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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Feature modeling and conversion-key Concepts to concurrent engineering显示文摘 | Bronsvoort W F Jansen F W | 1993 | Computer Ind1993，21，1： | 1 |
| 4 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 5 | Detection of vascular endothelial growth factor (VEGF) in moderate osteoarthritis in a rabbit model显示文摘 | Jansen H Meffert RH Birkenfeld F | 2012 | Ann Anat2012，194，5： | 1 |
| 6 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 7 | Complications of hysteroscopy: a prospective, multicenter study 显示文摘 | Jansen F W Vredevoogd C B Van-Uzen K | 2000 | Obstet Gynaecol2000，96，2： | 1 |
| 8 | The adipocyte fatty acidbinding protein locus:characterization and association with intramuscular fat content in pigs显示文摘 | Gerbens F Jansen A van Erp A J | | 0，，12： | 1 |
| 9 | ExploratoryInnovation, Exploitative Innovation, and Performance : Effects ofOrganizational Antecedents and Environmental Moderators 显示文摘 | Jansen J J P Van Den Bosch F A J Volberda H W | 2006 | Management Science2006，52，11： | 1 |
| 10 | Dynamic contrast-enhanced magnetic resonance ima-ging as a predictor of outcome in head-and-neck squa- mous cell carcinoma patients with nodal metastases 显示文摘 | SHUKLA-DAVE A LEE N Y JANSEN J F | 2012 | Int J Radiat Oncol Biol Phys2012，82，： | 1 |
| 11 | Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles显示文摘 | Jansen F Yang X Hoelscher M | 2013 | Circulation2013，128，18： | 1 |
| 12 | A hyaluronan-based nerve guide:in vitro cytotoxicity,subcutaneous tissue reactions,and degradation in the rat显示文摘 | Jansen K Werff J F A van der Wachem P B van | 2004 | Biomaterials2004，25，3： | 1 |
| 13 | Model calculations of the magnetic anisotropy in 3d transition metals 显示文摘 | Jansen H J F | 1998 | J Appl Phys1998，64，： | 1 |
| 14 | Veep insight study,a speculative methed for ingrown toenail显示文摘 | Bossers A M Jansen I M Eggink-W F | 1992 | Kanslawel Plastic Beligum1992，58，3： | 1 |
| 15 | Duodenal injuries: surgical management adapted to circumstances 显示文摘 | Jansen M Du Toit D F Warren B L | 2002 | Inju- ry2002，33，7： | 1 |
| 16 | Immunoglobulin coating of faecal bacteria in inflammatory bowel disease显示文摘 | Laurens A van der Waaij Frans GM Kroese Annie Visser Gerardus F Nelis Bram D Westerveld Peter LM Jansen John O Hunter | 2004 | European Journal of Gastroenterology & Hepatology2004，，7： | 1 |
| 17 | Noninvasive as-sessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18 F- fluoromisoni-dazole positron emission tomography imaging in neck nodalmetastases显示文摘 | JANSEN J F SCHODR H LEE N Y | 2010 | Int J Radiat Oncol Biol Phys2010，77，5： | 1 |
| 18 | Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients显示文摘 | Bos I W Hoogland G Meine Jansen C F | 2006 | Neurochem Int2006，48，4： | 1 |
| 19 | The adipocyte fatty acid-binding protein locus: Characterization and association with intramuscular fat content in pigs显示文摘 | Gerbens F Jansen A van Erp A J et a1 | 1998 | Mamm Genome1998，9，12： | 1 |
| 20 | Ex- ploratory innovation, exploitative innovation, and ambi- dexterity: The impact of environmental and organiza- tional antecedents显示文摘 | Jansen J P Volberda H W Van Den Bosch F J | 2005 | Schmalenbach Business Review2005，57，4： | 1 |
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