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| 1 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 2 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease显示文摘 | Nico H.J. Pijls William F. Fearon Pim A.L. Tonino Uwe Siebert Fumiaki Ikeno Bernhard Bornschein Marcel van't Veer Volker Klauss Ganesh Manoharan Thomas Engstr?m Keith G. Oldroyd Peter N. Ver Lee Philip A. MacCarthy Bernard De Bruyne | 2010 | Journal of the American College of Cardiology2010，，3： | 2 |
| 3 | Serological assessment of gastric mucosal atrophy in gastric cancer显示文摘 | Jan Bornschein Michael Selgrad Thomas Wex et : | 2012 | BMC Gastroenterology2012，12，10： | 1 |
| 4 | Helicobacter pylori: clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curr Opin Gastroenterol2012，28，6： | 1 |
| 5 | Guidelines for treatment of Helicobacter pylori in the East and West显示文摘 | Selgrad M Bornschein J Malfertheiner P | 2011 | Expert Rev Anti Infect Ther2011，9，8： | 1 |
| 6 | Hepatocellular carcinoma-epidemiological trends and risk factors显示文摘 | Schütte K Bornschein J Malfertheiner P | | 0，，27： | 1 |
| 7 | Lack of associa-tion between gene polymorphisms of Angiotensin converting enzyme,Nod-like receptor 1,Toll-like receptor 4,FAS/FASL and the presence of Helicobacter pylori-induced pre-malignant gastric lesions and gastric cancer in Caucasians 显示文摘 | Kupcinskas J Wex T Bornschein J | 2011 | BMC Med Genet2011，12，： | 1 |
| 8 | Gastric carcinogenesis显示文摘 | Bornschein J Malfertheiner P | 2011 | La-ngenbecks Arch Surg2011，396，6： | 1 |
| 9 | Helicobacter pylori : clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curt Opin Gastroenterol2012，28，6： | 1 |
| 10 | Tritium tests with a technical PERM- CAT for final clean-up of ITER exhaust gases 显示文摘 | BORNSCHEIN B GLUGLA M GUNTHER K | 2003 | Fusion Eng Des2003，69，： | 1 |
| 11 | Helicobacter pylori: clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curt Opin Gastroenterol2012，28，6： | 1 |
| 12 | Gastric cancer: clini- cal aspects, epidemiology and molecular background 显示文摘 | Bornschein J Rokkas T Selgrad M | 2011 | Helico- bacter2011，16，1： | 1 |
| 13 | Tritium tests with a technical PERMCAT for final clean-up of ITER exhaust gases显示文摘 | BORNSCHEIN B GLUGLA M GUNTHER K | 2003 | Fusion Eng Des2003，69，： | 1 |
| 14 | Hpylori infection is a key risk factor for proximal gastric cancer显示文摘 | Bornschein J Selgrad M Warnecke M | | 0，，： | 1 |
| 15 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 16 | Helicobacter pylori: clinical management 显示文摘 | Malfertheiner P Selgrad M Bornschein J | 2012 | Curt Opin Gastroenterol2012，28，6： | 1 |
| 17 | Hepatocellular carcinomaepidemiological trends and risk factors显示文摘 | Schütte K Bornschein J Malfertheiner P | 2009 | Dig Dis2009，27，2： | 1 |
| 18 | Economic evaluation of fractional flow reserve-guided percutaneous coronary intervention in pa- tients with muhivessel disease 显示文摘 | Fearon WF Bornschein B | 2010 | Circulation2010，122，24： | 1 |
| 19 | Function and Topological Properties in Hepatocellu- lar Carcinoma Transcriptome PloS 显示文摘 | DROZDOV I BORNSCHEIN J WEX T | 2012 | One2012，，7： | 1 |
| 20 | HER2 status in gastroesophageal cancer: a tissue microarray study of 1040 cases显示文摘 | Rocco Cappellesso Matteo Fassan Esther Hanspeter Jan Bornschein Emanuele S.G. d’Amore Lucia V. Cuorvo Guido Mazzoleni Mattia Barbareschi Marco Pizzi Vincenza Guzzardo Peter Malfertheiner Marjan Micev Maria Guido Luciano Giacomelli Vladislav V. Tsukanov Vi | 2015 | Human Pathology2015，，5： | 1 |
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