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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 3 | Coordination compounds of hydrazine derivatives with transition metals III: The reaction of aroyl hydrazones with Ni( Ⅲ ) and Cu ( Ⅱ ) salts显示文摘 | Sayed L E Iskander M F | 1971 | J Inorg Nucl Chem1971，33，2： | 1 |
| 4 | State of the practice review in FRP composite piling 显示文摘 | ISKANDER M G HASSAN M | 1998 | Journal of Composites for Construction1998，2，3： | 1 |
| 5 | 显示文摘 | ISLAM M N SONG Y ISKANDER M N | 2003 | Journal of Molecular Graphics and Modelling2003，21，4： | 1 |
| 6 | Root causes for late presentation of severe neonatal hyperbilirubinaemia in Egypt显示文摘 | Iskander I Gamaleldin R Kabbani M | 2012 | East Mediterr Health J2012，18，8： | 1 |
| 7 | Coordination compounds of hydrazine derivatives with transition metals显示文摘 | Sayed L E Iskander M F | 1971 | J Inorg Nucl Chem1971，33，： | 1 |
| 8 | Bootstrapping bispectra: an application to testing for departure from Gaussianity of stationary signals显示文摘 | Zoubir A M Iskander D R | 1999 | IEEE Transactions on Signal Processing1999，47，3： | 1 |
| 9 | Drilled shaft defects: detection, and effects on capacity in valved clay显示文摘 | ISKANDER M ROY D KELLEY S | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，12： | 1 |
| 10 | Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics 显示文摘 | Read SA Collins M J Iskander DR | 2008 | In- vest Ophthalmol Vis Sci2008，49，7： | 1 |
| 11 | Transparent amorphous silica to model clay显示文摘 | ISKANDER M C L1U J SADEK S | 2002 | Journal of Geotechnieal and Geoenvironmental Engineering2002，128，3： | 1 |
| 12 | Adaptive cross correlation for imaging displacements in soils显示文摘 | LIU J ISKANDER M | 2004 | Journal of Computing in Civil Engineering2004，18，1： | 1 |
| 13 | Coordination compounds of hydrazine derivatives with transition metals Ⅲ 显示文摘 | EL-SAYED L ISKANDER M F | 1971 | J Inorg Nucl Chem1971，33，： | 1 |
| 14 | Drilled shafted defects: detection, and effects on capacity in varied clay显示文摘 | ISKANDER M ROY D KELLEY S | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，12： | 1 |
| 15 | Estimation of parameters of the K-distribution using higher order and fractional moment显示文摘 | Iskander D R and Zoubir A M | 1999 | IEEE Transactions on Aerospace and Electronic Systems1999，35，4： | 1 |
| 16 | Antiinflammatory screening of the medicinal plant Gynura procumbens显示文摘 | Iskander M N Song Y Coupar I M | 2002 | Plant Foods for Human Nutrition2002，57，34： | 1 |
| 17 | Geotechnical properties of transparent silica显示文摘 | SADEK S ISKANDER M L1U J | 2001 | Canadian Geotechnical Joumal2001，39，1： | 1 |
| 18 | Antiinflam- matory screening of the medicinal plant C, ynura procumbens 显示文摘 | Iskander M N Song Y Coupar I M | 2002 | Plant Food Hum Nutr2002，57，34： | 1 |
| 19 | Dynamics of ocular surface topography显示文摘 | Zhu M Collins MJ Iskander DR | 2006 | Eye2006，21，5： | 1 |
| 20 | Modeling capacity of transparent soil显示文摘 | L1U J ISKANDER M | 2010 | Canadian Geotechnical Journal2010，47，4： | 1 |
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