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| 1 | Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study显示文摘BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)imaging.However,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy tissue.This study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese patients.METHODS:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR imaging.MR imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded radiologists.The primary efficacy endpoint was sensitivity in lesion detection.RESULTS:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than 1cm.Gd-EOB-DTPA improved diagnostic accuracy in lesion classification.CONCLUSIONS:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 cm.Gd-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions. | Meng-Su Zeng Hui-Yi Ye Liang Guo Wei-Jun Peng Jian-Ping Lu Gao-Jun Teng Josy Breuer Yi Huan Ping Li Jian-Rong Xu Chang-Hong Liang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 31 |
| 2 | 职业教育基本问题访谈录(I) 职业教育是什么显示文摘全国教育科学“十五”规划国家一般课题《职业教育几个基本问题研究》(BJA010100)课题组就“职业教育的基本问题”对国内外职业教育界的专家、学者进行了访谈,使我们看到了对此问题的不同角度和层面的理解。这是一次思想的碰撞,有利于我们深化对职业教育基本问题的认识。本刊特将访谈记录分专题编辑处理,并从本期起连续刊发,本期论题为“职业教育是什么?” | 王明达 杨金土 刘来泉 余祖光 高奇 Josie Misko Susan Dave Jorn Saunder 钱景舫 Friedhelm Eicker James R Stone | 2006 | 中国职业技术教育2006，22，14： | 12 |
| 3 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 4 | Genevestigator Transcriptome Meta-Analysis and Biomarker Search Using Rice and Barley Gene Expression Databases显示文摘到学习植物 transcriptomes 的 microarray 技术的普遍使用导致了重要发现并且盖住大量不同纸巾,发展阶段,不安,和遗传型到介绍数据的累积。查询很多 microarray 实验能提供不能被分析单个实验获得的卓见。然而,如此的元分析关于数据提出重要挑战相似性和正规化,系统的样品注解,和分析工具。Genevestigator 用一个大 curated 表达式数据库和在因特网上是可存取的一套明确地发达的分析工具处理这些问题。这联合已经证明了基于 Arabidopsis 数据的一个大集合在植物研究的区域有用(Grennan, 2006 ) 。这里,我们在场 Genevestigator 米饭的版本和包含质量控制、好的注解 microarray 的大麦基因表示数据库试验使用本体论。数据库当前从病理,植物营养,不能生活的压力,荷尔蒙处理,遗传型,和空间或时间的分析包括实验,但是被期望作为更试验性的数据盖住研究区域的一个宽广变化变得可得到。模型种类米饭和大麦的 transcriptome 元分析被期望交付能在谷物被用于功能的 genomics 和 biotechnological 应用程序的结果。 | Philip Zimmermann Oliver Laule Josy Schmitz Tomas Hruz Stefan Bleuler Wilhelm Gruissema | 2008 | Molecular Plant2008，1，5： | 5 |
| 5 | Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial显示文摘 | Paul Moayyedi Michael G. Surette Peter T. Kim Josie Libertucci Melanie Wolfe Catherine Onischi David Armstrong John K. Marshall Zain Kassam Walter Reinisch Christine H. Lee | 2015 | Gastroenterology2015，，： | 3 |
| 6 | Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation显示文摘AIM To evaluate the effects of melatonin(Mel) on oxidative stress in an experimental model of bile duct ligation(BDL).METHODS Male Wistar rats(n = 32, weight ± 300 g) were allocated across four groups: CO(sham BDL), BDL(BDL surgery), CO + Mel(sham BDL and Mel administration) and BDL + Mel(BDL surgery and Mel administration). Mel was administered intraperitoneally for 2 wk, starting on postoperative day 15, at a dose of 20 mg/kg.RESULTS Mel was effective at the different standards, reestablishing normal liver enzyme levels, reducing the hepatosomatic and splenosomatic indices, restoring lipoperoxidation and antioxidant enzyme concentrations, reducing fibrosis and inflammation, and thereby reducing liver tissue injury in the treated animals.CONCLUSION The results of this study suggest a protective effect of Mel when administered to rats with secondary biliary cirrhosis induced by BDL. | Josieli Raskopf Colares Elizângela Goncalves Schemitt Renata Minuzzo Hartmann Francielli Licks Mariana do Couto Soares Adriane Dal Bosco Norma Possa Marroni | 2016 | World Journal of Gastroenterology2016，22，40： | 3 |
| 7 | N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats显示文摘AIM: To evaluate the antioxidant effect of N-acetylcysteine(NAC) on the stomach of rats with portal hypertension.METHODS: Twenty-four male Wistar rats weighing ± 250 g were divided into four experimental groups(n =6 each): Sham-operated(SO),SO + NAC,partial portal vein ligation(PPVL),and PPVL + NAC. Treatment with NAC in a dose of 10 mg/kg(i.p.) diluted in 0.6 m L of saline solution was administered daily for 7 d starting 8 d after the surgery. Animals from the PPVL and SO group received saline solution(0.6 m L) for the same period of time as the PPVL + NAC and SO + NAC group. On the 15 th day the animals were anesthetized and we evaluated portal pressure by cannulating mesenteric artery. After,we removed the stomach for further analysis. We performed immunohistochemical analysis for endothelial nitric oxide synthase(e NOS),vascular endothelial growth factor(VEGF),and nitrotirosine(NTT) proteins in stomach. We also evaluated e NOS and VEGF by Western blot analysis and assessed DNA damage in blood samples by the comet assay.RESULTS: The portal hypertension group exhibited increases in portal pressure when compared to SO group(29.8 ± 1.8 vs 12.0 ± 0.3 mm Hg)(P < 0.001). The same was observed when we compared the e NOS(56.8 ± 3.7 vs 13.46 ± 2.8 pixels)(P < 0.001),VEGF(34.9 ± 4.7 vs 17.46 ± 2.6 pixels)(P < 0.05),and NTT(39.01 ± 4.0 vs 12.77 ± 2.3 pixels)(P < 0.05) expression by immunohistochemistry of the PPVL animals with the SO group. The expression of e NOS(0.39 ± 0.03 vs 0.25 ± 0.03 a.μ)(P < 0.01) and VEGF(0.38 ± 0.04 vs 0.26 ± 0.04 a.μ)(P < 0.01) were also evaluated by Western blot analysis,and we observed an increase of both proteins on PPVL animals. We also evaluated the DNA damage by comet assay,and observed an increase on damage index and damage frequency on those animals. NAC decreased portal pressure values in PPVL + NAC animals(16.46 ± 2 vs 29.8 ± 1.8 mm Hg)(P < 0.001) when compared to PPVL. The expression of e NOS(14.60 ± 4.1 vs 56.8 ± 3.7 pixels)(P < 0.001),VEGF(19.53 ± 3.2 vs 34.9 ± 4.7 pixels)(P < 0.05) and NTT(21.84 ± 0.7 vs 39.01 ± 4.0 pixels)(P < 0.05) evaluated by immunohistochemistry were also reduced in PPVL + NAC animals. Also,when evaluated by Western blot e NOS expression(0.32 ± 0.03 vs 0.39 ± 0.03 a.μ)(P < 0.05) and VEGF expression(0.31 ± 0.09 vs 0.38 ± 0.04 a.μ)(P < 0.01). Furthermore,NAC modulated DNA damage in PPVL + NAC animals.CONCLUSION: In view of these results,we believe NAC is able to protect the stomach from the alterations induced by the PPVL procedure. | Francielli Licks Renata Minuzzo Hartmann Camila Marques Elizangela Schemitt Josieli Raskopf Colares Mariana do Couto Soares Juliana Reys Camila Fisher Juliana da Silva Norma Possa Marroni | 2015 | World Journal of Gastroenterology2015，21，43： | 2 |
| 8 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，： | 2 |
| 9 | Diagnostic Performance and Description of Morphological Features of Focal Nodular Hyperplasia in Gd-EOB-DTPA-Enhanced Liver Magnetic Resonance Imaging: Results of a Multicenter Trial显示文摘 | Christoph J. Zech Luigi Grazioli Josy Breuer Maximilian F. Reiser Stefan O. Schoenberg | 2008 | Investigative Radiology2008，，7： | 2 |
| 10 | What is the ideal approach for emergent pericardiocentesis using point-of-care ultrasound guidance?显示文摘BACKGROUND:Traditionally performed using a subxiphoid approach,the increasing use of point-of-care ultrasound in the emergency department has made other approaches(parasternal and apical)for pericardiocentesis viable.The aim of this study is to identify the ideal approach for emergency-physician-performed ultrasound-guided pericardiocentesis as determined by ultrasound image quality,distance from surface to pericardial fl uid,and likely obstructions or complications.METHODS:A retrospective review of point-of-care cardiac ultrasound examinations was performed in two urban academic emergency departments for the presence of pericardial eff usions.The images were reviewed for technical quality,distance of eff usion from skin surface,and predicted complications.RESULTS:A total of 166 pericardial effusions were identified during the study period.The mean skin-to-pericardial fl uid distance was 5.6 cm(95%confi dence interval[95%CI]5.2-6.0 cm)for the subxiphoid views,which was signifi cantly greater than that for the parasternal(2.7 cm[95%CI 2.5-2.8 cm],P<0.001)and apical(2.5 cm[95%CI 2.3-2.7 cm],P<0.001)views.The subxiphoid view had the highest predicted complication rate at 79.7%(95%CI 71.5%-86.4%),which was signifi cantly greater than the apical(31.9%;95%CI 21.4%-44.0%,P<0.001)and parasternal(20.2%;95%CI 12.8%-29.5%,P<0.001)views.CONCLUSIONS:Our results suggest that complication rates with pericardiocentesis will be lower via the parasternal or apical approach compared to the subxiphoid approach.The distance from skin to fl uid collection is the least in both of these views. | Lori Stolz Elaine Situ-LaCasse Josie Acuña Matthew Thompson Nicolaus Hawbaker Josephine Valenzuela Uwe Stolz Srikar Adhikari | 2021 | World Journal of Emergency Medicine2021，12，3： | 2 |
| 11 | 从金砖国家视角看公共基础设施投资的包容性可持续发展显示文摘本文旨在探讨公共基础设施投资在金砖国家发展规划中对整合可持续发展目标(SDG)所发挥的作用。全文首先详细探讨了公共基础设施投资在实现金砖国家可持续发展目标中扮演的角色,并指出公共基础设施服务是保障个人生活水平、社会经济与政治权益长期可持续发展的主要影响因素。其次,从一个长期的视角评述了与金砖国家固定资本形成总额相关的基础设施投资领域的趋势,并从金砖国家公共基础设施融资、基础设施投资指标资本存量、金砖国家固定资本形成总额三个方面阐述了这种趋势。同时,还提出可在公共投资理论的框架下来解决金砖国家包容性可持续发展和基础设施服务储备短缺的问题,从而实现可持续发展目标。最后,探讨了金砖国家开发性金融机构在公共基础设施融资中扮演的角色,并提出了相关建议。 | Jaya Josie | 2016 | 开发性金融研究2016，0，1： | 2 |
| 12 | Tenore ectopic pregnancy显示文摘 | Josie L | 2000 | Am Fam Physician2000，61，： | 1 |
| 13 | Design of division specific primers of Ralstonia solanacearum and application to the identification of European isolates显示文摘 | Boudazin G Claire Le Roux A Josi K | 1999 | European Journal of Plant Pathology1999，105，4： | 1 |
| 14 | How is Japan’s nuclear disaster different显示文摘 | Josie G | 2011 | National Geographic News2011，，3： | 1 |
| 15 | A wireless controller to enhance dynamic performance of parallel invertel in distributed generation systems 显示文摘 | JOSEP M GUERRERO LUIS GARCA DE VICU 1 A JOSI MATAS | 2004 | IEEE Transactions on Power Electronics2004，19，5： | 1 |
| 16 | Matrix Converters: A Technology Review 显示文摘 | PATRICK W WHEELER JOSI RODRfGUEZ JON C CLARE | 2002 | IEEE Transaction on Industry and Etetronics2002，49，2： | 1 |
| 17 | Beyond shape and weight: Exploring the relationship between nonbody determinants of self-esteem and eating disorder symptoms in adolescent females显示文摘 | JOSIE G SHANNON LZ SUJA S | 2002 | Int J Eat Disord2002，32，3： | 1 |
| 18 | Visual Space Perception and Visually Directed Action显示文摘 | Jack M Loomis Naofumi Fujita Josi A Da Silva Sergio S Fukusima | 1992 | Journal of Experimental Psychology:Human Perception and Performance (S0096-1523)1992，18，4： | 1 |
| 19 | Corporate Governance and Business Ethics:Insights from the Strategic Planning Experience显示文摘 | Ingrid Bonn Josie Fisher | 2005 | Corporate Governance2005，13，6： | 1 |
| 20 | CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo显示文摘 | Frank L. Bos Maresa Caunt Josi Peterson-Maduro Lara Planas-Paz Joe Kowalski Terhi Karpanen Andreas van Impel Raymond Tong James A. Ernst Jeroen Korving Johan H. van Es Eckhard Lammert Henricus J. Duckers Stefan Schulte-Merker | 2011 | Circulation Research2011，，5： | 1 |
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