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| 1 | STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer显示文摘 | Dimitrios Iliopoulos Savina A. Jaeger Heather A. Hirsch Martha L. Bulyk Kevin Struhl | 2010 | Molecular Cell2010，，4： | 5 |
| 2 | An unclassified tibial plateau fracture: Reverse Schatzker type Ⅳ显示文摘 | Tien Yeoh Efthymios Iliopoulos Alex Trompeter | 2018 | Chinese Journal of Traumatology2018，21，4： | 5 |
| 3 | E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer显示文摘 | Fabio Petrocca Rosa Visone Mariadele Rapazzotti Onelli Manisha H. Shah Milena S. Nicoloso Ivana de Martino Dimitrios Iliopoulos Emanuela Pilozzi Chang-Gong Liu Massimo Negrini Luigi Cavazzini Stefano Volinia Hansjuerg Alder Luigi P. Ruco Gustavo Baldassar | 2008 | Cancer Cell2008，，3： | 4 |
| 4 | Posterior shoulder fracture-dislocation:A systematic review of the literature and current aspects of management显示文摘Purpose Posterior fracture-dislocation of shoulder is an infrequent traumatic event;however,most orthopaedic surgeons may face the challenge of treating it.The aim of this study is to review and summarise systematically the current principles of the management of this complex injury,and create a treatment algorithm.Methods Both PubMed and Scopus Databases were systematically searched for the terms“posterior shoulder fracture-dislocation”or“posterior glenohumeral fracture-dislocation”or“posterior glenoid fracture-dislocation”for articles written in English and published in the last decade.Results A total of 900 articles were identified,of which 13 were retained for analysis.A total of 153 patients(161 shoulders)were identified.These patients were treated either with open reduction and internal fixation,modified McLaughlin procedure,allograft/autograft humeral head reconstruction or shoulder arthroplasty.The mean age was 40.15 years.The mean postoperative Constant score in cases treated by open reduction and internal fixation was 86.45,whereas by bone graft was 84.18.Further,the mean postoperative Constant score was between 79.6 and 67.1 in those that were managed by modified McLaughlin and arthroplasty procedure,respectively.Conclusion The management of posterior shoulder fracture-dislocation may be challenging,and the best surgical option depends on many variables such as the chronicity of the injury,the presence of a fracture at the level of the surgical neck or tuberosities and the extend of the Hill-Sachs lesion if any.A treatment algorithm is proposed,based on the current literature in an effort to create a consensus for these injuries.For the acute shoulder fracture-dislocations,an open reduction should be performed.For the chronic fracture/dislocations in the elderly low-demand patients,conservative treatment should be performed.For the rest of the patients,depending on the severity of the Hill-Sachs lesion different surgical options are available such as the McLaughlin technique,the use of an allograft,osteotomy or arthroplasty. | Georgios Paparoidamis Efthymios Iliopoulos AAli Narvani Ofer Levy Eleftherios Tsiridis loannis Polyzois | 2021 | Chinese Journal of Traumatology2021，24，1： | 3 |
| 5 | An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation显示文摘 | Dimitrios Iliopoulos Heather A. Hirsch Kevin Struhl | 2009 | Cell2009，，： | 2 |
| 6 | X盒结合蛋白1在三阴性乳腺癌发生和发展中的重要作用显示文摘肿瘤微环境不同于正常组织的生理环境,其表现为低氧、低糖及炎性细胞浸润等,而肿瘤细胞如何在这种不利细胞生长的条件下生存呢?最近康奈尔大学的Glimcher教授发表在Nature上的论文表明,在低氧条件下,三阴性乳腺癌(triple negative breast cancer,TNBC)细胞内质网应激反应信号通路中的内质网跨膜蛋白肌醇酶1α(inositol-requiring enzyme 1α,IRE1α)、内质网类似激酶(PKR like ER kinase,PERK)被活化,活化的IREa1、PERK通过剪切X-盒结合蛋白1(X-box binding protein 1,XBP1)mRNA产生剪切体XBP1s,XBP1s和另外一个低氧诱导的转录因子缺氧诱导因子1a(hypoxia-inducible factor-1a,HIF1a)在细胞核内结合,协同HIF1a的目的基因转录,促进三阴性肿瘤细胞的生长和复发。 | 谈勤春(摘译) 刘秋燕(审阅) Chen X Iliopoulos D Zhang Q | 2014 | 中国肿瘤生物治疗杂志2014，21，4： | 2 |
| 7 | Novel approaches for the treatment of ventricular tachycardia显示文摘Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications. | Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis | 2018 | World Journal of Cardiology2018，10，7： | 2 |
| 8 | MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis显示文摘 | Georgios Koukos Christos Polytarchou Jess L. Kaplan Alessio Morley–Fletcher Beatriz Gras–Miralles Efi Kokkotou Mariah Baril–Dore Charalabos Pothoulakis Harland S. Winter Dimitrios Iliopoulos | 2013 | Gastroenterology2013，，： | 2 |
| 9 | MicroRNA-124 Regulates STAT3 Expression and is Downregulated in Colon Tissues of Pediatric Patients with Ulcerative Colitis显示文摘 | Georgios Koukos Christos Polytarchou Jess L. Kaplan Alessio Morley-Fletcher Beatriz Gras-Miralles Efi Kokkotou Mariah Baril-Dore Charalabos Pothoulakis harland s. Winter Dimitrios Iliopoulos | 2013 | Gastroenterology2013，，： | 2 |
| 10 | Helicobacter pylori seroprevalence in patients with chronic obstructive pulmonary disease显示文摘 | Anastasios Roussos Nikiforos Philippou Vasiliki Krietsepi Evgenia Anastasakou Dionissia Alepopoulou Panagiotis Koursarakos Irineos Iliopoulos Konstantinos Gourgoulianis | 2004 | Respiratory Medicine2004，，3： | 2 |
| 11 | Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oneogenesis progression 显示文摘 | ILIOPOULOS D OIKONOMOU P MESSINIS I | 2009 | Oneol Rep2009，22，1： | 1 |
| 12 | STAT3 activation of miR -21 and miR - 181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer 显示文摘 | Iliopoulos D Jaeger SA Hirsch HA | 2010 | Mol Cell2010，39，4： | 1 |
| 13 | Lipoprotein (a) in plasma,arterial wall,and thrombus from patients with aortic aneurysm显示文摘 | Papagrigorakis E Iliopoulos D Asimacopoulos PJ | 1997 | Clin Genet1997，52，： | 1 |
| 14 | Loss of miR-200 inhibition of Suz12 leads to poly- comb-mediated repression required for the formation and ma intenance of cancer stem cells显示文摘 | ILIOPOULOS D LINDAHL ALLEN M POLYTARCHOU C | 2010 | Mol Ce112010，39，76： | 1 |
| 15 | Metformin inhibits the inflammatory re- sponse associated with cellular transformation and cancer stem cell growth显示文摘 | Hirsch HA Iliopoulos Struhl K | 2013 | Proceedings of the National Academy of Sciences of the Unit- ed States of America2013，110，3： | 1 |
| 16 | Loss of miR- 200 inhibition of Suzl2 leads to poly comb-mediated repression required for the formation and maintenance of cancer stem cells显示文摘 | Iliopoulos D Lindahl-Allen M Polytarchou C | 2010 | Mol Cell2010，39，5： | 1 |
| 17 | An epigenetic switch invol-ving NF-κB,lin 28,let-7 microRNA,and IL6 links inflamma-tion to cell transformation显示文摘 | Iliopoulos D Hirsch HA Struhl K | 2009 | Cell2009，139，4： | 1 |
| 18 | Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel - Lindau tumor suppressor gene 显示文摘 | Levy AP Levy NS Iliopoulos O | 1997 | Kidney Int1997，51，2： | 1 |
| 19 | Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer 显示文摘 | Iliopoulos D Guler G Han SY | 2005 | Oncogene2005，24，9： | 1 |
| 20 | Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor Growth and prolong remission 显示文摘 | Hirsch HA Iliopoulos D Tsichlis PN | 2009 | Cancer Res2009，69，19： | 1 |
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