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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Dynamic changes of typeⅠ,Ⅲand N collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis显示文摘AIM To find out the relationship between the gene transcription of different types ofprocollagen and the deposition of the relevant collagens in the liver tissue and to confirm the types of collagen producing cells in liverfibrogenesis.METHODS Dynamic changes of the expression of α1(Ⅰ ), α1 (Ⅲ ) and α1 (Ⅳ) procollagen mRNAand relevant collagens and the distribution ofcollagen producing cells during liver fibrogenesis of rat induced by CCl4 (20 weeks)were investigated with Northern blot analysis,in situ hybridization and immunohistochemicaltechniques.RESULTS The increased expression of α1 (Ⅲ)procollagen mRNA by Northern blot analysis was the most predominant one among the threemRNAs during fibrogenesis. However, theenhanced expression of al (Ⅳ) procollagenmRNA occurred very early while the expressionof α1 (Ⅰ) mRNA was not enhanced much until themiddle stage of the exPeriment. D6smin (Dm)positive hepatic stellate cells (HSCs) and fewmyofibroblasts (MFs) in and around the necrotic areas expressed α1 (Ⅰ), α1 (Ⅲ) and α1 (Ⅳ)procollagen mRNA signals detected by in situhybridization at the early stage of theexperiment. All the three procollagen mRNAsignals thereafter mainly localized in fibroblasts (Fbs) and MFs in fibrotic septa during the middle and late stages of fibrosis, which distributedparallel to the corresponding collagens detected by immunohistochemical study. ln addition, the endothelial cells of sinusoids and the small blood vessels within the septa also showed α1(Ⅳ) procollagen mRNA and type Ⅳ collagen expressionCONCLUSION It is considered that 'HSC-MF-Fb' effect cell system is the major cellularsource of collagen production in liver fibrosis, in which HSCs are collagen producing precursor cells in the early liver fibrogenesis, thereafter the synthesis of type Ⅰ, Ⅲ and Ⅳ collagens (Col Ⅰ, Col Ⅲ and Col Ⅳ) mainly derives fromMFs and Fbs, which play a very important role in the progress of liver fibrosis. The endothelialcells along sinusoids, as another source of Col Ⅳ production, might participate in the capillization of liver sinusoids. | DU Wei-Dong ZHANG Yue-E ZHAl Wei-Rong and ZHOU Xiao-Mei(Department of Pathology, Shanghai Medical University, Shanghai200032, China)(National Laboratory for Oncogenes and Related Genes, ShanghaiCencer Institute)See invited commentary on page 388 | 1999 | World Journal of Gastroenterology1999，5，5： | 47 |
| 3 | 流动儿童心理韧性对其抑郁、孤独的影响显示文摘本研究采用心理韧性和抑郁、孤独量表作为研究工具,对685名流动儿童心理韧性特点及对抑郁、孤独影响进行研究。结果发现:男生、转学次数多、打工子弟学校、来北京时间较少、家庭收入低的流动儿童,他们抑郁、孤独感更高;流动儿童心理韧性比其个人、家庭、学校因素对抑郁和孤独的预测能力更强,在控制了这些因素之后,心理韧性仍然能够显著地预测其抑郁和孤独感。 | 王中金 Gening Jin 蔺秀云 | 2014 | 中国特殊教育2014，，4： | 36 |
| 4 | Dissection of genetic overlap of salt tolerance QTLs at the seedling and tillering stages using backcross introgression lines in rice显示文摘QTLs for salt-tolerance(ST)related traits at the seedling and tillering stages were identified using 99 BC2F8 introgression lines(IL)derived from a cross between IR64(indica)as a recurrent parent and Binam(japonica)from Iran as the donor parent.Thirteen QTLs affecting survival days of seedlings(SDS), score of salt toxicity of leaves(SST),shoot K + concentration(SKC)and shoot Na + concentration(SNC) at the seedling stage and 22 QTLs underlying fresh weight of shoots(FW),tiller number per plant(TN) and plant height(PH)at the tillering stage were identified.Most QTLs detected at the tillering stage showed obvious differential expression to salt stress and were classified into three types based on their differential behaviors.Type I included 11 QTLs which were expressed only under the non-stress condition.Type II included five QTLs expressed in the control and the salt stress conditions,and three of them(QPh5,QPh8 and QTn9)had similar quantity and the same direction of gene effect,suggesting their expression was less influenced by salt stress.Type III included six QTLs which were detectable only under salt stress,suggesting that these QTLs were apparently induced by the stress.Thirteen QTLs affecting trait difference or trait stability of ILs between the stress and non-stress conditions were identified and the Binam alleles at all loci except QPh4,QTn2 and QFw2a decreased trait difference.The three QTLs less influenced by the stress and 13 QTLs affecting trait stability were considered as ST QTLs which contributed to ST.Comparing the distribution of QTLs detected at the seedling and tillering stages,most(69%)of them were genetically independent.Only four were the same or adjacent regions on chromosomes 1,2,8 and 11 harboring ST QTLs detected at the two stages,suggesting that partial genetic overlap of ST across the two stages occurs.It is likely,therefore,to develop ST rice variety for both stages by pyramiding of ST QTLs of different stages or selection against the overlapping QTLs between the two stages via marker-assisted selection(MAS). | ZANG JinPing 1 ,SUN Yong 1 ,WANG Yun 1 ,YANG Jing 1 ,LI Fang 1 ,ZHOU YongLi 1 ,ZHU LingHua 1 , Reys JESSICA2,Fotokian MOHAMMADHOSEIN 2,XU JianLong 1&LI ZhiKang 1,2 1Institute of Crop Sciences/National Key Facility for Crop Gene Resources&Genetic Improvement,Chinese Academy of Agricul- tural Sciences,Beijing 100081,China 2International Rice Research Institute,DAPO Box 7777,Metro Manila,Philippines | 2008 | Science China(Life Sciences)2008，51，7： | 32 |
| 5 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 6 | Preparation of human single chain Fv antibody against hepatitis C virus E2 protein and its identification in immunohistochemistry显示文摘AIM: To screen human single chain Fv antibody (scFv)against hepatitis C virus E2 antigen and identify its applicationin immunohistochemistry.METHODS: The phage antibody library was panned by HCVE2 antigen, which was coated in microtiter plate. After fiverounds of biopanning,56 phage clones were identified specificto HCV E2 antigen. The selected scFv clones were digestedby SfiI/NotI and DNA was sequenced. Then it was subclonedinto the vector pCANTABSE for expression as E-taggedsoluble scFv. The liver tissue sections from normal personand patients with chronic hepatitis B and chronic hepatitis Cwere immunostained with HCV E2 scFv antibody.RESULTS: The data of scFv-E2 DNA digestion and DNAsequencing showed that the scFv gene is composed of 750bp. ELISA and immunohistochemistry demonstrated that thehuman single chain Fy antibody against hepatitis C E2 antigenhas a specific binding character with hepatitis virus E2 antigenand paraffin-embedded tissue, but did not react with liver tissuesfrom healthy persons or patients with chronic hepatitis B.CONCLUSION: We have successfully screened andidentified HCV E2 scFv and the scFv could be used in theimmunostaining of liver tissue sections from patients withchronic hepatitis C. | Yan-Wei Zhong Jun Cheng Gang Wang Shuang-Shuang Shi Li Li Ling-Xia Zhang Ju-Mei Chen Gene Therapy Research Center,Institute of Infectious Diseases,302 Hospital of PLA,26 Fengtai Road,Beijing 100039,China | 2002 | World Journal of Gastroenterology2002，8，5： | 21 |
| 7 | 综合性卒中中心医疗质量的度量标准:对脑卒中联盟综合性卒中中心推荐意见的详细随访美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景卒中是一种主要的残疾和死亡原因。脑卒巾联盟提议,建立初级卒中中心(primary stroke center,PSC)和综合性卒中中心(comprehensive stroke center,csc)以分别为需要基本或高级下预的卒中患者提供适当的医疗服务。从2003年开始,美国医疗卫生机构认证联合委员会和各州已指定了一些PSC,目前正在考虑CSC的指定工作。为了推进该过程,我们提出了一套CSC应追踪监测医疗质量并促进质量改进的标准和相关数据。方法和结果我们分析了现有指南、综述和其他文献,以识别区分CSC与PSC的主要特征;起草了一套标准和相关数据元素,以评价这些卒中医疗方面的关键部分;然后通过反复修改达成共识。我们提出的这套标准和相关数据元素,涵盖了CSC内缺血性脯血管病、非外伤性蛛网膜下腔出血和腩出血患者专、№医疗的主要方面。结论我们提出这套标准,旨在为CSC的标准化数据采集提供一个框架,以促进当地医疗质量改进,并允许对来自不同CSC的数据进行合并分析。这将有助于将来CSC国家执行标准的制定。 | 何晟(译) 蔡可夫(译) 张元媛(译) 胡旻婧(译) 倪耀辉(译) 芮瑛(译) 柯开富(译) Dana Leifer Dawn M. Bravata J.J. (Buddy) Connors Ⅲ Judith A. Hinchey Edward C. Jauch S. Claibome Johnston Richard Latchaw William kikosky Christopher Ogilvy Adrian I. Qureshi Debbie Summers Gene Y. Sung Linda S. Williams Richard Zorowitz | 2011 | 国际脑血管病杂志2011，19，3： | 21 |
| 8 | 大亚湾海域多溴联苯醚的生物累积特征显示文摘于2003年9月在大亚湾海域采集生物(鱼、虾、蟹和乌贼)样品,分析其多溴联苯醚(PBDEs)的浓度和脂含量,以及同位素δ15N与δ13C的值.结果表明,鱼、虾、蟹和乌贼的PBDEs总平均含量分别为5.43±3.97,1.18±0.67,3.37±2.33,5.66ng/g脂重.肉食性的鱼类PBDEs的生物累积比植食性的鱼类相对较高.BDE47为最优势组分,占总PBDEs的30%,且在所有样品中均被检出.生物体中PBDEs的含量与脂含量和δ15N值均呈正相关,脂含量对生物体富集PBDEs的影响远比生物所处的营养级的影响大. | 丘耀文 张干 郭玲利 Zheng Gene J 李向东 李军 刘向 | 2006 | 中国环境科学2006，26，6： | 17 |
| 9 | Bile acid interactions with cholangiocytes显示文摘Cholangiocytes 在他们的顶端的膜暴露于胆汁酸的高集中。为胆汁酸的选择 transporter,顶端的钠胆汁酸 Cotransporter (ASBT )( 也叫作 Ibat;基因名字 Slc10a2 ) 在 cholangiocyte 上是局部性的顶端的膜。在 basolateral 膜上,四个运输系统被识别了(t-ASBT,多药抵抗(MDR ) 3,一个未辩别出的阴离子 exchanger 系统和器官的溶质 transporter (Ost ) 异侧 transporter, Ostalpha-Ostbeta。一起,这些单向性地搬运 ers 从管的胆汁的行动胆汁酸到发行量。cholangiocytes 吸收的胆汁酸为重新分泌物经由仙子胆管丛再循环回到 hepatocytes 进胆汁。这再循环在 hepatocytes 和 cholangiocytes 之间的胆汁酸被叫作 cholehepatic 分流小径。最近的研究建议 cholehepatic 分流小径可以由于额外的肝的阻塞在胆汁酸并且到改编的全面肝胆管运输作出贡献到长期的胆汁郁积。ASBT 被腺苷 3' 尖锐地调整, 5'-monophosphate (营地) 依赖者易位到顶端的膜并且由 phosphorylation 依赖的 ubiquitination 和 proteasome 降级。ASBT 被变化长期地响应胆汁的胆汁酸集中和煽动性的 cytokines 在基因表示调整。cholangiocyte ASBT 的另一潜在的功能是允许 cholangiocytes 取样胆汁的胆汁酸以便激活细胞内部的表明小径。在细胞内部的钙,蛋白质激酶 C (PKC ) , phosphoinositide 3-kinase (PI3K ) ,激活 mitogen 的蛋白质(地图) 激酶和细胞外的调整信号的蛋白质激酶(英皇家空军之阶级最低之兵) 的胆汁酸扳机变化细胞内部的信号。胆汁酸显著地改变 cholangiocyte 分泌物,增长和幸存。不同胆汁酸在 cholangiocyte 上有微分效果细胞内部发信号,并且在一些例子,扳机反对在 cholangiocyte 上完成分泌物,增长和幸存。在这些之上基于概念和观察, cholangiocyte 被建议了是为在肝的胆汁酸的原则目标房间。 | Xuefeng Xia Heather Francis Shannon Glaser Gianfranco Alpini Gene LeSage | 2006 | World Journal of Gastroenterology2006，12，22： | 16 |
| 10 | 65岁以上老年人预防跌倒的指南显示文摘老年人常常跌倒,这是一个严重的大众健康问题,对人们的健康及医疗花费有很大的影响。本指南依据试验证据,提出了在不同环境下切实可行的预防跌倒的建议。目的是减少65岁以上老人的跌倒率及跌倒后的损伤。 | Gene Feder Colin Cryer Sheila Donovan YvonneCater代表指南发展小组 周谋望 | 2003 | 英国医学杂志中文版2003，6，4： | 15 |
| 11 | 深圳湾海域多溴联苯醚(PBDEs)生物累积及其高分辨沉积记录显示文摘深圳湾,毗邻香港,是深圳经济特区的重要经济发展和生态调节区域。为了更好地了解该湾多溴联苯醚(PBDEs)的生物累积规律及其污染历史,作者采集该海域19个鱼、2个虾、2个蟹和柱状沉积物样品,分析其中PBDE的组分与含量,以及生物体的δ15N同位素、总脂含量和柱状沉积物的沉积年龄(210Pb)、总有机碳(TOC)。结果表明,深圳湾海域鱼类Σ15PBDEs组分的残余量为21—167ng/glw(或0.17—4.16ng/gfw),平均为(67±42)ng/glw或(2.00±1.14)ng/gfw,其含量与生物体的δ15N同位素和脂含量正相关,BDE-47、BDE-100为生物体中PBDE最优势组分且在所有生物样品中均检出,分别占46.5%、13.5%,肉食性的鱼类较植食性的鱼类PBDEs的生物累积总体上较高。柱状沉积物中Σ22PBDEs含量(0.07—4.85ng/gdw)近二十几年来有明显的上升趋势,平均沉积通量为0.25ng/(cm2·a),丰度最高的PBDE组分为BDE-47、BDE-49、BDE-99、BDE-183(不包括BDE-209);PBDEs在生物体和柱状沉积物中的含量位于全球PBDEs含量的中低端范围;鱼类等生物体中PBDE的生物-沉积物累积比值(BSAF)比值(<0.8)较小,与相应的PBDE的log KOW(辛醇/水分配比)存在一定的正相关性。 | 丘耀文 张干 郭玲利 Gene J Zheng 李军 刘向 | 2009 | 海洋与湖沼2009，40，3： | 15 |
| 12 | Copper-chelating therapeutic effect in Wilson disease with different clinical phenotypes and polymorphisms of ATP7B gene显示文摘CopperchelatingtherapeuticefectinWilsondiseasewithdiferentclinicalphenotypesandpolymorphismsofATP7BgeneRENMingShan1,HUWen?.. | REN MingShan1, HU WenBin1, ZHANG Zhi1, JU ShuangWu1, FAN YuXin2, WANG GongQiang1 and YANG RenMin1Keywords Wilson disease/therapy copper chelating agents ATP7B gene mutations | 1998 | World Journal of Gastroenterology1998，4，4： | 15 |
| 13 | The Arabidopsis bZIP1 Transcription Factor Is Involved in Sugar Signaling, Protein Networking, and DNA Binding显示文摘糖发信号是种使用集成各种各样的内部、外部的暗示完成滋养的动态平衡的机制,调停发展节目,和清晰压力回答。许多 bZIP 抄写因素被知道涉及营养素或应力发信号。Arabidopsis S1 组 bZIP 基因, AtbZIP1,在介绍学习的以前的基因表情作为糖敏感的基因被识别(植物房间。16, 21282150 ) 。在这份报告,我们证明 AtbZIP1 的表示被糖以一个快、敏感、可逆的方法镇压。AtbZIP1 的糖压抑被表明部件的保存的糖影响, hexokinase。除是调整糖的基因以外, AtbZIP1 能调停糖发信号并且影响基因表示,植物生长,和开发。当碳营养素是有限的时, AtbZIP1 原因的功能的获得或损失处于早幼苗建立的率变化。phenotypic 分析的结果显示 AtbZIP1 充当早幼苗生长的一个否定管理者。用在 microarray 分析的 gain-of-function 和 loss-of-function 植物,通常认为的调整 AtbZIP1 的基因的二个集合被识别了。在他们之中,糖应答的基因是高度过去代表的,含有在调停糖的基因表示的 AtbZIP1 的一个角色。用酵母二混血儿(Y-2-H ) 屏蔽,双分子的荧光互补(BiFC ) 分析,我们能概括广泛的 C/S1 AtbZIP 蛋白质交往在生活房间的网络。最后,我们证明 AtbZIP1 能在 vitro 绑基于 ACGT 的主题并且有约束力的特征看起来被在 AtbZIP1 和 C 组 AtbZIPs 之间的 heterodimerization 影响,包括 AtbZIP10 和 AtbZIP63。 | Shin Gene Kang John Price Pei-Chi Lin Jong Chan Hong Jyan-Chyun Jang | 2010 | Molecular Plant2010，3，2： | 13 |
| 14 | The tumor-selective over-expression of the human Hsp 70 gene is attributed to the aberrant controls at both initiation and elongation levels of transcription显示文摘The tumor selective over-expression of the human Hsp70 gene has been well documented in human tumors,linked to the poor prognosis,being refractory to chemo-and radio-therapies as well as the advanced stage of tumorous lesions in particular.However,both the nature and details of aberrations in the control of the Hsp70 expression in tumor remain enigmatic.By comparing various upstream segments of the Hsp70 gene for each''s ability to drive the luciferase reporter genes in the context of the tumor cell lines varying in their p53 status and an immortal normal liver cell line,we demonstrated in a great detail the defects in the control mechanisms at the both initiation and elongation levels of transcription being instrumental to the tumor selective profile of its expression.Our data should not only offer new insights into our understanding of the tumor specific over-expression of the human Hsp70 gene,but also paved the way for the rational utilization of the tumor selective mechanism with the Hsp70 at the central stage fortargeting the therapeutic gene expression to human tumors. | LING CAI, JING DE ZHU,The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 25/2200, Xie-tu Road, Shanghai 200032, China | 2003 | Cell Research2003，13，2： | 13 |
| 15 | 流动儿童社会认同与文化适应的相关研究显示文摘为探究流动儿童社会认同对其文化适应的影响,本研究采用流动儿童社会认同问卷和流动儿童文化适应问卷,对北京市695名流动儿童进行问卷调查,使用方差分析、独立样本T检验以及相关、回归分析等统计方法对所得数据进行分析。研究发现:(1)流动儿童的性别、其所在学校种类(公立、私立)、是否在移入地出生都在不同维度上和流动儿童的社会认同、文化适应有显著相关。(2)流动儿童的社会认同与文化适应之间存在显著的相关。(3)社会认同对文化适应具有显著的预测作用,尤其是自我否定这一维度对文化适应具有非常显著的负向预测作用。 | 王中会 张盼 Gening Jin | 2014 | 中国特殊教育2014，，12： | 12 |
| 16 | 流动儿童城市适应及其社会认同的追踪研究显示文摘为了探讨流动儿童城市适应和社会认同随时间变化的规律,以及社会认同对城市适应的影响作用及机制,本研究从北京市公立学校和打工子弟学校选取271名流动儿童,采用问卷调查的形式对流动儿童的城市适应和社会认同进行了为期两年的测查。对数据进行分析发现:(1)经前后两次对流动儿童的调查表明,流动儿童社会认同的过程中对农村归类方面更积极,对城市适应产生影响,城市适应得分降低。(2)流动儿童的城市适应总体水平在公私立学校上存在显著的差异,公立学校更有利于增加流动儿童的城市适应。(3)流动儿童社会认同中自我否定、和北京孩子比、农村归类三个维度对城市适应有负向预测作用,而北京认同、自我肯定两个维度对城市适应有正向的预测作用。 | 王中会 周晓娟 Gening Jin | 2014 | 中国特殊教育2014，，1： | 12 |
| 17 | Detection of soluble TRAIL in HBV infected patients and its clinical implications显示文摘AIM: To detect the expression of soluble TRAIL (TNF-related apoptosis inducing ligand, TRAIL) in the peripheral blood of HBV infected patients and try to elucidate whether the expression level of sTRAIL have any correlativity with the clinical staging, the expression level of HBV markers and the degree of liver damage.METHODS: 52 cases of HBV infected patients were investigated, induding 8 HBV carriers, 30 chronic hepatitis B, 11 drrhotics and 3 HBV infection related hepatocellular carcinoma. Expression of soluble TRAIL and markers of the hepatitis B were mearsured by enzyme-linked immunosorbent assay.RESULTS: The expression level of sTRAIL in the peripheral blood of the HBV infected patients was significantly higher than that of healthy controls (1378.35±540.23 pg/ml vs 613.75±175.80 pg/ml, P<0.001). In the group of chronic hepatitis, the expression level of sTRAIL was coincident with the status of the disease and was significantly correlated with the level of ALT. In the group of cirrhosis and liver cancer, its expression level was significantly higher than that of the healthy persons and HBV carriers, but lower than that of the hepatitis B patients; meanwhile, the expression of siRAIL did not have any correlativity with the functional indexes of the liver. CONCLUSION: The soluble TRAIL in the HBV infected people may participate in the liver damage. Our results indicated that the expression level of soluble TRAIL may reflect the ravage of liver caused by host immune reaction to a certain degree. | Li-Hui Han Wen-Sheng Sun Chun-Hong Ma Li-Ning Zhang Su-Xia Liu Qiu Zhang Li-Fen Gao,Institute of Immunology,Medical College of Shandong University,Jinan 250012,Shandong Province,China You-Hai Chen,Institute for Human Gene Therapy,University of Pennsylvania,Philadelphia PA 19104,USA | 2002 | World Journal of Gastroenterology2002，8，6： | 12 |
| 18 | Diagnosis of clinical and subclinical varicocele: how has it evolved?显示文摘在这评论,我们为在一个精索静脉曲张病人的评估以 venography, scintigraphy,和 thermography 和他们的角色开始的精索静脉曲张检验各种各样的诊断形式的进化和申请。一些这些方法被不太侵略、更容易执行的诊断形式,特别超声和阴囊的 Doppler 检查取代了。在超声和磁性的回声成像的进展保持潜力在精索静脉曲张的视觉证实和描述的以外扩展成像的角色。基于成像调查结果识别阴囊的机能障碍的早指示物的能力以后可以为精索静脉曲张的管理有含意。 | Ruth E Belay Gene Omar Huang Jim Ken-Chie Shen Edmund Yuey Kun Ko | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 19 | Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart显示文摘This work characterizes the mitochondrial proteomic profile in the failing heart and elucidates the molecular basis of mitochondria in heart failure. Heart failure was induced in rats by myocardial infarction, and mitochondria were isolated from hearts by differential centrifugation. Using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry, a system biology approach was employed to investigate differences in mitochondrial proteins between normal and failing hearts. Mass spectrometry identified 27 proteins differentially expressed that involved in energy metabolism. Among those, the up-regulated proteins included tricarboxylic acid cycle enzymes and pyruvate dehydrogenase complex subunits while the down-regulated proteins were involved in fatty acid oxidation and the OXPHOS complex. These results suggest a substantial metabolic switch from free fatty acid oxidation to glycolysis in heart failure and provide molecular evidence for alterations in the structural and functional parameters of mitochondria that may contribute to cardiac dysfunction during ischemic injury. | WANG Jun1,2, BAI Ling1,2, LI Jing3, SUN ChaoFeng1,2, ZHAO Jin1, CUI ChangCong1,2, HAN Ke1,2, LIU Yu1,2, ZHUO XiaoZhen1,2, WANG TingZhong1,2, LIU Ping1,2, FAN FenLing1,2, GUAN YouFei3 & MA AiQun1,2 1 Department of Cardiology, First affiliated hospital of medical college of Xi’an Jiaotong University, Xi’an 710061, China 2 Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi’an 710061, China 3 Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education, Peking University Health Science Center, Beijing 100083, China | 2009 | Science China(Life Sciences)2009，52，11： | 10 |
| 20 | Selection of candidates for surgery as local therapy among early-stage small cell lung cancer patients: a population-based analysis显示文摘Background:Surgery and radiotherapy are considered local therapies for small cell lung cancer(SCLC).The present study aimed to select candidates for surgery as local therapy among patients with stage I or II SCLC,based on the eighth edition of the TNM classification for lung cancer.Methods:Patients diagnosed with SCLC between 2004 and 2013 were selected from the Surveillance,Epidemiology,And End Results database.The TNM stage of SCLC in these patients was re-classified according to the eighth edition of the TNM classification for lung cancer.Patients with stage I or II SCLC were included in the present study.Overall survival(OS)and lung cancer-specific survival(LCSS)were separately compared in the different TNM stages between patients who received surgery and radiotherapy as local therapy.Multivariate analysis was applied to evaluate multi-ple factors associated with survival.Results:Among the 2129 patients included in the present study,387(18.2%)received surgery,1032(48.5%)under-went radiotherapy as local therapy,154(7.2%)underwent surgery and radiotherapy,and 556(26.1%)did not undergo either surgery or radiotherapy.Among patients with T1-2N0(tumor size≤50 mm without positive lymph nodes)dis-ease,patients who underwent surgery had higher 5-year OS and LCSS rates than patients who received radiotherapy(T1N0:46.0%vs.23.8%,P<0.001,and 58.4%vs.36.4%,P<0.001,respectively;T2N0:42.6%vs.24.7%,P=0.004,and 48.8%vs.31.3%,P=0.011,respectively).Multivariate analysis results revealed that surgery was associated with low risk of death.However,among T3N0 or T1-2N1(stage IIB)SCLC patients,patients who underwent surgery did not have higher 5-year OS and LCSS rates than patients who received radiotherapy(T3N0:16.2%vs.26.5%,P=0.085,and 28.7%vs.30.9%,P=0.372,respectively;T1-2N1:20.3%vs.29.0%,P=0.146,and 25.6%vs.35.5%,P=0.064,respectively).Conclusions:Based on the assumption that the overwhelming majority of stage I or II SCLC patients who underwent surgery or radiotherapy also received certain types of systemic therapy,only patients with T1-2N0 SCLC may benefit from surgery as local therapy.Patients with T3N0 or T1-2N1 SCLC may consider radiotherapy as local therapy. | Kaiqi Jin Kaixuan Zhang Feng Zhou Jie Dai Peng Zhang Gening Jiang | 2018 | Cancer Communications2018，38，1： | 9 |
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