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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Carcinoma-associated fibroblasts provide operational flexibility in metastasis显示文摘 | Olivier De Wever Mieke Van Bockstal Marc Mareel An Hendrix Marc Bracke | 2014 | Seminars in Cancer Biology2014，，： | 2 |
| 3 | Thin layer thinkness measurements based on the acoustic-optic technique显示文摘 | Devolder S Wevers M DeMeester D | 1996 | Application Physical Letters1996，68，12： | 2 |
| 4 | Biodegradation and toxicity of benzothiazoles显示文摘 | H. De Wever H. Verachtert | 1997 | Water Research1997，，11： | 2 |
| 5 | Post-synthetic changes in creatine kinase isozymes显示文摘 | Delsing M Kleingebbink JA | 1978 | Clin Chim Acta1978，86，： | 1 |
| 6 | Two Greek Siblings with Sepiapterin Reductase Deficiency 显示文摘 | VERBEEK M M WILLEMSEN M A A P WEVERS R A eL al | 2008 | Molecular Genetics and Metabolism2008，94，4： | 1 |
| 7 | A branch sit mutation leading to aherrant splicing of the human tyrosine hydroxylase gene in a child with a severe extrapyrmidal move- ment disorder显示文摘 | Janssen RJ Wevers RA Hausslers M | 2000 | Ann Hum Genet2000，581，839： | 1 |
| 8 | Scoliosis correction with shape-memory metal: results of an experimental study 显示文摘 | Wever DJ Elstrodt JA Wvldhuizen AG | 2002 | Eur Spine J2002，11，2： | 1 |
| 9 | Conduciveness of different soilless growing media to Pythium root and crown rot of cucumber under near-commercial conditions显示文摘 | van der Gaag DJ Wever G | 2005 | European Journal of Plant Pathology2005，112，1： | 1 |
| 10 | Quality-of-life effects of prostate-specific antigen screening显示文摘 | Heijnsdijk EA Wever EM Auvinen A | | 0，，： | 1 |
| 11 | Biochemical hallmarks of tyrosine hydroxylase deficiency显示文摘 | Br(a)utigam C Wevers RA Jansen RJ | | 0，，： | 1 |
| 12 | Towards 3-D Petrography:Application of Microfocus Computer Tomography in Geological Science显示文摘 | Van Geet M Swennen R Wevers M | | 0，，： | 1 |
| 13 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 14 | Using online periodontal case- based discussions to synchronize theoretical and clinical undergraduatedental education显示文摘 | Koole S De Wever B Aper L | 2012 | EurJ Dent Educ2012，16，1： | 1 |
| 15 | Interval debulking surgery:an alternative for primary surgical debulking? 显示文摘 | Vergote I Wever Tjalma W Van Gramberen M | 2000 | Semin Surg Oncol2000，19，： | 1 |
| 16 | Micro-rotary fatigue of tooth-biomaterial interfaces显示文摘 | DE-MUNCK J BRAEM M WEVERS M | 2005 | Biomaterials2005，26，10： | 1 |
| 17 | Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front 显示文摘 | De Wever O Pauwels P De Craene B | 2008 | Histochem Cell Biol2008，130，3： | 1 |
| 18 | Defective E-cadherin/ eatenincomplexes inhunmancancer 显示文摘 | van Aken E de Wever O da Roeha AS | 2001 | Virchows Arch2001，439，： | 1 |
| 19 | Taperin (c9orf75), a mutated gene in nonsyn- dromic deafness, encodes a vertebrate specific, nucle- ar localized protein phosphatase one alpha (PP1α) docking protein显示文摘 | FERRAR T CHAMOUSSET D DE WEVER V | 2012 | Biol Open2012，15，： | 1 |
| 20 | Pulmonary vein anatomy and long-term outcome after multi-electrode pulmonary vein isolation with phased radiofrequency energy for paroxysmal atrial fibril ation显示文摘 | Mulder A Wijffels M Wever E | | 0，，11： | 1 |
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