|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B显示文摘250 million people worldwide continue to be chronically infected with the virus.While patients may be treated with nucleoside/nucleotide analogues,this only suppresses HBV titre to sub-detection levels without eliminating the persistent HBV covalently closed circular DNA(cccDNA)genome.As a result,HBV infection cannot be cured,and the virus reactivates when conditions are favorable.Interferons(IFNs)are cytokines known to induce powerful antiviral mechanisms that clear viruses from infected cells.They have been shown to induce cccDNA clearance,but their use in the treatment of HBV infection is limited as HBVtargeting immune cells are exhausted and HBV has evolved multiple mechanisms to evade and suppress IFN signalling.Thus,to fully utilize IFN-mediated intracellular mechanisms to effectively eliminate HBV,instead of direct IFN administration,novel strategies to sustain IFN-mediated anti-cccDNA and antiviral mechanisms need to be developed.This review will consolidate what is known about how IFNs act to achieve its intracellular antiviral effects and highlight the critical interferon-stimulated gene targets and effector mechanisms with potent anti-cccDNA functions.These include cccDNA degradation by APOBECs and cccDNA silencing and transcription repression by epigenetic modifications.In addition,the mechanisms that HBV employs to disrupt IFN signalling will be discussed.Drugs that have been developed or are in the pipeline for components of the IFN signalling pathway and HBV targets that detract IFN signalling mechanisms will also be identified and discussed for utility in the treatment of HBV infections.Together,these will provide useful insights into design strategies that specifically target cccDNA for the eradication of HBV. | Zhi Yi Goh Ee Chee Ren Hui Ling Ko | 2021 | World Journal of Gastroenterology2021，27，14： | 5 |
| 2 | OPERATIONAL TROPICAL CYCLONE FORECAST VERIFICATION PRACTICE IN THE WESTERN NORTH PACIFIC REGION显示文摘This paper summarizes results of a survey of the operational status of tropical cyclone(TC) forecast verifi-cation in the western North Pacific region, covering the Members of the ESCAP/WMO Typhoon Committee, RSMC Tokyo-Typhoon Center, and JTWC. Results of the survey indicate that significant efforts have been focused on the verification of TC forecast guidance by operational forecast agencies in the region, either individually or through international cooperation. A variety of TC forecast verification products are available to the forecasters in either real time or in post-season through multiple means, with the main focus on the deterministic track and intensity forecasts. Only a few verification products are available for probabilistic forecasts. Verification of TC precipitation and high wind forecasts are also lacking sufficient attention in the region. It would be helpful in the future to focus more attention toward these aspects and incorporate methods that will provide a greater depth of information regarding the TC forecast performance. | HUI YU SAI TICK CHAN BARBARA BROWN MASASHI KUNITSUGU EDWARD FUKADA SANGWOOK PARK WOOJEONG LEE YINGLONG XU PEOU PHALLA BOUNTEUMSYSOUPHANTHAVONG SAU WA CHANG CHE GAYAH ISMAIL RENITO BPACIENTE PATRICIA EE CHAMNONG KAEOCHADA HOA VO VAN | 2012 | Tropical Cyclone Research and Review2012，1，3： | 3 |
| 3 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 4 | CharaCterization of the 'deqi' response in acupuncture显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Altern Med2007，，7： | 1 |
| 5 | Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro 显示文摘 | March S Hui EE Underhill GH | 2009 | Hepatology2009，50，3： | 1 |
| 6 | Characterization of the 'deqi' response in acupuncture显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Altem Med2007，7，1： | 1 |
| 7 | MR renography using a dynamic gradient-echo sequence and low-dose gadopentetate dimeglumine as an alternative to radionuclide renegraphy显示文摘 | Hui Seong The Ee Sin Ang Weng Cheong Wong | 2003 | AJR2003，181，： | 1 |
| 8 | Characterization of the deqi re- sponse in acupuncture 显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Ahem Med2007，317，： | 1 |
| 9 | Information technology (IT) investment and the role of a firm: an exploratory study显示文摘 | Thompson S.H. Teo Poh Kam Wong Ee Hui Chia | 2000 | International Journal of Information Management2000，，4： | 1 |
| 10 | Information technology investment and the role of a firm : an exploratory study 显示文摘 | Thompson S H Teo Poh Kam Wong Ee Hui Chia | 2000 | International Journal of Information Management2000，，20： | 1 |
| 11 | Characterization of the ' deqi' response in acupuncture 显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Altern Med2007，7，： | 1 |
| 12 | Characterization of the' deqi' response in acupuncture 显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Altern Med2007，7，7： | 1 |
| 13 | Micreenvironmental regula- tion of the sinusoidal endothelial cell phenotype in v/tro显示文摘 | March S Hui EE Underhill GH | 2009 | Hepatol- ogy2009，50，3： | 1 |
| 14 | Systemic approach to improving treat- ment outcome in nasopharyngeal carcinoma : current and future directions 显示文摘 | Ma EE Hui EP Chan AT | 2008 | Cancer Sci2008，99，7： | 1 |
| 15 | Micromechanical control of cell-cell interactions 显示文摘 | Hui EE Bhatia SN | 2007 | Proc Natl Acad Sci U S A2007，104，14： | 1 |
| 16 | Characterization of the'de qi'response in acupuncture显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Altern Med2007，7，1： | 1 |
| 17 | Characterization of the 'deqi' response in acupuneture显示文摘 | Hui KK Nixon EE Vangel MG | 2007 | BMC Complement Ahem Med2007，，7： | 1 |
| 18 | Equity,Resilience,and Achievements in High Performing Asian Education Systems显示文摘In the latest 2012 PISA results,the top performers were all Asian countries and regions.Common among these high performing education systems is the emergence of quality improvement in education as a means of achieving equity.This replaces the conventional focus on system inputs in education mainly influenced by the economic and sociological beliefs of the time,based on the human capital theory and the compensatory theory for the disadvantaged as a means of rectifying inequities. | Wing-On LEE Chenri HUI LOW Ee Ling | 2016 | Frontiers of Education in China2016，11，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员