance P,neurokinin A,neuropeptide K,and neurokinin B in the cerebral circulation I;vasomotor responses in vitro and in situ显示文摘 | Jansen I Alafaci C Mc-Culloch J | 1991 | J Cereb Blood Flow Metab1991，11，4： | 1 |
| 17 | Ecological impact assessment in data-poor systems: a case study on metapopulation persistence 显示文摘 | Etienne R S Vos C C Jansen M J W | 2003 | Environmental Management2003，32，6： | 1 |
| 18 | Differences in the population structure of invasive Streptococcus suis strains isolated from pigs and from humans in the Netherlands显示文摘 | Schultsz C Jansen E Keijzers W | 2012 | PLoS One2012，7，33： | 1 |
| 19 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 20 | Epidermal ex-pression of the translation inhibitor programmed celldeath 4 suppresses tumorigenesis显示文摘 | Jansen A P Camalier C E Colburn N H | 2005 | Cancer Res2005，65，14： | 1 |
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