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| 1 | Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy. | Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz | 2015 | World Journal of Stem Cells2015，7，4： | 6 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Adult bone marrow stromal stem cells express germline,ectodermal,endodermal,and mesodermal genes prior to neurogenesis显示文摘 | Woodbury D Reynolds K Black IB | 2002 | J Neurosci Res2002，69，： | 1 |
| 4 | C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodel- ing and clinical heart failure in survivors of myocardial infarction 显示文摘 | Kelly D Squire IB Khan SQ | 2008 | J Card Fail2008，14，9： | 1 |
| 5 | Primary probing for con- genital nasolacfimal duct obstruction with manually curved Bowman probes 显示文摘 | Serin D Buttanri IB Sevim MS | 2013 | Clin Ophthalmo12013，7，7： | 1 |
| 6 | C-terminal provasopressin(copeptin)is associated with left ventricular dysfunction,remodeling,and clinical heart failure in survivors of myocardial infarction显示文摘 | Kelly D Squire IB Khan SQ | 2008 | J Card Fail2008，14，9： | 1 |
| 7 | Adult rat and human bone marrow stromal stem cells differentiate into neurons 显示文摘 | Black IB Woodbury D | 2001 | Blood Cells Mol Dis2001，27，3： | 1 |
| 8 | Short-term effects of polyphenol-rich black tea on blood pressure in men and women显示文摘 | Hodgson JM Woodman RJ Puddey IB Mulder T Fuchs D Croft KD | | 0，，： | 1 |
| 9 | The efficacy of the combined procedure in involutional entropion surgery:a comparative study 显示文摘 | Serin D Buttanri IB Karslioglu S | 2013 | Korean J Ophthalmol2013，27，6： | 1 |
| 10 | Adult rat and human bone marrow stromal stem cells differentiate into neurons显示文摘 | Black IB Woodbury D | 2001 | Blood Cells Mol Dis2001，27，8： | 1 |
| 11 | Adult rat and human bone marrow stromal cells differentiate into neurons显示文摘 | Woodbury D Prockop DJ Black IB | 2000 | Neurosci Res2000，61，3： | 1 |
| 12 | Intensive care syndrome:A literature review显示文摘 | Granberg A Engberg IB Lundberg D | 1996 | Intensive Crit Care Nurs1996，12，： | 1 |
| 13 | C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction,remode- ling, and clinical heart failure in survivors of myocardial infarction 显示文摘 | Kelly D Squire IB Khan SQ | 2008 | J Card Fail2008，14，9： | 1 |
| 14 | Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysis 显示文摘 | Ruige IB Mahmoud AM De Bacquer D | 2011 | Heart2011，97，11： | 1 |
| 15 | Intensive care syndrome: a literature review显示文摘 | Granberg A Engberg IB Lundberg D | 1996 | Intensive Crit Care Nurs1996，12，3： | 1 |
| 16 | Adult rat and human bone marrow stromal stem cells differentiate into neurons 显示文摘 | Black IB Woodbury D | 2001 | Blood Cells Mol Dis2001，27，3： | 1 |
| 17 | Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA 显示文摘 | Baxler D Mcinnes IB | 2012 | Immunol CellBio2012，90，3： | 1 |
| 18 | Gastrin and somatostatin in Helicobacter pylori infected antral nucosa显示文摘 | Moss D Petersen HD Andersen IB | 2004 | Gut2004，45，5： | 1 |
| 19 | Adult rat and human bone marrow stromal stem cells differentiate into neurons显示文摘 | Iblack IB Woodbury D | 2001 | Blood Cells Mol Dis2001，27，3： | 1 |
| 20 | Adult rat and human bone marrow stromal stem cells differentiate into neurons显示文摘 | Black IB Woodbury D | 2001 | Blood cells Mol Dis2001，27，3： | 1 |
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