共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DNA damage repair:historical perspectives,mechanistic pathways and clinical translation for targeted cancer therapy显示文摘Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage.The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.However,the adverse effects including normal tissues injury are also accompanied by the radiotherapy and chemotherapy.Targeted cancer therapy has the potential to suppress cancer cells'DNA damage response through tailoring therapy to cancer patients lacking specific DNA damage response functions.Obviously,understanding the broader role of DNA damage repair in cancers has became a basic and attractive strategy for targeted cancer therapy,in particular,raising novel hypothesis or theory in this field on the basis of previous scientists'findings would be important for future promising druggable emerging targets.In this review,we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed,then we summarize the mechanisms regarding DNA damage repair associated with targeted cancer therapy,highlighting the specific proteins behind targeting DNA damage repair that initiate functioning abnormally duo to extrinsic harm by environmental DNA damage factors,also,the DNA damage baseline drift leads to the harmful intrinsic targeted cancer therapy.In addition,clinical therapeutic drugs for DNA damage and repair including therapeutic effects,as well as the strategy and scheme of relative clinical trials were intensive discussed.Based on this background,we suggest two hypotheses,namely'environmental gear selection”to describe DNA damage repair pathway evolution,and'DNA damage baseline drift”,which may play a magnified role in mediating repair during cancer treatment.This two new hypothesis would shed new light on targeted cancer therapy,provide a much better or more comprehensive holistic view and also promote the development of new research direction and new overcoming strategies for patients. | Ruixue Huang Ping-Kun Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 6 |
| 2 | 活性氧在肾癌中的研究进展显示文摘活性氧(ROS)是细胞内一类氧的单电子还原产物,具有很高的氧化性,能参与细胞内多种生命活动,且与肾癌的发生发展和治疗有很大关系。诱导凋亡、自噬和周期阻滞的发生是目前治疗癌症的常规机制,而在肾癌中ROS又与其有着密切联系。放疗在以往肾癌的治疗中并不常见,调节ROS结合放疗是一种新的治疗手段。本文将对ROS在肾癌细胞的凋亡、自噬、细胞周期阻滞和放化疗过程中所起的作用以及靶向ROS所面临的困难进行综述。 | 何灼彬 罗帆 梁凯轩 叶木石 | 2024 | 临床医学研究与实践2024，9，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员