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| 1 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 2 | Advances in Hard Tissue Engineering Materials——Nanocellulose-based Composites显示文摘Nanocellulose(NC) has attracted much interest in the tissue engineering(TE) field because of its properties including biocompatibility,renewability, non-toxicity, functionality, and excellent mechanical performance. This review mainly focused on the advanced applications of NC-based composites in hard TE including cartilage TE, bone TE, and dental TE, illustrated the processing methods for synthesizing scaffolds including electrospinning, freeze-drying, and 3 D printing, reviewed the current status of hard TE, and presented perspective on the future of TE technology. | HuiZe Luo JuanJuan Li FengShan Zhou | 2018 | Paper And Biomaterials2018，3，4： | 10 |
| 3 | Local and long-range transport influences on PM_(2.5) at a cities-cluster in northern China,during summer 2008显示文摘Hourly PM2.5 concentrations were observed simultaneously at a cities-cluster comprising 10 cities/towns in Hebei province in China from July 1 to 31,2008. Among the 10 cities/towns, Baoding showed the highest average concentration level(161.57(jig/m3) and Yanjiao exhibited the lowest(99.35(jig/m3). These observed data were also studied using the joint potential source contribution function with 24-h and72-h backward trajectories, to identify more clearly the local and countrywide-scale long-range transport sources. For the local sources, three important influential areas were found, whereas five important influential areas were defined for long-range transport sources. Spatial characteristics of PM2.5 were determined by multivariate statistical analyses. Soil dust, coal combustion, and vehicle emissions might be the potential contributors in these areas. The results of a hierarchical cluster analysis for back trajectory endpoints and PM2.5 concentrations datasets show that the spatial characteristics of PM2.5 in the cities-cluster were influenced not only by local sources, but also by long-range transport sources. Different cities in the cities-cluster obtained different weighted contributions from local or long-range transport sources. Cangzhou, Shijiazhuang, and Baoding are near the source areas in the south of Hebei province,whereas Zhuozhou, Yangfang, Yanjiao, Xianghe, and Langfang are close to the sources areas near Beijing and Tianjin. | Lijie Gao Yingze Tian Caiyan Zhang Guoliang Shi Huize Hao Fang Zeng Chunli Shi Meigen Zhang Yinchang Feng Xiang Li | 2014 | Particuology2014，12，2： | 9 |
| 4 | Find and replace: editing human genome in pluripotent stem cells显示文摘Genetic manipulation of human pluripotent stem cells(hPSCs)provides a powerful tool for modeling diseases and developing future medicine.Recently a number of independent genome-editing techniques were developed,including plasmid,bacterial artificial chromosome,adeno-associated virus vector,zinc finger nuclease,transcription activator-like effecter nuclease,and helper-dependent adenoviral vector.Gene editing has been successfully employed in different aspects of stem cell research such as gene correction,mutation knock-in,and establishment of reporter cell lines(Raya et al.,2009;Howden et al.,2011;Li et al.,2011;Liu et al.,2011b;Papapetrou et al.,2011;Sebastiano et al.,2011;Soldner et al.,2011;Zou et al.,2011a).These techniques combined with the utility of hPSCs will significantly influence the area of regenerative medicine. | Huize Pan Weiqi Zhang Weizhou Zhang Guang-Hui Liu | 2011 | Protein & Cell2011，2，12： | 6 |
| 5 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 6 | Adiabatic Shear Mechanisms for the Hard Cutting Process显示文摘The most important consequence of adiabatic shear phenomenon is formation of sawtooth chip. Lots of scholars focused on the formation mechanism of sawtooth, and the research often depended on experimental approach. For the present, the mechanism of sawtooth chip formation still remains some ambiguous aspects. This study develops a combined numerical and experimental approach to get deeper understanding of sawtooth chip formation mechanism for Polycrystalline Cubic Boron Nitride(PCBN) tools orthogonal cutting hard steel GCr15. By adopting the Johnson-Cook material constitutive equations, the FEM simulation model established in this research effectively overcomes serious element distortions and cell singularity in high strain domain caused by large material deformation, and the adiabatic shear phenomenon is simulated successfully. Both the formation mechanism and process of sawtooth are simulated. Also, the change features regarding the cutting force as well as its effects on temperature are studied. More specifically, the contact of sawtooth formation frequency with cutting force fluctuation frequency is established. The cutting force and effect of cutting temperature on mechanism of adiabatic shear are investigated. Furthermore, the effects of the cutting condition on sawtooth chip formation are researched. The researching results show that cutting feed has the most important effect on sawtooth chip formation compared with cutting depth and speed. This research contributes a better understanding of mechanism, feature of chip formation in hard turning process, and supplies theoretical basis for the optimization of hard cutting process parameters. | YUE Caixu WANG Bo LIU Xianli FENG Huize CAI Chunbin | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 4 |
| 7 | Pathways and assays for DNA double-strand break repair by homologous recombination显示文摘Double strand breaks(DSBs)are the most detrimental type of DNA damage that must be repaired to ensure genome integrity and cell survival.Unrepaired or improperly repaired DSBs can potentially cause tumorigenesis or cell death.DSBs are primarily repaired by non-homologous end joining or homologous recombination(HR).The HR pathway is initiated by processing of the 5′-end of DSBs to generate 3′-end single-strand DNA(ssDNA).Furthermore,the intermediate is channeled to one of the HR sub-pathways,including:(i)double Holliday junction(dHJ)pathway,(ii)synthesis-dependent strand annealing(SDSA),(iii)break-induced replication(BIR),and(iv)single-strand annealing(SSA).In the dHJ sub-pathway,the 3′-ssDNA coated with Rad51 recombinase performs homology search and strand invasion,forming a displacement loop(D-loop).Capture of the second end by the D-loop generates a dHJ intermediate that is subsequently dissolved by DNA helicase or resolved by nucleases,producing non-crossover or crossover products.In SDSA,the newly synthesized strand is displaced from the D-loop and anneals to the end on the other side of the DSBs,producing non-crossovers.In contrast,BIR repairs one-end DSBs by copying the sequence up to the end of the template chromosome,resulting in translocation or loss of heterozygosity.SSA takes place when resection reveals flanking homologous repeats that can anneal,leading to deletion of the intervening sequences.A variety of reporter assays have been developed to monitor distinct HR sub-pathways in both Saccharomyces cerevisiae and mammals.Here,we summarize the principles and representative assays for different HR sub-pathways with an emphasis on the studies in the budding yeast. | Jinbao Li Huize Sun Yulin Huang Yali Wang Yuyan Liu Xuefeng Chen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 2 |
| 8 | Optic atrophies in metabolic disorders显示文摘 | Huizing M Brooks BP Anikster Y | 2005 | Mol Genet Metab2005，86，12： | 1 |
| 9 | Pharmacokinetics of paclitaxel and metabolism in a randomized comparative study in platinum-pretreated ovarian cancer patients显示文摘 | Huizing Anther CF | 1993 | J Clin Oncol1993，11，11： | 1 |
| 10 | Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients显示文摘 | Huizing MT Panday VR | 1999 | Br J Cancer1999，81，2： | 1 |
| 11 | High-performance liquid chromatographic procedures for the quantitative determination of paelitaxel (Taxol) in human urine显示文摘 | Huizing MT Rosing H Koopman F | 1995 | J Chromatogr A1995，664，4： | 1 |
| 12 | Transformation of the cultivated mushroom,Agaricus bisporus, to hygromycin B resistance显示文摘 | M. D. Rhee P. M. A. Gra?a H. J. Huizing H. Mooibroek | 1996 | MGG Molecular & General Genetics1996，，3： | 1 |
| 13 | Prognostic significance of oncogenic markers in ductal carcinoma in situ of the breast:a clinicopathologic study显示文摘 | Altintas S Lambein K Huizing MT | 2009 | Breast J2009，15，2： | 1 |
| 14 | Treatment of inferior turbinate pathology:A review and critical evaluation of the different techniques显示文摘 | Hol MK Huizing EH | 2000 | Rhinology2000，38，： | 1 |
| 15 | Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics显示文摘 | Huizing M Helip-Wooley A Westbroek W | 2008 | Annu Rev Genomies Hum Genet2008，9，： | 1 |
| 16 | Hermansky - Pudlak syndrome type 3 in Ashkenazi Jews and other non- Puerto Rican patients with hypopigmentation and platelet storage - pool deficiency显示文摘 | Huizing M Anikster Y Fitzpatrick DL | 2001 | AmJ Hum Genet2001，69，： | 1 |
| 17 | The Gne M712T Mouse as a Model for Human Glomerulopathy显示文摘 | Sravan Kakani Tal Yardeni Justin Poling Carla Ciccone Terren Niethamer Enriko D. Klootwijk Irini Manoli Daniel Darvish Shelley Hoogstraten-Miller Patricia Zerfas E. Tian Kelly G. Ten Hagen Jeffrey B. Kopp William A. Gahl Marjan Huizing | 2012 | The American Journal of Pathology2012，，4： | 1 |
| 18 | Hermansky - Pudlak syndrome type 4 (HPS- 4): clinical and molecular characteristics显示文摘 | Anderson PD Huizing M Claassen DA | 2003 | Hum Genet2003，113，： | 1 |
| 19 | Dos-finding and sequencing stuty of paclitaxel and carboplatin in non-small cell lung cancer显示文摘 | Huizing M Postmus PE | 1995 | Semin Oncol1995，22，49： | 1 |
| 20 | Hermansky-Pudlak syndrome type 1:gene organization,novel mutations,and clinical-molecular review of non-Puerto Rican cases显示文摘 | Hermos CR Huizing M Kaiser-Kupfer MI | 2002 | Hum Mutat2002，20，6： | 1 |
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