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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Slip-model Performance for Underexpanded Micro-scale Rocket Nozzle Flows显示文摘在太空微机电的系统(MEMS ) ,流动的典型长度规模接近分子的吝啬的免费路径,因此使连续统描述无效并且强制粒子方法的使用象直接模拟蒙特卡罗(DSMC ) 一样,处理非平衡区域。在滑倒政体以内(0.01 < Kn < 锝 ?.1 ) 两条途径,连续统并且基于粒子,似乎以精确性表现很好。现在的学习总结与第二顺序获得的实现和结果在一个海军司烧解答者滑动边界状况在嘴墙附近探讨变成稀薄。它到 300 渭 m 的一张冷气体的微规模的圆锥形的嘴的评价和申请咽直径,排出进低压的 freestream,组成工作的主要目的。滑倒模型合并速度滑倒与热爬并且温度跳,因此允许也处理非等温的流动。结果证明气体在嘴唇附近经历强烈变成稀薄,指向模型有效性的限制。而且,强壮的马赫减速被观察,归因于相当厚的亚声的边界层,超声的体积加热引起了由粘滞驱散,在有扩大到的对比在 underexpanded 期间发生在大火箭嘴操作。 | JoséA.Morí■igo JoséHermidaQuesada Francisco Caballero Requena | 2007 | Journal of Thermal Science2007，16，3： | 4 |
| 3 | Multiphysics Simulation of a Novel Concept of MEMS-based Solid Propellant Thruster for Space Propulsion显示文摘This work analyzes a novel MEMS-based architecture of submillimeter size thruster for the propulsion of small spacecrafts,addressing its preliminary characterization of performance.The architecture of microthruster comprises a setup of miniaturized channels surrounding the solid-propellant reservoir filled up with a high-energetic polymer.These channels guide the hot gases from the combustion region towards the nozzle entrance located at the opposite side of the thruster.Numerical simulations of the transient response of the combustion gases and wafer heating in thruster firings have been conducted with FLUENT under a multiphysics modelling that fully couples the gas and solid parts involved.The approach includes the gas-wafer and gas-polymer thermal exchange,burnback of the polymer with a simplified non-reacting gas pyrolysis model at its front,and a slip-model inside the nozzle portion to incorporate the effect of gas-surface and rarefaction onto the gas expansion.Besides,accurate characterization of thruster operation requires the inclusion of the receding front of the polymer and heat transfer in the moving gas-solid interfaces.The study stresses the improvement attained in thermal management by the inclusion of lateral micro-channels in the device.In particular,the temperature maps reveal the significant dependence of the thermal loss on the instantaneous surface of the reservoir wall exposed to the heat flux of hot gases.Specifically,the simulations stress the benefit of implementing such a pattern of micro-channels connecting the exit of the combustion reservoir with the nozzle.The results prove that hot gases flowing along the micro-channels exert a sealing action upon the heat flux at the reservoir wall and partly mitigate the overall thermal loss at the inner-wall vicinity during the burnback.The analysis shows that propellant decomposition rate is accelerated due to surface preheating and it suggests that a delay of the flame extinction into the reservoir is possible.The simulated operation of the thruster concept shows encouraging performance. | José A.Moríigo José Hermida-Quesada | 2011 | Journal of Thermal Science2011，20，6： | 4 |
| 4 | Electro-tribological properties of diamond like carbon coatings显示文摘Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical applications.In this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously monitored.Results show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical properties.Therefore,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the coatings.ECR also shows potential for on-line monitoring of coated parts in operation. | Iñigo BRACERAS Iñigo IBÁNEZ Santiago DOMINGUEZ-MEISTER Xabier VELASCO Marta BRIZUELA Iñaki GARMENDIA | 2020 | Friction2020，8，2： | 2 |
| 5 | The European Water Framework Directive and the DPSIR, a methodological approach to assess the risk of failing to achieve good ecological status显示文摘 | ángel Borja Ibon Galparsoro Oihana Solaun I?igo Muxika Eva María Tello Ainhize Uriarte Victoriano Valencia | 2005 | Estuarine Coastal and Shelf Science2005，，1： | 2 |
| 6 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
| 7 | Pneumococcal serotypes causing acute otitis media among children in Barcelona (1992-2011):emergence of the multiresistant clone ST320 of serotype 19A显示文摘 | Gene A del Amo E I(n)igo M | | 0，，04： | 1 |
| 8 | Momentum considerations inside near-zero index materials显示文摘Near-zero index (NZI) materials, i.e., materials having a phase refractive index close to zero, are known to enhance or inhibit light-matter interactions. Most theoretical derivations of fundamental radiative processes rely on energetic considerations and detailed balance equations, but not on momentum considerations. Because momentum exchange should also be incorporated into theoretical models, we investigate momentum inside the three categories of NZI materials, i.e., inside epsilon-and-mu-near-zero (EMNZ), epsilon-near-zero (ENZ) and mu-near-zero (MNZ) materials. In the context of Abraham–Minkowski debate in dispersive materials, we show that Minkowski-canonical momentum of light is zero inside all categories of NZI materials while Abraham-kinetic momentum of light is zero in ENZ and MNZ materials but nonzero inside EMNZ materials. We theoretically demonstrate that momentum recoil, transfer momentum from the field to the atom and Doppler shift are inhibited in NZI materials. Fundamental radiative processes inhibition is also explained due to those momentum considerations inside three-dimensional NZI materials. Absence of diffraction pattern in slits experiments is seen as a consequence of zero Minkowski momentum. Lastly, consequence on Heisenberg inequality, microscopy applications and on the canonical momentum as generator of translations are discussed. Those findings are appealing for a better understanding of fundamental light-matter interactions at the nanoscale as well as for lasing applications. | Michaël Lobet Iñigo Liberal Larissa Vertchenko Andrei VLavrinenko Nader Engheta Eric Mazur | 2022 | Light(Science & Applications)2022，11，8： | 1 |
| 9 | Effect of Cyclic Deformation on Pseudoelasticity Characteristics of Ti-Ni Alloys 显示文摘 | Miyazaki S Imai T Igo Y | 1986 | Metall Trans A1986，17，： | 1 |
| 10 | Near-Infrared Fluorescence Imaging as an Alternative to Bioluminescent Bacteria to Monitor Biomaterial-Associated Infections显示文摘 | Nina Dinjaski Suri Shalu Jaione Valle Susan M. Lehman I?igo Lasa María Auxiliadora Prieto Andrés J. García | 2014 | Acta Biomaterialia2014，，： | 1 |
| 11 | Immunization with 60-kD Ro peptide produces different stages of preclinical autoimmunity in a Sj(o)gren's syndrome model among multiple strains of inbred mice显示文摘 | Kurien BT Dsouza A Igoe A | 2013 | Clin Exp Immunol2013，173，： | 1 |
| 12 | Weathering and decay of granitic rocks:its relation to their pore network显示文摘 | I(N)IGO A C VICENTE M A RIVES V | | 0，，09： | 1 |
| 13 | Circadian variations of portalpressure and variceal hemorrhage in patients with cirrhosis显示文摘 | SIR IGO S BOLOND IL SOFIA S | 1994 | Hepatology1994，19，3： | 1 |
| 14 | Cell cycle arrest by transfor-ming growth factor beta1 enhances replication of respiratory syncytial vi-rus in lung epithelial cells显示文摘 | Gibbs J D Ornoff D M Igo H A | 2009 | J Virol2009，83，12： | 1 |
| 15 | In vitro validation of real-time three-dimensional color Doppler echocardiography for direct measurement of proximal isovelocity surface area in mitral regurgitation显示文摘 | Little SH Igo SR Pirat B | | 0，，10： | 1 |
| 16 | Tadalafil Enhances the Inhibitory Effects of Tamsulosin on Neurogenic Contractions of Human Prostate and Bladder Neck显示文摘 | Javier Angulo Pedro Cuevas Argentina Fernández José M. La Fuente Antonio Allona Ignacio Moncada I?igo Sáenz de Tejada | 2012 | The Journal of Sexual Medicine2012，，9： | 1 |
| 17 | Effect of thermal cycling on the transformation temperatures of Ti-Ni alloys显示文摘 | MIYAZAKI S IGO Y OTSUKA K | 1986 | Acta metal1986，34，10： | 1 |
| 18 | Ant colony system: A cooperative learning app roach to the traveling salesman problem显示文摘 | DOR IGO M GAMBARDELLA LM | 1997 | IEEE Transactions on Evolutionary Computation1997，1，1： | 1 |
| 19 | Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study 显示文摘 | Igo RP Jr Iyengar SK Nicholas SB | 2011 | 1 Am Nephol2011，33，5： | 1 |
| 20 | Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection显示文摘 | Castillo I Rodríguez-I(n)igo E Bartolomé J | | 0，，： | 1 |
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