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| 1 | Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection显示文摘 | Maria Van der Sluis Barbara A.E. De Koning Adrianus C.J.M. De Bruijn Anna Velcich Jules P.P. Meijerink Johannes B. Van Goudoever Hans A. Büller Jan Dekker Isabelle Van Seuningen Ingrid B. Renes Alexandra W.C. Einerhand | 2006 | Gastroenterology2006，，1： | 3 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Tests for geno- toxicity and mutagenicity of furan and its metabolite cis - 2 - bu- tene - 1,4 - dialin LS178Ytk + / - - mouse lymphoma cells 显示文摘 | Mareo K Andreas B Ingrid R Josef S Werner KL | 2008 | Mutation Research2008，657，： | 1 |
| 4 | Journal club: acute abdominal pain in elderly patients : effect of radiologist awareness of clinicobiologic information on CT accuracy显示文摘 | Ingrid M Chakib A Emmanuelle B P | 2013 | American Journal of Roentgenology2013，201，6： | 1 |
| 5 | Predictors of Outcome in Patients With Suspected Myocarditis显示文摘 | Ingrid Kindermann Michael Kindermann Reinhard Kandolf Karin Klingel Burkhard Bültmann Thomas Müller Angelika Lindinger Michael B?hm | 2008 | Circulation2008，，6： | 1 |
| 6 | The influence of tibolone on quality of life in postmenopausal women显示文摘 | Ingrid B Meeuwsen Monique M Samson Sijmen A Duursma et al | 2002 | Maturitas2002，41，： | 1 |
| 7 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 8 | Evaluation of different sized blood sampling tubes for thromboelastometry, platelet function, and platelet count显示文摘 | Jo B?nding Andreasen Thea Unger Pistor-Riebold Ingrid Hell Knudsen Hanne Berg Ravn Anne-Mette Hvas | 2014 | Clinical Chemistry and Laboratory Medicine2014，，5： | 1 |
| 9 | RTX toxin genotypes and phenotypes in Actinobacillus pleuropueumoniae field strains显示文摘 | Marianne B Johannes F D B Ingrid M C A J | 1994 | Journal of Clinical Microbiology1994，32，11： | 1 |
| 10 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 11 | Some surprising findings on the involvement of the parietal lobe in human memory显示文摘 | INGRID R O MARIAN B | 2008 | Neurobiology of Learning and Memory2008，9，： | 1 |
| 12 | Selective sparing of goblet cells and paneth cells in the intestine of methotrexate-treated rats显示文摘 | Melissa V Ingrid B Genes | 2000 | Am J Physiol Gastrointest Liver Physiol2000，279，5： | 1 |
| 13 | Fosmidomycin plus clindamycin for treat ment of pediatric patients aged 1 to 14 years with Plasmodiu fal ciparum malaria显示文摘 | Steffen B Ingrid L | 2006 | Antimicrobial Agents and Chemotherapy2006，50，8： | 1 |
| 14 | Effects of shift and night work in the offshore petroleum industry~ a systematicreview显示文摘 | Ingrid Nesdal F BjRn B Siri W | 2013 | Industrial Health2013，51，5： | 1 |
| 15 | Fatal West Nile Virus Infection After Probable Transfusion-Associated Transmission - Colorado, 2012显示文摘 | Kelly Sharon Le Tuan N Brown Jennifer A Lawaczek Elisabeth W Kuehnert Matthew Rabe Ingrid B Staples J Erin Fischer Marc | 2013 | MMWR Morbidity and Mortality Weekly Report2013，，31： | 1 |
| 16 | The influence of tibolone on quality of life in postmenopausal women显示文摘 | Ingrid B Meeuwsen Monique M Samson Sijmen A Duursma etal | 2002 | Maturitas2002，41，： | 1 |
| 17 | Work Zone Speed LimitProcedeur显示文摘 | Migletz James Graham Jerry L Ingrid B Anderson etc | 1999 | Transportation Re-search Board1999，，1657： | 1 |
| 18 | Chemical form and distribution of selenium and sulfur in the selenium hyperaccumulator Astragalus bisulcatus显示文摘 | INGRID J P CARRIE W BEN B | 2003 | Plant Physiology2003，131，3： | 1 |
| 19 | Spatial variability in structural and functional aspects of macrofauna communities and their environmental parameters in the Jade Bay (Wadden Sea Lower Saxony, southern North Sea) 显示文摘 | ULRIKE S MELANIE B INGRID K | 2013 | Helgoland Marine Research2013，67，： | 1 |
| 20 | Disruption of the interaction between the rieske iron-sulfur protein and cytochrome B in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome B显示文摘 | NICHOLAS F INGRID B PHILIP H | 2004 | European Journal of Biochemistry2004，271，7： | 1 |
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