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| 1 | 对就地养老的反思——“人”与“地方”关系视角显示文摘在有关养老的老年学和地理学研究中,'就地养老'是一个广泛使用的概念,并一直被认为是解决老龄人口养老需求的有效政策手段。迄今为止,关于就地养老的研究主要关注了很多能够让老年人健康就地(或在家)养老的物质方面的因素,比如住房条件或家庭照护。有些老年学研究者们认识到,就地养老受到居住环境中实体环境和社会、情感因素的共同影响。但我们认为,在养老体验研究中,要更加深入地审视'人'和'地方'之间的复杂关系。特别是,我们主张就地养老成功的因素是地方具有维持良好关系的潜力。提到'地方(place)'一词的时候,人们过分局限于关注老年人身体上接近的地理空间,或是具有实体边界的地方,例如房子或社区。而我们通过回顾现有文献发现,对许多选择就地养老的人来说,更具有意义的是随着时间的推移,他们在不同空间尺度上所建立起来的多元的、网络化的社会和非社会关系。基于这个新的视角,可以更好地理解老年人与地方的多层次的联系,以及从不同尺度和不同类型的人与地方的关系来考察就地养老的意义。 | Alexandra BOYLE Janine L.WILES Robin A.KEARNS | 2015 | 地理科学进展2015，34，12： | 17 |
| 2 | The CRISPR/Cas revolution continues: From efficient gene editing for crop breeding to plant synthetic biology显示文摘Since the discovery that nucleases of the bacterial CRISPR(clustered regularly interspaced palindromic repeat)-associated(Cas) system can be used as easily programmable tools for genome engineering,their application massively transformed different areas of plant biology. In this review, we assess the current state of their use for crop breeding to incorporate attractive new agronomical traits into specific cultivars of various crop plants. This can be achieved by the use of Cas9/12 nucleases for double-strand break induction,resulting in mutations by non-homologous recombinatr e-tion. Strategies for performing such experiments à from Rthe design of guide RNA to the use of different transformation technologies à are evaluated. Furtherweive-more, we sum up recent developments regarding the use of nuclease-deficient Cas9/12 proteins, as DNAbinding moieties for targeting different kinds of enzyme activities to specific sites within the genome. Progress in base deamination, transcriptional induction and transcriptional repression, as well as in imaging in plants, is also discussed. As different Cas9/12 enzymes are at hand, the simultaneous application of various enzyme activities, to multiple genomic sites, is now in reach to redirect plant metabolism in a multifunctional manner and pave the way for a new level of plant synthetic biology. | Jochen Kumlehn Janine Pietralla Goetz Hensel Michael Pacher Holger Puchta | 2018 | Journal of Integrative Plant Biology2018，60，12： | 9 |
| 3 | Transient elastography improves detection of liver cirrhosis compared to routine screening tests显示文摘AIM:To investigate the diagnostic significance oftransient elastography(TE) in a daily routine clinical setting in comparison to clinical signs,laboratory parameters and ultrasound.METHODS:TE,ultrasound,laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver disease of various aetiologies who underwent liver biopsy in daily routine.RESULTS:Sensitivity of TE for the detection of liver cirrhosis was 90.4%,compared to 80.1% for ultrasound,58.0% for platelet count and 45.1% for cutaneous liver signs(P < 0.0001 for comparisons with histology).AUROC for TE was 0.760(95%CI:0.694-0.825).Combination of TE with ultrasound increased sensitivity to 96.1% and AUROC to 0.825(95%CI:0.768-0.882).TE correlated with laboratory parameters of cirrhosis progression like albumin(r =-0.43),prothrombin time(r =-0.44),and bilirubin(r = 0.34; P < 0.001 for each).Particularly,in patients with Child Pugh score A or normal platelet count TE improved sensitivity for the detection of liver cirrhosis compared to ultrasound by 14.1%(P < 0.04) and 16.3%(P < 0.02),respectively.CONCLUSION:Transient elastography is superior to routine diagnostic tests allowing detection of liver cirrhosis in additional 10%-16% of patients with chronic liver disease that would have been missed by clinical examinations. | Thomas Gobel Janine Schadewaldt-Tümmers Lucas Greiner Christopher Poremba Dieter Haussinger Andreas Erhardt | 2015 | World Journal of Gastroenterology2015，21，3： | 8 |
| 4 | Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy显示文摘Severe reactions to mesalamine products are rarely seen in pediatric patients. We report a case of a 12-year-old boy who had a severe cardiac reaction to a mesalamine product Asacol. Past medical history is significant for ulcerative colitis (UC) diagnosed at 9 years of age. Colo- noscopy one week prior to admission revealed pancoli- tis. He was treated with Asacol 800 mg three times per day and prednisone 20 mg/d. He was subsequently ad- mitted to the hospital for an exacerbation of his UC and started on intravenous solumedrol. He had improvement of his abdominal pain and diarrhea. The patient com- plained of new onset of chest pain upon initiating Asacol therapy. Electrocardiogram (ECG) revealed non-specific ST-T wave changes with T-wave inversion in the lateral leads. Echocardiogram (ECHO) revealed low-normal to mildly depressed left ventricular systolic function. The left main coronary artery and left anterior descending artery were mildly prominent measuring 5 mm and 4.7 mm, respectively. His chest pain completely resolved within 24-36 h of discontinuing Asacol. A repeat echo- cardiogram performed two days later revealed normal left ventricular function with normal coronary arteries (< 3.5 mm). Onset of chest pain after Asacol and im- mediate improvement of chest pain, as well as improve- ment of echocardiogram and ECG findings after discon- tinuing Asacol suggests that our patient suffered from a rare drug-hypersensitivity reaction to Asacol. | Orhan Atay Kadakkal Radhakrishnan Janine Arruda Robert Wyllie | 2008 | World Journal of Gastroenterology2008，14，27： | 6 |
| 5 | Differential regulation of the anthocyanin profile in purple kiwifruit(Actinidia species)显示文摘Anthocyanins are a group of secondary metabolites that colour fruit and flowers orange,red,purple or blue depending on a number of factors,such as the basic structure,co-pigmentation,metal ion complexation and vacuolar pH.The biosynthesis of anthocyanin is regulated at the transcriptional level by a group of transcription factors,the MYB–bHLH–WD40(MBW)complex.In this study,the purple colouration in several kiwifruit(Actinidia)species was identified and characterised as red cyanidin-based and blue delphinidin-based anthocyanins.The differential pigmentation in the skin and flesh can be attributed to the differential ratio of cyanidin and delphinidin derivatives accumulated in the total anthocyanin profile.The expression of anthocyanin biosynthetic genes chalcone synthase(CHS),flavonoid 3-O-glucosyltransferase(F3GT),flavonoid 3′-hydroxylase(F3′H)and flavonoid 3′5′-hydroxylase(F3′5′H)is crucial for anthocyanin accumulation.However,the balance of expression of the F3′H and F3′5′H genes appears responsible for the ratio of cyanidin and delphinidin derivatives,while a lack of CHS,F3GT and MYB110 expression is responsible for a lack of total anthocyanins.The transcriptional regulation of the F3′H and F3′5′H promoters by the R2R3 MYB transcription factor MYB110 is markedly different in tobacco transient assays.When kiwifruit MYB10 or MYB110 are over-expressed in Actinidia chinensis both cyanidin-based and delphinidin-based anthocyanins are elevated,but F3′H and F3′5′H genes are not strongly correlated with MYB expression.These results suggest that the core kiwifruit anthocyanin pathway genes are dependent on characterised MYB transcription factors,while other regulatory proteins are more directly responsible for the expression of the F3′H and F3′5′H genes. | Yongyan Peng Kui Lin-Wang Janine M.Cooney Tianchi Wang Richard V.Espley Andrew C.Allan | 2019 | Horticulture Research2019，6，1： | 6 |
| 6 | Risk factors for endophthalmitis after cataract surgery in diabetic patients: a case control study显示文摘AIM: To identify risk factors associated with post-cataract surgery endophthalmitis(PCE) in type 2 diabetic patients.METHODS: A hospital-based retrospective case-control study was conducted on 194 type 2 diabetic patients undergoing cataract surgery in Rajavithi Hospital from January 2007 to December 2015. Fifteen patients with PCE were included as the case group and 179 patients without PCE were included as the control group. Potential factors associated with PCE among both groups including demographics, pre-operative characteristics, surgical settings and complications, were statistically analyzed using Chi-square testing and a logistic regression model.RESULTS: Within the case group, 53% were females and the median age was 68 y. Univariate analysis of pre-operative characteristics, surgical settings and complications revealed that recent pre-operative fasting plasma glucose, insulin therapy, presence of diabetic retinopathy, and severe non-proliferative or proliferative diabetic retinopathy were significantly associated with PCE. In a multivariate analysis adjusting for blood glucose level, insulin treatment was the only significant factor associated with an increased risk of PCE(OR 3.9, 95%CI 1.0-15.0, P=0.04) compared to patients without insulin treatment. The most common causative organisms were gram-positive bacteria(89%). Staphylococcus species represented the most common group(67%). Median best corrected visual acuity at 1-month and 3-month follow-up was equal at 0.7 logMAR(20/100).CONCLUSION: The authors identify insulin treatment as the only risk factor associated with endophthalmitis after cataract surgery in type 2 diabetic patients. Further studies with serum levels of pre-operative glycated hemoglobin(HbA_(1c)) and post-operative fasting plasma glucose level are essential to truly demonstrate the role of peri-operative glycemic markers as a risk factor for PCE. | Sukhum Silpa-archa Apichaya Papirachnart Panisa Singhanetr Janine M Preble | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 6 |
| 7 | Changes in demand and supply of ecosystem services under scenarios of future land use in Vorarlberg, Austria显示文摘Ecosystem services(ES)are highly impacted by human-induced land-use change.Progressive urbanization and agricultural land abandonment in Western Europe necessitate assessments of future land-change impacts on ES to ensure sustainable service management.The present study aims at evaluating future demand and supply of three key services(flood protection,nearby recreation and biodiversity)in the mountainous region of Vorarlberg,Austria.We mapped the ES for the referenced time step 2016 and two scenarios for 2050,assuming the continuation of current land-change trends and pressure on landscape development.Results for the referenced landscape in 2016 show the highest ES supply for intermediate levels,while ES supply was low in the lowlands and valley bottoms and in high-elevation areas.We found a high positive correlation of ES with the distribution of forested areas.In contrast,service demand was highest in lowelevation areas and decreased with increasing elevation.This indicates that densely settled and intensively used agricultural areas currently suffer from ES undersupply.The projected future development of land use showed an increase in both supply and demand of the selected ES.The overall service supply increased more than the respective demand due to some reforestation of open land.As forests were found to be important synergistic areas for overall service provision,we expect decreasing demand on related services.Locally,demand was found to exceed the supply of ES,especially in the densely populated Rhine valley-requiring further policy interventions.Such ES-related information may contribute to regional policy making and ensure the long-term provision of ESs for future generations. | SAUTER Isabel KIENAST Felix BOLLIGER Janine WINTER Benjamin PAZuR Robert | 2019 | Journal of Mountain Science2019，16，12： | 5 |
| 8 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 9 | Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling显示文摘 | Kandice R. Levental Hongmei Yu Laura Kass Johnathon N. Lakins Mikala Egeblad Janine T. Erler Sheri F.T. Fong Katalin Csiszar Amato Giaccia Wolfgang Weninger Mitsuo Yamauchi David L. Gasser Valerie M. Weaver | 2009 | Cell2009，，5： | 4 |
| 10 | 全球数字平台劳动者就业研究显示文摘国际劳工组织于2015年和2017年开展了两次问卷调查,样本覆盖全球75个国家的3500名劳动者。这些劳动者在全球运作的5家大型微任务平台工作。基于问卷调查结果,本文阐述了劳动者的基本特点及其从事这类工作任务的动机,分析了微任务平台的工作条件,介绍了鼓励平台和平台用户遵守最低标准的做法与实践,并提出了改善数字就业平台工作条件的一系列原则。 | Janine Berg Marianne Furrer Ellie Harmon Uma Rani M Six Silberman 孟彤 | 2019 | 中国劳动2019，，4： | 3 |
| 11 | Older people and their social spaces: A study of well-being and attachment to place in Aotearoa New Zealand显示文摘 | Janine L. Wiles Ruth E.S. Allen Anthea J. Palmer Karen J. Hayman Sally Keeling Ngaire Kerse | 2008 | Social Science & Medicine2008，，4： | 3 |
| 12 | Poor prognostic factors in post-traumatic endophthalmitis following open globe injury显示文摘AIM:To demonstrate prognostic factors for poor visual outcome in patients with post-traumatic endophthalmitis(PTE)following open globe injury.METHODS:A retrospective study was conducted on 66 patients(66 eyes)with PTE following open globe injury from 2005 to 2015.Potential factors accounting for good and poor visual outcome were statistically analyzed by Chisquare test and Logistic regression model.RESULTS:In 66 cases,39 cases(59%)had a poor visual outcome.Univariate and multivariate Logistic regression analysis identified retained intraocular foreign body(IOFB)as the only factor significantly associated with poor visual outcome[adjusted odds ratio,4.62;95%confidence interval(1.04-20.53);P=0.04].The most common causative agents were gram-positive organisms(83%),of which Bacillus cereus(33%),was the most common pathogen.All cases received intravitreal antibiotic injections.Oral ciprofloxacin was the most used systemic antibiotic(33%).Pars plana vitrectomy was performed in 83%(55/66)of cases.At 6 mo follow-up,mean BCVA was 1.74±0.72 log MAR units.CONCLUSION:In patients with PTE following open globe injury,the only predictor of poor visual outcome is the presence of IOFB.Bacillus cereus is the most isolated microorganism. | Sukhum Silpa-archa Akkaranisorn Dejkong Kwanchanoke Kumsiang Peranut Chotcomwongse Janine M Preble C.Stephen Foster | 2020 | International Journal of Ophthalmology(English edition)2020，13，12： | 3 |
| 13 | 心肌超声心动图造影冠状动脉内注射微泡造影剂剂量与效应的相互关系显示文摘在九只开胸狗的实验中,将Renografin进行声处理后的超声造影剂注入左冠脉前降支内,使用二维超声心动图分析造影剂对心肌的毒性作用。结果表明,室壁运动异常持续时间与微泡大小和剂量有明显的关系(P<0.01)。未进行声处理的Renografin仅引起轻度的室壁增厚受抑(P<0.05),室壁运动异常持续时间较短(P<0.05),造影作用较差(P<0.001),造影剂清除较快(P<0.001)。室壁运动异常持续时间与造影剂清除较快(P<0.001)。室壁运动异常持续时间与造影剂消除时间有极好的相关性(r=0.93)。结论:1)左室功能暂时性受抑是由于载体溶液本身和微泡所致;2)较小的微泡和较低的剂量可产生足够的对比作用和较轻的室壁运动异常;3)造影剂消除时间与室壁运动异常持续时间相关。 | 谢峰 Janine R.shapiro Richard S.Meltzer | 1989 | 中国超声医学杂志1989，5，4： | 3 |
| 14 | Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR显示文摘 | Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer | 2010 | Molecular Plant2010，3，1： | 2 |
| 15 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 16 | 中国和瑞典高中生学习负担与课外活动的比较研究显示文摘中学生的学习负担与课余活动受国家的经济、文化和社会发展的影响,了解国外高中生的学习负担与课余活动,对反思和改善我国高中生的学习与生活状况具有重要的借鉴意义。因此,运用问卷调查法和访谈法,对我国宁波市和瑞典隆德市高中生的学习负担与课余活动进行了调查,比较分析结果显示:两国高中生在作息时间、课内外学习、学习兴趣、作业考试、校外休闲活动和心理状态等维度上存在显著差异,亦即,我国高中生的学习负担显著高于瑞典高中生,而课余活动明显比瑞典高中生单调。 | 陈传锋 杨娜 Janine Sages | 2014 | 湖州师范学院学报2014，36，12： | 2 |
| 17 | Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer显示文摘 | Masahito Tachibana Paula Amato Michelle Sparman Nuria Marti Gutierrez Rebecca Tippner-Hedges Hong Ma Eunju Kang Alimujiang Fulati Hyo-Sang Lee Hathaitip Sritanaudomchai Keith Masterson Janine Larson Deborah Eaton Karen Sadler-Fredd David Battaglia David L | 2013 | Cell2013，，6： | 2 |
| 18 | Daily geographies of caregivers: mobility, routine, scale显示文摘 | Janine Wiles | 2002 | Social Science & Medicine2002，，7： | 2 |
| 19 | MR-arterioportography: A new technical approach for detection of liver lesions显示文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast. | Janine Rennert Ernst-Michael Jung Andreas G Schreyer Patrick Hoffstetter Peter Heiss Stefan Feuerbach Niels Zorger | 2011 | World Journal of Gastroenterology2011，17，13： | 2 |
| 20 | Challenges in Constructing a Multi-dimensional European Job Quality Index显示文摘 | Janine Leschke Andrew Watt | 2014 | Social Indicators Research2014，，1： | 2 |
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