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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 3 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 4 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 5 | Panniculitis in childhood显示文摘 | Ingrid C Polcari Sarah L Stein | 2010 | Dermatologic Therapy2010，23，： | 1 |
| 6 | Chemical characterization and functional properties of a potato protein concentrate prepared by large-scale expanded bed adsorption chromatography显示文摘 | Sissel Lkra Merete H Helland Ingrid C Claussen | 2008 | LWT-Food Science and Technology2008，41，6： | 1 |
| 7 | Collaborative conflict resolution at devilstower national monument显示文摘 | Daniel D L Ingrid S E | 2001 | Parks & Recreation2001，36，7： | 1 |
| 8 | Long-term anatomic and visual acuity outcomes after initial anatomic success with macular hole surgery显示文摘 | Ingrid U Scott Alexei L Moraczewski William E Smiddy Harry W Flynn William J Feuer | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 9 | Storage and drivers of organic carbon in forest soils of southeast Germany (Bavaria) – Implications for carbon sequestration显示文摘 | Martin Wiesmeier J?rg Prietzel Frauke Barthold Peter Sp?rlein Uwe Geu? Edzard Hangen Arthur Reischl Bernd Schilling Margit von Lützow Ingrid K?gel-Knabner | 2013 | Forest Ecology and Management2013，，： | 1 |
| 10 | Aetiology and clinical characteristics of syncope in Chinese children显示文摘 | Chen L Zhang QY Ingrid S | 2007 | Acta Paediatr2007，96，10： | 1 |
| 11 | Dural puncture and activated protein C resistance:risk factors for cerebral venous sinus thrombosis显示文摘 | Einar WS Ingrid KM Bernhard L | 1997 | J Neurol Neurosurg Psychiatry1997，63，3： | 1 |
| 12 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 1 |
| 13 | Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics显示文摘 | INGRID Y L BI X N | 2003 | Proe Natl Ac ad Sci USA2003，100，14： | 1 |
| 14 | Fosmidomycin plus clindamycin for treat ment of pediatric patients aged 1 to 14 years with Plasmodiu fal ciparum malaria显示文摘 | Steffen B Ingrid L | 2006 | Antimicrobial Agents and Chemotherapy2006，50，8： | 1 |
| 15 | The compai'ison of organic protec- tive layers on bronze and copper显示文摘 | Tadeja K Andraz L Ingrid M | 2010 | Prog Org Coat2010，69，2： | 1 |
| 16 | On-line Preparation of Solutions for Dialysis: Practical Aspects Versus Safety and Regulations显示文摘 | Ingrid L | 2002 | J Am Soc Nephrol2002，13，1： | 1 |
| 17 | A etiologic and clinical characteristics of syncope in Chinese children 显示文摘 | Chen L Zhang Q Ingrid S | 2007 | Acta Paediatr2007，96，10： | 1 |
| 18 | Apparent digestibility co- efficients of feed ingredients and their prediction in diets for tilapia Oreochromis niloticus x Oreochro- mis aureus (Teleostei, Cichlidae) 显示文摘 | David S Tal P Ingrid L | 2004 | AquacultureResearch2004，35，4： | 1 |
| 19 | Enzyme conversion immunoassay for determining total homocysteine in plasma or serum显示文摘 | Arne L F Ingrid A | 1998 | Clin Chem1998，44，2： | 1 |
| 20 | Dural puncture and activated protein C resistance:risk factors for cerebral venous sinus thrombosis显示文摘 | Einar WS Ingrid KM Bernhard L | 1997 | J Neurol Neurosurg Psychiatry1997，63，： | 1 |
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