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| 1 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 2 | Treatment of Helicobacter pylori显示文摘 | Michael Selgrad Peter Malfertheiner | 2011 | Current Opinion in Gastroenterology2011，，6： | 2 |
| 3 | Helicobacter pylori infection and current clinical areas of contention显示文摘 | Peter Malfertheiner Michael Selgrad | 2010 | Current Opinion in Gastroenterology2010，，6： | 2 |
| 4 | Helicobacter pylori infection: selected aspects in clinical management显示文摘 | Peter Malfertheiner Marino Venerito Michael Selgrad | 2013 | Current Opinion in Gastroenterology2013，，6： | 2 |
| 5 | Safety As- sessment of Biotechnology Products for Potential Risk of Food Allergy : Implications of New Reserch 显示文摘 | SELGRADE M K BOWMAN C C LADICS G S | 2009 | Toxicol Sci2009，0，： | 1 |
| 6 | Gilmour ML Kinetic profile of in- fluenza virus infection in three rat strains显示文摘 | Daniels MJ Selgrade MK Doerfler D | 2003 | Comp Med2003，53，3： | 1 |
| 7 | Serological assessment of gastric mucosal atrophy in gastric cancer显示文摘 | Jan Bornschein Michael Selgrad Thomas Wex et : | 2012 | BMC Gastroenterology2012，12，10： | 1 |
| 8 | Helicobacter pylori: diagnosis and treatment显示文摘 | Michael Selgrad Arne Kandulski Peter Malfertheiner | 2009 | Current Opinion in Gastroenterology2009，，6： | 1 |
| 9 | Helicobacter pylori: clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curr Opin Gastroenterol2012，28，6： | 1 |
| 10 | Treatment of HeZicobacter pylori 显示文摘 | Selgrad M Malfertheiner P | 2011 | Curr Opin Gastroenterol2011，27，6： | 1 |
| 11 | Guidelines for treatment of Helicobacter pylori in the East and West显示文摘 | Selgrad M Bornschein J Malfertheiner P | 2011 | Expert Rev Anti Infect Ther2011，9，8： | 1 |
| 12 | Prevalence and spread of enterohepatic Helicobacter Species in mice reared in a specific-pathogenfree animal facility 显示文摘 | Bohr U R M Selgrad M Ochmann C | 2006 | J Clin Microbiol2006，44，3： | 1 |
| 13 | Helicobacter pylori : clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curt Opin Gastroenterol2012，28，6： | 1 |
| 14 | Hyperbolicity and cycles显示文摘 | Franke J E Selgrade J F | 1978 | Trans Amer Math Soc1978，245，： | 1 |
| 15 | Helicobacter pylori: clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curt Opin Gastroenterol2012，28，6： | 1 |
| 16 | Gastric cancer: clini- cal aspects, epidemiology and molecular background 显示文摘 | Bornschein J Rokkas T Selgrad M | 2011 | Helico- bacter2011，16，1： | 1 |
| 17 | Abstract ω- limit sets, chain recurrent sets, and basic sets for flows显示文摘 | Franke J E Selgrade J F | 1976 | Proc Amer Math Soc1976，60，： | 1 |
| 18 | Gastric cancer--epidemiologic and clinical aspects显示文摘 | Venerito M Nardone G Selgrad M | 2014 | Helicobacter2014，191，： | 1 |
| 19 | Hyperbolicity and chain recurrence J显示文摘 | Franke J E Selgrade J F | 1977 | Equ1977，26，： | 1 |
| 20 | Prevalence and spread of enterohepatic Helicobacter species in mice reared in a specific-pathogen-free animal facility 显示文摘 | Bohr UR Selgrad M Ochmann C | 2006 | J Clin Microbiol2006，44，3： | 1 |
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