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| 1 | Current knowledge on diabetic retinopathy from human donor tissues显示文摘According to the American Diabetes Association,diabetes was the seventh leading cause of death,and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010.Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance,and over time,this chronic metabolic condition may lead to various complications including kidney failure,heart attacks,and retinal degeneration.In order to better understand the molecular basis of this disease and its complications,animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body,including the retina.However,inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human pathology.These difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications,especially diabetic retinopathy,on tissues from human donors.This review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to the main aspects of diabetic retinopathy:retinal vasculature dysfunction,inflammation,and neurodegeneration.This review discusses the importance of those studies to discriminate and establish the relevance of the findings obtained from animal models but also the limitations of such approaches. | Jessica H Eisma Jennifer E Dulle Patrice E Fort | 2015 | World Journal of Diabetes2015，6，2： | 19 |
| 2 | Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。 | Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 3 | Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?显示文摘 | Yasser H Shaib Jessica A Davila Kathryn McGlynn Hashem B El-Serag | 2003 | Journal of Hepatology2003，，3： | 3 |
| 4 | Colorectal cancer in the young显示文摘 | Jessica B O’Connell Melinda A Maggard Edward H Livingston Cifford K Yo | 2004 | The American Journal of Surgery2004，，： | 2 |
| 5 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 6 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 7 | 由地震简正模式观测得到的内核各向异性区域变化显示文摘地球的固体内核被对流的液体外核包围,由此创建了驱动地球磁场的地核发电机。用压缩体波研究地震显示出内核各向异性结构的半球性变化,但由于受地震和接收器分布状况所限,这一结论还不够充分。本文中,利用大地震的简正模式分裂函数测定结果,并基于扩展交叉耦合理论,我们观测到了区域变化和内核中东、西两半球的各向异性。这一模式与地球磁场的相似性说明在固化或组构演变过程中由Maxwell应力引起的晶体排列的凝入是产生各向异性的根源。这些观测结果限制了内核超速旋转的总量,但与振荡相符。 | Arwen Deuss Jessica C E Irving John H Woodhouse 洪启宇(译) 左玉玲(校) | 2010 | 国际地震动态2010，，10： | 2 |
| 8 | internalization in technology innovation : a case of CRM adoption 显示文摘 | CHEN Jessica H F WANG Eric T G | 2001 | IEEE TRANSACTIONS ON POWER SYSTEMS2001，16，2： | 1 |
| 9 | A point mutation in a Drosophila GABA receptor confers insecticide resistance 显示文摘 | Ffrench-Constant Richard H Rocheleau Thomas A Steichen Jessica C Chalmers Alison E | 1993 | Nature (London)1993，363，： | 1 |
| 10 | Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent显示文摘 | Jessica M. Leers Carlo Vivaldi Hartmut Sch?fer Marc Bludau Jan Brabender Georg Lurje Till Herbold Arnulf H. H?lscher Ralf Metzger | 2009 | Surgical Endoscopy2009，，10： | 1 |
| 11 | Botox, dilation, or myotomy? Clinical outcome of interventional and surgical therapies for achalasia显示文摘 | Christian Alexander Gutschow Ulrich T?x Jessica Leers Hartmut Sch?fer Klaus Ludwig Prenzel Arnulf H. H?lscher | 2010 | Langenbeck’s Archives of Surgery2010，，8： | 1 |
| 12 | A new car, a new grid显示文摘 | LARRY D JESSICA H | 2010 | IEEE Power and Energy Magazine2010，8，2： | 1 |
| 13 | Airway compromise due to laryngopharyngeal edema after anterior cervical spine surgery 显示文摘 | Mark A P Jessica P A Alan H D | 2013 | J Clin Anesth2013，25，1： | 1 |
| 14 | Vascular smooth muscle tumors:13 cases and a review of the literature显示文摘 | Jagdish B Gursharan S Jessica H | 2006 | Int J Angiol2006，15，1： | 1 |
| 15 | The Influence of Governance E- quilibrium on ERP Project Success显示文摘 | Eric T G Wang Jessica H F Chen | 2006 | Decision Support Systems2006，41，4： | 1 |
| 16 | BBC Licence Fee Should Be Cut, Tory Panel to Argue显示文摘 | JESSICA H | 2004 | Knight Ridder Tribune Business New2004，，04： | 1 |
| 17 | Engineered clay products for the paper industry 显示文摘 | MmTay H H Jessica E K | 2005 | Applied Clay Science2005，29，： | 1 |
| 18 | photoaging: mechanism and repair 显示文摘 | Jessica H Rabe Adam J Mamelak Patrick J S Mcelgunn | 2006 | Am Acad Dermatol2006，55，： | 1 |
| 19 | HPV16 E7 oncogene expression in normal human epithelial cells causes molec- ular changes indicative of an epithelial to mesenchymal transition显示文摘 | Karin H Jessica M Frank F | 2009 | Virology2009，391，1： | 1 |
| 20 | Relative roles of the cellular and humoral responses in the Drosophila host de- fense against three Gram-positive bacterial infections 显示文摘 | Nadine T N Jessica Q Ju H C | 2011 | PLoS One2011，6，3： | 1 |
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