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| 1 | Current status of clinical islet transplantation显示文摘Islet transplantation(IT) is today a well-established treatment modality for selected patients with type 1 diabetes mellitus(T1DM). After the success of the University of Alberta group with a modified approach to the immune protection of islets, the international experience grew along with the numbers of transplants in highly specialized centers. Yet, long-term analysis of those initial results from the Edmonton group indicated that insulin-independence was not durable and most patients return to modest amounts of insulin around the fifth year, without recurrent hypoglycemia events. Many phenomena have been identified as limiting factor for the islet engraftment and survival, and today all efforts are aimed to improve the quality of islets and their engrafting process, as well as more optimized immunosuppression to facilitate tolerance and ultimately, better long term survival. This brief overview presents recent progress in IT. A concise historical perspective is provided, along with the latest efforts to improve islet engraftment, immune protection and ultimately, prolonged graft survival. It is apparent that as the community continues to work together further optimizing IT, it is hopeful a cure for T1 DM will soon be achievable. | Andrew R Pepper Boris Gala-Lopez Oliver Ziff AM James Shapiro | 2013 | World Journal of Transplantation2013，3，4： | 3 |
| 2 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 3 | Resolution of genital chlamydia muridarum Infection, protects against oviduct pathology, and Is highly dependent upon endogenous gamma interferon production 显示文摘 | Ashlesh KM James PC Patricia AM | 2007 | Infection Immun2007，75，2： | 1 |
| 4 | Effects of a new modified balanced hydroxyethyl starch preparation ( Hextend ) on measures of coagulation 显示文摘 | Roche AM Mythen MG James MF | 2004 | Br J Anaesth2004，92，： | 1 |
| 5 | Mitochondriatargeted redox probes as tools in the study of oxidative damage and ageing 显示文摘 | James AM Cocheme HM Murphy MP | 2005 | Mech Ageing Dev2005，126，9： | 1 |
| 6 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 7 | The prognostic value of natriuratic peptide in patients with acute coronary syndromes显示文摘 | James AD David AM Jane HB | 2001 | N Engl J Med2001，345，： | 1 |
| 8 | Transgenic apple and strawberry: advances in transformation, introduction of genes for insect resistance and field studies of tissue cultured plant 显示文摘 | James DJ Passey AJ Webster AD Barbara DJ Dandekar AM Uratsu SL | 1993 | Acta Horiculturae1993，336，： | 1 |
| 9 | Phase I safety, pharma- cokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer显示文摘 | James J Murry DJ Treston AM | 2007 | Invest New Drugs2007，25，1： | 1 |
| 10 | Alternatives to swanganz caridac output monitoring 显示文摘 | James B | 1991 | Surgical Critical Care of North Amireca1991，71，4： | 1 |
| 11 | Injuri-ous mechanical compression of bovine articular carti-lage induces chondrocyte apoptosis显示文摘 | Loening AM James IE Levenston ME | 2000 | Arch BiochemBiophys2000，381，2： | 1 |
| 12 | Usefulness of high sensitivity C - reactive protein in predicting long - term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction 显示文摘 | James SZ Jeffrey LA Chloe AM | 2002 | Am J Cardiol2002，89，： | 1 |
| 13 | Association Between Plamsa Levels of Monocyte Ghemoattractant Protein - 1 and Long - Term Clinical Outcomes in Patients with Acute Coronary Syndromes显示文摘 | James AL David AM Marc SS | 2003 | Cirvulation2003，107，5： | 1 |
| 14 | Three-dimensional nasal changes following maxillary advancement in cleft patients 显示文摘 | Stewart A McCand AM James DR | 1996 | Int J Oral Macillofac Surg1996，25，： | 1 |
| 15 | Hemophilic pseudotumor: ra- diologic - pathologic correlation 显示文摘 | Stafford JM James 'IT Alien AM | 2003 | Radiographics2003，23，4： | 1 |
| 16 | Invasion and metastasis of a mammary tumor involves TGF-β signaling 显示文摘 | Julie AM James JK Vivian M | 2001 | Int J Cancer2001，91，1： | 1 |
| 17 | Automated air load planning显示文摘 | Heidelberg K R Parnell G S James E Ames IV | 1999 | Naval Research Lagistics1999，45，8： | 1 |
| 18 | Fronto-striatal cognitive deficits at different stages of Parkinson's disease显示文摘 | Owen AM James M Leigh PN | 1992 | Brain1992，115，： | 1 |
| 19 | Predisposi- tion to nevirapine hypersensitivity associated with HLA-DRB1 : 0101 and abrogated by low CD4 T- cell counts 显示文摘 | Martin AM Nolan D James I | 2005 | AIDS2005，19，1： | 1 |
| 20 | Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing 显示文摘 | James AM Cochem6 HM Murphy MP | 2005 | Mech Ageing Dev2005，126，9： | 1 |
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